Clusterin-associated protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative intraflagellar transport protein A1

Species:

Leishmania braziliensis

UniProt:

A4HEE7_LEIBR

TriTrypDb:

LbrM.25.2040 , LBRM2903_250023500

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0031514	motile cilium	5	1

Expansion

Sequence features

A4HEE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEE7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0030030	cell projection organization	4	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0010970	transport along microtubule	4	1
GO:0022607	cellular component assembly	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035720	intraciliary anterograde transport	4	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.579
CLV_C14_Caspase3-7	448	452	PF00656	0.690
CLV_NRD_NRD_1	179	181	PF00675	0.300
CLV_NRD_NRD_1	294	296	PF00675	0.466
CLV_NRD_NRD_1	314	316	PF00675	0.733
CLV_NRD_NRD_1	378	380	PF00675	0.772
CLV_NRD_NRD_1	416	418	PF00675	0.669
CLV_PCSK_KEX2_1	179	181	PF00082	0.300
CLV_PCSK_KEX2_1	314	316	PF00082	0.664
CLV_PCSK_KEX2_1	378	380	PF00082	0.770
CLV_PCSK_KEX2_1	416	418	PF00082	0.725
CLV_PCSK_PC7_1	310	316	PF00082	0.649
CLV_PCSK_SKI1_1	106	110	PF00082	0.376
CLV_PCSK_SKI1_1	182	186	PF00082	0.276
CLV_PCSK_SKI1_1	419	423	PF00082	0.677
DEG_APCC_DBOX_1	181	189	PF00400	0.276
DEG_SCF_FBW7_1	322	327	PF00400	0.653
DEG_SCF_FBW7_1	455	461	PF00400	0.518
DOC_CDC14_PxL_1	15	23	PF14671	0.276
DOC_CKS1_1	455	460	PF01111	0.518
DOC_CYCLIN_RxL_1	179	186	PF00134	0.342
DOC_CYCLIN_RxL_1	257	266	PF00134	0.393
DOC_MAPK_gen_1	76	83	PF00069	0.300
DOC_MAPK_MEF2A_6	76	83	PF00069	0.300
DOC_MAPK_NFAT4_5	76	84	PF00069	0.335
DOC_PP1_RVXF_1	258	265	PF00149	0.393
DOC_PP1_RVXF_1	60	66	PF00149	0.301
DOC_PP4_FxxP_1	27	30	PF00568	0.278
DOC_USP7_MATH_1	458	462	PF00917	0.530
DOC_USP7_UBL2_3	105	109	PF12436	0.300
DOC_USP7_UBL2_3	212	216	PF12436	0.276
DOC_USP7_UBL2_3	271	275	PF12436	0.341
DOC_USP7_UBL2_3	296	300	PF12436	0.541
DOC_USP7_UBL2_3	76	80	PF12436	0.276
DOC_WW_Pin1_4	320	325	PF00397	0.657
DOC_WW_Pin1_4	334	339	PF00397	0.484
DOC_WW_Pin1_4	454	459	PF00397	0.522
LIG_14-3-3_CanoR_1	170	177	PF00244	0.276
LIG_14-3-3_CanoR_1	20	25	PF00244	0.270
LIG_14-3-3_CanoR_1	379	385	PF00244	0.528
LIG_14-3-3_CanoR_1	62	66	PF00244	0.335
LIG_14-3-3_CanoR_1	7	16	PF00244	0.489
LIG_Actin_WH2_2	287	302	PF00022	0.590
LIG_Actin_WH2_2	90	107	PF00022	0.276
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_BRCT_BRCA1_1	147	151	PF00533	0.276
LIG_BRCT_BRCA1_1	460	464	PF00533	0.721
LIG_Clathr_ClatBox_1	21	25	PF01394	0.276
LIG_EH1_1	91	99	PF00400	0.393
LIG_FHA_1	10	16	PF00498	0.337
LIG_FHA_1	321	327	PF00498	0.513
LIG_FHA_1	51	57	PF00498	0.393
LIG_FHA_2	109	115	PF00498	0.300
LIG_FHA_2	205	211	PF00498	0.211
LIG_FHA_2	327	333	PF00498	0.599
LIG_FHA_2	397	403	PF00498	0.525
LIG_GBD_Chelix_1	100	108	PF00786	0.276
LIG_Integrin_RGD_1	161	163	PF01839	0.341
LIG_LIR_Apic_2	25	30	PF02991	0.276
LIG_LIR_Gen_1	115	126	PF02991	0.300
LIG_LIR_Nem_3	115	121	PF02991	0.300
LIG_LIR_Nem_3	148	154	PF02991	0.276
LIG_LIR_Nem_3	2	6	PF02991	0.396
LIG_LIR_Nem_3	257	262	PF02991	0.288
LIG_LIR_Nem_3	64	69	PF02991	0.418
LIG_LYPXL_yS_3	18	21	PF13949	0.276
LIG_MLH1_MIPbox_1	148	152	PF16413	0.335
LIG_NRBOX	180	186	PF00104	0.335
LIG_PDZ_Class_1	475	480	PF00595	0.608
LIG_PTB_Apo_2	231	238	PF02174	0.393
LIG_PTB_Apo_2	258	265	PF02174	0.276
LIG_REV1ctd_RIR_1	63	71	PF16727	0.278
LIG_SH2_GRB2like	241	244	PF00017	0.393
LIG_SH2_SRC	241	244	PF00017	0.393
LIG_SH2_SRC	46	49	PF00017	0.276
LIG_SH2_STAT3	255	258	PF00017	0.276
LIG_SH2_STAT5	255	258	PF00017	0.276
LIG_SH2_STAT5	336	339	PF00017	0.497
LIG_SH2_STAT5	436	439	PF00017	0.534
LIG_TRAF2_1	349	352	PF00917	0.637
LIG_TRAF2_1	355	358	PF00917	0.630
LIG_TRAF2_1	93	96	PF00917	0.276
LIG_TYR_ITIM	16	21	PF00017	0.276
LIG_UBA3_1	97	105	PF00899	0.276
LIG_WRC_WIRS_1	24	29	PF05994	0.317
LIG_WRC_WIRS_1	6	11	PF05994	0.337
MOD_CDK_SPK_2	334	339	PF00069	0.500
MOD_CK1_1	141	147	PF00069	0.282
MOD_CK1_1	169	175	PF00069	0.276
MOD_CK1_1	23	29	PF00069	0.296
MOD_CK1_1	309	315	PF00069	0.505
MOD_CK1_1	359	365	PF00069	0.542
MOD_CK1_1	369	375	PF00069	0.539
MOD_CK1_1	387	393	PF00069	0.676
MOD_CK1_1	447	453	PF00069	0.645
MOD_CK1_1	456	462	PF00069	0.659
MOD_CK1_1	466	472	PF00069	0.580
MOD_CK2_1	108	114	PF00069	0.300
MOD_CK2_1	200	206	PF00069	0.307
MOD_CK2_1	23	29	PF00069	0.425
MOD_CK2_1	324	330	PF00069	0.710
MOD_CK2_1	351	357	PF00069	0.648
MOD_CK2_1	443	449	PF00069	0.729
MOD_CK2_1	457	463	PF00069	0.677
MOD_CK2_1	5	11	PF00069	0.339
MOD_Cter_Amidation	312	315	PF01082	0.747
MOD_GlcNHglycan	202	205	PF01048	0.393
MOD_GlcNHglycan	228	231	PF01048	0.393
MOD_GlcNHglycan	311	314	PF01048	0.789
MOD_GlcNHglycan	316	319	PF01048	0.618
MOD_GlcNHglycan	351	357	PF01048	0.696
MOD_GlcNHglycan	361	364	PF01048	0.604
MOD_GlcNHglycan	460	463	PF01048	0.673
MOD_GlcNHglycan	47	51	PF01048	0.300
MOD_GlcNHglycan	471	475	PF01048	0.612
MOD_GSK3_1	138	145	PF00069	0.273
MOD_GSK3_1	200	207	PF00069	0.357
MOD_GSK3_1	226	233	PF00069	0.382
MOD_GSK3_1	314	321	PF00069	0.701
MOD_GSK3_1	352	359	PF00069	0.627
MOD_GSK3_1	380	387	PF00069	0.639
MOD_GSK3_1	441	448	PF00069	0.650
MOD_GSK3_1	449	456	PF00069	0.631
MOD_GSK3_1	458	465	PF00069	0.518
MOD_GSK3_1	46	53	PF00069	0.393
MOD_GSK3_1	466	473	PF00069	0.655
MOD_GSK3_1	5	12	PF00069	0.359
MOD_N-GLC_1	128	133	PF02516	0.393
MOD_N-GLC_1	200	205	PF02516	0.306
MOD_NEK2_1	9	14	PF00069	0.343
MOD_PKA_1	314	320	PF00069	0.726
MOD_PKA_2	169	175	PF00069	0.276
MOD_PKA_2	309	315	PF00069	0.699
MOD_PKA_2	387	393	PF00069	0.745
MOD_PKA_2	61	67	PF00069	0.335
MOD_PKB_1	164	172	PF00069	0.276
MOD_PKB_1	417	425	PF00069	0.809
MOD_Plk_1	116	122	PF00069	0.300
MOD_Plk_1	407	413	PF00069	0.723
MOD_Plk_1	50	56	PF00069	0.393
MOD_Plk_1	70	76	PF00069	0.155
MOD_Plk_2-3	364	370	PF00069	0.787
MOD_Plk_2-3	445	451	PF00069	0.638
MOD_Plk_2-3	463	469	PF00069	0.677
MOD_Plk_2-3	5	11	PF00069	0.339
MOD_Plk_4	146	152	PF00069	0.335
MOD_Plk_4	195	201	PF00069	0.393
MOD_Plk_4	407	413	PF00069	0.723
MOD_Plk_4	61	67	PF00069	0.348
MOD_ProDKin_1	320	326	PF00069	0.657
MOD_ProDKin_1	334	340	PF00069	0.483
MOD_ProDKin_1	454	460	PF00069	0.521
MOD_SUMO_rev_2	131	136	PF00179	0.393
MOD_SUMO_rev_2	205	213	PF00179	0.276
MOD_SUMO_rev_2	240	248	PF00179	0.383
MOD_SUMO_rev_2	281	287	PF00179	0.452
MOD_SUMO_rev_2	292	302	PF00179	0.541
TRG_DiLeu_BaEn_1	11	16	PF01217	0.339
TRG_DiLeu_BaEn_1	407	412	PF01217	0.723
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.225
TRG_DiLeu_LyEn_5	11	16	PF01217	0.339
TRG_ENDOCYTIC_2	18	21	PF00928	0.276
TRG_ENDOCYTIC_2	259	262	PF00928	0.276
TRG_ER_diArg_1	164	167	PF00400	0.276
TRG_ER_diArg_1	179	182	PF00400	0.276
TRG_ER_diArg_1	344	347	PF00400	0.710
TRG_ER_diArg_1	378	380	PF00400	0.688
TRG_ER_diArg_1	415	417	PF00400	0.732
TRG_ER_diArg_1	433	436	PF00400	0.723
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV6	Leptomonas seymouri	76%	100%
A0A0S4IPW0	Bodo saltans	66%	100%
A0A3S7WZA7	Leishmania donovani	88%	99%
A0A422N0X8	Trypanosoma rangeli	66%	96%
A4I1I7	Leishmania infantum	88%	99%
C9ZJX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AXM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9V0	Leishmania major	85%	100%