TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HEB3_LEIBR

TriTrypDb:

LbrM.25.1670 , LBRM2903_250030100

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEB3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	15
GO:0009987	cellular process	1	15

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	17
GO:0005515	protein binding	2	15
GO:0030544	Hsp70 protein binding	4	15
GO:0031072	heat shock protein binding	3	15
GO:0051879	Hsp90 protein binding	4	15
GO:0003676	nucleic acid binding	3	8
GO:0008270	zinc ion binding	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.425
CLV_NRD_NRD_1	289	291	PF00675	0.519
CLV_NRD_NRD_1	353	355	PF00675	0.524
CLV_PCSK_FUR_1	353	357	PF00082	0.551
CLV_PCSK_KEX2_1	115	117	PF00082	0.544
CLV_PCSK_KEX2_1	34	36	PF00082	0.465
CLV_PCSK_KEX2_1	353	355	PF00082	0.539
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.502
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.465
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.540
CLV_PCSK_SKI1_1	16	20	PF00082	0.397
CLV_PCSK_SKI1_1	171	175	PF00082	0.414
CLV_PCSK_SKI1_1	204	208	PF00082	0.274
CLV_PCSK_SKI1_1	302	306	PF00082	0.570
DEG_APCC_DBOX_1	15	23	PF00400	0.354
DEG_Nend_UBRbox_1	1	4	PF02207	0.469
DOC_CYCLIN_RxL_1	186	198	PF00134	0.516
DOC_MAPK_gen_1	34	41	PF00069	0.263
DOC_MAPK_gen_1	88	96	PF00069	0.325
DOC_USP7_MATH_1	25	29	PF00917	0.506
DOC_USP7_MATH_1	286	290	PF00917	0.589
DOC_USP7_MATH_1	316	320	PF00917	0.593
DOC_USP7_MATH_1	328	332	PF00917	0.568
DOC_USP7_UBL2_3	233	237	PF12436	0.559
DOC_USP7_UBL2_3	249	253	PF12436	0.499
LIG_14-3-3_CanoR_1	302	311	PF00244	0.582
LIG_Actin_WH2_2	238	255	PF00022	0.463
LIG_FHA_1	261	267	PF00498	0.456
LIG_FHA_1	299	305	PF00498	0.571
LIG_FHA_1	60	66	PF00498	0.547
LIG_FHA_2	198	204	PF00498	0.544
LIG_FHA_2	290	296	PF00498	0.514
LIG_FHA_2	51	57	PF00498	0.437
LIG_LIR_Gen_1	257	266	PF02991	0.418
LIG_LIR_Gen_1	334	341	PF02991	0.569
LIG_LIR_Gen_1	50	58	PF02991	0.504
LIG_LIR_Gen_1	74	85	PF02991	0.432
LIG_LIR_Nem_3	257	262	PF02991	0.416
LIG_LIR_Nem_3	334	338	PF02991	0.526
LIG_LIR_Nem_3	50	55	PF02991	0.491
LIG_LIR_Nem_3	74	80	PF02991	0.432
LIG_PTB_Apo_2	131	138	PF02174	0.338
LIG_PTB_Phospho_1	131	137	PF10480	0.340
LIG_RPA_C_Fungi	206	218	PF08784	0.342
LIG_RPA_C_Fungi	285	297	PF08784	0.596
LIG_SH2_CRK	259	263	PF00017	0.416
LIG_SH2_CRK	77	81	PF00017	0.325
LIG_SH2_NCK_1	117	121	PF00017	0.402
LIG_SH2_NCK_1	124	128	PF00017	0.386
LIG_SH2_NCK_1	52	56	PF00017	0.413
LIG_SH2_SRC	117	120	PF00017	0.348
LIG_SH2_SRC	181	184	PF00017	0.506
LIG_SH2_STAP1	117	121	PF00017	0.264
LIG_SH2_STAT5	137	140	PF00017	0.443
LIG_SH2_STAT5	181	184	PF00017	0.414
LIG_SH2_STAT5	215	218	PF00017	0.536
LIG_SH2_STAT5	335	338	PF00017	0.429
LIG_SH2_STAT5	52	55	PF00017	0.422
LIG_SH3_3	92	98	PF00018	0.196
LIG_SUMO_SIM_anti_2	92	97	PF11976	0.196
LIG_TRAF2_1	109	112	PF00917	0.481
LIG_TRAF2_1	175	178	PF00917	0.529
LIG_TRAF2_1	292	295	PF00917	0.519
LIG_UBA3_1	19	23	PF00899	0.344
MOD_CK1_1	125	131	PF00069	0.349
MOD_CK1_1	289	295	PF00069	0.589
MOD_CK1_1	319	325	PF00069	0.616
MOD_CK1_1	331	337	PF00069	0.642
MOD_CK1_1	347	353	PF00069	0.369
MOD_CK1_1	50	56	PF00069	0.478
MOD_CK2_1	125	131	PF00069	0.453
MOD_CK2_1	197	203	PF00069	0.442
MOD_CK2_1	289	295	PF00069	0.509
MOD_CK2_1	342	348	PF00069	0.446
MOD_CK2_1	50	56	PF00069	0.435
MOD_GlcNHglycan	124	127	PF01048	0.422
MOD_GlcNHglycan	155	158	PF01048	0.552
MOD_GlcNHglycan	211	214	PF01048	0.343
MOD_GlcNHglycan	222	226	PF01048	0.386
MOD_GlcNHglycan	318	321	PF01048	0.508
MOD_GlcNHglycan	330	333	PF01048	0.638
MOD_GlcNHglycan	49	52	PF01048	0.463
MOD_GlcNHglycan	73	76	PF01048	0.314
MOD_GSK3_1	194	201	PF00069	0.523
MOD_GSK3_1	298	305	PF00069	0.636
MOD_GSK3_1	324	331	PF00069	0.732
MOD_GSK3_1	50	57	PF00069	0.350
MOD_LATS_1	300	306	PF00433	0.430
MOD_N-GLC_1	209	214	PF02516	0.338
MOD_N-GLC_1	339	344	PF02516	0.557
MOD_N-GLC_1	71	76	PF02516	0.280
MOD_N-GLC_2	337	339	PF02516	0.560
MOD_NEK2_1	122	127	PF00069	0.479
MOD_NEK2_1	314	319	PF00069	0.452
MOD_PKA_1	354	360	PF00069	0.575
MOD_PKA_2	10	16	PF00069	0.386
MOD_PKA_2	289	295	PF00069	0.563
MOD_PKB_1	296	304	PF00069	0.499
MOD_Plk_1	347	353	PF00069	0.425
MOD_Plk_1	59	65	PF00069	0.314
MOD_Plk_4	347	353	PF00069	0.628
MOD_SUMO_rev_2	156	162	PF00179	0.531
MOD_SUMO_rev_2	230	239	PF00179	0.273
TRG_DiLeu_BaEn_1	203	208	PF01217	0.500
TRG_ENDOCYTIC_2	24	27	PF00928	0.330
TRG_ENDOCYTIC_2	259	262	PF00928	0.415
TRG_ENDOCYTIC_2	335	338	PF00928	0.561
TRG_ENDOCYTIC_2	52	55	PF00928	0.364
TRG_ENDOCYTIC_2	77	80	PF00928	0.376
TRG_ER_diArg_1	1	4	PF00400	0.469
TRG_ER_diArg_1	352	354	PF00400	0.530
TRG_ER_diArg_1	356	359	PF00400	0.550
TRG_ER_diArg_1	65	68	PF00400	0.392
TRG_NES_CRM1_1	84	97	PF08389	0.196
TRG_NLS_MonoExtC_3	353	358	PF00514	0.524
TRG_NLS_MonoExtN_4	353	359	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTR8	Leptomonas seymouri	25%	100%
A0A0N1IBD2	Leptomonas seymouri	63%	100%
A0A0S4JRK3	Bodo saltans	34%	100%
A0A1X0NZH9	Trypanosomatidae	39%	98%
A0A3Q8IJP8	Leishmania donovani	24%	100%
A0A3R7LE97	Trypanosoma rangeli	40%	100%
A0A3S7WZC1	Leishmania donovani	84%	100%
A4I1Q9	Leishmania infantum	84%	100%
A4ICY0	Leishmania infantum	24%	100%
C9ZKB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AXU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q271	Leishmania major	25%	100%
Q4Q9M8	Leishmania major	82%	100%
V5BCJ3	Trypanosoma cruzi	40%	100%