Signal peptidase complex subunit 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microsomal signal peptidase 12 kDa subunit (SPC12), putative

Species:

Leishmania braziliensis

UniProt:

A4HED5_LEIBR

TriTrypDb:

LbrM.25.1910 , LBRM2903_250032400

Length:

145

Annotations

LeishMANIAdb annotations

These kinetoplastid proteins share some structural homology to the signal peptidase complex subunit 1 of other Eukaryotes.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005787	signal peptidase complex	3	9
GO:0016020	membrane	2	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

A4HED5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HED5

Function

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Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	9
GO:0006508	proteolysis	4	9
GO:0006518	peptide metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0016485	protein processing	5	9
GO:0019538	protein metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043603	amide metabolic process	3	9
GO:0044238	primary metabolic process	2	9

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.544
CLV_PCSK_KEX2_1	115	117	PF00082	0.330
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.330
DEG_Nend_UBRbox_1	1	4	PF02207	0.593
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.675
DOC_PP1_RVXF_1	45	51	PF00149	0.418
DOC_PP2B_LxvP_1	83	86	PF13499	0.438
DOC_USP7_MATH_2	136	142	PF00917	0.599
DOC_WW_Pin1_4	129	134	PF00397	0.742
DOC_WW_Pin1_4	28	33	PF00397	0.642

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M9	Leptomonas seymouri	54%	100%
A0A1X0NYN0	Trypanosomatidae	41%	100%
A0A3S7WZI3	Leishmania donovani	79%	100%
A4I1T2	Leishmania infantum	78%	100%
C9ZKD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AXW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q95ZB5	Leishmania major	75%	100%

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