BRO1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRO1-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEB8_LEIBR

TriTrypDb:

LbrM.25.1720 , LBRM2903_250030600

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.364
CLV_NRD_NRD_1	4	6	PF00675	0.477
CLV_NRD_NRD_1	96	98	PF00675	0.442
CLV_PCSK_KEX2_1	313	315	PF00082	0.385
CLV_PCSK_KEX2_1	4	6	PF00082	0.477
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.385
CLV_PCSK_SKI1_1	114	118	PF00082	0.454
CLV_PCSK_SKI1_1	21	25	PF00082	0.444
CLV_PCSK_SKI1_1	314	318	PF00082	0.429
CLV_PCSK_SKI1_1	45	49	PF00082	0.381
CLV_PCSK_SKI1_1	5	9	PF00082	0.480
DEG_APCC_DBOX_1	16	24	PF00400	0.475
DEG_APCC_DBOX_1	163	171	PF00400	0.364
DEG_APCC_KENBOX_2	268	272	PF00400	0.243
DEG_APCC_KENBOX_2	97	101	PF00400	0.243
DEG_Nend_UBRbox_3	1	3	PF02207	0.484
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.243
DOC_MAPK_DCC_7	45	53	PF00069	0.438
DOC_MAPK_gen_1	299	306	PF00069	0.243
DOC_MAPK_gen_1	357	367	PF00069	0.330
DOC_MAPK_gen_1	4	12	PF00069	0.477
DOC_MAPK_gen_1	79	87	PF00069	0.523
DOC_MAPK_MEF2A_6	360	367	PF00069	0.317
DOC_MAPK_MEF2A_6	415	422	PF00069	0.501
DOC_MAPK_MEF2A_6	45	53	PF00069	0.506
DOC_MAPK_NFAT4_5	360	368	PF00069	0.265
DOC_PP1_SILK_1	309	314	PF00149	0.243
DOC_PP2B_LxvP_1	363	366	PF13499	0.385
DOC_PP2B_LxvP_1	406	409	PF13499	0.496
DOC_USP7_MATH_1	231	235	PF00917	0.494
DOC_USP7_UBL2_3	360	364	PF12436	0.369
DOC_USP7_UBL2_3	75	79	PF12436	0.543
DOC_WW_Pin1_4	134	139	PF00397	0.488
DOC_WW_Pin1_4	147	152	PF00397	0.342
LIG_14-3-3_CanoR_1	189	193	PF00244	0.454
LIG_14-3-3_CanoR_1	277	285	PF00244	0.403
LIG_14-3-3_CanoR_1	381	390	PF00244	0.350
LIG_14-3-3_CanoR_1	54	61	PF00244	0.508
LIG_APCC_ABBA_1	243	248	PF00400	0.385
LIG_APCC_ABBA_1	85	90	PF00400	0.243
LIG_BRCT_BRCA1_1	209	213	PF00533	0.454
LIG_BRCT_BRCA1_1	260	264	PF00533	0.444
LIG_BRCT_BRCA1_1	299	303	PF00533	0.243
LIG_BRCT_BRCA1_1	326	330	PF00533	0.364
LIG_BRCT_BRCA1_1	418	422	PF00533	0.572
LIG_BRCT_BRCA1_2	326	332	PF00533	0.521
LIG_EH1_1	171	179	PF00400	0.339
LIG_FHA_1	125	131	PF00498	0.383
LIG_FHA_1	273	279	PF00498	0.389
LIG_FHA_1	306	312	PF00498	0.469
LIG_FHA_1	375	381	PF00498	0.462
LIG_FHA_1	382	388	PF00498	0.363
LIG_FHA_2	347	353	PF00498	0.243
LIG_LIR_Gen_1	137	147	PF02991	0.523
LIG_LIR_Gen_1	162	172	PF02991	0.385
LIG_LIR_Gen_1	300	311	PF02991	0.388
LIG_LIR_Gen_1	315	325	PF02991	0.389
LIG_LIR_Nem_3	11	16	PF02991	0.469
LIG_LIR_Nem_3	137	143	PF02991	0.420
LIG_LIR_Nem_3	157	163	PF02991	0.280
LIG_LIR_Nem_3	201	206	PF02991	0.321
LIG_LIR_Nem_3	210	215	PF02991	0.321
LIG_LIR_Nem_3	300	306	PF02991	0.403
LIG_LIR_Nem_3	315	320	PF02991	0.389
LIG_LIR_Nem_3	370	375	PF02991	0.391
LIG_LIR_Nem_3	89	95	PF02991	0.359
LIG_LYPXL_SIV_4	321	329	PF13949	0.243
LIG_MLH1_MIPbox_1	209	213	PF16413	0.454
LIG_SH2_CRK	203	207	PF00017	0.321
LIG_SH2_GRB2like	171	174	PF00017	0.372
LIG_SH2_PTP2	46	49	PF00017	0.369
LIG_SH2_SRC	322	325	PF00017	0.334
LIG_SH2_STAP1	126	130	PF00017	0.321
LIG_SH2_STAT5	115	118	PF00017	0.499
LIG_SH2_STAT5	126	129	PF00017	0.390
LIG_SH2_STAT5	145	148	PF00017	0.213
LIG_SH2_STAT5	184	187	PF00017	0.413
LIG_SH2_STAT5	212	215	PF00017	0.333
LIG_SH2_STAT5	354	357	PF00017	0.481
LIG_SH2_STAT5	46	49	PF00017	0.369
LIG_SH3_1	19	25	PF00018	0.474
LIG_SH3_1	46	52	PF00018	0.502
LIG_SH3_2	49	54	PF14604	0.507
LIG_SH3_3	19	25	PF00018	0.474
LIG_SH3_3	230	236	PF00018	0.454
LIG_SH3_3	402	408	PF00018	0.622
LIG_SH3_3	46	52	PF00018	0.463
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.410
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.243
LIG_SUMO_SIM_par_1	234	240	PF11976	0.514
LIG_TRFH_1	18	22	PF08558	0.478
LIG_TYR_ITIM	284	289	PF00017	0.385
MOD_CDK_SPK_2	134	139	PF00069	0.331
MOD_CK1_1	150	156	PF00069	0.464
MOD_CK1_1	27	33	PF00069	0.645
MOD_CK1_1	307	313	PF00069	0.381
MOD_CK1_1	336	342	PF00069	0.339
MOD_CK2_1	119	125	PF00069	0.243
MOD_CK2_1	193	199	PF00069	0.364
MOD_CK2_1	346	352	PF00069	0.413
MOD_CK2_1	60	66	PF00069	0.529
MOD_GlcNHglycan	108	111	PF01048	0.385
MOD_GlcNHglycan	209	212	PF01048	0.434
MOD_GlcNHglycan	264	267	PF01048	0.405
MOD_GlcNHglycan	335	338	PF01048	0.281
MOD_GSK3_1	146	153	PF00069	0.361
MOD_GSK3_1	258	265	PF00069	0.416
MOD_GSK3_1	272	279	PF00069	0.440
MOD_GSK3_1	288	295	PF00069	0.276
MOD_N-GLC_1	381	386	PF02516	0.377
MOD_NEK2_1	106	111	PF00069	0.426
MOD_NEK2_1	146	151	PF00069	0.258
MOD_NEK2_1	246	251	PF00069	0.387
MOD_NEK2_1	355	360	PF00069	0.385
MOD_NEK2_1	8	13	PF00069	0.478
MOD_PIKK_1	355	361	PF00454	0.308
MOD_PIKK_1	60	66	PF00454	0.600
MOD_PK_1	98	104	PF00069	0.454
MOD_PKA_2	188	194	PF00069	0.454
MOD_PKA_2	276	282	PF00069	0.389
MOD_PKA_2	346	352	PF00069	0.385
MOD_PKA_2	53	59	PF00069	0.488
MOD_Plk_1	304	310	PF00069	0.402
MOD_Plk_1	416	422	PF00069	0.555
MOD_Plk_1	8	14	PF00069	0.474
MOD_Plk_1	98	104	PF00069	0.353
MOD_Plk_2-3	346	352	PF00069	0.243
MOD_Plk_4	193	199	PF00069	0.399
MOD_Plk_4	307	313	PF00069	0.321
MOD_Plk_4	336	342	PF00069	0.436
MOD_Plk_4	346	352	PF00069	0.232
MOD_Plk_4	389	395	PF00069	0.350
MOD_ProDKin_1	134	140	PF00069	0.488
MOD_ProDKin_1	147	153	PF00069	0.342
MOD_SUMO_rev_2	68	77	PF00179	0.541
MOD_SUMO_rev_2	99	107	PF00179	0.372
TRG_DiLeu_BaEn_2	241	247	PF01217	0.418
TRG_ENDOCYTIC_2	165	168	PF00928	0.344
TRG_ENDOCYTIC_2	171	174	PF00928	0.322
TRG_ENDOCYTIC_2	203	206	PF00928	0.321
TRG_ENDOCYTIC_2	212	215	PF00928	0.321
TRG_ENDOCYTIC_2	286	289	PF00928	0.537
TRG_ENDOCYTIC_2	92	95	PF00928	0.243
TRG_ER_diArg_1	3	5	PF00400	0.477
TRG_NES_CRM1_1	242	256	PF08389	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN4	Leptomonas seymouri	67%	100%
A0A0S4JPD3	Bodo saltans	26%	98%
A0A1X0NY42	Trypanosomatidae	35%	100%
A0A3Q8ICM9	Leishmania donovani	84%	100%
A0A422P4K0	Trypanosoma rangeli	37%	100%
A4I1R3	Leishmania infantum	84%	100%
C9ZKB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AXU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9M3	Leishmania major	81%	100%