LeishMANIAdb
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Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-like domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HEC0_LEIBR
TriTrypDb:
LbrM.25.1740 , LBRM2903_250030700 *
Length:
301

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HEC0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEC0

PDB structure(s): 7ane_av

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 229 233 PF00656 0.450
CLV_NRD_NRD_1 51 53 PF00675 0.419
CLV_NRD_NRD_1 67 69 PF00675 0.635
CLV_NRD_NRD_1 99 101 PF00675 0.489
CLV_PCSK_KEX2_1 67 69 PF00082 0.635
CLV_PCSK_KEX2_1 99 101 PF00082 0.506
CLV_PCSK_SKI1_1 112 116 PF00082 0.375
CLV_PCSK_SKI1_1 180 184 PF00082 0.193
CLV_PCSK_SKI1_1 99 103 PF00082 0.511
DOC_CDC14_PxL_1 271 279 PF14671 0.447
DOC_CYCLIN_RxL_1 63 76 PF00134 0.434
DOC_MAPK_gen_1 154 163 PF00069 0.462
DOC_MAPK_gen_1 67 74 PF00069 0.592
DOC_MAPK_MEF2A_6 170 178 PF00069 0.288
DOC_MAPK_MEF2A_6 67 74 PF00069 0.533
DOC_MAPK_NFAT4_5 67 75 PF00069 0.526
DOC_PP1_RVXF_1 152 158 PF00149 0.357
DOC_PP4_FxxP_1 5 8 PF00568 0.475
DOC_USP7_MATH_1 94 98 PF00917 0.596
DOC_WW_Pin1_4 112 117 PF00397 0.453
DOC_WW_Pin1_4 194 199 PF00397 0.450
DOC_WW_Pin1_4 261 266 PF00397 0.410
DOC_WW_Pin1_4 74 79 PF00397 0.423
LIG_14-3-3_CanoR_1 156 161 PF00244 0.508
LIG_14-3-3_CanoR_1 52 61 PF00244 0.457
LIG_14-3-3_CanoR_1 67 71 PF00244 0.588
LIG_14-3-3_CanoR_1 99 108 PF00244 0.636
LIG_Clathr_ClatBox_1 33 37 PF01394 0.354
LIG_FHA_1 17 23 PF00498 0.389
LIG_FHA_2 113 119 PF00498 0.426
LIG_FHA_2 181 187 PF00498 0.523
LIG_FHA_2 217 223 PF00498 0.468
LIG_FHA_2 241 247 PF00498 0.536
LIG_IRF3_LxIS_1 198 203 PF10401 0.393
LIG_LIR_Apic_2 104 110 PF02991 0.469
LIG_LIR_Apic_2 3 8 PF02991 0.474
LIG_LIR_Gen_1 197 207 PF02991 0.450
LIG_LIR_Gen_1 227 234 PF02991 0.505
LIG_LIR_Nem_3 159 163 PF02991 0.440
LIG_LIR_Nem_3 197 202 PF02991 0.450
LIG_LIR_Nem_3 227 231 PF02991 0.505
LIG_LIR_Nem_3 59 64 PF02991 0.449
LIG_MYND_1 275 279 PF01753 0.508
LIG_SH2_NCK_1 228 232 PF00017 0.509
LIG_SH2_PTP2 42 45 PF00017 0.376
LIG_SH2_STAP1 90 94 PF00017 0.457
LIG_SH2_STAT5 199 202 PF00017 0.450
LIG_SH2_STAT5 239 242 PF00017 0.362
LIG_SH2_STAT5 42 45 PF00017 0.376
LIG_SH2_STAT5 80 83 PF00017 0.455
LIG_TRAF2_1 233 236 PF00917 0.455
LIG_TYR_ITIM 40 45 PF00017 0.370
LIG_WRC_WIRS_1 157 162 PF05994 0.435
LIG_WRC_WIRS_1 202 207 PF05994 0.450
MOD_CDC14_SPxK_1 264 267 PF00782 0.402
MOD_CDK_SPxK_1 261 267 PF00069 0.412
MOD_CK1_1 125 131 PF00069 0.446
MOD_CK1_1 56 62 PF00069 0.483
MOD_CK2_1 162 168 PF00069 0.368
MOD_CK2_1 180 186 PF00069 0.450
MOD_CK2_1 240 246 PF00069 0.537
MOD_CK2_1 85 91 PF00069 0.571
MOD_DYRK1A_RPxSP_1 112 116 PF00069 0.418
MOD_GlcNHglycan 124 127 PF01048 0.521
MOD_GlcNHglycan 164 167 PF01048 0.436
MOD_GlcNHglycan 293 297 PF01048 0.478
MOD_GlcNHglycan 48 51 PF01048 0.393
MOD_GlcNHglycan 83 86 PF01048 0.524
MOD_GSK3_1 112 119 PF00069 0.416
MOD_GSK3_1 12 19 PF00069 0.476
MOD_GSK3_1 201 208 PF00069 0.419
MOD_GSK3_1 81 88 PF00069 0.481
MOD_GSK3_1 99 106 PF00069 0.488
MOD_N-GLC_1 194 199 PF02516 0.250
MOD_NEK2_1 101 106 PF00069 0.476
MOD_NEK2_1 200 205 PF00069 0.493
MOD_NEK2_1 28 33 PF00069 0.363
MOD_NEK2_1 66 71 PF00069 0.596
MOD_NEK2_1 81 86 PF00069 0.414
MOD_NEK2_2 201 206 PF00069 0.521
MOD_PIKK_1 101 107 PF00454 0.412
MOD_PIKK_1 12 18 PF00454 0.467
MOD_PIKK_1 85 91 PF00454 0.556
MOD_PKA_1 99 105 PF00069 0.423
MOD_PKA_2 66 72 PF00069 0.586
MOD_PKA_2 99 105 PF00069 0.496
MOD_PKB_1 154 162 PF00069 0.430
MOD_Plk_1 180 186 PF00069 0.450
MOD_Plk_1 226 232 PF00069 0.458
MOD_Plk_2-3 216 222 PF00069 0.509
MOD_Plk_4 125 131 PF00069 0.423
MOD_Plk_4 156 162 PF00069 0.433
MOD_Plk_4 29 35 PF00069 0.343
MOD_ProDKin_1 112 118 PF00069 0.449
MOD_ProDKin_1 194 200 PF00069 0.450
MOD_ProDKin_1 261 267 PF00069 0.412
MOD_ProDKin_1 74 80 PF00069 0.420
MOD_SUMO_rev_2 204 214 PF00179 0.477
MOD_SUMO_rev_2 215 220 PF00179 0.452
TRG_DiLeu_BaEn_1 236 241 PF01217 0.517
TRG_ENDOCYTIC_2 199 202 PF00928 0.450
TRG_ENDOCYTIC_2 228 231 PF00928 0.509
TRG_ENDOCYTIC_2 266 269 PF00928 0.424
TRG_ENDOCYTIC_2 294 297 PF00928 0.448
TRG_ENDOCYTIC_2 42 45 PF00928 0.376
TRG_ER_diArg_1 153 156 PF00400 0.330
TRG_ER_diArg_1 66 68 PF00400 0.576
TRG_ER_diArg_1 99 101 PF00400 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IST6 Bodo saltans 47% 100%
A0A1X0NY44 Trypanosomatidae 65% 100%
A0A3R7MC48 Trypanosoma rangeli 67% 100%
A0A3S7WZF0 Leishmania donovani 90% 100%
A4I1R5 Leishmania infantum 90% 100%
C9ZKC1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9AXV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q9M1 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS