Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HED1_LEIBR

TriTrypDb:

LbrM.25.1850 , LBRM2903_250031800

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HED1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HED1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.576
CLV_NRD_NRD_1	14	16	PF00675	0.635
CLV_NRD_NRD_1	249	251	PF00675	0.826
CLV_PCSK_FUR_1	110	114	PF00082	0.587
CLV_PCSK_KEX2_1	112	114	PF00082	0.584
CLV_PCSK_KEX2_1	14	16	PF00082	0.635
CLV_PCSK_KEX2_1	251	253	PF00082	0.828
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.584
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.828
CLV_PCSK_SKI1_1	112	116	PF00082	0.575
CLV_PCSK_SKI1_1	121	125	PF00082	0.440
CLV_PCSK_SKI1_1	129	133	PF00082	0.361
CLV_PCSK_SKI1_1	168	172	PF00082	0.449
DEG_MDM2_SWIB_1	42	49	PF02201	0.750
DEG_SPOP_SBC_1	231	235	PF00917	0.625
DOC_CKS1_1	178	183	PF01111	0.549
DOC_CYCLIN_RxL_1	109	120	PF00134	0.770
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	28	31	PF00134	0.549
DOC_MAPK_gen_1	165	173	PF00069	0.650
DOC_MAPK_JIP1_4	110	116	PF00069	0.779
DOC_PP2B_LxvP_1	28	31	PF13499	0.549
DOC_PP2B_LxvP_1	36	39	PF13499	0.410
DOC_PP4_FxxP_1	200	203	PF00568	0.583
DOC_USP7_MATH_1	231	235	PF00917	0.625
DOC_USP7_MATH_1	85	89	PF00917	0.763
DOC_WW_Pin1_4	150	155	PF00397	0.785
DOC_WW_Pin1_4	177	182	PF00397	0.549
DOC_WW_Pin1_4	54	59	PF00397	0.639
DOC_WW_Pin1_4	7	12	PF00397	0.844
LIG_14-3-3_CanoR_1	129	134	PF00244	0.773
LIG_14-3-3_CanoR_1	21	26	PF00244	0.825
LIG_14-3-3_CanoR_1	67	73	PF00244	0.449
LIG_14-3-3_CanoR_1	86	94	PF00244	0.576
LIG_BRCT_BRCA1_1	233	237	PF00533	0.623
LIG_BRCT_BRCA1_1	31	35	PF00533	0.549
LIG_BRCT_BRCA1_1	69	73	PF00533	0.549
LIG_DLG_GKlike_1	21	28	PF00625	0.823
LIG_FHA_1	118	124	PF00498	0.750
LIG_FHA_1	20	26	PF00498	0.825
LIG_LIR_Apic_2	198	203	PF02991	0.580
LIG_LIR_Gen_1	32	43	PF02991	0.549
LIG_LIR_Nem_3	180	186	PF02991	0.549
LIG_LIR_Nem_3	208	213	PF02991	0.576
LIG_LIR_Nem_3	24	29	PF02991	0.818
LIG_LIR_Nem_3	32	38	PF02991	0.410
LIG_LIR_Nem_3	40	45	PF02991	0.269
LIG_LIR_Nem_3	64	69	PF02991	0.609
LIG_NRBOX	74	80	PF00104	0.549
LIG_PDZ_Class_1	250	255	PF00595	0.627
LIG_Pex14_2	179	183	PF04695	0.549
LIG_Pex14_2	184	188	PF04695	0.462
LIG_Pex14_2	42	46	PF04695	0.549
LIG_SH2_CRK	26	30	PF00017	0.650
LIG_SH2_CRK	66	70	PF00017	0.449
LIG_SH2_NCK_1	204	208	PF00017	0.579
LIG_SH2_SRC	174	177	PF00017	0.549
LIG_SH2_STAP1	174	178	PF00017	0.549
LIG_SH2_STAP1	189	193	PF00017	0.338
LIG_SH2_STAT5	122	125	PF00017	0.752
LIG_SH2_STAT5	189	192	PF00017	0.529
LIG_SH3_3	52	58	PF00018	0.633
LIG_TRAF2_1	218	221	PF00917	0.611
LIG_TRFH_1	26	30	PF08558	0.650
LIG_WRC_WIRS_1	185	190	PF05994	0.549
MOD_CDK_SPxxK_3	7	14	PF00069	0.844
MOD_CK1_1	127	133	PF00069	0.771
MOD_CK1_1	187	193	PF00069	0.650
MOD_CK1_1	37	43	PF00069	0.549
MOD_GlcNHglycan	129	132	PF01048	0.572
MOD_GlcNHglycan	46	49	PF01048	0.796
MOD_GlcNHglycan	63	66	PF01048	0.608
MOD_GSK3_1	246	253	PF00069	0.624
MOD_GSK3_1	34	41	PF00069	0.549
MOD_GSK3_1	61	68	PF00069	0.623
MOD_NEK2_1	117	122	PF00069	0.750
MOD_NEK2_1	124	129	PF00069	0.676
MOD_NEK2_1	184	189	PF00069	0.549
MOD_NEK2_1	232	237	PF00069	0.625
MOD_PIKK_1	122	128	PF00454	0.757
MOD_PIKK_1	216	222	PF00454	0.606
MOD_PKA_2	160	166	PF00069	0.758
MOD_PKA_2	85	91	PF00069	0.769
MOD_Plk_4	232	238	PF00069	0.626
MOD_Plk_4	38	44	PF00069	0.549
MOD_Plk_4	68	74	PF00069	0.549
MOD_ProDKin_1	150	156	PF00069	0.781
MOD_ProDKin_1	177	183	PF00069	0.549
MOD_ProDKin_1	54	60	PF00069	0.642
MOD_ProDKin_1	7	13	PF00069	0.844
MOD_SUMO_rev_2	130	140	PF00179	0.773
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.818
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.549
TRG_ENDOCYTIC_2	26	29	PF00928	0.818
TRG_ENDOCYTIC_2	66	69	PF00928	0.606
TRG_ER_diArg_1	13	15	PF00400	0.842
TRG_ER_diArg_1	247	250	PF00400	0.623
TRG_NLS_MonoExtN_4	247	254	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.370