DUF2061 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HEE1_LEIBR

TriTrypDb:

LbrM.25.1970 , LBRM2903_250033100

Length:

Annotations

LeishMANIAdb annotations

The TM segment is conserved among Kinetoplastids. Unknown function.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HEE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	7	11	PF00082	0.381
DEG_Nend_UBRbox_3	1	3	PF02207	0.597
DOC_CYCLIN_RxL_1	59	67	PF00134	0.494
DOC_USP7_UBL2_3	7	11	PF12436	0.597
LIG_14-3-3_CanoR_1	36	44	PF00244	0.466
LIG_BRCT_BRCA1_1	49	53	PF00533	0.299
LIG_deltaCOP1_diTrp_1	14	21	PF00928	0.548
LIG_FHA_1	32	38	PF00498	0.579
LIG_IRF3_LxIS_1	44	50	PF10401	0.218
LIG_LIR_Nem_3	55	61	PF02991	0.423
LIG_MLH1_MIPbox_1	49	53	PF16413	0.299
LIG_Pex14_1	17	21	PF04695	0.546
LIG_Pex14_2	40	44	PF04695	0.218
LIG_SH2_STAT5	52	55	PF00017	0.331
LIG_SH2_STAT5	58	61	PF00017	0.453
LIG_TYR_ITIM	59	64	PF00017	0.392
MOD_CK1_1	30	36	PF00069	0.612
MOD_GlcNHglycan	55	58	PF01048	0.228
MOD_GSK3_1	27	34	PF00069	0.587
MOD_GSK3_1	47	54	PF00069	0.315
MOD_NEK2_1	47	52	PF00069	0.356
MOD_NEK2_1	53	58	PF00069	0.431
MOD_PKA_2	35	41	PF00069	0.546
TRG_ENDOCYTIC_2	61	64	PF00928	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M8	Leptomonas seymouri	62%	100%
A0A3Q8IBY2	Leishmania donovani	68%	100%
E9ACT1	Leishmania major	69%	100%
E9AH99	Leishmania infantum	68%	100%
E9AXX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%