Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEC9_LEIBR

TriTrypDb:

LbrM.25.1830 , LBRM2903_250031600

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HEC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.390
CLV_NRD_NRD_1	151	153	PF00675	0.703
CLV_NRD_NRD_1	400	402	PF00675	0.804
CLV_NRD_NRD_1	412	414	PF00675	0.661
CLV_NRD_NRD_1	470	472	PF00675	0.699
CLV_PCSK_KEX2_1	153	155	PF00082	0.704
CLV_PCSK_KEX2_1	400	402	PF00082	0.767
CLV_PCSK_KEX2_1	412	414	PF00082	0.700
CLV_PCSK_KEX2_1	470	472	PF00082	0.699
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.704
CLV_PCSK_PC7_1	408	414	PF00082	0.701
CLV_PCSK_SKI1_1	153	157	PF00082	0.632
CLV_PCSK_SKI1_1	25	29	PF00082	0.641
CLV_PCSK_SKI1_1	250	254	PF00082	0.683
CLV_PCSK_SKI1_1	412	416	PF00082	0.780
CLV_PCSK_SKI1_1	526	530	PF00082	0.420
DOC_CYCLIN_RxL_1	151	158	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.522
DOC_MAPK_DCC_7	203	212	PF00069	0.529
DOC_MAPK_gen_1	152	159	PF00069	0.435
DOC_PP1_RVXF_1	524	531	PF00149	0.615
DOC_PP2B_LxvP_1	206	209	PF13499	0.528
DOC_PP4_FxxP_1	530	533	PF00568	0.620
DOC_USP7_MATH_1	127	131	PF00917	0.476
DOC_USP7_MATH_1	263	267	PF00917	0.546
DOC_USP7_MATH_1	377	381	PF00917	0.528
DOC_USP7_MATH_1	399	403	PF00917	0.603
DOC_WW_Pin1_4	14	19	PF00397	0.563
DOC_WW_Pin1_4	160	165	PF00397	0.383
DOC_WW_Pin1_4	277	282	PF00397	0.408
DOC_WW_Pin1_4	310	315	PF00397	0.515
DOC_WW_Pin1_4	335	340	PF00397	0.541
DOC_WW_Pin1_4	476	481	PF00397	0.426
LIG_14-3-3_CanoR_1	154	160	PF00244	0.450
LIG_14-3-3_CanoR_1	250	256	PF00244	0.436
LIG_14-3-3_CanoR_1	297	305	PF00244	0.489
LIG_14-3-3_CanoR_1	376	385	PF00244	0.598
LIG_14-3-3_CanoR_1	439	445	PF00244	0.594
LIG_14-3-3_CanoR_1	471	477	PF00244	0.513
LIG_Actin_WH2_2	502	520	PF00022	0.380
LIG_FHA_1	167	173	PF00498	0.528
LIG_FHA_1	175	181	PF00498	0.397
LIG_FHA_1	233	239	PF00498	0.463
LIG_FHA_1	317	323	PF00498	0.495
LIG_FHA_1	342	348	PF00498	0.574
LIG_FHA_1	413	419	PF00498	0.444
LIG_FHA_2	270	276	PF00498	0.543
LIG_FHA_2	278	284	PF00498	0.473
LIG_FHA_2	45	51	PF00498	0.384
LIG_FHA_2	460	466	PF00498	0.431
LIG_Integrin_RGD_1	522	524	PF01839	0.390
LIG_KLC1_Yacidic_2	9	14	PF13176	0.338
LIG_LIR_Apic_2	32	38	PF02991	0.551
LIG_LIR_Apic_2	475	480	PF02991	0.511
LIG_LIR_Gen_1	419	429	PF02991	0.474
LIG_LIR_Gen_1	492	502	PF02991	0.469
LIG_LIR_Nem_3	142	146	PF02991	0.341
LIG_LIR_Nem_3	184	188	PF02991	0.341
LIG_LIR_Nem_3	419	425	PF02991	0.581
LIG_LIR_Nem_3	492	497	PF02991	0.431
LIG_LIR_Nem_3	500	506	PF02991	0.369
LIG_LIR_Nem_3	72	77	PF02991	0.435
LIG_LIR_Nem_3	9	13	PF02991	0.491
LIG_LYPXL_S_1	125	129	PF13949	0.658
LIG_LYPXL_yS_3	126	129	PF13949	0.460
LIG_Pex14_2	181	185	PF04695	0.302
LIG_SH2_CRK	503	507	PF00017	0.513
LIG_SH2_CRK	74	78	PF00017	0.385
LIG_SH2_SRC	12	15	PF00017	0.359
LIG_SH2_STAP1	166	170	PF00017	0.451
LIG_SH2_STAP1	300	304	PF00017	0.491
LIG_SH2_STAP1	353	357	PF00017	0.485
LIG_SH2_STAP1	503	507	PF00017	0.261
LIG_SH2_STAT3	455	458	PF00017	0.458
LIG_SH2_STAT5	12	15	PF00017	0.380
LIG_SH2_STAT5	300	303	PF00017	0.469
LIG_SH2_STAT5	54	57	PF00017	0.512
LIG_SH3_3	240	246	PF00018	0.434
LIG_SH3_3	368	374	PF00018	0.516
LIG_SUMO_SIM_par_1	168	174	PF11976	0.434
LIG_SUMO_SIM_par_1	313	319	PF11976	0.594
LIG_TRAF2_1	363	366	PF00917	0.604
LIG_TRAF2_1	417	420	PF00917	0.407
LIG_TYR_ITIM	124	129	PF00017	0.456
MOD_CDC14_SPxK_1	17	20	PF00782	0.400
MOD_CDK_SPxK_1	14	20	PF00069	0.392
MOD_CK1_1	131	137	PF00069	0.308
MOD_CK1_1	254	260	PF00069	0.497
MOD_CK1_1	277	283	PF00069	0.383
MOD_CK1_1	332	338	PF00069	0.580
MOD_CK1_1	341	347	PF00069	0.506
MOD_CK1_1	394	400	PF00069	0.466
MOD_CK1_1	423	429	PF00069	0.587
MOD_CK1_1	44	50	PF00069	0.429
MOD_CK1_1	451	457	PF00069	0.471
MOD_CK1_1	82	88	PF00069	0.323
MOD_CK2_1	132	138	PF00069	0.467
MOD_CK2_1	263	269	PF00069	0.533
MOD_CK2_1	400	406	PF00069	0.475
MOD_CK2_1	423	429	PF00069	0.406
MOD_CK2_1	459	465	PF00069	0.472
MOD_CK2_1	492	498	PF00069	0.453
MOD_GlcNHglycan	444	447	PF01048	0.720
MOD_GlcNHglycan	498	502	PF01048	0.513
MOD_GlcNHglycan	519	522	PF01048	0.375
MOD_GSK3_1	127	134	PF00069	0.303
MOD_GSK3_1	155	162	PF00069	0.451
MOD_GSK3_1	221	228	PF00069	0.427
MOD_GSK3_1	254	261	PF00069	0.383
MOD_GSK3_1	400	407	PF00069	0.556
MOD_GSK3_1	434	441	PF00069	0.510
MOD_GSK3_1	44	51	PF00069	0.314
MOD_GSK3_1	459	466	PF00069	0.538
MOD_GSK3_1	472	479	PF00069	0.467
MOD_N-GLC_1	341	346	PF02516	0.776
MOD_N-GLC_1	42	47	PF02516	0.632
MOD_N-GLC_1	492	497	PF02516	0.578
MOD_N-GLC_1	57	62	PF02516	0.646
MOD_NEK2_1	1	6	PF00069	0.410
MOD_NEK2_1	148	153	PF00069	0.482
MOD_NEK2_1	234	239	PF00069	0.543
MOD_NEK2_1	251	256	PF00069	0.329
MOD_NEK2_1	274	279	PF00069	0.469
MOD_NEK2_1	305	310	PF00069	0.511
MOD_NEK2_1	31	36	PF00069	0.544
MOD_NEK2_1	316	321	PF00069	0.574
MOD_NEK2_1	347	352	PF00069	0.578
MOD_NEK2_1	41	46	PF00069	0.386
MOD_NEK2_1	442	447	PF00069	0.485
MOD_NEK2_1	463	468	PF00069	0.459
MOD_NEK2_1	472	477	PF00069	0.497
MOD_NEK2_1	48	53	PF00069	0.309
MOD_NEK2_1	482	487	PF00069	0.526
MOD_NEK2_1	497	502	PF00069	0.263
MOD_NEK2_1	517	522	PF00069	0.583
MOD_NEK2_1	81	86	PF00069	0.366
MOD_PIKK_1	29	35	PF00454	0.404
MOD_PIKK_1	316	322	PF00454	0.514
MOD_PIKK_1	347	353	PF00454	0.575
MOD_PIKK_1	406	412	PF00454	0.603
MOD_PKA_1	400	406	PF00069	0.600
MOD_PKA_1	412	418	PF00069	0.430
MOD_PKA_2	19	25	PF00069	0.415
MOD_PKA_2	332	338	PF00069	0.502
MOD_PKA_2	366	372	PF00069	0.536
MOD_PKA_2	399	405	PF00069	0.602
MOD_PKA_2	412	418	PF00069	0.470
MOD_PKA_2	438	444	PF00069	0.594
MOD_PKA_2	489	495	PF00069	0.373
MOD_PKA_2	517	523	PF00069	0.643
MOD_Plk_1	113	119	PF00069	0.340
MOD_Plk_1	132	138	PF00069	0.246
MOD_Plk_1	316	322	PF00069	0.509
MOD_Plk_1	341	347	PF00069	0.579
MOD_Plk_1	353	359	PF00069	0.518
MOD_Plk_1	492	498	PF00069	0.495
MOD_Plk_2-3	269	275	PF00069	0.455
MOD_Plk_4	166	172	PF00069	0.373
MOD_Plk_4	208	214	PF00069	0.518
MOD_Plk_4	234	240	PF00069	0.531
MOD_Plk_4	269	275	PF00069	0.552
MOD_Plk_4	31	37	PF00069	0.547
MOD_Plk_4	332	338	PF00069	0.433
MOD_Plk_4	353	359	PF00069	0.567
MOD_Plk_4	366	372	PF00069	0.489
MOD_Plk_4	44	50	PF00069	0.315
MOD_Plk_4	472	478	PF00069	0.451
MOD_Plk_4	492	498	PF00069	0.389
MOD_Plk_4	82	88	PF00069	0.403
MOD_ProDKin_1	14	20	PF00069	0.567
MOD_ProDKin_1	160	166	PF00069	0.378
MOD_ProDKin_1	277	283	PF00069	0.410
MOD_ProDKin_1	310	316	PF00069	0.513
MOD_ProDKin_1	335	341	PF00069	0.537
MOD_ProDKin_1	476	482	PF00069	0.425
MOD_SUMO_for_1	36	39	PF00179	0.477
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.590
TRG_ENDOCYTIC_2	126	129	PF00928	0.445
TRG_ENDOCYTIC_2	494	497	PF00928	0.460
TRG_ENDOCYTIC_2	503	506	PF00928	0.447
TRG_ENDOCYTIC_2	74	77	PF00928	0.383
TRG_ER_diArg_1	247	250	PF00400	0.446
TRG_ER_diArg_1	411	413	PF00400	0.435
TRG_ER_diArg_1	470	472	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.801

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD48	Leptomonas seymouri	34%	100%
A0A3S7WZJ8	Leishmania donovani	73%	100%
A4I1S4	Leishmania infantum	74%	100%
E9AXV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	96%
Q4Q9L2	Leishmania major	72%	100%