Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEE4_LEIBR

TriTrypDb:

LbrM.25.2010 , LBRM2903_250033700

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HEE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.559
CLV_NRD_NRD_1	146	148	PF00675	0.520
CLV_NRD_NRD_1	35	37	PF00675	0.538
CLV_NRD_NRD_1	86	88	PF00675	0.557
CLV_PCSK_KEX2_1	112	114	PF00082	0.559
CLV_PCSK_KEX2_1	146	148	PF00082	0.531
CLV_PCSK_KEX2_1	245	247	PF00082	0.370
CLV_PCSK_KEX2_1	35	37	PF00082	0.597
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.359
CLV_PCSK_SKI1_1	112	116	PF00082	0.611
CLV_PCSK_SKI1_1	13	17	PF00082	0.613
CLV_PCSK_SKI1_1	146	150	PF00082	0.460
CLV_PCSK_SKI1_1	26	30	PF00082	0.588
CLV_PCSK_SKI1_1	46	50	PF00082	0.472
CLV_PCSK_SKI1_1	83	87	PF00082	0.550
DEG_APCC_DBOX_1	145	153	PF00400	0.307
DEG_SCF_FBW7_1	121	128	PF00400	0.420
DOC_CKS1_1	122	127	PF01111	0.348
DOC_CKS1_1	42	47	PF01111	0.390
DOC_MAPK_gen_1	161	170	PF00069	0.391
DOC_MAPK_gen_1	251	261	PF00069	0.610
DOC_MAPK_gen_1	35	41	PF00069	0.327
DOC_MAPK_gen_1	63	69	PF00069	0.237
DOC_MAPK_gen_1	8	17	PF00069	0.409
DOC_PP1_RVXF_1	11	18	PF00149	0.409
DOC_PP4_FxxP_1	122	125	PF00568	0.408
DOC_PP4_FxxP_1	169	172	PF00568	0.300
DOC_USP7_MATH_1	142	146	PF00917	0.411
DOC_USP7_UBL2_3	254	258	PF12436	0.652
DOC_WW_Pin1_4	121	126	PF00397	0.342
DOC_WW_Pin1_4	41	46	PF00397	0.390
LIG_BIR_II_1	1	5	PF00653	0.420
LIG_BRCT_BRCA1_1	165	169	PF00533	0.321
LIG_BRCT_BRCA1_1	184	188	PF00533	0.335
LIG_EH_1	74	78	PF12763	0.431
LIG_eIF4E_1	221	227	PF01652	0.358
LIG_FHA_1	193	199	PF00498	0.324
LIG_FHA_1	52	58	PF00498	0.351
LIG_FHA_1	7	13	PF00498	0.375
LIG_LIR_Apic_2	119	125	PF02991	0.412
LIG_LIR_Apic_2	166	172	PF02991	0.309
LIG_LIR_Apic_2	93	99	PF02991	0.409
LIG_LIR_Gen_1	93	102	PF02991	0.383
LIG_LIR_Nem_3	55	61	PF02991	0.316
LIG_LIR_Nem_3	72	77	PF02991	0.384
LIG_LIR_Nem_3	93	97	PF02991	0.370
LIG_NRBOX	221	227	PF00104	0.475
LIG_PCNA_PIPBox_1	215	224	PF02747	0.413
LIG_PCNA_yPIPBox_3	213	222	PF02747	0.341
LIG_PTB_Apo_2	68	75	PF02174	0.317
LIG_PTB_Phospho_1	68	74	PF10480	0.352
LIG_SH2_PTP2	78	81	PF00017	0.402
LIG_SH2_STAT5	156	159	PF00017	0.408
LIG_SH2_STAT5	175	178	PF00017	0.294
LIG_SH2_STAT5	221	224	PF00017	0.328
LIG_SH2_STAT5	52	55	PF00017	0.357
LIG_SH2_STAT5	61	64	PF00017	0.197
LIG_SH2_STAT5	68	71	PF00017	0.279
LIG_SH2_STAT5	78	81	PF00017	0.263
LIG_SH2_STAT5	96	99	PF00017	0.307
LIG_SH3_3	154	160	PF00018	0.416
LIG_SH3_3	167	173	PF00018	0.306
LIG_SH3_3	39	45	PF00018	0.319
LIG_SH3_3	54	60	PF00018	0.319
LIG_TRFH_1	169	173	PF08558	0.306
LIG_WW_1	172	175	PF00397	0.295
MOD_CDK_SPK_2	41	46	PF00069	0.390
MOD_CK1_1	6	12	PF00069	0.424
MOD_CK2_1	194	200	PF00069	0.243
MOD_GSK3_1	121	128	PF00069	0.391
MOD_GSK3_1	190	197	PF00069	0.350
MOD_GSK3_1	202	209	PF00069	0.346
MOD_GSK3_1	37	44	PF00069	0.389
MOD_N-GLC_1	108	113	PF02516	0.556
MOD_N-GLC_2	212	214	PF02516	0.584
MOD_NEK2_1	130	135	PF00069	0.404
MOD_NEK2_1	136	141	PF00069	0.398
MOD_NEK2_1	4	9	PF00069	0.416
MOD_PKA_2	136	142	PF00069	0.439
MOD_PKA_2	37	43	PF00069	0.374
MOD_Plk_1	199	205	PF00069	0.402
MOD_Plk_4	125	131	PF00069	0.423
MOD_Plk_4	163	169	PF00069	0.322
MOD_Plk_4	171	177	PF00069	0.291
MOD_Plk_4	48	54	PF00069	0.254
MOD_ProDKin_1	121	127	PF00069	0.347
MOD_ProDKin_1	41	47	PF00069	0.389
MOD_SUMO_for_1	116	119	PF00179	0.426
TRG_ENDOCYTIC_2	221	224	PF00928	0.337
TRG_ENDOCYTIC_2	74	77	PF00928	0.399
TRG_ENDOCYTIC_2	78	81	PF00928	0.363
TRG_ENDOCYTIC_2	94	97	PF00928	0.177
TRG_ER_diArg_1	112	114	PF00400	0.380
TRG_ER_diArg_1	146	148	PF00400	0.243
TRG_ER_diArg_1	34	36	PF00400	0.418
TRG_NES_CRM1_1	104	119	PF08389	0.266
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYG4	Leptomonas seymouri	80%	100%
A0A0S4JRT7	Bodo saltans	49%	100%
A0A1X0ND76	Trypanosomatidae	61%	100%
A0A3Q8ICJ6	Leishmania donovani	88%	100%
A0A3R7N4J0	Trypanosoma rangeli	61%	100%
C9ZKA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AHA2	Leishmania infantum	88%	100%
E9AXX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9J6	Leishmania major	88%	100%
V5B2F8	Trypanosoma cruzi	61%	100%