J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain/Zinc-finger double-stranded RNA-binding, putative

Species:

Leishmania braziliensis

UniProt:

A4HEC3_LEIBR

TriTrypDb:

LbrM.25.1770 , LBRM2903_250031000

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.564
CLV_NRD_NRD_1	16	18	PF00675	0.320
CLV_NRD_NRD_1	182	184	PF00675	0.433
CLV_NRD_NRD_1	213	215	PF00675	0.416
CLV_NRD_NRD_1	247	249	PF00675	0.471
CLV_PCSK_FUR_1	243	247	PF00082	0.514
CLV_PCSK_KEX2_1	182	184	PF00082	0.433
CLV_PCSK_KEX2_1	213	215	PF00082	0.400
CLV_PCSK_KEX2_1	232	234	PF00082	0.390
CLV_PCSK_KEX2_1	245	247	PF00082	0.382
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.485
CLV_PCSK_PC7_1	243	249	PF00082	0.527
CLV_PCSK_SKI1_1	17	21	PF00082	0.360
CLV_PCSK_SKI1_1	329	333	PF00082	0.263
CLV_Separin_Metazoa	293	297	PF03568	0.664
DOC_PP4_FxxP_1	322	325	PF00568	0.512
DOC_USP7_UBL2_3	168	172	PF12436	0.444
DOC_USP7_UBL2_3	328	332	PF12436	0.445
DOC_USP7_UBL2_3	345	349	PF12436	0.453
LIG_14-3-3_CanoR_1	132	137	PF00244	0.460
LIG_14-3-3_CanoR_1	157	163	PF00244	0.456
LIG_14-3-3_CanoR_1	17	22	PF00244	0.310
LIG_14-3-3_CanoR_1	202	208	PF00244	0.459
LIG_deltaCOP1_diTrp_1	145	152	PF00928	0.495
LIG_FHA_2	18	24	PF00498	0.371
LIG_FXI_DFP_1	101	105	PF00024	0.313
LIG_LIR_Apic_2	320	325	PF02991	0.406
LIG_LIR_Gen_1	113	123	PF02991	0.243
LIG_LIR_Gen_1	143	153	PF02991	0.404
LIG_LIR_Gen_1	20	28	PF02991	0.389
LIG_LIR_Gen_1	235	244	PF02991	0.343
LIG_LIR_Gen_1	98	108	PF02991	0.329
LIG_LIR_Nem_3	108	114	PF02991	0.415
LIG_LIR_Nem_3	135	139	PF02991	0.395
LIG_LIR_Nem_3	143	149	PF02991	0.418
LIG_LIR_Nem_3	160	165	PF02991	0.366
LIG_LIR_Nem_3	20	24	PF02991	0.380
LIG_LIR_Nem_3	235	241	PF02991	0.350
LIG_LIR_Nem_3	98	104	PF02991	0.391
LIG_Pex14_1	167	171	PF04695	0.438
LIG_Pex14_2	152	156	PF04695	0.355
LIG_SH2_CRK	115	119	PF00017	0.380
LIG_SH2_CRK	58	62	PF00017	0.304
LIG_SH2_GRB2like	41	44	PF00017	0.333
LIG_SH2_SRC	21	24	PF00017	0.424
LIG_SH2_STAP1	129	133	PF00017	0.448
LIG_SH2_STAP1	180	184	PF00017	0.568
LIG_SH2_STAT3	41	44	PF00017	0.368
LIG_SH2_STAT5	112	115	PF00017	0.363
LIG_SH2_STAT5	200	203	PF00017	0.411
LIG_SH2_STAT5	95	98	PF00017	0.405
LIG_SUMO_SIM_par_1	11	16	PF11976	0.361
LIG_TRAF2_1	263	266	PF00917	0.500
LIG_TYR_ITSM	111	118	PF00017	0.464
LIG_WRC_WIRS_1	162	167	PF05994	0.440
MOD_CK1_1	59	65	PF00069	0.365
MOD_CK2_1	17	23	PF00069	0.322
MOD_CK2_1	276	282	PF00069	0.612
MOD_CK2_1	69	75	PF00069	0.480
MOD_GlcNHglycan	108	111	PF01048	0.471
MOD_GSK3_1	106	113	PF00069	0.489
MOD_GSK3_1	124	131	PF00069	0.462
MOD_GSK3_1	157	164	PF00069	0.505
MOD_LATS_1	155	161	PF00433	0.391
MOD_N-GLC_1	157	162	PF02516	0.387
MOD_NEK2_1	139	144	PF00069	0.429
MOD_NEK2_1	276	281	PF00069	0.639
MOD_NEK2_1	96	101	PF00069	0.416
MOD_NEK2_2	110	115	PF00069	0.376
MOD_PKA_1	17	23	PF00069	0.304
MOD_PKA_1	29	35	PF00069	0.304
MOD_PKA_2	178	184	PF00069	0.447
MOD_PKA_2	288	294	PF00069	0.594
MOD_Plk_1	157	163	PF00069	0.394
MOD_Plk_2-3	277	283	PF00069	0.442
MOD_Plk_4	110	116	PF00069	0.385
MOD_Plk_4	317	323	PF00069	0.607
MOD_Plk_4	56	62	PF00069	0.371
MOD_SUMO_for_1	196	199	PF00179	0.446
MOD_SUMO_for_1	218	221	PF00179	0.517
MOD_SUMO_for_1	231	234	PF00179	0.440
MOD_SUMO_for_1	331	334	PF00179	0.389
MOD_SUMO_rev_2	11	20	PF00179	0.304
MOD_SUMO_rev_2	169	173	PF00179	0.426
MOD_SUMO_rev_2	223	231	PF00179	0.480
TRG_ENDOCYTIC_2	115	118	PF00928	0.407
TRG_ENDOCYTIC_2	162	165	PF00928	0.534
TRG_ENDOCYTIC_2	21	24	PF00928	0.302
TRG_ENDOCYTIC_2	58	61	PF00928	0.350
TRG_ENDOCYTIC_2	9	12	PF00928	0.305
TRG_ENDOCYTIC_2	93	96	PF00928	0.420
TRG_ER_diArg_1	182	184	PF00400	0.463
TRG_ER_diArg_1	212	214	PF00400	0.421
TRG_ER_diArg_1	243	246	PF00400	0.450
TRG_NLS_Bipartite_1	17	33	PF00514	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE61	Leptomonas seymouri	87%	100%
A0A0S4J1C8	Bodo saltans	52%	81%
A0A1X0NZG6	Trypanosomatidae	62%	100%
A0A3Q8IDF1	Leishmania donovani	92%	100%
A0A422P4I6	Trypanosoma rangeli	60%	100%
A4HQE6	Leishmania braziliensis	29%	100%
A4I1R8	Leishmania infantum	92%	100%
C9ZKC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AXV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9Q8D0	Mus musculus	39%	71%
O14213	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	99%
Q0II91	Bos taurus	39%	71%
Q4Q9L8	Leishmania major	91%	100%
Q5F1R6	Homo sapiens	40%	71%
Q6PGY5	Danio rerio	38%	69%
V5ASJ0	Trypanosoma cruzi	59%	100%