Vacuolar protein sorting-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEC2_LEIBR

TriTrypDb:

LbrM.25.1760 , LBRM2903_250030900

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	1
GO:0032991	protein-containing complex	1	1
GO:0033263	CORVET complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099023	vesicle tethering complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	324	326	PF00675	0.245
CLV_NRD_NRD_1	370	372	PF00675	0.250
CLV_NRD_NRD_1	398	400	PF00675	0.390
CLV_PCSK_KEX2_1	324	326	PF00082	0.245
CLV_PCSK_KEX2_1	372	374	PF00082	0.267
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.339
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.287
CLV_PCSK_SKI1_1	156	160	PF00082	0.396
CLV_PCSK_SKI1_1	167	171	PF00082	0.248
CLV_PCSK_SKI1_1	183	187	PF00082	0.179
CLV_PCSK_SKI1_1	205	209	PF00082	0.224
CLV_PCSK_SKI1_1	286	290	PF00082	0.310
CLV_PCSK_SKI1_1	332	336	PF00082	0.256
CLV_PCSK_SKI1_1	372	376	PF00082	0.361
CLV_PCSK_SKI1_1	423	427	PF00082	0.410
CLV_PCSK_SKI1_1	465	469	PF00082	0.207
CLV_PCSK_SKI1_1	526	530	PF00082	0.167
CLV_PCSK_SKI1_1	588	592	PF00082	0.516
DEG_APCC_DBOX_1	449	457	PF00400	0.273
DEG_APCC_KENBOX_2	428	432	PF00400	0.304
DEG_SCF_FBW7_1	245	250	PF00400	0.248
DOC_CKS1_1	244	249	PF01111	0.245
DOC_CYCLIN_RxL_1	180	190	PF00134	0.298
DOC_CYCLIN_RxL_1	402	414	PF00134	0.313
DOC_CYCLIN_RxL_1	420	430	PF00134	0.245
DOC_CYCLIN_RxL_1	585	594	PF00134	0.395
DOC_MAPK_DCC_7	491	500	PF00069	0.167
DOC_MAPK_gen_1	202	212	PF00069	0.273
DOC_MAPK_gen_1	399	409	PF00069	0.359
DOC_MAPK_gen_1	421	428	PF00069	0.309
DOC_MAPK_gen_1	585	593	PF00069	0.453
DOC_MAPK_gen_1	60	69	PF00069	0.309
DOC_MAPK_JIP1_4	111	117	PF00069	0.390
DOC_MAPK_MEF2A_6	156	164	PF00069	0.390
DOC_MAPK_MEF2A_6	491	500	PF00069	0.167
DOC_MAPK_MEF2A_6	60	69	PF00069	0.167
DOC_PP1_RVXF_1	238	245	PF00149	0.244
DOC_PP2B_LxvP_1	115	118	PF13499	0.339
DOC_PP4_FxxP_1	244	247	PF00568	0.309
DOC_USP7_UBL2_3	335	339	PF12436	0.245
DOC_WW_Pin1_4	243	248	PF00397	0.312
DOC_WW_Pin1_4	566	571	PF00397	0.167
LIG_14-3-3_CanoR_1	563	570	PF00244	0.382
LIG_14-3-3_CanoR_1	585	591	PF00244	0.390
LIG_Actin_WH2_2	377	393	PF00022	0.452
LIG_Actin_WH2_2	542	560	PF00022	0.339
LIG_BRCT_BRCA1_1	134	138	PF00533	0.390
LIG_BRCT_BRCA1_1	240	244	PF00533	0.309
LIG_BRCT_BRCA1_1	366	370	PF00533	0.273
LIG_BRCT_BRCA1_2	366	372	PF00533	0.366
LIG_Clathr_ClatBox_1	235	239	PF01394	0.287
LIG_Clathr_ClatBox_1	590	594	PF01394	0.506
LIG_eIF4E_2	493	499	PF01652	0.309
LIG_FHA_1	138	144	PF00498	0.231
LIG_FHA_1	157	163	PF00498	0.469
LIG_FHA_1	232	238	PF00498	0.309
LIG_FHA_1	33	39	PF00498	0.423
LIG_FHA_1	442	448	PF00498	0.397
LIG_FHA_1	5	11	PF00498	0.577
LIG_FHA_1	576	582	PF00498	0.307
LIG_FHA_2	548	554	PF00498	0.245
LIG_LIR_Apic_2	241	247	PF02991	0.390
LIG_LIR_Gen_1	147	158	PF02991	0.292
LIG_LIR_Gen_1	293	304	PF02991	0.301
LIG_LIR_Gen_1	401	411	PF02991	0.282
LIG_LIR_Nem_3	135	141	PF02991	0.298
LIG_LIR_Nem_3	147	153	PF02991	0.282
LIG_LIR_Nem_3	165	169	PF02991	0.280
LIG_LIR_Nem_3	190	196	PF02991	0.259
LIG_LIR_Nem_3	253	257	PF02991	0.245
LIG_LIR_Nem_3	293	299	PF02991	0.274
LIG_LIR_Nem_3	301	307	PF02991	0.313
LIG_LIR_Nem_3	401	406	PF02991	0.282
LIG_LIR_Nem_3	443	448	PF02991	0.410
LIG_LIR_Nem_3	462	467	PF02991	0.316
LIG_NRBOX	408	414	PF00104	0.390
LIG_PCNA_yPIPBox_3	584	597	PF02747	0.426
LIG_Pex14_2	166	170	PF04695	0.390
LIG_SH2_CRK	436	440	PF00017	0.252
LIG_SH2_CRK	464	468	PF00017	0.229
LIG_SH2_CRK	493	497	PF00017	0.298
LIG_SH2_PTP2	150	153	PF00017	0.390
LIG_SH2_SRC	493	496	PF00017	0.266
LIG_SH2_STAP1	103	107	PF00017	0.310
LIG_SH2_STAT3	116	119	PF00017	0.390
LIG_SH2_STAT5	103	106	PF00017	0.149
LIG_SH2_STAT5	116	119	PF00017	0.339
LIG_SH2_STAT5	150	153	PF00017	0.409
LIG_SH2_STAT5	392	395	PF00017	0.271
LIG_SH2_STAT5	76	79	PF00017	0.309
LIG_SH2_STAT5	84	87	PF00017	0.455
LIG_SH2_STAT5	9	12	PF00017	0.362
LIG_SH3_2	592	597	PF14604	0.510
LIG_SH3_3	589	595	PF00018	0.511
LIG_SUMO_SIM_anti_2	233	239	PF11976	0.288
LIG_SUMO_SIM_anti_2	514	522	PF11976	0.288
LIG_SUMO_SIM_par_1	233	239	PF11976	0.311
LIG_SUMO_SIM_par_1	408	414	PF11976	0.304
LIG_SUMO_SIM_par_1	424	430	PF11976	0.304
LIG_TRAF2_1	18	21	PF00917	0.395
LIG_TRFH_1	84	88	PF08558	0.339
LIG_TYR_ITIM	148	153	PF00017	0.380
LIG_TYR_ITIM	252	257	PF00017	0.260
LIG_UBA3_1	295	302	PF00899	0.309
LIG_UBA3_1	425	429	PF00899	0.309
LIG_WRC_WIRS_1	442	447	PF05994	0.309
MOD_CDK_SPxK_1	566	572	PF00069	0.167
MOD_CK1_1	165	171	PF00069	0.390
MOD_CK1_1	176	182	PF00069	0.390
MOD_CK1_1	24	30	PF00069	0.399
MOD_CK1_1	362	368	PF00069	0.390
MOD_CK1_1	463	469	PF00069	0.380
MOD_CK1_1	552	558	PF00069	0.445
MOD_CK1_1	566	572	PF00069	0.167
MOD_CK2_1	227	233	PF00069	0.308
MOD_CK2_1	271	277	PF00069	0.352
MOD_CK2_1	424	430	PF00069	0.352
MOD_CK2_1	547	553	PF00069	0.245
MOD_GlcNHglycan	108	111	PF01048	0.222
MOD_GlcNHglycan	277	281	PF01048	0.347
MOD_GlcNHglycan	45	48	PF01048	0.424
MOD_GlcNHglycan	457	460	PF01048	0.378
MOD_GlcNHglycan	553	557	PF01048	0.293
MOD_GlcNHglycan	565	568	PF01048	0.378
MOD_GlcNHglycan	581	584	PF01048	0.201
MOD_GlcNHglycan	77	80	PF01048	0.334
MOD_GSK3_1	106	113	PF00069	0.205
MOD_GSK3_1	223	230	PF00069	0.313
MOD_GSK3_1	243	250	PF00069	0.129
MOD_GSK3_1	271	278	PF00069	0.323
MOD_GSK3_1	352	359	PF00069	0.260
MOD_GSK3_1	361	368	PF00069	0.247
MOD_GSK3_1	382	389	PF00069	0.255
MOD_GSK3_1	455	462	PF00069	0.321
MOD_GSK3_1	470	477	PF00069	0.303
MOD_GSK3_1	562	569	PF00069	0.327
MOD_GSK3_1	575	582	PF00069	0.239
MOD_GSK3_1	88	95	PF00069	0.381
MOD_N-GLC_1	176	181	PF02516	0.309
MOD_N-GLC_1	289	294	PF02516	0.318
MOD_N-GLC_1	4	9	PF02516	0.448
MOD_N-GLC_1	474	479	PF02516	0.360
MOD_N-GLC_1	483	488	PF02516	0.417
MOD_NEK2_1	101	106	PF00069	0.284
MOD_NEK2_1	132	137	PF00069	0.341
MOD_NEK2_1	22	27	PF00069	0.325
MOD_NEK2_1	275	280	PF00069	0.367
MOD_NEK2_1	500	505	PF00069	0.372
MOD_NEK2_1	586	591	PF00069	0.321
MOD_PIKK_1	101	107	PF00454	0.339
MOD_PIKK_1	132	138	PF00454	0.291
MOD_PIKK_1	247	253	PF00454	0.245
MOD_PIKK_1	362	368	PF00454	0.249
MOD_PKA_2	562	568	PF00069	0.382
MOD_Plk_1	176	182	PF00069	0.318
MOD_Plk_1	238	244	PF00069	0.243
MOD_Plk_1	4	10	PF00069	0.620
MOD_Plk_1	474	480	PF00069	0.360
MOD_Plk_1	483	489	PF00069	0.353
MOD_Plk_1	552	558	PF00069	0.245
MOD_Plk_2-3	227	233	PF00069	0.390
MOD_Plk_2-3	424	430	PF00069	0.352
MOD_Plk_4	110	116	PF00069	0.347
MOD_Plk_4	118	124	PF00069	0.288
MOD_Plk_4	165	171	PF00069	0.345
MOD_Plk_4	176	182	PF00069	0.337
MOD_Plk_4	231	237	PF00069	0.270
MOD_Plk_4	306	312	PF00069	0.254
MOD_Plk_4	411	417	PF00069	0.262
MOD_Plk_4	441	447	PF00069	0.334
MOD_Plk_4	5	11	PF00069	0.574
MOD_Plk_4	500	506	PF00069	0.359
MOD_Plk_4	516	522	PF00069	0.390
MOD_ProDKin_1	243	249	PF00069	0.312
MOD_ProDKin_1	566	572	PF00069	0.167
MOD_SUMO_for_1	18	21	PF00179	0.389
MOD_SUMO_rev_2	125	135	PF00179	0.350
MOD_SUMO_rev_2	149	158	PF00179	0.390
MOD_SUMO_rev_2	327	337	PF00179	0.245
MOD_SUMO_rev_2	519	528	PF00179	0.343
TRG_DiLeu_BaEn_1	231	236	PF01217	0.339
TRG_DiLeu_BaEn_1	346	351	PF01217	0.245
TRG_DiLeu_BaEn_1	449	454	PF01217	0.192
TRG_DiLeu_BaEn_1	524	529	PF01217	0.287
TRG_DiLeu_BaEn_2	332	338	PF01217	0.245
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.390
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.260
TRG_DiLeu_LyEn_5	346	351	PF01217	0.245
TRG_ENDOCYTIC_2	150	153	PF00928	0.380
TRG_ENDOCYTIC_2	254	257	PF00928	0.245
TRG_ENDOCYTIC_2	464	467	PF00928	0.330
TRG_ER_diArg_1	370	373	PF00400	0.245
TRG_ER_FFAT_2	239	250	PF00635	0.273
TRG_NES_CRM1_1	227	239	PF08389	0.290
TRG_NES_CRM1_1	42	57	PF08389	0.304
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.238
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV5	Leptomonas seymouri	76%	100%
A0A0S4IXS0	Bodo saltans	46%	99%
A0A1X0NZL8	Trypanosomatidae	49%	99%
A0A3Q8IDK4	Leishmania donovani	86%	100%
A0A3R7P4L0	Trypanosoma rangeli	46%	100%
A4I1R7	Leishmania infantum	86%	100%
C9ZKC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AXV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P20795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	86%
P34260	Caenorhabditis elegans	23%	99%
P34815	Caenorhabditis elegans	22%	89%
P38932	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P59016	Mus musculus	27%	97%
Q15833	Homo sapiens	22%	100%
Q18891	Caenorhabditis elegans	21%	97%
Q28288	Canis lupus familiaris	21%	100%
Q2HJ18	Bos taurus	27%	97%
Q4Q9L9	Leishmania major	87%	100%
Q54GE3	Dictyostelium discoideum	22%	100%
Q58EN8	Danio rerio	27%	97%
Q62753	Rattus norvegicus	21%	100%
Q63615	Rattus norvegicus	33%	100%
Q63616	Rattus norvegicus	27%	97%
Q64324	Mus musculus	22%	100%
Q94KJ7	Arabidopsis thaliana	31%	100%
Q96AX1	Homo sapiens	33%	100%
Q9D2N9	Mus musculus	33%	100%
Q9H267	Homo sapiens	27%	97%
Q9P7V6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9Y1I2	Drosophila melanogaster	25%	97%
V5D8I9	Trypanosoma cruzi	48%	100%