KIF-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

KIF-binding protein

Gene product:

KIF-1 binding protein C terminal, putative

Species:

Leishmania braziliensis

UniProt:

A4HEB4_LEIBR

TriTrypDb:

LbrM.25.1680 , LBRM2903_250030200

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HEB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEB4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.452
CLV_NRD_NRD_1	34	36	PF00675	0.317
CLV_NRD_NRD_1	415	417	PF00675	0.232
CLV_NRD_NRD_1	464	466	PF00675	0.332
CLV_NRD_NRD_1	484	486	PF00675	0.298
CLV_NRD_NRD_1	524	526	PF00675	0.278
CLV_NRD_NRD_1	85	87	PF00675	0.242
CLV_PCSK_FUR_1	413	417	PF00082	0.307
CLV_PCSK_KEX2_1	34	36	PF00082	0.413
CLV_PCSK_KEX2_1	374	376	PF00082	0.157
CLV_PCSK_KEX2_1	415	417	PF00082	0.232
CLV_PCSK_KEX2_1	524	526	PF00082	0.278
CLV_PCSK_KEX2_1	85	87	PF00082	0.285
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.157
CLV_PCSK_PC7_1	520	526	PF00082	0.243
CLV_PCSK_SKI1_1	158	162	PF00082	0.325
CLV_PCSK_SKI1_1	444	448	PF00082	0.238
CLV_PCSK_SKI1_1	473	477	PF00082	0.322
CLV_PCSK_SKI1_1	579	583	PF00082	0.327
DEG_APCC_DBOX_1	310	318	PF00400	0.468
DEG_APCC_DBOX_1	443	451	PF00400	0.412
DEG_APCC_DBOX_1	578	586	PF00400	0.420
DEG_Nend_UBRbox_2	1	3	PF02207	0.444
DEG_SCF_FBW7_2	533	540	PF00400	0.357
DOC_CYCLIN_RxL_1	441	449	PF00134	0.412
DOC_MAPK_gen_1	34	40	PF00069	0.239
DOC_MAPK_gen_1	524	530	PF00069	0.443
DOC_MAPK_MEF2A_6	588	596	PF00069	0.479
DOC_PP1_RVXF_1	551	558	PF00149	0.426
DOC_USP7_MATH_1	384	388	PF00917	0.456
DOC_USP7_MATH_1	569	573	PF00917	0.492
DOC_USP7_UBL2_3	370	374	PF12436	0.468
DOC_WW_Pin1_4	50	55	PF00397	0.279
DOC_WW_Pin1_4	533	538	PF00397	0.507
DOC_WW_Pin1_4	98	103	PF00397	0.392
LIG_14-3-3_CanoR_1	258	262	PF00244	0.441
LIG_14-3-3_CanoR_1	416	426	PF00244	0.462
LIG_14-3-3_CanoR_1	485	489	PF00244	0.519
LIG_14-3-3_CanoR_1	499	509	PF00244	0.513
LIG_14-3-3_CterR_2	598	601	PF00244	0.542
LIG_Actin_WH2_2	180	198	PF00022	0.337
LIG_BIR_III_4	300	304	PF00653	0.357
LIG_BRCT_BRCA1_1	23	27	PF00533	0.590
LIG_BRCT_BRCA1_1	272	276	PF00533	0.443
LIG_deltaCOP1_diTrp_1	169	175	PF00928	0.398
LIG_deltaCOP1_diTrp_1	341	347	PF00928	0.396
LIG_eIF4E_1	403	409	PF01652	0.459
LIG_FHA_1	195	201	PF00498	0.450
LIG_FHA_1	217	223	PF00498	0.318
LIG_FHA_1	261	267	PF00498	0.426
LIG_FHA_1	388	394	PF00498	0.412
LIG_FHA_1	500	506	PF00498	0.492
LIG_FHA_2	157	163	PF00498	0.367
LIG_FHA_2	323	329	PF00498	0.507
LIG_FHA_2	359	365	PF00498	0.411
LIG_FHA_2	534	540	PF00498	0.507
LIG_FHA_2	6	12	PF00498	0.239
LIG_FXI_DFP_1	344	348	PF00024	0.261
LIG_GBD_Chelix_1	442	450	PF00786	0.212
LIG_LIR_Apic_2	496	501	PF02991	0.412
LIG_LIR_Gen_1	137	145	PF02991	0.194
LIG_LIR_Gen_1	245	256	PF02991	0.303
LIG_LIR_Gen_1	279	287	PF02991	0.459
LIG_LIR_Gen_1	477	488	PF02991	0.484
LIG_LIR_Gen_1	539	546	PF02991	0.360
LIG_LIR_Gen_1	79	88	PF02991	0.282
LIG_LIR_Nem_3	137	141	PF02991	0.198
LIG_LIR_Nem_3	245	251	PF02991	0.307
LIG_LIR_Nem_3	279	285	PF02991	0.497
LIG_LIR_Nem_3	341	347	PF02991	0.410
LIG_LIR_Nem_3	435	439	PF02991	0.472
LIG_LIR_Nem_3	477	483	PF02991	0.457
LIG_LIR_Nem_3	539	544	PF02991	0.412
LIG_LIR_Nem_3	79	84	PF02991	0.513
LIG_LYPXL_SIV_4	277	285	PF13949	0.507
LIG_LYPXL_SIV_4	438	446	PF13949	0.507
LIG_LYPXL_yS_3	439	442	PF13949	0.412
LIG_MAD2	14	22	PF02301	0.396
LIG_Pex14_2	27	31	PF04695	0.478
LIG_Pex14_2	494	498	PF04695	0.420
LIG_REV1ctd_RIR_1	516	524	PF16727	0.426
LIG_SH2_CRK	138	142	PF00017	0.341
LIG_SH2_CRK	248	252	PF00017	0.263
LIG_SH2_CRK	320	324	PF00017	0.468
LIG_SH2_CRK	403	407	PF00017	0.443
LIG_SH2_CRK	541	545	PF00017	0.413
LIG_SH2_NCK_1	278	282	PF00017	0.459
LIG_SH2_NCK_1	541	545	PF00017	0.369
LIG_SH2_SRC	81	84	PF00017	0.234
LIG_SH2_STAP1	168	172	PF00017	0.227
LIG_SH2_STAP1	218	222	PF00017	0.320
LIG_SH2_STAP1	272	276	PF00017	0.412
LIG_SH2_STAP1	278	282	PF00017	0.412
LIG_SH2_STAP1	454	458	PF00017	0.468
LIG_SH2_STAT3	454	457	PF00017	0.460
LIG_SH2_STAT5	148	151	PF00017	0.303
LIG_SH2_STAT5	218	221	PF00017	0.312
LIG_SH2_STAT5	241	244	PF00017	0.303
LIG_SH2_STAT5	313	316	PF00017	0.418
LIG_SH2_STAT5	532	535	PF00017	0.468
LIG_SH3_1	345	351	PF00018	0.459
LIG_SH3_3	345	351	PF00018	0.435
LIG_TRAF2_1	537	540	PF00917	0.426
LIG_TYR_ITIM	136	141	PF00017	0.336
LIG_UBA3_1	581	588	PF00899	0.433
LIG_WRC_WIRS_1	359	364	PF05994	0.412
LIG_WRC_WIRS_1	385	390	PF05994	0.443
MOD_CDK_SPK_2	50	55	PF00069	0.257
MOD_CDK_SPK_2	533	538	PF00069	0.507
MOD_CK1_1	216	222	PF00069	0.443
MOD_CK1_1	260	266	PF00069	0.477
MOD_CK1_1	387	393	PF00069	0.513
MOD_CK2_1	180	186	PF00069	0.392
MOD_CK2_1	322	328	PF00069	0.507
MOD_CK2_1	358	364	PF00069	0.488
MOD_CK2_1	449	455	PF00069	0.539
MOD_CK2_1	5	11	PF00069	0.364
MOD_CK2_1	533	539	PF00069	0.507
MOD_CK2_1	98	104	PF00069	0.264
MOD_CMANNOS	171	174	PF00535	0.306
MOD_GlcNHglycan	129	132	PF01048	0.511
MOD_GlcNHglycan	268	271	PF01048	0.212
MOD_GSK3_1	116	123	PF00069	0.548
MOD_GSK3_1	152	159	PF00069	0.242
MOD_GSK3_1	187	194	PF00069	0.479
MOD_GSK3_1	214	221	PF00069	0.292
MOD_GSK3_1	228	235	PF00069	0.437
MOD_GSK3_1	266	273	PF00069	0.412
MOD_GSK3_1	540	547	PF00069	0.478
MOD_N-GLC_1	117	122	PF02516	0.493
MOD_N-GLC_1	16	21	PF02516	0.458
MOD_N-GLC_1	233	238	PF02516	0.444
MOD_NEK2_1	117	122	PF00069	0.450
MOD_NEK2_1	126	131	PF00069	0.340
MOD_NEK2_1	147	152	PF00069	0.309
MOD_NEK2_1	214	219	PF00069	0.328
MOD_NEK2_1	228	233	PF00069	0.295
MOD_NEK2_1	266	271	PF00069	0.439
MOD_NEK2_1	340	345	PF00069	0.507
MOD_NEK2_1	40	45	PF00069	0.333
MOD_NEK2_1	494	499	PF00069	0.412
MOD_NEK2_2	218	223	PF00069	0.349
MOD_NEK2_2	242	247	PF00069	0.293
MOD_PIKK_1	228	234	PF00454	0.447
MOD_PIKK_1	236	242	PF00454	0.474
MOD_PIKK_1	352	358	PF00454	0.357
MOD_PIKK_1	417	423	PF00454	0.357
MOD_PKA_2	257	263	PF00069	0.317
MOD_PKA_2	40	46	PF00069	0.339
MOD_PKA_2	484	490	PF00069	0.462
MOD_Plk_1	117	123	PF00069	0.527
MOD_Plk_1	214	220	PF00069	0.363
MOD_Plk_1	340	346	PF00069	0.512
MOD_Plk_1	511	517	PF00069	0.483
MOD_Plk_2-3	449	455	PF00069	0.562
MOD_Plk_4	156	162	PF00069	0.368
MOD_Plk_4	205	211	PF00069	0.311
MOD_Plk_4	218	224	PF00069	0.296
MOD_Plk_4	287	293	PF00069	0.418
MOD_Plk_4	40	46	PF00069	0.398
MOD_Plk_4	449	455	PF00069	0.530
MOD_Plk_4	528	534	PF00069	0.515
MOD_ProDKin_1	50	56	PF00069	0.269
MOD_ProDKin_1	533	539	PF00069	0.507
MOD_ProDKin_1	98	104	PF00069	0.395
MOD_SUMO_for_1	29	32	PF00179	0.465
MOD_SUMO_for_1	537	540	PF00179	0.426
MOD_SUMO_rev_2	24	31	PF00179	0.423
MOD_SUMO_rev_2	295	304	PF00179	0.458
MOD_SUMO_rev_2	469	475	PF00179	0.364
TRG_DiLeu_BaEn_1	580	585	PF01217	0.426
TRG_DiLeu_BaEn_4	511	517	PF01217	0.484
TRG_ENDOCYTIC_2	138	141	PF00928	0.343
TRG_ENDOCYTIC_2	247	250	PF00928	0.286
TRG_ENDOCYTIC_2	320	323	PF00928	0.419
TRG_ENDOCYTIC_2	403	406	PF00928	0.412
TRG_ENDOCYTIC_2	439	442	PF00928	0.447
TRG_ENDOCYTIC_2	491	494	PF00928	0.461
TRG_ENDOCYTIC_2	541	544	PF00928	0.426
TRG_ENDOCYTIC_2	81	84	PF00928	0.459
TRG_ENDOCYTIC_2	88	91	PF00928	0.384
TRG_ER_diArg_1	413	416	PF00400	0.441
TRG_ER_diArg_1	458	461	PF00400	0.471
TRG_ER_diArg_1	523	525	PF00400	0.478
TRG_ER_diArg_1	84	86	PF00400	0.318
TRG_NES_CRM1_1	398	410	PF08389	0.459
TRG_NES_CRM1_1	566	580	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.226
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFB1	Leptomonas seymouri	72%	100%
A0A1X0NY49	Trypanosomatidae	47%	100%
A0A3Q8IGQ4	Leishmania donovani	84%	100%
A0A3R7RTL1	Trypanosoma rangeli	46%	100%
A4I1R0	Leishmania infantum	85%	100%
A8WE67	Danio rerio	27%	95%
C9ZKB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q0IIZ5	Xenopus tropicalis	25%	98%
Q4Q9M7	Leishmania major	84%	100%
Q5ZIL9	Gallus gallus	27%	100%
Q6ZPU9	Mus musculus	26%	97%
Q96EK5	Homo sapiens	26%	97%
Q9VMX1	Drosophila melanogaster	24%	100%
V5ASJ5	Trypanosoma cruzi	46%	97%