LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HED2_LEIBR
TriTrypDb:
LbrM.25.1860 , LBRM2903_250031900 *
Length:
453

Annotations

LeishMANIAdb annotations

Unique Kinetoplastid protein of unclear topology and structure. Might not be a TM protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HED2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HED2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.581
CLV_NRD_NRD_1 198 200 PF00675 0.573
CLV_NRD_NRD_1 202 204 PF00675 0.552
CLV_NRD_NRD_1 38 40 PF00675 0.401
CLV_NRD_NRD_1 43 45 PF00675 0.363
CLV_NRD_NRD_1 99 101 PF00675 0.469
CLV_PCSK_FUR_1 199 203 PF00082 0.462
CLV_PCSK_KEX2_1 14 16 PF00082 0.454
CLV_PCSK_KEX2_1 198 200 PF00082 0.593
CLV_PCSK_KEX2_1 201 203 PF00082 0.583
CLV_PCSK_KEX2_1 34 36 PF00082 0.219
CLV_PCSK_KEX2_1 401 403 PF00082 0.642
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.482
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.219
CLV_PCSK_PC1ET2_1 401 403 PF00082 0.626
CLV_PCSK_PC7_1 198 204 PF00082 0.638
CLV_PCSK_SKI1_1 108 112 PF00082 0.433
CLV_PCSK_SKI1_1 150 154 PF00082 0.365
CLV_PCSK_SKI1_1 210 214 PF00082 0.532
CLV_PCSK_SKI1_1 272 276 PF00082 0.579
CLV_PCSK_SKI1_1 401 405 PF00082 0.622
CLV_PCSK_SKI1_1 48 52 PF00082 0.368
CLV_PCSK_SKI1_1 69 73 PF00082 0.367
CLV_Separin_Metazoa 151 155 PF03568 0.658
DEG_SPOP_SBC_1 124 128 PF00917 0.577
DOC_CDC14_PxL_1 57 65 PF14671 0.647
DOC_CYCLIN_RxL_1 9 22 PF00134 0.604
DOC_CYCLIN_yClb1_LxF_4 13 18 PF00134 0.609
DOC_CYCLIN_yCln2_LP_2 228 231 PF00134 0.363
DOC_CYCLIN_yCln2_LP_2 301 307 PF00134 0.519
DOC_CYCLIN_yCln2_LP_2 404 410 PF00134 0.419
DOC_MAPK_gen_1 164 174 PF00069 0.486
DOC_MAPK_MEF2A_6 167 176 PF00069 0.444
DOC_MAPK_MEF2A_6 310 319 PF00069 0.414
DOC_MAPK_MEF2A_6 69 76 PF00069 0.608
DOC_PP1_RVXF_1 12 19 PF00149 0.603
DOC_PP1_RVXF_1 165 171 PF00149 0.556
DOC_PP1_RVXF_1 270 276 PF00149 0.284
DOC_PP1_RVXF_1 430 436 PF00149 0.426
DOC_PP2B_LxvP_1 228 231 PF13499 0.334
DOC_PP2B_LxvP_1 404 407 PF13499 0.420
DOC_PP2B_LxvP_1 63 66 PF13499 0.607
DOC_PP4_FxxP_1 449 452 PF00568 0.265
DOC_USP7_MATH_1 122 126 PF00917 0.756
DOC_USP7_MATH_1 224 228 PF00917 0.386
DOC_USP7_MATH_1 255 259 PF00917 0.357
DOC_USP7_MATH_1 308 312 PF00917 0.481
DOC_USP7_UBL2_3 422 426 PF12436 0.431
LIG_14-3-3_CanoR_1 20 26 PF00244 0.548
LIG_14-3-3_CanoR_1 210 215 PF00244 0.314
LIG_14-3-3_CanoR_1 328 337 PF00244 0.504
LIG_14-3-3_CanoR_1 9 13 PF00244 0.614
LIG_Actin_WH2_2 347 362 PF00022 0.414
LIG_AP2alpha_1 445 449 PF02296 0.442
LIG_BIR_II_1 1 5 PF00653 0.702
LIG_BIR_III_4 238 242 PF00653 0.452
LIG_BRCT_BRCA1_1 310 314 PF00533 0.472
LIG_EH1_1 256 264 PF00400 0.245
LIG_FHA_1 163 169 PF00498 0.549
LIG_FHA_1 184 190 PF00498 0.415
LIG_FHA_1 258 264 PF00498 0.292
LIG_FHA_2 215 221 PF00498 0.378
LIG_FHA_2 369 375 PF00498 0.452
LIG_LIR_Apic_2 447 452 PF02991 0.274
LIG_LIR_Gen_1 294 303 PF02991 0.437
LIG_LIR_Nem_3 207 212 PF02991 0.344
LIG_LIR_Nem_3 294 298 PF02991 0.425
LIG_LIR_Nem_3 311 317 PF02991 0.355
LIG_LIR_Nem_3 443 448 PF02991 0.361
LIG_MYND_1 335 339 PF01753 0.422
LIG_NRBOX 167 173 PF00104 0.493
LIG_PCNA_yPIPBox_3 129 143 PF02747 0.623
LIG_Pex14_1 192 196 PF04695 0.355
LIG_Pex14_2 445 449 PF04695 0.394
LIG_SH2_CRK 181 185 PF00017 0.441
LIG_SH2_CRK 225 229 PF00017 0.358
LIG_SH2_NCK_1 236 240 PF00017 0.450
LIG_SH2_STAP1 225 229 PF00017 0.424
LIG_SH2_STAP1 245 249 PF00017 0.164
LIG_SH2_STAP1 26 30 PF00017 0.593
LIG_SH2_STAT5 193 196 PF00017 0.322
LIG_SH2_STAT5 208 211 PF00017 0.316
LIG_SH2_STAT5 41 44 PF00017 0.562
LIG_SH2_STAT5 448 451 PF00017 0.419
LIG_SH2_STAT5 54 57 PF00017 0.596
LIG_SH3_3 52 58 PF00018 0.587
LIG_SUMO_SIM_anti_2 258 263 PF11976 0.258
LIG_TRAF2_1 94 97 PF00917 0.563
LIG_TYR_ITIM 179 184 PF00017 0.424
LIG_WW_1 222 225 PF00397 0.366
MOD_CK1_1 125 131 PF00069 0.674
MOD_CK1_1 183 189 PF00069 0.532
MOD_CK2_1 214 220 PF00069 0.401
MOD_CK2_1 277 283 PF00069 0.412
MOD_CK2_1 327 333 PF00069 0.457
MOD_CK2_1 368 374 PF00069 0.376
MOD_CK2_1 91 97 PF00069 0.594
MOD_Cter_Amidation 37 40 PF01082 0.307
MOD_GlcNHglycan 131 134 PF01048 0.483
MOD_GlcNHglycan 330 333 PF01048 0.710
MOD_GlcNHglycan 367 371 PF01048 0.577
MOD_GSK3_1 125 132 PF00069 0.683
MOD_GSK3_1 210 217 PF00069 0.360
MOD_N-GLC_1 328 333 PF02516 0.735
MOD_N-GLC_1 91 96 PF02516 0.397
MOD_NEK2_1 214 219 PF00069 0.444
MOD_NEK2_1 327 332 PF00069 0.496
MOD_NEK2_1 368 373 PF00069 0.410
MOD_NEK2_2 162 167 PF00069 0.485
MOD_PIKK_1 19 25 PF00454 0.604
MOD_PKA_2 116 122 PF00069 0.720
MOD_PKA_2 19 25 PF00069 0.552
MOD_PKA_2 327 333 PF00069 0.477
MOD_PKA_2 8 14 PF00069 0.613
MOD_Plk_1 416 422 PF00069 0.301
MOD_Plk_1 91 97 PF00069 0.594
MOD_Plk_2-3 291 297 PF00069 0.418
MOD_Plk_2-3 447 453 PF00069 0.457
MOD_Plk_4 116 122 PF00069 0.563
MOD_Plk_4 157 163 PF00069 0.618
MOD_Plk_4 224 230 PF00069 0.418
MOD_Plk_4 257 263 PF00069 0.388
MOD_Plk_4 346 352 PF00069 0.400
MOD_Plk_4 416 422 PF00069 0.309
MOD_Plk_4 50 56 PF00069 0.580
MOD_Plk_4 85 91 PF00069 0.639
TRG_DiLeu_BaLyEn_6 72 77 PF01217 0.676
TRG_ENDOCYTIC_2 181 184 PF00928 0.422
TRG_ENDOCYTIC_2 191 194 PF00928 0.244
TRG_ENDOCYTIC_2 225 228 PF00928 0.367
TRG_ENDOCYTIC_2 448 451 PF00928 0.353
TRG_ENDOCYTIC_2 54 57 PF00928 0.601
TRG_ER_diArg_1 15 18 PF00400 0.641
TRG_ER_diArg_1 197 199 PF00400 0.434
TRG_ER_diArg_1 200 203 PF00400 0.404
TRG_ER_diArg_1 36 39 PF00400 0.656
TRG_NES_CRM1_1 439 453 PF08389 0.421
TRG_NLS_MonoExtC_3 13 19 PF00514 0.620
TRG_NLS_MonoExtN_4 13 18 PF00514 0.626
TRG_Pf-PMV_PEXEL_1 100 104 PF00026 0.464
TRG_Pf-PMV_PEXEL_1 203 207 PF00026 0.578

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYH4 Leptomonas seymouri 64% 97%
A0A0S4J1E4 Bodo saltans 40% 100%
A0A1X0NYG5 Trypanosomatidae 49% 100%
A0A3Q8ICN7 Leishmania donovani 85% 100%
C9ZKD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AXW1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q95ZC0 Leishmania major 85% 100%
V5BH15 Trypanosoma cruzi 48% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS