Protein ARV

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein ARV

Gene product:

Arv1-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4HEE2_LEIBR

TriTrypDb:

LbrM.25.1990 , LBRM2903_250033500

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	13
GO:0016020	membrane	2	13
GO:0031090	organelle membrane	3	13
GO:0031984	organelle subcompartment	2	13
GO:0032541	cortical endoplasmic reticulum	5	13
GO:0071782	endoplasmic reticulum tubular network	4	13
GO:0098827	endoplasmic reticulum subcompartment	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HEE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEE2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0006643	membrane lipid metabolic process	4	13
GO:0006665	sphingolipid metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0006810	transport	3	13
GO:0006869	lipid transport	5	13
GO:0007009	plasma membrane organization	5	13
GO:0008152	metabolic process	1	13
GO:0008202	steroid metabolic process	4	13
GO:0009987	cellular process	1	13
GO:0015850	organic hydroxy compound transport	5	13
GO:0015918	sterol transport	6	13
GO:0016043	cellular component organization	3	13
GO:0016125	sterol metabolic process	4	13
GO:0032365	intracellular lipid transport	4	13
GO:0032366	intracellular sterol transport	5	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044255	cellular lipid metabolic process	3	13
GO:0046907	intracellular transport	3	13
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051641	cellular localization	2	13
GO:0051649	establishment of localization in cell	3	13
GO:0061024	membrane organization	4	13
GO:0065007	biological regulation	1	13
GO:0065008	regulation of biological quality	2	13
GO:0071702	organic substance transport	4	13
GO:0071704	organic substance metabolic process	2	13
GO:0071840	cellular component organization or biogenesis	2	13
GO:0097035	regulation of membrane lipid distribution	3	13
GO:0097036	regulation of plasma membrane sterol distribution	4	13
GO:1901360	organic cyclic compound metabolic process	3	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901615	organic hydroxy compound metabolic process	3	13

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	52	54	PF00675	0.199
CLV_PCSK_KEX2_1	51	53	PF00082	0.209
CLV_PCSK_SKI1_1	13	17	PF00082	0.339
CLV_PCSK_SKI1_1	235	239	PF00082	0.325
DEG_APCC_DBOX_1	165	173	PF00400	0.577
DOC_CKS1_1	104	109	PF01111	0.325
DOC_MAPK_FxFP_2	158	161	PF00069	0.397
DOC_MAPK_gen_1	109	119	PF00069	0.346
DOC_MAPK_gen_1	51	60	PF00069	0.494
DOC_PP1_RVXF_1	166	172	PF00149	0.494
DOC_PP1_RVXF_1	66	73	PF00149	0.577
DOC_PP4_FxxP_1	158	161	PF00568	0.397
DOC_USP7_MATH_1	126	130	PF00917	0.197
DOC_USP7_MATH_1	175	179	PF00917	0.450
DOC_USP7_UBL2_3	16	20	PF12436	0.566
DOC_WW_Pin1_4	103	108	PF00397	0.313
DOC_WW_Pin1_4	242	247	PF00397	0.359
LIG_14-3-3_CanoR_1	109	115	PF00244	0.353
LIG_14-3-3_CanoR_1	118	128	PF00244	0.310
LIG_BRCT_BRCA1_1	131	135	PF00533	0.388
LIG_FHA_1	141	147	PF00498	0.256
LIG_FHA_1	17	23	PF00498	0.491
LIG_FHA_1	225	231	PF00498	0.384
LIG_FHA_1	65	71	PF00498	0.533
LIG_FHA_2	139	145	PF00498	0.433
LIG_FHA_2	32	38	PF00498	0.513
LIG_FHA_2	85	91	PF00498	0.197
LIG_GBD_Chelix_1	147	155	PF00786	0.472
LIG_LIR_Gen_1	178	187	PF02991	0.459
LIG_LIR_Gen_1	201	208	PF02991	0.352
LIG_LIR_Gen_1	63	74	PF02991	0.563
LIG_LIR_Nem_3	122	127	PF02991	0.328
LIG_LIR_Nem_3	132	138	PF02991	0.256
LIG_LIR_Nem_3	178	182	PF02991	0.459
LIG_LIR_Nem_3	183	188	PF02991	0.422
LIG_LIR_Nem_3	201	205	PF02991	0.193
LIG_LIR_Nem_3	37	41	PF02991	0.577
LIG_LIR_Nem_3	63	69	PF02991	0.523
LIG_LYPXL_S_1	222	226	PF13949	0.355
LIG_LYPXL_yS_3	223	226	PF13949	0.444
LIG_Pex14_1	154	158	PF04695	0.472
LIG_Pex14_2	138	142	PF04695	0.472
LIG_Pex14_2	217	221	PF04695	0.659
LIG_RPA_C_Fungi	48	60	PF08784	0.219
LIG_SH2_CRK	179	183	PF00017	0.472
LIG_SH2_CRK	66	70	PF00017	0.463
LIG_SH2_STAP1	66	70	PF00017	0.428
LIG_SH2_STAT5	105	108	PF00017	0.427
LIG_SH2_STAT5	184	187	PF00017	0.330
LIG_SH2_STAT5	204	207	PF00017	0.422
LIG_SH2_STAT5	240	243	PF00017	0.478
LIG_SH2_STAT5	66	69	PF00017	0.400
LIG_SH3_4	16	23	PF00018	0.219
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.336
LIG_UBA3_1	237	243	PF00899	0.520
LIG_WRC_WIRS_1	139	144	PF05994	0.433
MOD_CDK_SPxK_1	103	109	PF00069	0.472
MOD_CK1_1	103	109	PF00069	0.393
MOD_CK1_1	129	135	PF00069	0.219
MOD_CK1_1	150	156	PF00069	0.450
MOD_CK2_1	138	144	PF00069	0.433
MOD_CK2_1	31	37	PF00069	0.365
MOD_CK2_1	84	90	PF00069	0.373
MOD_GSK3_1	126	133	PF00069	0.219
MOD_GSK3_1	60	67	PF00069	0.425
MOD_GSK3_1	99	106	PF00069	0.362
MOD_N-GLC_1	100	105	PF02516	0.360
MOD_N-GLC_1	60	65	PF02516	0.418
MOD_N-GLC_1	84	89	PF02516	0.219
MOD_NEK2_1	138	143	PF00069	0.416
MOD_NEK2_1	147	152	PF00069	0.356
MOD_NEK2_1	99	104	PF00069	0.377
MOD_OFUCOSY	28	35	PF10250	0.219
MOD_Plk_1	100	106	PF00069	0.354
MOD_Plk_1	84	90	PF00069	0.427
MOD_Plk_2-3	18	24	PF00069	0.450
MOD_Plk_4	100	106	PF00069	0.428
MOD_Plk_4	120	126	PF00069	0.141
MOD_Plk_4	130	136	PF00069	0.330
MOD_Plk_4	150	156	PF00069	0.368
MOD_Plk_4	180	186	PF00069	0.431
MOD_Plk_4	192	198	PF00069	0.389
MOD_Plk_4	224	230	PF00069	0.350
MOD_Plk_4	84	90	PF00069	0.472
MOD_ProDKin_1	103	109	PF00069	0.381
MOD_ProDKin_1	242	248	PF00069	0.450
MOD_SUMO_for_1	15	18	PF00179	0.365
TRG_DiLeu_BaEn_2	166	172	PF01217	0.472
TRG_ENDOCYTIC_2	179	182	PF00928	0.371
TRG_ENDOCYTIC_2	184	187	PF00928	0.319
TRG_ENDOCYTIC_2	223	226	PF00928	0.444
TRG_ENDOCYTIC_2	66	69	PF00928	0.463
TRG_ER_diArg_1	50	53	PF00400	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P617	Leptomonas seymouri	69%	98%
A0A0S4J0J7	Bodo saltans	26%	91%
A0A1X0NDC9	Trypanosomatidae	39%	98%
A0A3S7WZF7	Leishmania donovani	85%	100%
A0A422P4H3	Trypanosoma rangeli	41%	98%
C9ZKE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9AHA0	Leishmania infantum	84%	100%
E9AXX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q9J8	Leishmania major	86%	100%
V5A4G3	Trypanosoma cruzi	38%	98%
V5A4W6	Trypanosoma cruzi	41%	98%