Eukaryotic translation initiation factor 3 30 kDa subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit j

Species:

Leishmania braziliensis

UniProt:

A4HEB5_LEIBR

TriTrypDb:

LbrM.25.1690 , LBRM2903_250030300

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	8
GO:0032991	protein-containing complex	1	8
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEB5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003743	translation initiation factor activity	4	8
GO:0005488	binding	1	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.468
CLV_NRD_NRD_1	58	60	PF00675	0.744
CLV_PCSK_KEX2_1	168	170	PF00082	0.452
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.452
CLV_PCSK_PC7_1	164	170	PF00082	0.522
CLV_PCSK_SKI1_1	134	138	PF00082	0.399
CLV_PCSK_SKI1_1	169	173	PF00082	0.517
CLV_PCSK_SKI1_1	51	55	PF00082	0.582
DEG_Nend_UBRbox_2	1	3	PF02207	0.658
DOC_USP7_MATH_1	86	90	PF00917	0.568
DOC_USP7_UBL2_3	168	172	PF12436	0.476
DOC_USP7_UBL2_3	176	180	PF12436	0.575
LIG_14-3-3_CanoR_1	122	127	PF00244	0.407
LIG_14-3-3_CanoR_1	93	101	PF00244	0.407
LIG_Actin_WH2_2	78	95	PF00022	0.560
LIG_FHA_1	142	148	PF00498	0.557
LIG_FHA_1	173	179	PF00498	0.514
LIG_LIR_Gen_1	129	140	PF02991	0.395
LIG_LIR_Nem_3	129	135	PF02991	0.431
LIG_LIR_Nem_3	138	143	PF02991	0.439
LIG_SH2_CRK	132	136	PF00017	0.480
LIG_SH2_GRB2like	4	7	PF00017	0.486
LIG_SH2_NCK_1	19	23	PF00017	0.548
LIG_SH2_NCK_1	4	8	PF00017	0.553
LIG_SH2_SRC	19	22	PF00017	0.602
LIG_SH2_SRC	4	7	PF00017	0.565
LIG_SH2_STAP1	132	136	PF00017	0.523
LIG_SH2_STAP1	19	23	PF00017	0.576
LIG_SH3_4	176	183	PF00018	0.590
LIG_SUMO_SIM_par_1	135	141	PF11976	0.317
LIG_TRAF2_1	30	33	PF00917	0.550
LIG_TRAF2_1	96	99	PF00917	0.532
LIG_WRC_WIRS_1	123	128	PF05994	0.409
MOD_CK1_1	127	133	PF00069	0.525
MOD_CK1_1	145	151	PF00069	0.470
MOD_CK1_1	87	93	PF00069	0.440
MOD_CK2_1	122	128	PF00069	0.485
MOD_CK2_1	188	194	PF00069	0.468
MOD_CK2_1	93	99	PF00069	0.427
MOD_GlcNHglycan	185	188	PF01048	0.680
MOD_GlcNHglycan	86	89	PF01048	0.565
MOD_GSK3_1	122	129	PF00069	0.418
MOD_GSK3_1	141	148	PF00069	0.566
MOD_NEK2_1	126	131	PF00069	0.545
MOD_NEK2_1	147	152	PF00069	0.539
MOD_NEK2_1	188	193	PF00069	0.451
MOD_PIKK_1	147	153	PF00454	0.479
MOD_PIKK_1	181	187	PF00454	0.609
MOD_PKA_2	121	127	PF00069	0.476
MOD_PKA_2	141	147	PF00069	0.514
MOD_Plk_1	127	133	PF00069	0.464
MOD_Plk_4	87	93	PF00069	0.599
MOD_SUMO_rev_2	165	170	PF00179	0.465
MOD_SUMO_rev_2	29	38	PF00179	0.558
TRG_ENDOCYTIC_2	132	135	PF00928	0.486
TRG_NLS_MonoExtC_3	43	49	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC3	Leptomonas seymouri	70%	100%
A0A3Q8ICH6	Leishmania donovani	83%	100%
A0A3R7NVZ4	Trypanosoma rangeli	34%	93%
A4I1R1	Leishmania infantum	83%	100%
C9ZKB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9AXU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q9M6	Leishmania major	83%	100%