VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HED6_LEIBR

TriTrypDb:

LbrM.25.1920 , LBRM2903_250032500

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HED6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HED6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	232	234	PF00675	0.628
CLV_NRD_NRD_1	277	279	PF00675	0.411
CLV_NRD_NRD_1	574	576	PF00675	0.526
CLV_PCSK_KEX2_1	232	234	PF00082	0.628
CLV_PCSK_KEX2_1	277	279	PF00082	0.411
CLV_PCSK_KEX2_1	574	576	PF00082	0.501
CLV_PCSK_SKI1_1	270	274	PF00082	0.406
CLV_PCSK_SKI1_1	344	348	PF00082	0.491
CLV_PCSK_SKI1_1	479	483	PF00082	0.223
CLV_PCSK_SKI1_1	575	579	PF00082	0.507
CLV_PCSK_SKI1_1	679	683	PF00082	0.584
CLV_PCSK_SKI1_1	740	744	PF00082	0.473
DEG_APCC_DBOX_1	343	351	PF00400	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.515
DOC_CYCLIN_RxL_1	676	686	PF00134	0.601
DOC_CYCLIN_RxL_1	731	739	PF00134	0.628
DOC_MAPK_gen_1	238	246	PF00069	0.344
DOC_MAPK_gen_1	574	582	PF00069	0.506
DOC_MAPK_MEF2A_6	238	246	PF00069	0.480
DOC_MAPK_MEF2A_6	552	561	PF00069	0.565
DOC_PP1_RVXF_1	615	622	PF00149	0.515
DOC_PP2B_LxvP_1	196	199	PF13499	0.711
DOC_PP2B_LxvP_1	613	616	PF13499	0.516
DOC_PP4_FxxP_1	104	107	PF00568	0.590
DOC_USP7_MATH_1	419	423	PF00917	0.628
DOC_USP7_MATH_1	723	727	PF00917	0.587
DOC_USP7_MATH_1	730	734	PF00917	0.536
DOC_USP7_MATH_1	83	87	PF00917	0.449
DOC_WW_Pin1_4	103	108	PF00397	0.497
DOC_WW_Pin1_4	187	192	PF00397	0.640
DOC_WW_Pin1_4	199	204	PF00397	0.621
DOC_WW_Pin1_4	407	412	PF00397	0.500
DOC_WW_Pin1_4	628	633	PF00397	0.678
DOC_WW_Pin1_4	724	729	PF00397	0.658
LIG_14-3-3_CanoR_1	116	123	PF00244	0.618
LIG_14-3-3_CanoR_1	186	191	PF00244	0.634
LIG_14-3-3_CanoR_1	308	312	PF00244	0.493
LIG_14-3-3_CanoR_1	321	330	PF00244	0.527
LIG_14-3-3_CanoR_1	37	47	PF00244	0.641
LIG_14-3-3_CanoR_1	420	428	PF00244	0.561
LIG_14-3-3_CanoR_1	477	482	PF00244	0.223
LIG_14-3-3_CanoR_1	740	749	PF00244	0.537
LIG_Actin_WH2_2	556	571	PF00022	0.332
LIG_BIR_III_4	584	588	PF00653	0.369
LIG_CSL_BTD_1	613	616	PF09270	0.411
LIG_CtBP_PxDLS_1	363	369	PF00389	0.305
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.585
LIG_EH1_1	507	515	PF00400	0.413
LIG_eIF4E_1	508	514	PF01652	0.328
LIG_FHA_1	250	256	PF00498	0.577
LIG_FHA_1	263	269	PF00498	0.426
LIG_FHA_1	284	290	PF00498	0.615
LIG_FHA_1	448	454	PF00498	0.262
LIG_FHA_1	509	515	PF00498	0.363
LIG_FHA_1	534	540	PF00498	0.333
LIG_FHA_1	597	603	PF00498	0.519
LIG_FHA_1	741	747	PF00498	0.584
LIG_FHA_1	98	104	PF00498	0.429
LIG_FHA_2	408	414	PF00498	0.506
LIG_FHA_2	525	531	PF00498	0.344
LIG_FHA_2	639	645	PF00498	0.613
LIG_FHA_2	8	14	PF00498	0.522
LIG_Integrin_isoDGR_2	319	321	PF01839	0.406
LIG_LIR_Apic_2	102	107	PF02991	0.581
LIG_LIR_Gen_1	217	227	PF02991	0.522
LIG_LIR_Nem_3	18	23	PF02991	0.411
LIG_LIR_Nem_3	217	223	PF02991	0.512
LIG_LIR_Nem_3	75	80	PF02991	0.344
LIG_LYPXL_yS_3	380	383	PF13949	0.508
LIG_MYND_1	199	203	PF01753	0.710
LIG_NRBOX	448	454	PF00104	0.449
LIG_NRBOX	677	683	PF00104	0.325
LIG_NRBOX	741	747	PF00104	0.557
LIG_PCNA_PIPBox_1	735	744	PF02747	0.386
LIG_PCNA_yPIPBox_3	538	552	PF02747	0.437
LIG_Pex14_1	214	218	PF04695	0.470
LIG_Pex14_2	276	280	PF04695	0.389
LIG_PTB_Apo_2	223	230	PF02174	0.363
LIG_PTB_Apo_2	634	641	PF02174	0.620
LIG_SH2_CRK	387	391	PF00017	0.481
LIG_SH2_NCK_1	236	240	PF00017	0.571
LIG_SH2_NCK_1	387	391	PF00017	0.534
LIG_SH2_PTP2	610	613	PF00017	0.553
LIG_SH2_STAP1	387	391	PF00017	0.534
LIG_SH2_STAP1	668	672	PF00017	0.536
LIG_SH2_STAT5	20	23	PF00017	0.437
LIG_SH2_STAT5	254	257	PF00017	0.586
LIG_SH2_STAT5	258	261	PF00017	0.495
LIG_SH2_STAT5	281	284	PF00017	0.452
LIG_SH2_STAT5	497	500	PF00017	0.363
LIG_SH2_STAT5	610	613	PF00017	0.441
LIG_SH2_STAT5	65	68	PF00017	0.328
LIG_SH2_STAT5	80	83	PF00017	0.328
LIG_SH2_STAT5	88	91	PF00017	0.377
LIG_SH3_2	729	734	PF14604	0.655
LIG_SH3_3	170	176	PF00018	0.481
LIG_SH3_3	25	31	PF00018	0.473
LIG_SH3_3	647	653	PF00018	0.552
LIG_SH3_3	726	732	PF00018	0.582
LIG_SH3_3	9	15	PF00018	0.647
LIG_SUMO_SIM_anti_2	599	604	PF11976	0.598
LIG_SUMO_SIM_anti_2	643	649	PF11976	0.561
LIG_SUMO_SIM_par_1	598	604	PF11976	0.601
LIG_TRAF2_1	527	530	PF00917	0.413
LIG_TRAF2_1	641	644	PF00917	0.613
MOD_CDK_SPxxK_3	199	206	PF00069	0.705
MOD_CK1_1	115	121	PF00069	0.588
MOD_CK1_1	222	228	PF00069	0.517
MOD_CK1_1	249	255	PF00069	0.520
MOD_CK1_1	38	44	PF00069	0.492
MOD_CK1_1	480	486	PF00069	0.223
MOD_CK1_1	591	597	PF00069	0.594
MOD_CK1_1	7	13	PF00069	0.614
MOD_CK1_1	86	92	PF00069	0.426
MOD_CK2_1	103	109	PF00069	0.347
MOD_CK2_1	524	530	PF00069	0.363
MOD_CK2_1	638	644	PF00069	0.581
MOD_CK2_1	689	695	PF00069	0.658
MOD_GlcNHglycan	126	129	PF01048	0.717
MOD_GlcNHglycan	176	179	PF01048	0.574
MOD_GlcNHglycan	181	184	PF01048	0.538
MOD_GlcNHglycan	323	326	PF01048	0.599
MOD_GlcNHglycan	40	43	PF01048	0.632
MOD_GlcNHglycan	486	489	PF01048	0.331
MOD_GlcNHglycan	590	593	PF01048	0.586
MOD_GlcNHglycan	60	63	PF01048	0.304
MOD_GlcNHglycan	669	672	PF01048	0.537
MOD_GlcNHglycan	83	86	PF01048	0.381
MOD_GSK3_1	112	119	PF00069	0.597
MOD_GSK3_1	124	131	PF00069	0.642
MOD_GSK3_1	264	271	PF00069	0.562
MOD_GSK3_1	303	310	PF00069	0.514
MOD_GSK3_1	31	38	PF00069	0.583
MOD_GSK3_1	334	341	PF00069	0.386
MOD_GSK3_1	43	50	PF00069	0.611
MOD_GSK3_1	443	450	PF00069	0.354
MOD_GSK3_1	463	470	PF00069	0.419
MOD_GSK3_1	477	484	PF00069	0.307
MOD_GSK3_1	508	515	PF00069	0.449
MOD_GSK3_1	587	594	PF00069	0.672
MOD_GSK3_1	624	631	PF00069	0.447
MOD_GSK3_1	99	106	PF00069	0.456
MOD_N-GLC_1	249	254	PF02516	0.614
MOD_NEK2_1	262	267	PF00069	0.475
MOD_NEK2_1	283	288	PF00069	0.448
MOD_NEK2_1	307	312	PF00069	0.485
MOD_NEK2_1	398	403	PF00069	0.492
MOD_NEK2_1	499	504	PF00069	0.428
MOD_NEK2_1	524	529	PF00069	0.323
MOD_NEK2_1	532	537	PF00069	0.296
MOD_NEK2_1	57	62	PF00069	0.571
MOD_NEK2_1	6	11	PF00069	0.614
MOD_NEK2_1	667	672	PF00069	0.475
MOD_NEK2_1	97	102	PF00069	0.504
MOD_NEK2_2	303	308	PF00069	0.623
MOD_OFUCOSY	282	287	PF10250	0.571
MOD_PIKK_1	31	37	PF00454	0.575
MOD_PIKK_1	385	391	PF00454	0.548
MOD_PIKK_1	421	427	PF00454	0.680
MOD_PIKK_1	443	449	PF00454	0.442
MOD_PIKK_1	467	473	PF00454	0.358
MOD_PIKK_1	497	503	PF00454	0.449
MOD_PIKK_1	525	531	PF00454	0.413
MOD_PIKK_1	638	644	PF00454	0.641
MOD_PIKK_1	699	705	PF00454	0.579
MOD_PK_1	477	483	PF00069	0.223
MOD_PKA_2	115	121	PF00069	0.474
MOD_PKA_2	179	185	PF00069	0.532
MOD_PKA_2	214	220	PF00069	0.600
MOD_PKA_2	307	313	PF00069	0.476
MOD_PKA_2	419	425	PF00069	0.648
MOD_PKA_2	467	473	PF00069	0.383
MOD_PKA_2	689	695	PF00069	0.675
MOD_PKA_2	86	92	PF00069	0.426
MOD_Plk_1	393	399	PF00069	0.496
MOD_Plk_1	643	649	PF00069	0.614
MOD_Plk_2-3	596	602	PF00069	0.589
MOD_Plk_4	219	225	PF00069	0.484
MOD_Plk_4	362	368	PF00069	0.559
MOD_Plk_4	540	546	PF00069	0.333
MOD_Plk_4	643	649	PF00069	0.637
MOD_Plk_4	99	105	PF00069	0.440
MOD_ProDKin_1	103	109	PF00069	0.500
MOD_ProDKin_1	187	193	PF00069	0.649
MOD_ProDKin_1	199	205	PF00069	0.618
MOD_ProDKin_1	407	413	PF00069	0.497
MOD_ProDKin_1	628	634	PF00069	0.675
MOD_ProDKin_1	724	730	PF00069	0.655
TRG_DiLeu_BaEn_1	643	648	PF01217	0.593
TRG_DiLeu_BaEn_4	643	649	PF01217	0.590
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.570
TRG_ENDOCYTIC_2	20	23	PF00928	0.431
TRG_ENDOCYTIC_2	380	383	PF00928	0.437
TRG_ENDOCYTIC_2	387	390	PF00928	0.403
TRG_ENDOCYTIC_2	610	613	PF00928	0.527
TRG_ER_diArg_1	232	234	PF00400	0.628
TRG_ER_diArg_1	241	244	PF00400	0.490
TRG_ER_diArg_1	276	278	PF00400	0.403
TRG_ER_diArg_1	51	54	PF00400	0.538
TRG_ER_diArg_1	676	679	PF00400	0.318
TRG_Pf-PMV_PEXEL_1	734	739	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV2	Leptomonas seymouri	62%	89%
A0A0S4IXM9	Bodo saltans	34%	70%
A0A1X0NY26	Trypanosomatidae	39%	82%
A0A3S7WZE1	Leishmania donovani	87%	89%
A0A422P4H0	Trypanosoma rangeli	37%	80%
A4I1T3	Leishmania infantum	88%	89%
C9ZKD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	81%
E9AXW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	89%
Q4Q9K3	Leishmania major	86%	100%
V5BH11	Trypanosoma cruzi	40%	85%