NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEB1_LEIBR

TriTrypDb:

LbrM.25.1650 , LBRM2903_250029900

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HEB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.446
CLV_C14_Caspase3-7	85	89	PF00656	0.751
CLV_NRD_NRD_1	167	169	PF00675	0.351
CLV_NRD_NRD_1	61	63	PF00675	0.456
CLV_NRD_NRD_1	72	74	PF00675	0.460
CLV_PCSK_SKI1_1	73	77	PF00082	0.457
DOC_CYCLIN_RxL_1	40	50	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.552
DOC_MAPK_FxFP_2	52	55	PF00069	0.562
DOC_PP2B_LxvP_1	45	48	PF13499	0.543
DOC_PP4_FxxP_1	112	115	PF00568	0.636
DOC_PP4_FxxP_1	186	189	PF00568	0.469
DOC_PP4_FxxP_1	52	55	PF00568	0.562
DOC_USP7_MATH_2	20	26	PF00917	0.579
DOC_WW_Pin1_4	107	112	PF00397	0.622
DOC_WW_Pin1_4	2	7	PF00397	0.700
LIG_14-3-3_CanoR_1	104	113	PF00244	0.628
LIG_14-3-3_CanoR_1	62	67	PF00244	0.690
LIG_BRCT_BRCA1_1	108	112	PF00533	0.623
LIG_BRCT_BRCA1_1	199	203	PF00533	0.477
LIG_EVH1_1	45	49	PF00568	0.543
LIG_EVH1_2	48	52	PF00568	0.551
LIG_FHA_1	11	17	PF00498	0.583
LIG_FHA_1	157	163	PF00498	0.594
LIG_FHA_1	90	96	PF00498	0.587
LIG_FHA_2	196	202	PF00498	0.476
LIG_FHA_2	83	89	PF00498	0.684
LIG_LIR_Apic_2	109	115	PF02991	0.619
LIG_LIR_Apic_2	127	131	PF02991	0.623
LIG_LIR_Apic_2	50	55	PF02991	0.557
LIG_LIR_Gen_1	201	212	PF02991	0.399
LIG_LIR_Nem_3	117	123	PF02991	0.631
LIG_LIR_Nem_3	127	132	PF02991	0.603
LIG_LIR_Nem_3	143	149	PF02991	0.656
LIG_LIR_Nem_3	201	207	PF02991	0.455
LIG_PDZ_Class_3	210	215	PF00595	0.408
LIG_SH2_CRK	38	42	PF00017	0.567
LIG_SH2_STAP1	120	124	PF00017	0.631
LIG_SH2_STAP1	38	42	PF00017	0.567
LIG_SH2_STAP1	67	71	PF00017	0.643
LIG_SH2_STAT5	128	131	PF00017	0.630
LIG_SH2_STAT5	171	174	PF00017	0.354
LIG_SH2_STAT5	177	180	PF00017	0.344
LIG_SH2_STAT5	183	186	PF00017	0.312
LIG_SH3_1	43	49	PF00018	0.546
LIG_SH3_3	202	208	PF00018	0.449
LIG_SH3_3	27	33	PF00018	0.570
LIG_SH3_3	3	9	PF00018	0.676
LIG_SH3_3	43	49	PF00018	0.513
LIG_SUMO_SIM_par_1	158	167	PF11976	0.611
LIG_TRFH_1	185	189	PF08558	0.355
LIG_TYR_ITIM	36	41	PF00017	0.564
LIG_UBA3_1	162	170	PF00899	0.601
MOD_CK1_1	18	24	PF00069	0.578
MOD_CK1_1	195	201	PF00069	0.447
MOD_CK1_1	50	56	PF00069	0.558
MOD_DYRK1A_RPxSP_1	107	111	PF00069	0.619
MOD_GlcNHglycan	194	197	PF01048	0.595
MOD_GSK3_1	18	25	PF00069	0.665
MOD_GSK3_1	50	57	PF00069	0.694
MOD_N-GLC_1	89	94	PF02516	0.483
MOD_NEK2_1	10	15	PF00069	0.757
MOD_NEK2_1	61	66	PF00069	0.656
MOD_NEK2_1	69	74	PF00069	0.619
MOD_PIKK_1	28	34	PF00454	0.697
MOD_PKA_1	62	68	PF00069	0.716
MOD_PKA_2	106	112	PF00069	0.624
MOD_PKA_2	61	67	PF00069	0.691
MOD_Plk_1	190	196	PF00069	0.401
MOD_Plk_4	119	125	PF00069	0.637
MOD_Plk_4	47	53	PF00069	0.554
MOD_Plk_4	62	68	PF00069	0.528
MOD_ProDKin_1	107	113	PF00069	0.625
MOD_ProDKin_1	2	8	PF00069	0.697
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.561
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.561
TRG_ENDOCYTIC_2	146	149	PF00928	0.657
TRG_ENDOCYTIC_2	177	180	PF00928	0.341
TRG_ENDOCYTIC_2	183	186	PF00928	0.325
TRG_ENDOCYTIC_2	38	41	PF00928	0.567
TRG_NLS_Bipartite_1	152	172	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V9	Leptomonas seymouri	85%	100%
A0A0S4JP84	Bodo saltans	63%	100%
A0A1X0NYC2	Trypanosomatidae	75%	100%
A0A3R7P4M5	Trypanosoma rangeli	74%	100%
A0A3S7WZB6	Leishmania donovani	91%	100%
A4I1Q7	Leishmania infantum	91%	100%
C9ZKB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AXU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q9N0	Leishmania major	91%	100%