Centrosomal protein of 70 kDa

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEB9_LEIBR

TriTrypDb:

LbrM.25.1730

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	212	214	PF00082	0.740
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.740
CLV_PCSK_SKI1_1	170	174	PF00082	0.572
CLV_PCSK_SKI1_1	212	216	PF00082	0.524
CLV_Separin_Metazoa	191	195	PF03568	0.348
DEG_APCC_DBOX_1	180	188	PF00400	0.377
DEG_Nend_UBRbox_2	1	3	PF02207	0.756
DEG_SCF_FBW7_1	226	233	PF00400	0.655
DOC_USP7_MATH_1	221	225	PF00917	0.702
DOC_USP7_MATH_1	230	234	PF00917	0.654
DOC_USP7_MATH_1	40	44	PF00917	0.621
DOC_WW_Pin1_4	226	231	PF00397	0.664
DOC_WW_Pin1_4	36	41	PF00397	0.770
DOC_WW_Pin1_4	67	72	PF00397	0.697
DOC_WW_Pin1_4	78	83	PF00397	0.780
LIG_14-3-3_CanoR_1	16	22	PF00244	0.466
LIG_14-3-3_CanoR_1	59	67	PF00244	0.682
LIG_FHA_1	145	151	PF00498	0.359
LIG_FHA_1	156	162	PF00498	0.359
LIG_FHA_1	167	173	PF00498	0.331
LIG_FHA_1	236	242	PF00498	0.532
LIG_FHA_1	26	32	PF00498	0.645
LIG_FHA_2	135	141	PF00498	0.478
LIG_FHA_2	178	184	PF00498	0.459
LIG_FHA_2	8	14	PF00498	0.677
LIG_FHA_2	89	95	PF00498	0.500
LIG_LIR_Gen_1	130	139	PF02991	0.615
LIG_LIR_Gen_1	99	109	PF02991	0.611
LIG_LIR_Nem_3	130	136	PF02991	0.612
LIG_LIR_Nem_3	186	192	PF02991	0.554
LIG_LIR_Nem_3	242	248	PF02991	0.557
LIG_LIR_Nem_3	35	41	PF02991	0.583
LIG_LIR_Nem_3	99	104	PF02991	0.626
LIG_NRBOX	183	189	PF00104	0.350
LIG_NRBOX	236	242	PF00104	0.569
LIG_SH2_CRK	38	42	PF00017	0.579
LIG_SH2_STAP1	27	31	PF00017	0.717
LIG_SH2_STAT5	160	163	PF00017	0.337
LIG_SH2_STAT5	27	30	PF00017	0.504
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.441
LIG_SUMO_SIM_par_1	106	112	PF11976	0.349
LIG_SUMO_SIM_par_1	39	46	PF11976	0.515
LIG_TYR_ITIM	187	192	PF00017	0.349
LIG_TYR_ITIM	36	41	PF00017	0.514
MOD_CDK_SPxxK_3	78	85	PF00069	0.785
MOD_CK1_1	107	113	PF00069	0.510
MOD_CK1_1	168	174	PF00069	0.613
MOD_CK1_1	29	35	PF00069	0.763
MOD_CK1_1	43	49	PF00069	0.612
MOD_CK1_1	88	94	PF00069	0.618
MOD_CK2_1	134	140	PF00069	0.434
MOD_CK2_1	177	183	PF00069	0.469
MOD_CK2_1	7	13	PF00069	0.679
MOD_CK2_1	86	92	PF00069	0.778
MOD_GlcNHglycan	111	114	PF01048	0.345
MOD_GlcNHglycan	144	147	PF01048	0.405
MOD_GSK3_1	103	110	PF00069	0.483
MOD_GSK3_1	226	233	PF00069	0.603
MOD_GSK3_1	25	32	PF00069	0.637
MOD_GSK3_1	36	43	PF00069	0.730
MOD_GSK3_1	54	61	PF00069	0.669
MOD_GSK3_1	84	91	PF00069	0.706
MOD_N-GLC_1	230	235	PF02516	0.541
MOD_N-GLC_1	57	62	PF02516	0.525
MOD_NEK2_1	122	127	PF00069	0.435
MOD_PIKK_1	29	35	PF00454	0.763
MOD_PIKK_1	86	92	PF00454	0.679
MOD_PIKK_1	94	100	PF00454	0.592
MOD_PKA_2	155	161	PF00069	0.348
MOD_PKA_2	58	64	PF00069	0.727
MOD_PKA_2	84	90	PF00069	0.790
MOD_Plk_1	14	20	PF00069	0.580
MOD_Plk_1	230	236	PF00069	0.470
MOD_Plk_4	104	110	PF00069	0.528
MOD_Plk_4	221	227	PF00069	0.579
MOD_Plk_4	69	75	PF00069	0.517
MOD_ProDKin_1	226	232	PF00069	0.663
MOD_ProDKin_1	36	42	PF00069	0.770
MOD_ProDKin_1	67	73	PF00069	0.699
MOD_ProDKin_1	78	84	PF00069	0.784
MOD_SUMO_rev_2	110	119	PF00179	0.457
TRG_DiLeu_BaEn_1	183	188	PF01217	0.503
TRG_DiLeu_BaEn_1	191	196	PF01217	0.578
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.483
TRG_ENDOCYTIC_2	189	192	PF00928	0.348
TRG_ENDOCYTIC_2	38	41	PF00928	0.580
TRG_NES_CRM1_1	13	26	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYI0	Leptomonas seymouri	33%	100%
A0A3Q8INN7	Leishmania donovani	65%	100%
A4I1R4	Leishmania infantum	65%	100%
E9AXU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q9M2	Leishmania major	68%	100%