Transcription initiation factor TFIID subunit 6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HED4_LEIBR

TriTrypDb:

LbrM.25.1900 , LBRM2903_250032300

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HED4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HED4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.434
CLV_C14_Caspase3-7	290	294	PF00656	0.433
CLV_C14_Caspase3-7	368	372	PF00656	0.594
CLV_NRD_NRD_1	148	150	PF00675	0.521
CLV_NRD_NRD_1	229	231	PF00675	0.475
CLV_NRD_NRD_1	45	47	PF00675	0.704
CLV_NRD_NRD_1	505	507	PF00675	0.538
CLV_NRD_NRD_1	98	100	PF00675	0.518
CLV_PCSK_KEX2_1	148	150	PF00082	0.521
CLV_PCSK_KEX2_1	229	231	PF00082	0.475
CLV_PCSK_KEX2_1	45	47	PF00082	0.704
CLV_PCSK_KEX2_1	505	507	PF00082	0.564
CLV_PCSK_KEX2_1	575	577	PF00082	0.561
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.561
CLV_PCSK_SKI1_1	115	119	PF00082	0.459
CLV_PCSK_SKI1_1	148	152	PF00082	0.464
CLV_PCSK_SKI1_1	245	249	PF00082	0.453
CLV_PCSK_SKI1_1	309	313	PF00082	0.472
CLV_PCSK_SKI1_1	468	472	PF00082	0.477
CLV_PCSK_SKI1_1	571	575	PF00082	0.522
CLV_PCSK_SKI1_1	59	63	PF00082	0.367
DEG_APCC_DBOX_1	147	155	PF00400	0.547
DEG_APCC_DBOX_1	467	475	PF00400	0.499
DEG_SPOP_SBC_1	539	543	PF00917	0.444
DOC_CKS1_1	1	6	PF01111	0.739
DOC_MAPK_gen_1	229	236	PF00069	0.336
DOC_MAPK_gen_1	280	289	PF00069	0.483
DOC_MAPK_MEF2A_6	229	238	PF00069	0.573
DOC_MAPK_MEF2A_6	282	291	PF00069	0.508
DOC_MAPK_MEF2A_6	425	432	PF00069	0.489
DOC_PP1_RVXF_1	113	119	PF00149	0.509
DOC_PP1_RVXF_1	243	250	PF00149	0.472
DOC_PP2B_LxvP_1	23	26	PF13499	0.727
DOC_PP4_FxxP_1	526	529	PF00568	0.712
DOC_USP7_MATH_1	127	131	PF00917	0.560
DOC_USP7_MATH_1	26	30	PF00917	0.573
DOC_USP7_MATH_1	384	388	PF00917	0.506
DOC_USP7_MATH_1	53	57	PF00917	0.560
DOC_USP7_MATH_1	535	539	PF00917	0.707
DOC_USP7_UBL2_3	571	575	PF12436	0.541
DOC_USP7_UBL2_3	59	63	PF12436	0.470
DOC_WW_Pin1_4	21	26	PF00397	0.600
DOC_WW_Pin1_4	270	275	PF00397	0.421
DOC_WW_Pin1_4	291	296	PF00397	0.426
DOC_WW_Pin1_4	317	322	PF00397	0.496
DOC_WW_Pin1_4	423	428	PF00397	0.512
DOC_WW_Pin1_4	525	530	PF00397	0.695
LIG_14-3-3_CanoR_1	15	23	PF00244	0.613
LIG_Actin_WH2_2	140	157	PF00022	0.588
LIG_Actin_WH2_2	216	231	PF00022	0.343
LIG_Actin_WH2_2	453	470	PF00022	0.437
LIG_BIR_II_1	1	5	PF00653	0.766
LIG_BRCT_BRCA1_1	194	198	PF00533	0.518
LIG_BRCT_BRCA1_1	396	400	PF00533	0.349
LIG_BRCT_BRCA1_1	448	452	PF00533	0.549
LIG_CaM_IQ_9	209	224	PF13499	0.346
LIG_EH_1	76	80	PF12763	0.495
LIG_eIF4E_1	466	472	PF01652	0.509
LIG_FHA_1	120	126	PF00498	0.510
LIG_FHA_1	197	203	PF00498	0.467
LIG_FHA_1	266	272	PF00498	0.368
LIG_FHA_1	32	38	PF00498	0.581
LIG_FHA_1	343	349	PF00498	0.563
LIG_FHA_1	49	55	PF00498	0.602
LIG_FHA_1	557	563	PF00498	0.409
LIG_FHA_2	1	7	PF00498	0.608
LIG_FHA_2	134	140	PF00498	0.626
LIG_FHA_2	205	211	PF00498	0.435
LIG_FHA_2	288	294	PF00498	0.523
LIG_FHA_2	31	37	PF00498	0.540
LIG_LIR_Apic_2	298	302	PF02991	0.472
LIG_LIR_Apic_2	378	384	PF02991	0.571
LIG_LIR_Gen_1	250	259	PF02991	0.381
LIG_LIR_Gen_1	268	274	PF02991	0.375
LIG_LIR_Gen_1	363	372	PF02991	0.502
LIG_LIR_Gen_1	498	504	PF02991	0.402
LIG_LIR_Gen_1	5	14	PF02991	0.651
LIG_LIR_Nem_3	268	272	PF02991	0.369
LIG_LIR_Nem_3	363	369	PF02991	0.475
LIG_LIR_Nem_3	498	502	PF02991	0.397
LIG_LIR_Nem_3	5	10	PF02991	0.639
LIG_MLH1_MIPbox_1	448	452	PF16413	0.549
LIG_PCNA_yPIPBox_3	555	569	PF02747	0.334
LIG_Pex14_1	564	568	PF04695	0.363
LIG_Pex14_2	447	451	PF04695	0.495
LIG_PTB_Apo_2	161	168	PF02174	0.334
LIG_PTB_Phospho_1	161	167	PF10480	0.427
LIG_SH2_CRK	167	171	PF00017	0.419
LIG_SH2_CRK	299	303	PF00017	0.386
LIG_SH2_CRK	318	322	PF00017	0.501
LIG_SH2_CRK	381	385	PF00017	0.577
LIG_SH2_NCK_1	318	322	PF00017	0.501
LIG_SH2_SRC	156	159	PF00017	0.330
LIG_SH2_SRC	381	384	PF00017	0.568
LIG_SH2_SRC	393	396	PF00017	0.356
LIG_SH2_STAP1	251	255	PF00017	0.445
LIG_SH2_STAT3	85	88	PF00017	0.548
LIG_SH2_STAT5	156	159	PF00017	0.550
LIG_SH2_STAT5	173	176	PF00017	0.493
LIG_SH2_STAT5	265	268	PF00017	0.379
LIG_SH2_STAT5	318	321	PF00017	0.499
LIG_SH2_STAT5	466	469	PF00017	0.411
LIG_SH3_3	159	165	PF00018	0.491
LIG_SH3_3	268	274	PF00018	0.435
LIG_SUMO_SIM_par_1	198	203	PF11976	0.311
LIG_SUMO_SIM_par_1	252	258	PF11976	0.397
LIG_SUMO_SIM_par_1	287	294	PF11976	0.553
LIG_UBA3_1	304	309	PF00899	0.405
LIG_WRC_WIRS_1	266	271	PF05994	0.362
LIG_WRC_WIRS_1	68	73	PF05994	0.482
LIG_WW_1	508	511	PF00397	0.628
LIG_WW_3	242	246	PF00397	0.492
MOD_CDK_SPK_2	270	275	PF00069	0.452
MOD_CDK_SPK_2	525	530	PF00069	0.479
MOD_CK1_1	107	113	PF00069	0.415
MOD_CK1_1	364	370	PF00069	0.423
MOD_CK1_1	48	54	PF00069	0.572
MOD_CK1_1	513	519	PF00069	0.704
MOD_CK1_1	528	534	PF00069	0.709
MOD_CK1_1	538	544	PF00069	0.620
MOD_CK1_1	546	552	PF00069	0.368
MOD_CK2_1	30	36	PF00069	0.544
MOD_CK2_1	333	339	PF00069	0.591
MOD_GlcNHglycan	106	109	PF01048	0.466
MOD_GlcNHglycan	158	161	PF01048	0.531
MOD_GlcNHglycan	184	187	PF01048	0.333
MOD_GlcNHglycan	26	29	PF01048	0.660
MOD_GlcNHglycan	298	302	PF01048	0.488
MOD_GlcNHglycan	386	389	PF01048	0.479
MOD_GlcNHglycan	42	45	PF01048	0.453
MOD_GlcNHglycan	536	540	PF01048	0.694
MOD_GSK3_1	156	163	PF00069	0.518
MOD_GSK3_1	182	189	PF00069	0.440
MOD_GSK3_1	192	199	PF00069	0.452
MOD_GSK3_1	200	207	PF00069	0.434
MOD_GSK3_1	26	33	PF00069	0.549
MOD_GSK3_1	287	294	PF00069	0.457
MOD_GSK3_1	342	349	PF00069	0.571
MOD_GSK3_1	360	367	PF00069	0.263
MOD_GSK3_1	400	407	PF00069	0.624
MOD_GSK3_1	513	520	PF00069	0.711
MOD_GSK3_1	535	542	PF00069	0.713
MOD_GSK3_1	67	74	PF00069	0.555
MOD_N-GLC_1	192	197	PF02516	0.575
MOD_NEK2_1	342	347	PF00069	0.587
MOD_NEK2_1	358	363	PF00069	0.372
MOD_NEK2_1	400	405	PF00069	0.640
MOD_NEK2_1	447	452	PF00069	0.489
MOD_NEK2_1	495	500	PF00069	0.415
MOD_NEK2_1	71	76	PF00069	0.568
MOD_PIKK_1	192	198	PF00454	0.488
MOD_PIKK_1	200	206	PF00454	0.535
MOD_PIKK_1	48	54	PF00454	0.593
MOD_PIKK_1	71	77	PF00454	0.563
MOD_PK_1	230	236	PF00069	0.536
MOD_PK_1	45	51	PF00069	0.636
MOD_PKA_1	45	51	PF00069	0.669
MOD_PKA_2	14	20	PF00069	0.555
MOD_PKA_2	346	352	PF00069	0.565
MOD_PKA_2	45	51	PF00069	0.544
MOD_Plk_1	447	453	PF00069	0.466
MOD_Plk_1	5	11	PF00069	0.578
MOD_Plk_4	204	210	PF00069	0.426
MOD_Plk_4	361	367	PF00069	0.474
MOD_Plk_4	447	453	PF00069	0.464
MOD_Plk_4	498	504	PF00069	0.485
MOD_ProDKin_1	21	27	PF00069	0.598
MOD_ProDKin_1	270	276	PF00069	0.423
MOD_ProDKin_1	291	297	PF00069	0.428
MOD_ProDKin_1	317	323	PF00069	0.493
MOD_ProDKin_1	423	429	PF00069	0.505
MOD_ProDKin_1	525	531	PF00069	0.697
MOD_SUMO_for_1	221	224	PF00179	0.616
MOD_SUMO_rev_2	210	219	PF00179	0.564
MOD_SUMO_rev_2	368	375	PF00179	0.649
MOD_SUMO_rev_2	56	61	PF00179	0.536
TRG_ENDOCYTIC_2	167	170	PF00928	0.418
TRG_ENDOCYTIC_2	251	254	PF00928	0.461
TRG_ENDOCYTIC_2	81	84	PF00928	0.477
TRG_ER_diArg_1	147	149	PF00400	0.505
TRG_ER_diArg_1	228	230	PF00400	0.453
TRG_ER_diArg_1	504	506	PF00400	0.592
TRG_ER_diLys_1	574	577	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P620	Leptomonas seymouri	72%	100%
A0A0S4J1E1	Bodo saltans	33%	97%
A0A1X0NY27	Trypanosomatidae	38%	100%
A0A3R7RTJ3	Trypanosoma rangeli	38%	100%
A0A3S7WZE8	Leishmania donovani	87%	100%
A4I1T1	Leishmania infantum	87%	100%
E9AXW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q95ZB6	Leishmania major	86%	100%
V5B817	Trypanosoma cruzi	41%	100%