Putative RNA triphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Capping enzyme RNA triphosphatase 1

Species:

Leishmania braziliensis

UniProt:

A4HEB2_LEIBR

TriTrypDb:

LbrM.25.1660 , LBRM2903_250030000

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HEB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEB2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016311	dephosphorylation	5	1
GO:0036260	RNA capping	7	1
GO:0098507	polynucleotide 5' dephosphorylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004651	polynucleotide 5'-phosphatase activity	6	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.202
CLV_NRD_NRD_1	133	135	PF00675	0.404
CLV_NRD_NRD_1	194	196	PF00675	0.355
CLV_NRD_NRD_1	235	237	PF00675	0.353
CLV_NRD_NRD_1	238	240	PF00675	0.323
CLV_PCSK_FUR_1	235	239	PF00082	0.353
CLV_PCSK_KEX2_1	102	104	PF00082	0.422
CLV_PCSK_KEX2_1	133	135	PF00082	0.403
CLV_PCSK_KEX2_1	193	195	PF00082	0.345
CLV_PCSK_KEX2_1	235	237	PF00082	0.353
CLV_PCSK_KEX2_1	238	240	PF00082	0.323
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.353
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.345
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.353
CLV_PCSK_SKI1_1	80	84	PF00082	0.439
DEG_SPOP_SBC_1	44	48	PF00917	0.522
DEG_SPOP_SBC_1	51	55	PF00917	0.509
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.523
DOC_MAPK_gen_1	133	139	PF00069	0.315
DOC_MAPK_gen_1	193	201	PF00069	0.288
DOC_MAPK_HePTP_8	191	203	PF00069	0.398
DOC_MAPK_JIP1_4	154	160	PF00069	0.202
DOC_MAPK_MEF2A_6	194	203	PF00069	0.343
DOC_MIT_MIM_1	286	294	PF04212	0.387
DOC_PP2B_LxvP_1	34	37	PF13499	0.514
DOC_USP7_MATH_1	13	17	PF00917	0.536
DOC_USP7_MATH_1	44	48	PF00917	0.540
DOC_USP7_MATH_1	51	55	PF00917	0.761
DOC_WD40_RPTOR_TOS_1	264	269	PF00400	0.398
DOC_WW_Pin1_4	3	8	PF00397	0.670
DOC_WW_Pin1_4	52	57	PF00397	0.678
LIG_14-3-3_CanoR_1	103	108	PF00244	0.213
LIG_14-3-3_CanoR_1	174	178	PF00244	0.295
LIG_14-3-3_CanoR_1	211	221	PF00244	0.338
LIG_14-3-3_CanoR_1	238	247	PF00244	0.310
LIG_14-3-3_CanoR_1	253	258	PF00244	0.290
LIG_Actin_WH2_2	68	86	PF00022	0.499
LIG_BIR_II_1	1	5	PF00653	0.729
LIG_BRCT_BRCA1_1	183	187	PF00533	0.353
LIG_CaM_IQ_9	95	111	PF13499	0.202
LIG_FHA_1	163	169	PF00498	0.286
LIG_FHA_1	174	180	PF00498	0.301
LIG_FHA_2	239	245	PF00498	0.257
LIG_GBD_Chelix_1	71	79	PF00786	0.397
LIG_HCF-1_HBM_1	258	261	PF13415	0.202
LIG_LIR_Gen_1	142	152	PF02991	0.341
LIG_LIR_Gen_1	248	257	PF02991	0.490
LIG_LIR_Nem_3	248	254	PF02991	0.490
LIG_LIR_Nem_3	258	264	PF02991	0.254
LIG_NRBOX	283	289	PF00104	0.422
LIG_Pex14_2	247	251	PF04695	0.353
LIG_PTAP_UEV_1	20	25	PF05743	0.623
LIG_Rb_LxCxE_1	184	200	PF01857	0.202
LIG_SH2_NCK_1	177	181	PF00017	0.363
LIG_SH2_SRC	177	180	PF00017	0.277
LIG_SH2_STAP1	175	179	PF00017	0.341
LIG_SH2_STAP1	208	212	PF00017	0.351
LIG_SH2_STAT5	175	178	PF00017	0.306
LIG_SH3_3	18	24	PF00018	0.526
LIG_SH3_3	198	204	PF00018	0.310
LIG_SH3_3	215	221	PF00018	0.281
LIG_SH3_3	59	65	PF00018	0.504
LIG_SUMO_SIM_par_1	67	74	PF11976	0.327
LIG_TRAF2_1	159	162	PF00917	0.202
LIG_TRAF2_1	8	11	PF00917	0.529
LIG_UBA3_1	75	80	PF00899	0.433
LIG_ULM_U2AF65_1	235	241	PF00076	0.353
MOD_CK1_1	213	219	PF00069	0.284
MOD_CK2_1	160	166	PF00069	0.398
MOD_CK2_1	238	244	PF00069	0.273
MOD_CK2_1	44	50	PF00069	0.598
MOD_CK2_1	83	89	PF00069	0.295
MOD_GlcNHglycan	139	142	PF01048	0.387
MOD_GlcNHglycan	14	18	PF01048	0.725
MOD_GlcNHglycan	38	41	PF01048	0.745
MOD_GSK3_1	114	121	PF00069	0.429
MOD_GSK3_1	15	22	PF00069	0.648
MOD_GSK3_1	249	256	PF00069	0.300
MOD_GSK3_1	93	100	PF00069	0.285
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	160	165	PF00069	0.398
MOD_NEK2_1	83	88	PF00069	0.301
MOD_PIKK_1	23	29	PF00454	0.633
MOD_PK_1	93	99	PF00069	0.272
MOD_PKA_1	101	107	PF00069	0.202
MOD_PKA_1	238	244	PF00069	0.353
MOD_PKA_2	173	179	PF00069	0.295
MOD_PKA_2	210	216	PF00069	0.349
MOD_PKA_2	238	244	PF00069	0.281
MOD_PKA_2	252	258	PF00069	0.281
MOD_PKA_2	83	89	PF00069	0.285
MOD_PKB_1	236	244	PF00069	0.353
MOD_Plk_1	243	249	PF00069	0.221
MOD_Plk_2-3	162	168	PF00069	0.202
MOD_Plk_4	103	109	PF00069	0.206
MOD_Plk_4	183	189	PF00069	0.383
MOD_Plk_4	71	77	PF00069	0.547
MOD_Plk_4	93	99	PF00069	0.336
MOD_ProDKin_1	3	9	PF00069	0.671
MOD_ProDKin_1	52	58	PF00069	0.680
MOD_SUMO_rev_2	255	262	PF00179	0.475
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.612
TRG_ENDOCYTIC_2	261	264	PF00928	0.243
TRG_ER_diArg_1	133	135	PF00400	0.403
TRG_ER_diArg_1	194	196	PF00400	0.353
TRG_ER_diArg_1	234	236	PF00400	0.353
TRG_ER_diArg_1	238	240	PF00400	0.314
TRG_NLS_MonoCore_2	235	240	PF00514	0.353
TRG_NLS_MonoExtN_4	235	241	PF00514	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I3	Leptomonas seymouri	53%	100%
A0A1X0NZM4	Trypanosomatidae	34%	100%
A0A3S7WZD5	Leishmania donovani	65%	100%
A0A422P4J1	Trypanosoma rangeli	36%	100%
A4I1Q8	Leishmania infantum	65%	100%
C9ZKB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AXU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q9M9	Leishmania major	66%	95%