DNA polymerase delta subunit 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase delta subunit 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HEE9_LEIBR

TriTrypDb:

LbrM.25.2060 , LBRM2903_250023300

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0043625	delta DNA polymerase complex	3	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

A4HEE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEE9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0022616	DNA strand elongation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	8
GO:0003887	DNA-directed DNA polymerase activity	5	8
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034061	DNA polymerase activity	4	8
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.419
CLV_NRD_NRD_1	37	39	PF00675	0.361
CLV_PCSK_KEX2_1	37	39	PF00082	0.362
CLV_PCSK_SKI1_1	146	150	PF00082	0.338
CLV_PCSK_SKI1_1	179	183	PF00082	0.451
CLV_PCSK_SKI1_1	276	280	PF00082	0.318
CLV_PCSK_SKI1_1	37	41	PF00082	0.360
CLV_PCSK_SKI1_1	472	476	PF00082	0.509
CLV_PCSK_SKI1_1	512	516	PF00082	0.428
CLV_PCSK_SKI1_1	56	60	PF00082	0.297
CLV_Separin_Metazoa	71	75	PF03568	0.338
DEG_APCC_DBOX_1	145	153	PF00400	0.319
DEG_APCC_DBOX_1	229	237	PF00400	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.309
DOC_CKS1_1	455	460	PF01111	0.419
DOC_MAPK_FxFP_2	442	445	PF00069	0.319
DOC_MAPK_gen_1	228	237	PF00069	0.338
DOC_MAPK_gen_1	252	261	PF00069	0.424
DOC_MAPK_gen_1	273	280	PF00069	0.304
DOC_MAPK_gen_1	313	322	PF00069	0.451
DOC_MAPK_gen_1	346	355	PF00069	0.315
DOC_MAPK_HePTP_8	310	322	PF00069	0.319
DOC_MAPK_MEF2A_6	156	165	PF00069	0.424
DOC_MAPK_MEF2A_6	228	237	PF00069	0.321
DOC_MAPK_MEF2A_6	313	322	PF00069	0.319
DOC_MAPK_MEF2A_6	530	539	PF00069	0.420
DOC_MAPK_NFAT4_5	230	238	PF00069	0.361
DOC_PP2B_LxvP_1	212	215	PF13499	0.198
DOC_PP2B_LxvP_1	342	345	PF13499	0.338
DOC_PP4_FxxP_1	442	445	PF00568	0.319
DOC_PP4_FxxP_1	551	554	PF00568	0.563
DOC_USP7_MATH_1	171	175	PF00917	0.408
DOC_USP7_MATH_1	205	209	PF00917	0.378
DOC_USP7_MATH_1	224	228	PF00917	0.361
DOC_USP7_MATH_1	229	233	PF00917	0.345
DOC_USP7_MATH_1	412	416	PF00917	0.424
DOC_USP7_MATH_1	499	503	PF00917	0.639
DOC_USP7_UBL2_3	273	277	PF12436	0.389
DOC_WW_Pin1_4	454	459	PF00397	0.389
DOC_WW_Pin1_4	491	496	PF00397	0.489
DOC_WW_Pin1_4	538	543	PF00397	0.394
LIG_14-3-3_CanoR_1	228	234	PF00244	0.340
LIG_14-3-3_CanoR_1	313	319	PF00244	0.366
LIG_14-3-3_CanoR_1	472	477	PF00244	0.521
LIG_14-3-3_CanoR_1	496	504	PF00244	0.508
LIG_AP2alpha_2	450	452	PF02296	0.304
LIG_BRCT_BRCA1_1	329	333	PF00533	0.319
LIG_BRCT_BRCA1_1	356	360	PF00533	0.439
LIG_BRCT_BRCA1_1	442	446	PF00533	0.308
LIG_Clathr_ClatBox_1	534	538	PF01394	0.374
LIG_Clathr_ClatBox_1	72	76	PF01394	0.292
LIG_EH_1	357	361	PF12763	0.424
LIG_eIF4E_1	55	61	PF01652	0.338
LIG_FHA_1	157	163	PF00498	0.304
LIG_FHA_1	267	273	PF00498	0.306
LIG_FHA_1	315	321	PF00498	0.340
LIG_FHA_1	350	356	PF00498	0.424
LIG_FHA_1	371	377	PF00498	0.419
LIG_FHA_1	544	550	PF00498	0.458
LIG_FHA_2	307	313	PF00498	0.420
LIG_FHA_2	417	423	PF00498	0.329
LIG_FHA_2	473	479	PF00498	0.465
LIG_LIR_Apic_2	440	445	PF02991	0.319
LIG_LIR_Apic_2	550	554	PF02991	0.465
LIG_LIR_Gen_1	470	479	PF02991	0.459
LIG_LIR_Nem_3	470	476	PF02991	0.387
LIG_MYND_1	341	345	PF01753	0.319
LIG_NRBOX	306	312	PF00104	0.424
LIG_Pex14_2	442	446	PF04695	0.319
LIG_PTAP_UEV_1	434	439	PF05743	0.304
LIG_SH2_CRK	166	170	PF00017	0.424
LIG_SH2_STAP1	10	14	PF00017	0.416
LIG_SH2_STAT3	27	30	PF00017	0.198
LIG_SH2_STAT5	203	206	PF00017	0.419
LIG_SH3_3	188	194	PF00018	0.453
LIG_SH3_3	30	36	PF00018	0.333
LIG_SH3_3	332	338	PF00018	0.304
LIG_SH3_3	353	359	PF00018	0.304
LIG_SH3_3	41	47	PF00018	0.387
LIG_SH3_3	432	438	PF00018	0.304
LIG_SH3_3	536	542	PF00018	0.394
LIG_SUMO_SIM_anti_2	232	238	PF11976	0.335
LIG_SUMO_SIM_anti_2	319	324	PF11976	0.319
LIG_SUMO_SIM_par_1	316	321	PF11976	0.339
LIG_SUMO_SIM_par_1	425	430	PF11976	0.451
LIG_SUMO_SIM_par_1	533	538	PF11976	0.388
LIG_WRC_WIRS_1	525	530	PF05994	0.377
LIG_WRC_WIRS_1	548	553	PF05994	0.492
MOD_CDK_SPK_2	491	496	PF00069	0.489
MOD_CDK_SPxxK_3	491	498	PF00069	0.489
MOD_CK1_1	208	214	PF00069	0.417
MOD_CK1_1	490	496	PF00069	0.702
MOD_CK1_1	502	508	PF00069	0.741
MOD_CK1_1	547	553	PF00069	0.503
MOD_CK1_1	97	103	PF00069	0.198
MOD_CK2_1	131	137	PF00069	0.361
MOD_CK2_1	306	312	PF00069	0.426
MOD_CK2_1	472	478	PF00069	0.464
MOD_GlcNHglycan	11	14	PF01048	0.377
MOD_GlcNHglycan	133	136	PF01048	0.332
MOD_GlcNHglycan	141	146	PF01048	0.265
MOD_GlcNHglycan	182	185	PF01048	0.525
MOD_GlcNHglycan	187	190	PF01048	0.440
MOD_GlcNHglycan	207	210	PF01048	0.351
MOD_GlcNHglycan	299	302	PF01048	0.314
MOD_GlcNHglycan	403	406	PF01048	0.342
MOD_GlcNHglycan	429	432	PF01048	0.361
MOD_GlcNHglycan	489	492	PF01048	0.676
MOD_GlcNHglycan	501	504	PF01048	0.719
MOD_GlcNHglycan	530	533	PF01048	0.446
MOD_GlcNHglycan	83	88	PF01048	0.387
MOD_GlcNHglycan	95	99	PF01048	0.307
MOD_GSK3_1	127	134	PF00069	0.352
MOD_GSK3_1	262	269	PF00069	0.357
MOD_GSK3_1	367	374	PF00069	0.256
MOD_GSK3_1	412	419	PF00069	0.334
MOD_GSK3_1	433	440	PF00069	0.304
MOD_GSK3_1	468	475	PF00069	0.420
MOD_GSK3_1	485	492	PF00069	0.511
MOD_GSK3_1	524	531	PF00069	0.375
MOD_GSK3_1	540	547	PF00069	0.407
MOD_GSK3_1	97	104	PF00069	0.430
MOD_N-GLC_1	171	176	PF02516	0.419
MOD_N-GLC_1	485	490	PF02516	0.461
MOD_NEK2_1	140	145	PF00069	0.377
MOD_NEK2_1	360	365	PF00069	0.394
MOD_NEK2_1	400	405	PF00069	0.305
MOD_NEK2_1	487	492	PF00069	0.623
MOD_NEK2_1	497	502	PF00069	0.665
MOD_NEK2_1	528	533	PF00069	0.351
MOD_NEK2_1	544	549	PF00069	0.369
MOD_NEK2_2	101	106	PF00069	0.198
MOD_NEK2_2	171	176	PF00069	0.353
MOD_PIKK_1	26	32	PF00454	0.198
MOD_PKA_2	196	202	PF00069	0.532
MOD_PKA_2	229	235	PF00069	0.384
MOD_PKA_2	412	418	PF00069	0.304
MOD_Plk_1	544	550	PF00069	0.458
MOD_Plk_2-3	127	133	PF00069	0.198
MOD_Plk_4	306	312	PF00069	0.439
MOD_Plk_4	437	443	PF00069	0.381
MOD_Plk_4	544	550	PF00069	0.444
MOD_ProDKin_1	454	460	PF00069	0.389
MOD_ProDKin_1	491	497	PF00069	0.489
MOD_ProDKin_1	538	544	PF00069	0.389
MOD_SUMO_for_1	377	380	PF00179	0.333
MOD_SUMO_rev_2	265	274	PF00179	0.389
MOD_SUMO_rev_2	284	293	PF00179	0.424
MOD_SUMO_rev_2	505	514	PF00179	0.724
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.338
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.399
TRG_ENDOCYTIC_2	166	169	PF00928	0.424
TRG_ENDOCYTIC_2	203	206	PF00928	0.333
TRG_ENDOCYTIC_2	473	476	PF00928	0.510
TRG_ENDOCYTIC_2	55	58	PF00928	0.318
TRG_ER_diArg_1	2	5	PF00400	0.378
TRG_ER_diArg_1	36	38	PF00400	0.351
TRG_NES_CRM1_1	308	321	PF08389	0.424
TRG_NLS_MonoExtC_3	274	279	PF00514	0.319
TRG_NLS_MonoExtC_3	387	393	PF00514	0.426
TRG_NLS_MonoExtN_4	273	280	PF00514	0.319
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P663	Leptomonas seymouri	70%	96%
A0A0S4IRV7	Bodo saltans	39%	100%
A0A1X0NMG0	Trypanosomatidae	46%	99%
A0A3Q8ING8	Leishmania donovani	86%	94%
A0A422P247	Trypanosoma rangeli	46%	99%
A4I1I5	Leishmania infantum	86%	94%
C9ZJY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9AXM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	94%
O35654	Mus musculus	26%	100%
O48520	Arabidopsis thaliana	26%	100%
O93610	Xenopus laevis	27%	100%
P46957	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P49004	Bos taurus	26%	100%
P87324	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q4Q9V2	Leishmania major	86%	100%
Q6AXY4	Rattus norvegicus	25%	100%
Q9LRE5	Oryza sativa subsp. japonica	26%	100%
Q9W088	Drosophila melanogaster	27%	100%
V5B3K0	Trypanosoma cruzi	47%	100%