Glycosome import protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosome import protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEC7_LEIBR

TriTrypDb:

LbrM.25.1810 , LBRM2903_250031400

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0016020	membrane	2	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HEC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006090	pyruvate metabolic process	7	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006096	glycolytic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006757	obsolete ATP generation from ADP	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009135	purine nucleoside diphosphate metabolic process	6	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	1
GO:0009185	ribonucleoside diphosphate metabolic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0017038	protein import	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0033036	macromolecule localization	2	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046031	ADP metabolic process	7	1
GO:0046034	ATP metabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046939	obsolete nucleotide phosphorylation	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.626
CLV_NRD_NRD_1	135	137	PF00675	0.337
CLV_NRD_NRD_1	152	154	PF00675	0.258
CLV_NRD_NRD_1	156	158	PF00675	0.254
CLV_NRD_NRD_1	255	257	PF00675	0.637
CLV_PCSK_KEX2_1	135	137	PF00082	0.337
CLV_PCSK_KEX2_1	255	257	PF00082	0.637
CLV_PCSK_SKI1_1	117	121	PF00082	0.285
CLV_PCSK_SKI1_1	125	129	PF00082	0.291
CLV_PCSK_SKI1_1	135	139	PF00082	0.234
CLV_PCSK_SKI1_1	157	161	PF00082	0.304
CLV_PCSK_SKI1_1	175	179	PF00082	0.276
CLV_PCSK_SKI1_1	255	259	PF00082	0.626
CLV_PCSK_SKI1_1	58	62	PF00082	0.272
CLV_Separin_Metazoa	55	59	PF03568	0.472
DEG_APCC_DBOX_1	114	122	PF00400	0.537
DEG_APCC_DBOX_1	254	262	PF00400	0.277
DEG_APCC_DBOX_1	57	65	PF00400	0.390
DEG_SPOP_SBC_1	264	268	PF00917	0.477
DOC_CYCLIN_RxL_1	111	124	PF00134	0.537
DOC_CYCLIN_RxL_1	252	262	PF00134	0.277
DOC_MAPK_gen_1	255	263	PF00069	0.279
DOC_PP1_RVXF_1	257	264	PF00149	0.282
DOC_PP2B_LxvP_1	146	149	PF13499	0.537
DOC_PP4_FxxP_1	65	68	PF00568	0.495
DOC_USP7_MATH_1	264	268	PF00917	0.430
DOC_USP7_MATH_1	323	327	PF00917	0.392
DOC_USP7_UBL2_3	154	158	PF12436	0.468
LIG_14-3-3_CanoR_1	117	122	PF00244	0.519
LIG_14-3-3_CanoR_1	210	215	PF00244	0.248
LIG_14-3-3_CanoR_1	256	262	PF00244	0.336
LIG_14-3-3_CanoR_1	91	95	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	259	263	PF00533	0.285
LIG_BRCT_BRCA1_1	26	30	PF00533	0.589
LIG_EH1_1	140	148	PF00400	0.512
LIG_FAT_LD_1	85	93	PF03623	0.556
LIG_FHA_1	122	128	PF00498	0.488
LIG_FHA_1	150	156	PF00498	0.518
LIG_FHA_1	225	231	PF00498	0.296
LIG_FHA_2	204	210	PF00498	0.262
LIG_GBD_Chelix_1	53	61	PF00786	0.262
LIG_GBD_Chelix_1	81	89	PF00786	0.312
LIG_LIR_Gen_1	195	204	PF02991	0.347
LIG_LIR_Gen_1	240	248	PF02991	0.287
LIG_LIR_Gen_1	27	38	PF02991	0.550
LIG_LIR_Gen_1	59	70	PF02991	0.499
LIG_LIR_Nem_3	195	199	PF02991	0.308
LIG_LIR_Nem_3	201	207	PF02991	0.227
LIG_LIR_Nem_3	240	244	PF02991	0.287
LIG_LIR_Nem_3	27	33	PF02991	0.567
LIG_LIR_Nem_3	59	65	PF02991	0.475
LIG_MYND_1	129	133	PF01753	0.476
LIG_NRBOX	84	90	PF00104	0.499
LIG_Pex14_1	241	245	PF04695	0.356
LIG_PTB_Apo_2	225	232	PF02174	0.251
LIG_PTB_Phospho_1	225	231	PF10480	0.251
LIG_SH2_CRK	182	186	PF00017	0.451
LIG_SH2_CRK	204	208	PF00017	0.251
LIG_SH2_GRB2like	231	234	PF00017	0.251
LIG_SH2_STAP1	182	186	PF00017	0.198
LIG_SH2_STAT3	218	221	PF00017	0.258
LIG_SH2_STAT3	231	234	PF00017	0.234
LIG_SH2_STAT5	12	15	PF00017	0.645
LIG_SH2_STAT5	150	153	PF00017	0.486
LIG_SH2_STAT5	253	256	PF00017	0.377
LIG_SH2_STAT5	297	300	PF00017	0.295
LIG_SUMO_SIM_anti_2	52	59	PF11976	0.456
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.537
LIG_SUMO_SIM_par_1	79	86	PF11976	0.533
LIG_TRAF2_1	76	79	PF00917	0.512
LIG_UBA3_1	118	125	PF00899	0.533
MOD_CK1_1	188	194	PF00069	0.379
MOD_CK1_1	243	249	PF00069	0.258
MOD_CK1_1	267	273	PF00069	0.447
MOD_CK1_1	309	315	PF00069	0.397
MOD_CK2_1	203	209	PF00069	0.259
MOD_CK2_1	269	275	PF00069	0.478
MOD_CMANNOS	238	241	PF00535	0.462
MOD_GlcNHglycan	245	248	PF01048	0.473
MOD_GlcNHglycan	267	270	PF01048	0.615
MOD_GlcNHglycan	278	281	PF01048	0.495
MOD_GSK3_1	117	124	PF00069	0.461
MOD_GSK3_1	127	134	PF00069	0.449
MOD_GSK3_1	188	195	PF00069	0.337
MOD_GSK3_1	24	31	PF00069	0.576
MOD_GSK3_1	259	266	PF00069	0.406
MOD_GSK3_1	311	318	PF00069	0.249
MOD_GSK3_1	90	97	PF00069	0.492
MOD_N-GLC_2	276	278	PF02516	0.532
MOD_NEK2_1	121	126	PF00069	0.519
MOD_NEK2_1	192	197	PF00069	0.336
MOD_NEK2_1	198	203	PF00069	0.319
MOD_NEK2_1	257	262	PF00069	0.393
MOD_NEK2_1	263	268	PF00069	0.422
MOD_NEK2_1	306	311	PF00069	0.350
MOD_NEK2_1	315	320	PF00069	0.376
MOD_NEK2_1	94	99	PF00069	0.503
MOD_OFUCOSY	320	327	PF10250	0.598
MOD_PIKK_1	217	223	PF00454	0.262
MOD_PKA_2	224	230	PF00069	0.262
MOD_PKA_2	315	321	PF00069	0.239
MOD_PKA_2	90	96	PF00069	0.512
MOD_PKB_1	115	123	PF00069	0.445
MOD_Plk_4	123	129	PF00069	0.452
MOD_Plk_4	142	148	PF00069	0.480
MOD_Plk_4	237	243	PF00069	0.261
MOD_Plk_4	90	96	PF00069	0.509
TRG_DiLeu_BaEn_1	114	119	PF01217	0.537
TRG_DiLeu_BaEn_1	79	84	PF01217	0.477
TRG_DiLeu_BaEn_3	79	85	PF01217	0.376
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.465
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.274
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.306
TRG_DiLeu_LyEn_5	114	119	PF01217	0.537
TRG_ENDOCYTIC_2	182	185	PF00928	0.424
TRG_ENDOCYTIC_2	204	207	PF00928	0.262
TRG_ENDOCYTIC_2	299	302	PF00928	0.311
TRG_ER_diArg_1	115	118	PF00400	0.537
TRG_ER_diArg_1	135	137	PF00400	0.320
TRG_ER_diArg_1	254	256	PF00400	0.439
TRG_NES_CRM1_1	55	71	PF08389	0.462
TRG_NES_CRM1_1	99	114	PF08389	0.512
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N2	Leptomonas seymouri	82%	100%
A0A0S4J1C5	Bodo saltans	36%	99%
A0A1X0NYP2	Trypanosomatidae	53%	100%
A0A422P4J9	Trypanosoma rangeli	53%	100%
A4I1S2	Leishmania infantum	92%	100%
C9ZKD0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
E9AXV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P24392	Rattus norvegicus	25%	100%
P28328	Homo sapiens	25%	100%
P55098	Mus musculus	26%	100%
P90634	Leishmania donovani	92%	100%
Q01964	Komagataella pastoris	26%	72%
Q06438	Cricetulus griseus	27%	100%
Q4Q9L4	Leishmania major	90%	100%
Q75JQ3	Dictyostelium discoideum	26%	78%
Q99155	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	87%
Q9CA86	Arabidopsis thaliana	29%	99%
V5ASI5	Trypanosoma cruzi	55%	100%