Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEC6_LEIBR

TriTrypDb:

LbrM.25.1800 , LBRM2903_250031300

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.536
CLV_C14_Caspase3-7	509	513	PF00656	0.614
CLV_C14_Caspase3-7	61	65	PF00656	0.528
CLV_MEL_PAP_1	218	224	PF00089	0.483
CLV_NRD_NRD_1	166	168	PF00675	0.528
CLV_NRD_NRD_1	32	34	PF00675	0.525
CLV_NRD_NRD_1	381	383	PF00675	0.493
CLV_NRD_NRD_1	441	443	PF00675	0.735
CLV_NRD_NRD_1	492	494	PF00675	0.621
CLV_NRD_NRD_1	497	499	PF00675	0.621
CLV_NRD_NRD_1	525	527	PF00675	0.539
CLV_NRD_NRD_1	601	603	PF00675	0.363
CLV_PCSK_KEX2_1	166	168	PF00082	0.525
CLV_PCSK_KEX2_1	32	34	PF00082	0.525
CLV_PCSK_KEX2_1	492	494	PF00082	0.598
CLV_PCSK_KEX2_1	525	527	PF00082	0.539
CLV_PCSK_KEX2_1	601	603	PF00082	0.558
CLV_PCSK_PC7_1	597	603	PF00082	0.359
CLV_PCSK_SKI1_1	227	231	PF00082	0.418
CLV_PCSK_SKI1_1	320	324	PF00082	0.402
CLV_PCSK_SKI1_1	526	530	PF00082	0.571
CLV_PCSK_SKI1_1	569	573	PF00082	0.564
DEG_APCC_DBOX_1	273	281	PF00400	0.522
DEG_APCC_KENBOX_2	528	532	PF00400	0.423
DEG_SPOP_SBC_1	415	419	PF00917	0.733
DOC_CKS1_1	294	299	PF01111	0.487
DOC_MAPK_gen_1	326	334	PF00069	0.478
DOC_MAPK_gen_1	610	620	PF00069	0.583
DOC_MAPK_MEF2A_6	326	334	PF00069	0.471
DOC_MAPK_MEF2A_6	581	589	PF00069	0.547
DOC_PP1_RVXF_1	405	411	PF00149	0.536
DOC_PP1_RVXF_1	615	621	PF00149	0.582
DOC_USP7_MATH_1	117	121	PF00917	0.460
DOC_USP7_MATH_1	415	419	PF00917	0.744
DOC_USP7_UBL2_3	403	407	PF12436	0.791
DOC_WW_Pin1_4	293	298	PF00397	0.456
DOC_WW_Pin1_4	366	371	PF00397	0.515
DOC_WW_Pin1_4	394	399	PF00397	0.757
DOC_WW_Pin1_4	477	482	PF00397	0.658
LIG_14-3-3_CanoR_1	173	183	PF00244	0.387
LIG_14-3-3_CanoR_1	192	197	PF00244	0.299
LIG_14-3-3_CanoR_1	257	261	PF00244	0.515
LIG_14-3-3_CanoR_1	320	325	PF00244	0.469
LIG_14-3-3_CanoR_1	503	508	PF00244	0.593
LIG_APCC_ABBA_1	72	77	PF00400	0.454
LIG_BRCT_BRCA1_1	194	198	PF00533	0.419
LIG_BRCT_BRCA1_1	43	47	PF00533	0.489
LIG_BRCT_BRCA1_1	75	79	PF00533	0.453
LIG_DLG_GKlike_1	503	510	PF00625	0.594
LIG_EH1_1	468	476	PF00400	0.647
LIG_FHA_1	121	127	PF00498	0.484
LIG_FHA_1	175	181	PF00498	0.410
LIG_FHA_1	257	263	PF00498	0.492
LIG_FHA_1	450	456	PF00498	0.702
LIG_FHA_1	602	608	PF00498	0.575
LIG_FHA_2	239	245	PF00498	0.517
LIG_FHA_2	478	484	PF00498	0.641
LIG_FHA_2	525	531	PF00498	0.606
LIG_FHA_2	590	596	PF00498	0.576
LIG_FHA_2	82	88	PF00498	0.513
LIG_LIR_Apic_2	291	297	PF02991	0.411
LIG_LIR_Gen_1	228	238	PF02991	0.545
LIG_LIR_Gen_1	296	307	PF02991	0.495
LIG_LIR_Gen_1	48	59	PF02991	0.411
LIG_LIR_LC3C_4	547	551	PF02991	0.497
LIG_LIR_Nem_3	105	110	PF02991	0.404
LIG_LIR_Nem_3	195	199	PF02991	0.397
LIG_LIR_Nem_3	208	213	PF02991	0.319
LIG_LIR_Nem_3	228	233	PF02991	0.531
LIG_LIR_Nem_3	296	302	PF02991	0.402
LIG_LIR_Nem_3	313	319	PF02991	0.381
LIG_LIR_Nem_3	48	54	PF02991	0.397
LIG_MLH1_MIPbox_1	43	47	PF16413	0.530
LIG_NRBOX	340	346	PF00104	0.534
LIG_PCNA_PIPBox_1	258	267	PF02747	0.514
LIG_PCNA_yPIPBox_3	367	375	PF02747	0.548
LIG_Pex14_2	147	151	PF04695	0.481
LIG_Pex14_2	68	72	PF04695	0.387
LIG_Pex14_2	75	79	PF04695	0.407
LIG_Rb_LxCxE_1	208	231	PF01857	0.395
LIG_SH2_CRK	316	320	PF00017	0.429
LIG_SH2_GRB2like	159	162	PF00017	0.569
LIG_SH2_GRB2like	458	461	PF00017	0.578
LIG_SH2_NCK_1	159	163	PF00017	0.439
LIG_SH2_PTP2	299	302	PF00017	0.445
LIG_SH2_PTP2	51	54	PF00017	0.512
LIG_SH2_SRC	299	302	PF00017	0.499
LIG_SH2_STAT3	357	360	PF00017	0.562
LIG_SH2_STAT3	458	461	PF00017	0.578
LIG_SH2_STAT5	294	297	PF00017	0.357
LIG_SH2_STAT5	299	302	PF00017	0.356
LIG_SH2_STAT5	458	461	PF00017	0.717
LIG_SH2_STAT5	51	54	PF00017	0.512
LIG_SH3_2	2	7	PF14604	0.720
LIG_SH3_3	13	19	PF00018	0.525
LIG_SH3_3	389	395	PF00018	0.741
LIG_SH3_4	403	410	PF00018	0.791
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.455
LIG_SUMO_SIM_par_1	258	263	PF11976	0.529
LIG_SUMO_SIM_par_1	300	305	PF11976	0.436
LIG_TRAF2_1	241	244	PF00917	0.543
LIG_TRAF2_1	592	595	PF00917	0.460
LIG_TRAF2_1	85	88	PF00917	0.481
LIG_TYR_ITIM	314	319	PF00017	0.383
LIG_UBA3_1	179	187	PF00899	0.395
LIG_UBA3_1	99	108	PF00899	0.516
LIG_WRC_WIRS_1	363	368	PF05994	0.564
MOD_CDC14_SPxK_1	369	372	PF00782	0.517
MOD_CDK_SPxK_1	366	372	PF00069	0.523
MOD_CK1_1	120	126	PF00069	0.490
MOD_CK1_1	256	262	PF00069	0.493
MOD_CK1_1	397	403	PF00069	0.734
MOD_CK1_1	418	424	PF00069	0.738
MOD_CK1_1	449	455	PF00069	0.555
MOD_CK1_1	82	88	PF00069	0.476
MOD_CK2_1	157	163	PF00069	0.487
MOD_CK2_1	238	244	PF00069	0.549
MOD_CK2_1	477	483	PF00069	0.637
MOD_CK2_1	524	530	PF00069	0.567
MOD_CK2_1	589	595	PF00069	0.479
MOD_CK2_1	81	87	PF00069	0.522
MOD_GlcNHglycan	119	122	PF01048	0.489
MOD_GlcNHglycan	20	23	PF01048	0.430
MOD_GlcNHglycan	423	426	PF01048	0.700
MOD_GlcNHglycan	433	437	PF01048	0.632
MOD_GlcNHglycan	448	451	PF01048	0.735
MOD_GlcNHglycan	60	63	PF01048	0.529
MOD_GSK3_1	282	289	PF00069	0.516
MOD_GSK3_1	362	369	PF00069	0.395
MOD_GSK3_1	394	401	PF00069	0.593
MOD_GSK3_1	414	421	PF00069	0.729
MOD_GSK3_1	602	609	PF00069	0.470
MOD_GSK3_1	95	102	PF00069	0.470
MOD_N-GLC_1	310	315	PF02516	0.387
MOD_N-GLC_1	627	632	PF02516	0.673
MOD_N-GLC_1	95	100	PF02516	0.498
MOD_NEK2_1	220	225	PF00069	0.409
MOD_NEK2_1	233	238	PF00069	0.273
MOD_NEK2_1	287	292	PF00069	0.454
MOD_NEK2_1	343	348	PF00069	0.604
MOD_NEK2_1	416	421	PF00069	0.774
MOD_NEK2_1	46	51	PF00069	0.501
MOD_NEK2_1	627	632	PF00069	0.448
MOD_NEK2_1	99	104	PF00069	0.438
MOD_PKA_1	601	607	PF00069	0.360
MOD_PKA_2	172	178	PF00069	0.446
MOD_PKA_2	220	226	PF00069	0.396
MOD_PKA_2	256	262	PF00069	0.513
MOD_PKA_2	524	530	PF00069	0.557
MOD_PKA_2	601	607	PF00069	0.571
MOD_Plk_1	283	289	PF00069	0.517
MOD_Plk_1	310	316	PF00069	0.361
MOD_Plk_1	47	53	PF00069	0.409
MOD_Plk_1	82	88	PF00069	0.485
MOD_Plk_1	95	101	PF00069	0.474
MOD_Plk_4	102	108	PF00069	0.387
MOD_Plk_4	250	256	PF00069	0.431
MOD_Plk_4	352	358	PF00069	0.460
MOD_Plk_4	41	47	PF00069	0.395
MOD_Plk_4	95	101	PF00069	0.439
MOD_ProDKin_1	293	299	PF00069	0.454
MOD_ProDKin_1	366	372	PF00069	0.523
MOD_ProDKin_1	394	400	PF00069	0.757
MOD_ProDKin_1	477	483	PF00069	0.653
MOD_SUMO_for_1	339	342	PF00179	0.593
TRG_DiLeu_BaEn_4	243	249	PF01217	0.531
TRG_ENDOCYTIC_2	299	302	PF00928	0.378
TRG_ENDOCYTIC_2	316	319	PF00928	0.392
TRG_ENDOCYTIC_2	51	54	PF00928	0.494
TRG_ER_diArg_1	31	33	PF00400	0.499
TRG_ER_diArg_1	491	493	PF00400	0.614
TRG_ER_diArg_1	601	603	PF00400	0.616
TRG_ER_diArg_1	629	632	PF00400	0.651
TRG_NES_CRM1_1	541	555	PF08389	0.547
TRG_NES_CRM1_1	576	588	PF08389	0.575
TRG_NES_CRM1_1	97	112	PF08389	0.456
TRG_NLS_MonoExtC_3	441	446	PF00514	0.665
TRG_NLS_MonoExtN_4	442	447	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P623	Leptomonas seymouri	78%	99%
A0A1X0NY32	Trypanosomatidae	43%	100%
A0A3Q8IDH9	Leishmania donovani	90%	100%
A0A422NY96	Trypanosoma rangeli	26%	100%
A0A422P4I7	Trypanosoma rangeli	45%	100%
A4I1S1	Leishmania infantum	90%	100%
C9ZKC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AXV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q9L5	Leishmania major	89%	99%
V5D5U6	Trypanosoma cruzi	27%	100%
V5D8I6	Trypanosoma cruzi	40%	100%