CLP1_P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEC1_LEIBR

TriTrypDb:

LbrM.25.1750 , LBRM2903_250030800

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HEC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	2
GO:0006378	mRNA polyadenylation	7	2
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	2
GO:0006397	mRNA processing	7	2
GO:0006399	tRNA metabolic process	7	2
GO:0008033	tRNA processing	8	2
GO:0008380	RNA splicing	7	2
GO:0016071	mRNA metabolic process	6	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031124	mRNA 3'-end processing	8	2
GO:0034470	ncRNA processing	7	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043631	RNA polyadenylation	6	2
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0019205	nucleobase-containing compound kinase activity	5	12
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	103	107	PF00082	0.426
CLV_PCSK_SKI1_1	160	164	PF00082	0.414
CLV_PCSK_SKI1_1	231	235	PF00082	0.343
CLV_PCSK_SKI1_1	440	444	PF00082	0.425
DEG_SPOP_SBC_1	79	83	PF00917	0.439
DOC_MAPK_FxFP_2	425	428	PF00069	0.440
DOC_MAPK_MEF2A_6	353	362	PF00069	0.348
DOC_PP4_FxxP_1	4	7	PF00568	0.604
DOC_PP4_FxxP_1	425	428	PF00568	0.447
DOC_USP7_MATH_1	35	39	PF00917	0.310
DOC_USP7_MATH_1	354	358	PF00917	0.486
DOC_WW_Pin1_4	370	375	PF00397	0.474
DOC_WW_Pin1_4	389	394	PF00397	0.234
DOC_WW_Pin1_4	399	404	PF00397	0.444
DOC_WW_Pin1_4	56	61	PF00397	0.351
LIG_14-3-3_CanoR_1	300	309	PF00244	0.501
LIG_14-3-3_CanoR_1	313	321	PF00244	0.336
LIG_14-3-3_CanoR_1	99	105	PF00244	0.312
LIG_14-3-3_CterR_2	440	445	PF00244	0.419
LIG_Actin_WH2_2	80	97	PF00022	0.318
LIG_BRCT_BRCA1_1	314	318	PF00533	0.358
LIG_BRCT_BRCA1_1	334	338	PF00533	0.441
LIG_BRCT_BRCA1_1	351	355	PF00533	0.221
LIG_BRCT_BRCA1_1	421	425	PF00533	0.425
LIG_Clathr_ClatBox_1	163	167	PF01394	0.287
LIG_FHA_1	100	106	PF00498	0.468
LIG_FHA_1	11	17	PF00498	0.512
LIG_FHA_1	116	122	PF00498	0.311
LIG_FHA_1	201	207	PF00498	0.337
LIG_FHA_1	291	297	PF00498	0.464
LIG_FHA_1	339	345	PF00498	0.542
LIG_FHA_1	431	437	PF00498	0.393
LIG_FHA_1	72	78	PF00498	0.352
LIG_FHA_1	79	85	PF00498	0.311
LIG_FHA_2	207	213	PF00498	0.467
LIG_GBD_Chelix_1	61	69	PF00786	0.318
LIG_LIR_Apic_2	2	7	PF02991	0.551
LIG_LIR_Apic_2	349	354	PF02991	0.475
LIG_LIR_Apic_2	422	428	PF02991	0.547
LIG_LIR_Apic_2	66	71	PF02991	0.409
LIG_LIR_Gen_1	111	116	PF02991	0.312
LIG_LIR_Gen_1	212	221	PF02991	0.340
LIG_LIR_Gen_1	288	296	PF02991	0.398
LIG_LIR_Gen_1	306	314	PF02991	0.538
LIG_LIR_Gen_1	315	326	PF02991	0.524
LIG_LIR_Gen_1	352	363	PF02991	0.415
LIG_LIR_Nem_3	111	115	PF02991	0.312
LIG_LIR_Nem_3	212	217	PF02991	0.301
LIG_LIR_Nem_3	288	294	PF02991	0.268
LIG_LIR_Nem_3	306	311	PF02991	0.550
LIG_LIR_Nem_3	315	321	PF02991	0.514
LIG_LIR_Nem_3	352	358	PF02991	0.445
LIG_LIR_Nem_3	64	70	PF02991	0.300
LIG_MLH1_MIPbox_1	334	338	PF16413	0.441
LIG_PCNA_yPIPBox_3	297	309	PF02747	0.305
LIG_Pex14_1	351	355	PF04695	0.473
LIG_PTB_Apo_2	198	205	PF02174	0.176
LIG_PTB_Phospho_1	198	204	PF10480	0.176
LIG_RPA_C_Fungi	143	155	PF08784	0.252
LIG_SH2_CRK	112	116	PF00017	0.312
LIG_SH2_CRK	406	410	PF00017	0.360
LIG_SH2_NCK_1	406	410	PF00017	0.441
LIG_SH2_PTP2	308	311	PF00017	0.378
LIG_SH2_SRC	277	280	PF00017	0.176
LIG_SH2_STAP1	153	157	PF00017	0.347
LIG_SH2_STAP1	334	338	PF00017	0.441
LIG_SH2_STAT5	204	207	PF00017	0.347
LIG_SH2_STAT5	226	229	PF00017	0.320
LIG_SH2_STAT5	295	298	PF00017	0.487
LIG_SH2_STAT5	308	311	PF00017	0.458
LIG_SH2_STAT5	337	340	PF00017	0.375
LIG_SH2_STAT5	68	71	PF00017	0.411
LIG_SH3_3	15	21	PF00018	0.497
LIG_SH3_3	171	177	PF00018	0.359
LIG_SH3_3	182	188	PF00018	0.294
LIG_SH3_3	317	323	PF00018	0.383
LIG_SH3_3	368	374	PF00018	0.491
LIG_SUMO_SIM_anti_2	357	362	PF11976	0.389
LIG_SUMO_SIM_anti_2	429	436	PF11976	0.375
LIG_SUMO_SIM_par_1	160	165	PF11976	0.295
LIG_SUMO_SIM_par_1	186	193	PF11976	0.296
LIG_SUMO_SIM_par_1	25	32	PF11976	0.410
LIG_SUMO_SIM_par_1	254	260	PF11976	0.291
LIG_SUMO_SIM_par_1	359	366	PF11976	0.349
LIG_SUMO_SIM_par_1	432	438	PF11976	0.326
LIG_TRAF2_1	376	379	PF00917	0.436
LIG_TRFH_1	67	71	PF08558	0.287
LIG_TYR_ITIM	110	115	PF00017	0.312
LIG_TYR_ITIM	404	409	PF00017	0.333
LIG_TYR_ITIM	65	70	PF00017	0.347
LIG_WRC_WIRS_1	211	216	PF05994	0.318
MOD_CDK_SPK_2	389	394	PF00069	0.238
MOD_CDK_SPxxK_3	370	377	PF00069	0.405
MOD_CK1_1	101	107	PF00069	0.318
MOD_CK1_1	12	18	PF00069	0.513
MOD_CK1_1	349	355	PF00069	0.292
MOD_CK1_1	392	398	PF00069	0.411
MOD_CK2_1	187	193	PF00069	0.315
MOD_CK2_1	206	212	PF00069	0.463
MOD_GlcNHglycan	251	254	PF01048	0.279
MOD_GlcNHglycan	263	266	PF01048	0.268
MOD_GlcNHglycan	37	40	PF01048	0.374
MOD_GlcNHglycan	394	397	PF01048	0.500
MOD_GlcNHglycan	46	49	PF01048	0.352
MOD_GSK3_1	195	202	PF00069	0.301
MOD_GSK3_1	206	213	PF00069	0.312
MOD_GSK3_1	312	319	PF00069	0.423
MOD_GSK3_1	408	415	PF00069	0.389
MOD_GSK3_1	419	426	PF00069	0.351
MOD_GSK3_1	56	63	PF00069	0.226
MOD_GSK3_1	8	15	PF00069	0.543
MOD_GSK3_1	97	104	PF00069	0.417
MOD_LATS_1	298	304	PF00433	0.363
MOD_N-GLC_1	200	205	PF02516	0.326
MOD_N-GLC_1	316	321	PF02516	0.472
MOD_NEK2_1	195	200	PF00069	0.408
MOD_NEK2_1	26	31	PF00069	0.347
MOD_NEK2_1	290	295	PF00069	0.381
MOD_NEK2_1	338	343	PF00069	0.526
MOD_NEK2_1	419	424	PF00069	0.338
MOD_NEK2_1	435	440	PF00069	0.448
MOD_NEK2_1	78	83	PF00069	0.328
MOD_NEK2_2	37	42	PF00069	0.347
MOD_PIKK_1	115	121	PF00454	0.318
MOD_PIKK_1	123	129	PF00454	0.328
MOD_PIKK_1	346	352	PF00454	0.485
MOD_PIKK_1	49	55	PF00454	0.177
MOD_PK_1	14	20	PF00069	0.418
MOD_PKA_2	312	318	PF00069	0.406
MOD_PKA_2	98	104	PF00069	0.287
MOD_Plk_1	200	206	PF00069	0.204
MOD_Plk_1	316	322	PF00069	0.494
MOD_Plk_1	63	69	PF00069	0.312
MOD_Plk_4	195	201	PF00069	0.424
MOD_Plk_4	290	296	PF00069	0.398
MOD_Plk_4	430	436	PF00069	0.380
MOD_Plk_4	80	86	PF00069	0.410
MOD_ProDKin_1	370	376	PF00069	0.477
MOD_ProDKin_1	389	395	PF00069	0.241
MOD_ProDKin_1	399	405	PF00069	0.441
MOD_ProDKin_1	56	62	PF00069	0.351
MOD_SUMO_for_1	363	366	PF00179	0.468
MOD_SUMO_for_1	376	379	PF00179	0.517
MOD_SUMO_for_1	41	44	PF00179	0.318
MOD_SUMO_rev_2	32	38	PF00179	0.318
TRG_DiLeu_BaEn_1	430	435	PF01217	0.360
TRG_DiLeu_BaEn_3	378	384	PF01217	0.399
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.334
TRG_ENDOCYTIC_2	112	115	PF00928	0.312
TRG_ENDOCYTIC_2	226	229	PF00928	0.347
TRG_ENDOCYTIC_2	308	311	PF00928	0.491
TRG_ENDOCYTIC_2	406	409	PF00928	0.436
TRG_ENDOCYTIC_2	67	70	PF00928	0.312
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q0	Leptomonas seymouri	71%	100%
A0A0S4J450	Bodo saltans	32%	100%
A0A1X0NYA9	Trypanosomatidae	43%	100%
A0A3S5H7F2	Leishmania donovani	86%	100%
A4I1R6	Leishmania infantum	86%	100%
A6S936	Botryotinia fuckeliana (strain B05.10)	25%	97%
A8PB32	Brugia malayi	24%	100%
A8X9U4	Caenorhabditis briggsae	22%	100%
C9ZKC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E7F3I6	Danio rerio	25%	100%
E9AXV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B114	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q0U2G5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	22%	95%
Q2H1L0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	25%	90%
Q4Q752	Leishmania major	24%	100%
Q4Q9M0	Leishmania major	87%	100%
Q59ST8	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	91%
Q6CTU5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
V5BCI8	Trypanosoma cruzi	42%	100%