Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEE6_LEIBR

TriTrypDb:

LbrM.25.2030 , LBRM2903_250023600

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEE6

Function

Biological processes
Term	Name	Level	Count
GO:0000738	obsolete DNA catabolic process, exonucleolytic	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006308	DNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004527	exonuclease activity	5	10
GO:0005488	binding	1	10
GO:0008408	3'-5' exonuclease activity	6	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.653
CLV_NRD_NRD_1	10	12	PF00675	0.558
CLV_NRD_NRD_1	135	137	PF00675	0.298
CLV_NRD_NRD_1	231	233	PF00675	0.290
CLV_NRD_NRD_1	3	5	PF00675	0.568
CLV_NRD_NRD_1	460	462	PF00675	0.755
CLV_PCSK_KEX2_1	10	12	PF00082	0.542
CLV_PCSK_KEX2_1	230	232	PF00082	0.290
CLV_PCSK_KEX2_1	3	5	PF00082	0.576
CLV_PCSK_KEX2_1	460	462	PF00082	0.582
CLV_PCSK_KEX2_1	477	479	PF00082	0.758
CLV_PCSK_KEX2_1	76	78	PF00082	0.535
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.768
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.535
CLV_PCSK_PC7_1	226	232	PF00082	0.290
CLV_PCSK_SKI1_1	166	170	PF00082	0.211
CLV_PCSK_SKI1_1	185	189	PF00082	0.311
CLV_PCSK_SKI1_1	232	236	PF00082	0.290
CLV_PCSK_SKI1_1	42	46	PF00082	0.441
CLV_PCSK_SKI1_1	454	458	PF00082	0.732
CLV_PCSK_SKI1_1	461	465	PF00082	0.681
CLV_PCSK_SKI1_1	89	93	PF00082	0.453
DEG_MDM2_SWIB_1	160	168	PF02201	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.693
DOC_AGCK_PIF_1	88	93	PF00069	0.357
DOC_ANK_TNKS_1	135	142	PF00023	0.557
DOC_CKS1_1	171	176	PF01111	0.508
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.372
DOC_MAPK_gen_1	10	17	PF00069	0.636
DOC_MAPK_gen_1	230	236	PF00069	0.531
DOC_MAPK_gen_1	3	9	PF00069	0.578
DOC_MAPK_gen_1	76	84	PF00069	0.525
DOC_MAPK_HePTP_8	74	86	PF00069	0.524
DOC_MAPK_MEF2A_6	77	86	PF00069	0.526
DOC_PP1_RVXF_1	164	171	PF00149	0.469
DOC_PP2B_LxvP_1	84	87	PF13499	0.383
DOC_PP4_FxxP_1	97	100	PF00568	0.490
DOC_USP7_MATH_1	196	200	PF00917	0.490
DOC_USP7_MATH_1	336	340	PF00917	0.697
DOC_USP7_MATH_1	348	352	PF00917	0.700
DOC_USP7_MATH_1	442	446	PF00917	0.644
DOC_WW_Pin1_4	116	121	PF00397	0.490
DOC_WW_Pin1_4	170	175	PF00397	0.508
DOC_WW_Pin1_4	252	257	PF00397	0.438
DOC_WW_Pin1_4	284	289	PF00397	0.414
DOC_WW_Pin1_4	32	37	PF00397	0.543
DOC_WW_Pin1_4	383	388	PF00397	0.645
LIG_14-3-3_CanoR_1	10	16	PF00244	0.613
LIG_14-3-3_CanoR_1	231	237	PF00244	0.444
LIG_14-3-3_CanoR_1	268	272	PF00244	0.561
LIG_14-3-3_CanoR_1	3	7	PF00244	0.607
LIG_14-3-3_CanoR_1	350	355	PF00244	0.796
LIG_14-3-3_CanoR_1	419	424	PF00244	0.753
LIG_14-3-3_CanoR_1	482	488	PF00244	0.537
LIG_14-3-3_CanoR_1	69	78	PF00244	0.482
LIG_14-3-3_CanoR_1	89	94	PF00244	0.170
LIG_AP2alpha_1	373	377	PF02296	0.646
LIG_BRCT_BRCA1_1	214	218	PF00533	0.531
LIG_BRCT_BRCA1_1	84	88	PF00533	0.378
LIG_Clathr_ClatBox_1	368	372	PF01394	0.701
LIG_Clathr_ClatBox_1	63	67	PF01394	0.423
LIG_deltaCOP1_diTrp_1	162	170	PF00928	0.531
LIG_FHA_1	107	113	PF00498	0.490
LIG_FHA_1	219	225	PF00498	0.506
LIG_FHA_1	322	328	PF00498	0.698
LIG_FHA_1	33	39	PF00498	0.527
LIG_FHA_1	363	369	PF00498	0.718
LIG_FHA_1	491	497	PF00498	0.741
LIG_FHA_1	73	79	PF00498	0.414
LIG_FHA_2	285	291	PF00498	0.402
LIG_IRF3_LxIS_1	248	255	PF10401	0.411
LIG_LIR_Apic_2	94	100	PF02991	0.490
LIG_LIR_Gen_1	123	133	PF02991	0.485
LIG_LIR_Gen_1	162	171	PF02991	0.508
LIG_LIR_Gen_1	270	279	PF02991	0.533
LIG_LIR_Gen_1	370	377	PF02991	0.548
LIG_LIR_Gen_1	5	13	PF02991	0.618
LIG_LIR_Gen_1	81	91	PF02991	0.370
LIG_LIR_Nem_3	123	129	PF02991	0.508
LIG_LIR_Nem_3	162	167	PF02991	0.503
LIG_LIR_Nem_3	242	246	PF02991	0.559
LIG_LIR_Nem_3	270	274	PF02991	0.520
LIG_LIR_Nem_3	370	376	PF02991	0.554
LIG_LIR_Nem_3	5	9	PF02991	0.557
LIG_LIR_Nem_3	81	86	PF02991	0.370
LIG_PDZ_Class_2	494	499	PF00595	0.710
LIG_Pex14_1	271	275	PF04695	0.396
LIG_Pex14_2	160	164	PF04695	0.490
LIG_Pex14_2	373	377	PF04695	0.546
LIG_Pex14_2	93	97	PF04695	0.490
LIG_SH2_CRK	118	122	PF00017	0.561
LIG_SH2_CRK	275	279	PF00017	0.521
LIG_SH2_PTP2	6	9	PF00017	0.426
LIG_SH2_STAP1	80	84	PF00017	0.479
LIG_SH2_STAT5	308	311	PF00017	0.505
LIG_SH2_STAT5	6	9	PF00017	0.426
LIG_SH2_STAT5	83	86	PF00017	0.361
LIG_SH3_3	114	120	PF00018	0.430
LIG_SH3_3	168	174	PF00018	0.561
LIG_SH3_3	33	39	PF00018	0.576
LIG_SUMO_SIM_anti_2	182	190	PF11976	0.591
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.490
LIG_SUMO_SIM_par_1	182	190	PF11976	0.508
LIG_SUMO_SIM_par_1	232	237	PF11976	0.531
LIG_SUMO_SIM_par_1	365	372	PF11976	0.738
LIG_TRAF2_1	388	391	PF00917	0.756
LIG_UBA3_1	186	194	PF00899	0.490
LIG_WRC_WIRS_1	90	95	PF05994	0.361
MOD_CDK_SPK_2	284	289	PF00069	0.414
MOD_CK1_1	339	345	PF00069	0.673
MOD_CK1_1	353	359	PF00069	0.806
MOD_CK1_1	362	368	PF00069	0.727
MOD_CK1_1	408	414	PF00069	0.749
MOD_CK1_1	468	474	PF00069	0.788
MOD_CK1_1	5	11	PF00069	0.643
MOD_CK2_1	284	290	PF00069	0.414
MOD_Cter_Amidation	134	137	PF01082	0.308
MOD_GlcNHglycan	258	261	PF01048	0.211
MOD_GlcNHglycan	334	337	PF01048	0.772
MOD_GlcNHglycan	350	353	PF01048	0.769
MOD_GlcNHglycan	355	358	PF01048	0.778
MOD_GlcNHglycan	361	364	PF01048	0.747
MOD_GlcNHglycan	401	405	PF01048	0.748
MOD_GlcNHglycan	442	445	PF01048	0.709
MOD_GlcNHglycan	483	486	PF01048	0.673
MOD_GSK3_1	106	113	PF00069	0.558
MOD_GSK3_1	252	259	PF00069	0.411
MOD_GSK3_1	332	339	PF00069	0.672
MOD_GSK3_1	359	366	PF00069	0.652
MOD_GSK3_1	408	415	PF00069	0.701
MOD_GSK3_1	438	445	PF00069	0.726
MOD_NEK2_1	187	192	PF00069	0.490
MOD_NEK2_1	2	7	PF00069	0.558
MOD_NEK2_1	218	223	PF00069	0.490
MOD_NEK2_1	274	279	PF00069	0.476
MOD_NEK2_1	321	326	PF00069	0.741
MOD_NEK2_1	400	405	PF00069	0.682
MOD_NEK2_1	410	415	PF00069	0.748
MOD_NEK2_1	481	486	PF00069	0.550
MOD_NEK2_1	82	87	PF00069	0.524
MOD_NEK2_1	95	100	PF00069	0.484
MOD_PIKK_1	25	31	PF00454	0.428
MOD_PIKK_1	410	416	PF00454	0.657
MOD_PIKK_1	69	75	PF00454	0.452
MOD_PK_1	11	17	PF00069	0.697
MOD_PKA_1	11	17	PF00069	0.658
MOD_PKA_2	2	8	PF00069	0.580
MOD_PKA_2	267	273	PF00069	0.561
MOD_PKA_2	336	342	PF00069	0.534
MOD_PKA_2	481	487	PF00069	0.758
MOD_PKB_1	230	238	PF00069	0.531
MOD_PKB_1	304	312	PF00069	0.371
MOD_Plk_1	143	149	PF00069	0.498
MOD_Plk_1	196	202	PF00069	0.490
MOD_Plk_2-3	106	112	PF00069	0.490
MOD_Plk_4	11	17	PF00069	0.683
MOD_Plk_4	196	202	PF00069	0.490
MOD_Plk_4	212	218	PF00069	0.490
MOD_Plk_4	274	280	PF00069	0.522
MOD_Plk_4	321	327	PF00069	0.666
MOD_Plk_4	412	418	PF00069	0.516
MOD_ProDKin_1	116	122	PF00069	0.490
MOD_ProDKin_1	170	176	PF00069	0.508
MOD_ProDKin_1	252	258	PF00069	0.438
MOD_ProDKin_1	284	290	PF00069	0.414
MOD_ProDKin_1	32	38	PF00069	0.539
MOD_ProDKin_1	383	389	PF00069	0.647
MOD_SUMO_rev_2	386	394	PF00179	0.750
MOD_SUMO_rev_2	54	64	PF00179	0.459
TRG_DiLeu_BaEn_1	183	188	PF01217	0.490
TRG_DiLeu_BaEn_2	155	161	PF01217	0.563
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.561
TRG_ENDOCYTIC_2	118	121	PF00928	0.561
TRG_ENDOCYTIC_2	275	278	PF00928	0.412
TRG_ENDOCYTIC_2	6	9	PF00928	0.562
TRG_ENDOCYTIC_2	83	86	PF00928	0.380
TRG_ER_diArg_1	2	4	PF00400	0.597
TRG_ER_diArg_1	230	232	PF00400	0.490
TRG_ER_diArg_1	9	11	PF00400	0.537
TRG_NLS_MonoExtN_4	460	465	PF00514	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P667	Leptomonas seymouri	72%	100%
A0A3R7N9L3	Trypanosoma rangeli	54%	100%
A0A3S7WZ67	Leishmania donovani	80%	98%
A4I1I8	Leishmania infantum	80%	98%
C9ZJX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AXM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4Q9U9	Leishmania major	79%	100%
V5B841	Trypanosoma cruzi	54%	100%