SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module, putative

Species:

Leishmania braziliensis

UniProt:

A4HEF0_LEIBR

TriTrypDb:

LbrM.25.2070 , LBRM2903_250023200

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HEF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEF0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0045292	mRNA cis splicing, via spliceosome	9	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.528
CLV_C14_Caspase3-7	85	89	PF00656	0.647
CLV_NRD_NRD_1	136	138	PF00675	0.659
CLV_NRD_NRD_1	150	152	PF00675	0.566
CLV_NRD_NRD_1	215	217	PF00675	0.339
CLV_NRD_NRD_1	257	259	PF00675	0.427
CLV_NRD_NRD_1	33	35	PF00675	0.442
CLV_PCSK_KEX2_1	123	125	PF00082	0.529
CLV_PCSK_KEX2_1	136	138	PF00082	0.659
CLV_PCSK_KEX2_1	215	217	PF00082	0.459
CLV_PCSK_KEX2_1	256	258	PF00082	0.427
CLV_PCSK_KEX2_1	33	35	PF00082	0.453
CLV_PCSK_KEX2_1	379	381	PF00082	0.649
CLV_PCSK_KEX2_1	48	50	PF00082	0.456
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.435
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.649
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.443
CLV_PCSK_SKI1_1	215	219	PF00082	0.392
CLV_PCSK_SKI1_1	248	252	PF00082	0.419
CLV_PCSK_SKI1_1	258	262	PF00082	0.407
CLV_Separin_Metazoa	126	130	PF03568	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.691
DEG_SPOP_SBC_1	165	169	PF00917	0.535
DEG_SPOP_SBC_1	315	319	PF00917	0.676
DEG_SPOP_SBC_1	356	360	PF00917	0.690
DEG_SPOP_SBC_1	99	103	PF00917	0.558
DOC_CKS1_1	332	337	PF01111	0.493
DOC_CYCLIN_RxL_1	213	224	PF00134	0.579
DOC_MAPK_gen_1	151	158	PF00069	0.562
DOC_MAPK_gen_1	280	289	PF00069	0.580
DOC_MAPK_gen_1	48	55	PF00069	0.411
DOC_PP1_RVXF_1	214	221	PF00149	0.468
DOC_PP1_RVXF_1	268	274	PF00149	0.428
DOC_PP2B_LxvP_1	351	354	PF13499	0.563
DOC_PP4_FxxP_1	311	314	PF00568	0.719
DOC_USP7_MATH_1	315	319	PF00917	0.720
DOC_USP7_MATH_1	337	341	PF00917	0.659
DOC_USP7_MATH_1	356	360	PF00917	0.744
DOC_USP7_UBL2_3	119	123	PF12436	0.424
DOC_USP7_UBL2_3	175	179	PF12436	0.431
DOC_WW_Pin1_4	310	315	PF00397	0.704
DOC_WW_Pin1_4	331	336	PF00397	0.680
LIG_14-3-3_CanoR_1	215	221	PF00244	0.551
LIG_14-3-3_CanoR_1	270	276	PF00244	0.591
LIG_14-3-3_CanoR_1	283	289	PF00244	0.622
LIG_AP2alpha_2	141	143	PF02296	0.489
LIG_BRCT_BRCA1_1	312	316	PF00533	0.476
LIG_BRCT_BRCA1_1	357	361	PF00533	0.725
LIG_BRCT_BRCA1_1	57	61	PF00533	0.480
LIG_CtBP_PxDLS_1	14	20	PF00389	0.425
LIG_eIF4E_1	365	371	PF01652	0.683
LIG_FHA_1	103	109	PF00498	0.521
LIG_FHA_1	153	159	PF00498	0.521
LIG_FHA_1	279	285	PF00498	0.576
LIG_FHA_1	328	334	PF00498	0.580
LIG_FHA_1	55	61	PF00498	0.505
LIG_FHA_1	7	13	PF00498	0.395
LIG_FHA_2	129	135	PF00498	0.571
LIG_FHA_2	225	231	PF00498	0.510
LIG_FHA_2	239	245	PF00498	0.310
LIG_FHA_2	261	267	PF00498	0.442
LIG_LIR_Apic_2	310	314	PF02991	0.577
LIG_LIR_Gen_1	274	284	PF02991	0.399
LIG_LIR_Nem_3	212	217	PF02991	0.514
LIG_LIR_Nem_3	274	279	PF02991	0.403
LIG_LIR_Nem_3	358	364	PF02991	0.604
LIG_LIR_Nem_3	58	64	PF02991	0.374
LIG_MYND_1	76	80	PF01753	0.501
LIG_PCNA_yPIPBox_3	268	279	PF02747	0.563
LIG_Pex14_2	61	65	PF04695	0.341
LIG_PTB_Apo_2	188	195	PF02174	0.478
LIG_RPA_C_Fungi	22	34	PF08784	0.452
LIG_SH2_CRK	214	218	PF00017	0.363
LIG_SH2_NCK_1	249	253	PF00017	0.386
LIG_SH2_STAP1	172	176	PF00017	0.360
LIG_SH2_STAP1	249	253	PF00017	0.386
LIG_SH2_STAP1	347	351	PF00017	0.498
LIG_SH2_STAT5	138	141	PF00017	0.484
LIG_SH2_STAT5	172	175	PF00017	0.281
LIG_SH2_STAT5	237	240	PF00017	0.472
LIG_SH2_STAT5	64	67	PF00017	0.374
LIG_SH3_3	326	332	PF00018	0.705
LIG_SH3_3	77	83	PF00018	0.591
LIG_SH3_3	9	15	PF00018	0.413
LIG_SUMO_SIM_par_1	154	159	PF11976	0.496
LIG_TRAF2_1	263	266	PF00917	0.448
LIG_WRC_WIRS_1	217	222	PF05994	0.341
LIG_WRC_WIRS_1	279	284	PF05994	0.491
MOD_CK1_1	318	324	PF00069	0.587
MOD_CK1_1	340	346	PF00069	0.562
MOD_CK1_1	67	73	PF00069	0.506
MOD_CK2_1	128	134	PF00069	0.655
MOD_CK2_1	216	222	PF00069	0.509
MOD_CK2_1	224	230	PF00069	0.482
MOD_CK2_1	238	244	PF00069	0.336
MOD_CK2_1	260	266	PF00069	0.455
MOD_Cter_Amidation	377	380	PF01082	0.740
MOD_GlcNHglycan	28	31	PF01048	0.466
MOD_GlcNHglycan	339	342	PF01048	0.599
MOD_GSK3_1	108	115	PF00069	0.630
MOD_GSK3_1	152	159	PF00069	0.559
MOD_GSK3_1	166	173	PF00069	0.411
MOD_GSK3_1	274	281	PF00069	0.503
MOD_GSK3_1	310	317	PF00069	0.643
MOD_GSK3_1	327	334	PF00069	0.486
MOD_GSK3_1	337	344	PF00069	0.669
MOD_GSK3_1	98	105	PF00069	0.624
MOD_N-GLC_1	307	312	PF02516	0.517
MOD_NEK2_1	112	117	PF00069	0.686
MOD_NEK2_1	166	171	PF00069	0.285
MOD_NEK2_1	210	215	PF00069	0.295
MOD_NEK2_1	238	243	PF00069	0.518
MOD_NEK2_1	271	276	PF00069	0.561
MOD_NEK2_1	316	321	PF00069	0.635
MOD_NEK2_1	366	371	PF00069	0.577
MOD_NEK2_1	43	48	PF00069	0.514
MOD_NEK2_1	54	59	PF00069	0.282
MOD_PIKK_1	231	237	PF00454	0.460
MOD_PKA_2	128	134	PF00069	0.572
MOD_PKA_2	26	32	PF00069	0.533
MOD_PKA_2	282	288	PF00069	0.558
MOD_Plk_1	156	162	PF00069	0.526
MOD_Plk_1	307	313	PF00069	0.682
MOD_Plk_1	55	61	PF00069	0.374
MOD_Plk_4	233	239	PF00069	0.488
MOD_Plk_4	307	313	PF00069	0.648
MOD_Plk_4	366	372	PF00069	0.577
MOD_Plk_4	6	12	PF00069	0.636
MOD_ProDKin_1	310	316	PF00069	0.706
MOD_ProDKin_1	331	337	PF00069	0.680
MOD_SUMO_for_1	122	125	PF00179	0.408
MOD_SUMO_rev_2	148	153	PF00179	0.630
MOD_SUMO_rev_2	84	89	PF00179	0.602
TRG_ENDOCYTIC_2	214	217	PF00928	0.389
TRG_ER_diArg_1	136	138	PF00400	0.668
TRG_ER_diArg_1	214	216	PF00400	0.441
TRG_ER_diArg_1	256	258	PF00400	0.521
TRG_ER_diArg_1	267	270	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXM6	Leptomonas seymouri	71%	100%
A0A0S4IPX0	Bodo saltans	36%	86%
A0A1X0NNP0	Trypanosomatidae	44%	80%
A0A3R7KXN8	Trypanosoma rangeli	48%	88%
A0A3S7WZ46	Leishmania donovani	88%	100%
A4I1I4	Leishmania infantum	88%	100%
C9ZJY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AXL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9V3	Leishmania major	88%	100%
V5BCN7	Trypanosoma cruzi	46%	81%