COP9 signalosome complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEC5_LEIBR

TriTrypDb:

LbrM.25.1790 , LBRM2903_250031200

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0008180	COP9 signalosome	3	12
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0000502	proteasome complex	3	3
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:1905368	peptidase complex	3	3
GO:1905369	endopeptidase complex	4	3

Expansion

Sequence features

A4HEC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC5

Function

Biological processes
Term	Name	Level	Count
GO:0000338	protein deneddylation	6	1
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.387
CLV_NRD_NRD_1	204	206	PF00675	0.473
CLV_NRD_NRD_1	214	216	PF00675	0.500
CLV_NRD_NRD_1	404	406	PF00675	0.342
CLV_PCSK_KEX2_1	153	155	PF00082	0.387
CLV_PCSK_KEX2_1	214	216	PF00082	0.453
CLV_PCSK_SKI1_1	108	112	PF00082	0.427
CLV_PCSK_SKI1_1	153	157	PF00082	0.361
CLV_PCSK_SKI1_1	405	409	PF00082	0.330
CLV_PCSK_SKI1_1	78	82	PF00082	0.431
DEG_COP1_1	141	151	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.608
DOC_CYCLIN_RxL_1	194	202	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.514
DOC_MAPK_DCC_7	222	232	PF00069	0.572
DOC_MAPK_gen_1	125	133	PF00069	0.497
DOC_MAPK_gen_1	153	159	PF00069	0.417
DOC_MAPK_MEF2A_6	125	133	PF00069	0.459
DOC_PP1_RVXF_1	404	411	PF00149	0.571
DOC_PP1_RVXF_1	90	97	PF00149	0.425
DOC_PP2B_LxvP_1	327	330	PF13499	0.548
DOC_PP4_FxxP_1	96	99	PF00568	0.519
DOC_USP7_MATH_1	226	230	PF00917	0.574
DOC_USP7_MATH_1	300	304	PF00917	0.492
DOC_USP7_MATH_1	74	78	PF00917	0.284
DOC_USP7_UBL2_3	108	112	PF12436	0.401
DOC_USP7_UBL2_3	64	68	PF12436	0.330
DOC_WW_Pin1_4	285	290	PF00397	0.505
LIG_14-3-3_CanoR_1	125	130	PF00244	0.532
LIG_14-3-3_CanoR_1	153	158	PF00244	0.461
LIG_14-3-3_CanoR_1	255	260	PF00244	0.275
LIG_14-3-3_CanoR_1	412	418	PF00244	0.600
LIG_Actin_WH2_2	200	216	PF00022	0.255
LIG_APCC_ABBA_1	342	347	PF00400	0.509
LIG_APCC_ABBAyCdc20_2	154	160	PF00400	0.485
LIG_BRCT_BRCA1_1	361	365	PF00533	0.561
LIG_deltaCOP1_diTrp_1	247	257	PF00928	0.380
LIG_FHA_1	126	132	PF00498	0.435
LIG_FHA_1	154	160	PF00498	0.400
LIG_FHA_1	183	189	PF00498	0.596
LIG_FHA_1	353	359	PF00498	0.560
LIG_FHA_1	365	371	PF00498	0.506
LIG_FHA_1	387	393	PF00498	0.542
LIG_FHA_1	429	435	PF00498	0.582
LIG_FHA_1	89	95	PF00498	0.531
LIG_FHA_2	286	292	PF00498	0.318
LIG_FHA_2	335	341	PF00498	0.454
LIG_FHA_2	95	101	PF00498	0.510
LIG_GBD_Chelix_1	316	324	PF00786	0.180
LIG_IRF3_LxIS_1	315	321	PF10401	0.446
LIG_LIR_Gen_1	208	218	PF02991	0.384
LIG_LIR_Gen_1	321	331	PF02991	0.496
LIG_LIR_Gen_1	87	96	PF02991	0.437
LIG_LIR_Nem_3	10	16	PF02991	0.584
LIG_LIR_Nem_3	141	146	PF02991	0.463
LIG_LIR_Nem_3	202	207	PF02991	0.468
LIG_LIR_Nem_3	208	213	PF02991	0.432
LIG_LIR_Nem_3	321	326	PF02991	0.496
LIG_LIR_Nem_3	339	345	PF02991	0.484
LIG_LIR_Nem_3	362	368	PF02991	0.499
LIG_LIR_Nem_3	66	70	PF02991	0.366
LIG_LIR_Nem_3	87	93	PF02991	0.439
LIG_RPA_C_Fungi	250	262	PF08784	0.504
LIG_SH2_CRK	204	208	PF00017	0.419
LIG_SH2_CRK	273	277	PF00017	0.445
LIG_SH2_CRK	90	94	PF00017	0.412
LIG_SH2_GRB2like	17	20	PF00017	0.695
LIG_SH2_PTP2	278	281	PF00017	0.421
LIG_SH2_PTP2	345	348	PF00017	0.454
LIG_SH2_SRC	164	167	PF00017	0.403
LIG_SH2_SRC	17	20	PF00017	0.680
LIG_SH2_SRC	34	37	PF00017	0.468
LIG_SH2_SRC	345	348	PF00017	0.421
LIG_SH2_SRC	357	360	PF00017	0.365
LIG_SH2_STAP1	13	17	PF00017	0.501
LIG_SH2_STAP1	164	168	PF00017	0.447
LIG_SH2_STAP1	361	365	PF00017	0.400
LIG_SH2_STAP1	90	94	PF00017	0.380
LIG_SH2_STAT5	278	281	PF00017	0.327
LIG_SH2_STAT5	34	37	PF00017	0.468
LIG_SH2_STAT5	345	348	PF00017	0.376
LIG_SH2_STAT5	357	360	PF00017	0.283
LIG_SH2_STAT5	90	93	PF00017	0.528
LIG_SH3_3	143	149	PF00018	0.524
LIG_SUMO_SIM_anti_2	367	372	PF11976	0.403
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.644
LIG_SUMO_SIM_par_1	131	137	PF11976	0.524
LIG_SUMO_SIM_par_1	22	28	PF11976	0.531
LIG_SUMO_SIM_par_1	366	372	PF11976	0.390
LIG_TRAF2_1	294	297	PF00917	0.573
LIG_TYR_ITIM	276	281	PF00017	0.345
LIG_WRC_WIRS_1	320	325	PF05994	0.421
MOD_CK1_1	181	187	PF00069	0.670
MOD_CK1_1	364	370	PF00069	0.429
MOD_CK1_1	428	434	PF00069	0.577
MOD_CK2_1	232	238	PF00069	0.434
MOD_CK2_1	334	340	PF00069	0.330
MOD_CK2_1	366	372	PF00069	0.448
MOD_GlcNHglycan	179	183	PF01048	0.492
MOD_GlcNHglycan	238	241	PF01048	0.391
MOD_GlcNHglycan	266	269	PF01048	0.462
MOD_GlcNHglycan	389	392	PF01048	0.401
MOD_GlcNHglycan	426	430	PF01048	0.492
MOD_GSK3_1	125	132	PF00069	0.484
MOD_GSK3_1	178	185	PF00069	0.557
MOD_GSK3_1	195	202	PF00069	0.498
MOD_GSK3_1	232	239	PF00069	0.471
MOD_GSK3_1	357	364	PF00069	0.422
MOD_GSK3_1	36	43	PF00069	0.452
MOD_GSK3_1	413	420	PF00069	0.508
MOD_GSK3_1	425	432	PF00069	0.532
MOD_GSK3_1	84	91	PF00069	0.449
MOD_N-GLC_1	300	305	PF02516	0.462
MOD_NEK2_1	199	204	PF00069	0.433
MOD_NEK2_1	232	237	PF00069	0.476
MOD_NEK2_1	318	323	PF00069	0.411
MOD_NEK2_1	387	392	PF00069	0.413
MOD_NEK2_1	40	45	PF00069	0.492
MOD_NEK2_2	63	68	PF00069	0.391
MOD_PIKK_1	114	120	PF00454	0.516
MOD_PKA_1	153	159	PF00069	0.389
MOD_PKA_1	205	211	PF00069	0.269
MOD_PKA_2	153	159	PF00069	0.506
MOD_PKA_2	411	417	PF00069	0.605
MOD_PKA_2	74	80	PF00069	0.447
MOD_Plk_1	295	301	PF00069	0.566
MOD_Plk_1	318	324	PF00069	0.423
MOD_Plk_4	147	153	PF00069	0.438
MOD_Plk_4	189	195	PF00069	0.465
MOD_Plk_4	199	205	PF00069	0.395
MOD_Plk_4	232	238	PF00069	0.379
MOD_Plk_4	271	277	PF00069	0.452
MOD_Plk_4	319	325	PF00069	0.439
MOD_Plk_4	36	42	PF00069	0.428
MOD_Plk_4	366	372	PF00069	0.370
MOD_ProDKin_1	285	291	PF00069	0.510
MOD_SUMO_for_1	162	165	PF00179	0.418
MOD_SUMO_rev_2	26	35	PF00179	0.536
TRG_ENDOCYTIC_2	143	146	PF00928	0.472
TRG_ENDOCYTIC_2	204	207	PF00928	0.410
TRG_ENDOCYTIC_2	210	213	PF00928	0.358
TRG_ENDOCYTIC_2	217	220	PF00928	0.332
TRG_ENDOCYTIC_2	273	276	PF00928	0.363
TRG_ENDOCYTIC_2	278	281	PF00928	0.305
TRG_ENDOCYTIC_2	83	86	PF00928	0.388
TRG_ENDOCYTIC_2	90	93	PF00928	0.397
TRG_ER_diArg_1	124	127	PF00400	0.498
TRG_ER_diArg_1	152	154	PF00400	0.390
TRG_ER_diArg_1	213	215	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE5	Leptomonas seymouri	62%	99%
A0A0S4J4F8	Bodo saltans	27%	97%
A0A1X0NY12	Trypanosomatidae	30%	99%
A0A3S7WZD2	Leishmania donovani	85%	100%
A0A422P4P2	Trypanosoma rangeli	30%	99%
A4I1S0	Leishmania infantum	85%	100%
C9ZKC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O01422	Caenorhabditis elegans	21%	89%
P61201	Homo sapiens	22%	99%
P61202	Mus musculus	22%	99%
P61203	Rattus norvegicus	22%	99%
Q4Q9L6	Leishmania major	85%	100%
Q54HL6	Dictyostelium discoideum	21%	98%
Q5B3U7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	22%	87%
Q6IQT4	Danio rerio	22%	99%
Q6IR75	Xenopus laevis	22%	100%
Q7SI58	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	20%	90%
Q8W207	Arabidopsis thaliana	21%	100%
Q94899	Drosophila melanogaster	20%	99%
Q9HFR0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
V5BH20	Trypanosoma cruzi	30%	99%