LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HED8_LEIBR
TriTrypDb:
LbrM.25.1940 , LBRM2903_250032700 *
Length:
365

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HED8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HED8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 121 125 PF00656 0.655
CLV_C14_Caspase3-7 256 260 PF00656 0.633
CLV_C14_Caspase3-7 281 285 PF00656 0.554
CLV_C14_Caspase3-7 3 7 PF00656 0.675
CLV_NRD_NRD_1 32 34 PF00675 0.592
CLV_NRD_NRD_1 345 347 PF00675 0.441
CLV_PCSK_KEX2_1 172 174 PF00082 0.627
CLV_PCSK_KEX2_1 224 226 PF00082 0.373
CLV_PCSK_KEX2_1 273 275 PF00082 0.582
CLV_PCSK_KEX2_1 32 34 PF00082 0.592
CLV_PCSK_KEX2_1 343 345 PF00082 0.384
CLV_PCSK_PC1ET2_1 172 174 PF00082 0.654
CLV_PCSK_PC1ET2_1 224 226 PF00082 0.373
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.636
CLV_PCSK_PC1ET2_1 343 345 PF00082 0.364
CLV_PCSK_PC7_1 339 345 PF00082 0.418
CLV_PCSK_SKI1_1 221 225 PF00082 0.584
CLV_PCSK_SKI1_1 346 350 PF00082 0.510
DEG_SIAH_1 16 24 PF03145 0.582
DEG_SPOP_SBC_1 130 134 PF00917 0.445
DOC_CDC14_PxL_1 79 87 PF14671 0.794
DOC_CYCLIN_yClb5_NLxxxL_5 299 308 PF00134 0.336
DOC_MAPK_MEF2A_6 131 140 PF00069 0.406
DOC_PP2B_LxvP_1 85 88 PF13499 0.792
DOC_USP7_MATH_1 102 106 PF00917 0.766
DOC_USP7_MATH_1 108 112 PF00917 0.625
DOC_USP7_MATH_1 125 129 PF00917 0.597
DOC_USP7_MATH_1 130 134 PF00917 0.564
DOC_USP7_MATH_1 242 246 PF00917 0.669
DOC_USP7_MATH_1 327 331 PF00917 0.381
DOC_USP7_MATH_1 78 82 PF00917 0.633
DOC_USP7_MATH_1 92 96 PF00917 0.753
DOC_USP7_UBL2_3 343 347 PF12436 0.574
DOC_WW_Pin1_4 60 65 PF00397 0.778
LIG_14-3-3_CanoR_1 131 140 PF00244 0.497
LIG_APCC_ABBA_1 304 309 PF00400 0.341
LIG_BRCT_BRCA1_1 25 29 PF00533 0.592
LIG_deltaCOP1_diTrp_1 215 222 PF00928 0.374
LIG_FHA_1 114 120 PF00498 0.546
LIG_FHA_1 261 267 PF00498 0.731
LIG_FHA_1 293 299 PF00498 0.483
LIG_FHA_1 88 94 PF00498 0.669
LIG_FHA_2 144 150 PF00498 0.382
LIG_FHA_2 159 165 PF00498 0.614
LIG_FHA_2 172 178 PF00498 0.761
LIG_FHA_2 203 209 PF00498 0.645
LIG_FHA_2 254 260 PF00498 0.640
LIG_LIR_Gen_1 295 304 PF02991 0.435
LIG_LIR_Nem_3 215 219 PF02991 0.622
LIG_LIR_Nem_3 295 300 PF02991 0.435
LIG_PTAP_UEV_1 79 84 PF05743 0.541
LIG_Rb_pABgroove_1 23 31 PF01858 0.594
LIG_SH2_CRK 14 18 PF00017 0.600
LIG_SH2_CRK 354 358 PF00017 0.455
LIG_SH2_PTP2 297 300 PF00017 0.531
LIG_SH2_STAP1 219 223 PF00017 0.534
LIG_SH2_STAP1 246 250 PF00017 0.689
LIG_SH2_STAP1 276 280 PF00017 0.515
LIG_SH2_STAT5 297 300 PF00017 0.531
LIG_SH3_3 17 23 PF00018 0.498
LIG_SH3_3 179 185 PF00018 0.710
LIG_SH3_3 62 68 PF00018 0.790
LIG_SH3_3 77 83 PF00018 0.799
LIG_SH3_3 86 92 PF00018 0.660
LIG_SUMO_SIM_par_1 277 284 PF11976 0.618
LIG_TRAF2_1 212 215 PF00917 0.605
LIG_WRC_WIRS_1 24 29 PF05994 0.594
MOD_CK1_1 134 140 PF00069 0.530
MOD_CK1_1 60 66 PF00069 0.737
MOD_CK1_1 81 87 PF00069 0.545
MOD_CK2_1 143 149 PF00069 0.374
MOD_CK2_1 37 43 PF00069 0.563
MOD_GlcNHglycan 104 107 PF01048 0.531
MOD_GlcNHglycan 127 130 PF01048 0.462
MOD_GlcNHglycan 133 136 PF01048 0.386
MOD_GlcNHglycan 2 5 PF01048 0.642
MOD_GlcNHglycan 268 271 PF01048 0.665
MOD_GlcNHglycan 325 328 PF01048 0.327
MOD_GlcNHglycan 60 63 PF01048 0.770
MOD_GlcNHglycan 80 83 PF01048 0.537
MOD_GSK3_1 125 132 PF00069 0.686
MOD_GSK3_1 158 165 PF00069 0.639
MOD_GSK3_1 323 330 PF00069 0.446
MOD_GSK3_1 34 41 PF00069 0.599
MOD_NEK2_1 143 148 PF00069 0.531
MOD_NEK2_1 171 176 PF00069 0.822
MOD_NEK2_1 230 235 PF00069 0.600
MOD_NEK2_1 34 39 PF00069 0.489
MOD_PK_1 261 267 PF00069 0.576
MOD_PKA_2 130 136 PF00069 0.567
MOD_Plk_1 108 114 PF00069 0.736
MOD_Plk_1 162 168 PF00069 0.667
MOD_Plk_1 194 200 PF00069 0.689
MOD_Plk_1 34 40 PF00069 0.573
MOD_Plk_2-3 278 284 PF00069 0.612
MOD_Plk_4 118 124 PF00069 0.616
MOD_Plk_4 194 200 PF00069 0.660
MOD_Plk_4 23 29 PF00069 0.570
MOD_Plk_4 261 267 PF00069 0.702
MOD_Plk_4 34 40 PF00069 0.430
MOD_ProDKin_1 60 66 PF00069 0.782
MOD_SUMO_rev_2 254 263 PF00179 0.663
TRG_DiLeu_BaEn_4 277 283 PF01217 0.613
TRG_DiLeu_BaLyEn_6 136 141 PF01217 0.374
TRG_DiLeu_BaLyEn_6 20 25 PF01217 0.537
TRG_ENDOCYTIC_2 219 222 PF00928 0.568
TRG_ENDOCYTIC_2 276 279 PF00928 0.482
TRG_ENDOCYTIC_2 297 300 PF00928 0.531
TRG_ER_diArg_1 173 176 PF00400 0.658
TRG_ER_diArg_1 31 33 PF00400 0.592
TRG_NLS_MonoExtC_3 171 176 PF00514 0.686
TRG_NLS_MonoExtC_3 342 347 PF00514 0.337

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKE1 Leptomonas seymouri 43% 100%
A0A1X0NZJ6 Trypanosomatidae 28% 100%
A0A3R7KZA5 Trypanosoma rangeli 26% 92%
A0A3S5H7F3 Leishmania donovani 67% 100%
A4I1T5 Leishmania infantum 67% 100%
E9AXW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
Q4Q9K1 Leishmania major 71% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS