Parkin coregulated gene protein homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

parkin co-regulated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEC4_LEIBR

TriTrypDb:

LbrM.25.1780 , LBRM2903_250031100

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 16
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HEC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC4

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060548	negative regulation of cell death	5	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2
GO:0051087	protein-folding chaperone binding	3	2
GO:0051879	Hsp90 protein binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.602
CLV_C14_Caspase3-7	354	358	PF00656	0.427
CLV_NRD_NRD_1	115	117	PF00675	0.706
CLV_NRD_NRD_1	180	182	PF00675	0.692
CLV_NRD_NRD_1	220	222	PF00675	0.348
CLV_NRD_NRD_1	352	354	PF00675	0.444
CLV_NRD_NRD_1	60	62	PF00675	0.427
CLV_PCSK_KEX2_1	110	112	PF00082	0.610
CLV_PCSK_KEX2_1	211	213	PF00082	0.451
CLV_PCSK_KEX2_1	220	222	PF00082	0.315
CLV_PCSK_KEX2_1	351	353	PF00082	0.441
CLV_PCSK_KEX2_1	58	60	PF00082	0.425
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.617
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.467
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.324
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.425
CLV_PCSK_PC7_1	54	60	PF00082	0.410
CLV_PCSK_SKI1_1	17	21	PF00082	0.373
CLV_PCSK_SKI1_1	300	304	PF00082	0.340
CLV_PCSK_SKI1_1	337	341	PF00082	0.351
DEG_APCC_DBOX_1	336	344	PF00400	0.435
DEG_APCC_DBOX_1	60	68	PF00400	0.446
DEG_Nend_UBRbox_1	1	4	PF02207	0.361
DEG_SPOP_SBC_1	129	133	PF00917	0.484
DOC_CDC14_PxL_1	289	297	PF14671	0.340
DOC_CYCLIN_RxL_1	14	23	PF00134	0.366
DOC_CYCLIN_RxL_1	58	68	PF00134	0.443
DOC_CYCLIN_RxL_1	69	80	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	213	216	PF00134	0.585
DOC_MAPK_DCC_7	287	297	PF00069	0.340
DOC_MAPK_DCC_7	337	345	PF00069	0.435
DOC_MAPK_gen_1	58	67	PF00069	0.441
DOC_MAPK_MEF2A_6	225	232	PF00069	0.340
DOC_MAPK_MEF2A_6	337	345	PF00069	0.435
DOC_PP2B_LxvP_1	213	216	PF13499	0.585
DOC_PP2B_LxvP_1	295	298	PF13499	0.340
DOC_PP4_FxxP_1	85	88	PF00568	0.417
DOC_USP7_MATH_1	136	140	PF00917	0.760
DOC_USP7_MATH_1	176	180	PF00917	0.602
DOC_USP7_MATH_1	96	100	PF00917	0.447
DOC_USP7_UBL2_3	347	351	PF12436	0.369
DOC_WW_Pin1_4	89	94	PF00397	0.424
LIG_14-3-3_CanoR_1	17	23	PF00244	0.380
LIG_14-3-3_CanoR_1	220	224	PF00244	0.197
LIG_14-3-3_CanoR_1	352	361	PF00244	0.447
LIG_APCC_ABBA_1	255	260	PF00400	0.340
LIG_Clathr_ClatBox_1	64	68	PF01394	0.458
LIG_EVH1_2	215	219	PF00568	0.329
LIG_FHA_1	153	159	PF00498	0.480
LIG_FHA_1	312	318	PF00498	0.284
LIG_FHA_1	374	380	PF00498	0.334
LIG_FHA_1	46	52	PF00498	0.397
LIG_FHA_1	74	80	PF00498	0.423
LIG_FHA_2	107	113	PF00498	0.575
LIG_GBD_Chelix_1	12	20	PF00786	0.344
LIG_Integrin_RGD_1	225	227	PF01839	0.281
LIG_LIR_Apic_2	26	30	PF02991	0.429
LIG_LIR_Gen_1	266	273	PF02991	0.367
LIG_LIR_Gen_1	386	397	PF02991	0.338
LIG_LIR_Nem_3	250	254	PF02991	0.333
LIG_LIR_Nem_3	26	32	PF02991	0.430
LIG_LIR_Nem_3	266	272	PF02991	0.318
LIG_LIR_Nem_3	386	392	PF02991	0.338
LIG_LIR_Nem_3	80	85	PF02991	0.426
LIG_NRBOX	15	21	PF00104	0.362
LIG_Pex14_2	81	85	PF04695	0.429
LIG_PTB_Apo_2	388	395	PF02174	0.340
LIG_PTB_Phospho_1	388	394	PF10480	0.340
LIG_SH2_CRK	269	273	PF00017	0.283
LIG_SH2_CRK	27	31	PF00017	0.432
LIG_SH2_CRK	336	340	PF00017	0.353
LIG_SH2_CRK	394	398	PF00017	0.353
LIG_SH2_GRB2like	389	392	PF00017	0.353
LIG_SH2_NCK_1	118	122	PF00017	0.584
LIG_SH2_PTP2	389	392	PF00017	0.353
LIG_SH2_SRC	254	257	PF00017	0.353
LIG_SH2_SRC	389	392	PF00017	0.353
LIG_SH2_STAP1	399	403	PF00017	0.353
LIG_SH2_STAT3	100	103	PF00017	0.552
LIG_SH2_STAT3	22	25	PF00017	0.405
LIG_SH2_STAT3	335	338	PF00017	0.345
LIG_SH2_STAT5	254	257	PF00017	0.342
LIG_SH2_STAT5	389	392	PF00017	0.353
LIG_SH3_1	27	33	PF00018	0.431
LIG_SH3_1	287	293	PF00018	0.340
LIG_SH3_3	159	165	PF00018	0.564
LIG_SH3_3	27	33	PF00018	0.431
LIG_SH3_3	287	293	PF00018	0.340
LIG_SUMO_SIM_par_1	10	15	PF11976	0.316
LIG_TRFH_1	29	33	PF08558	0.429
LIG_TRFH_1	85	89	PF08558	0.411
LIG_UBA3_1	295	300	PF00899	0.340
LIG_UBA3_1	339	347	PF00899	0.284
MOD_CK1_1	139	145	PF00069	0.776
MOD_CK1_1	23	29	PF00069	0.419
MOD_CK1_1	236	242	PF00069	0.320
MOD_GlcNHglycan	143	146	PF01048	0.787
MOD_GlcNHglycan	200	203	PF01048	0.565
MOD_GSK3_1	137	144	PF00069	0.659
MOD_GSK3_1	298	305	PF00069	0.342
MOD_GSK3_1	73	80	PF00069	0.428
MOD_N-GLC_1	373	378	PF02516	0.444
MOD_N-GLC_1	89	94	PF02516	0.424
MOD_N-GLC_2	45	47	PF02516	0.404
MOD_NEK2_1	12	17	PF00069	0.330
MOD_NEK2_1	20	25	PF00069	0.387
MOD_NEK2_1	345	350	PF00069	0.222
MOD_NEK2_1	40	45	PF00069	0.393
MOD_NEK2_1	73	78	PF00069	0.425
MOD_NEK2_2	176	181	PF00069	0.566
MOD_PIKK_1	137	143	PF00454	0.586
MOD_PK_1	111	117	PF00069	0.544
MOD_PKA_1	137	143	PF00069	0.597
MOD_PKA_1	351	357	PF00069	0.427
MOD_PKA_2	219	225	PF00069	0.328
MOD_PKA_2	236	242	PF00069	0.282
MOD_PKA_2	262	268	PF00069	0.328
MOD_PKA_2	351	357	PF00069	0.444
MOD_PKA_2	40	46	PF00069	0.420
MOD_Plk_1	111	117	PF00069	0.653
MOD_Plk_1	373	379	PF00069	0.353
MOD_Plk_4	47	53	PF00069	0.395
MOD_Plk_4	77	83	PF00069	0.423
MOD_ProDKin_1	89	95	PF00069	0.427
MOD_SUMO_rev_2	236	244	PF00179	0.309
TRG_DiLeu_BaEn_1	375	380	PF01217	0.309
TRG_DiLeu_BaEn_3	266	272	PF01217	0.353
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.586
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.433
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.442
TRG_ENDOCYTIC_2	254	257	PF00928	0.332
TRG_ENDOCYTIC_2	269	272	PF00928	0.342
TRG_ENDOCYTIC_2	336	339	PF00928	0.340
TRG_ENDOCYTIC_2	389	392	PF00928	0.353
TRG_ER_diArg_1	219	221	PF00400	0.340
TRG_ER_diArg_1	352	355	PF00400	0.479
TRG_ER_diArg_1	59	61	PF00400	0.424
TRG_NLS_MonoExtC_3	180	185	PF00514	0.688
TRG_NLS_MonoExtC_3	350	355	PF00514	0.324
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N4	Leptomonas seymouri	82%	100%
A0A0S4J0U8	Bodo saltans	61%	100%
A0A1X0NY39	Trypanosomatidae	73%	100%
A0A1X0P4X2	Trypanosomatidae	52%	100%
A0A3S7WZF1	Leishmania donovani	90%	100%
A0A3S7XA05	Leishmania donovani	57%	100%
A0A422P4M1	Trypanosoma rangeli	72%	100%
A4HND5	Leishmania braziliensis	56%	100%
A4I1R9	Leishmania infantum	90%	100%
A4IC08	Leishmania infantum	57%	100%
C9ZKC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AFU6	Leishmania major	58%	100%
E9AXV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B6Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4Q9L7	Leishmania major	90%	100%
V5B824	Trypanosoma cruzi	73%	100%