Rieske domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rieske [2Fe-2S] domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEA9_LEIBR

TriTrypDb:

LbrM.25.1630 , LBRM2903_250029700

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051537	2 iron, 2 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0008942	nitrite reductase [NAD(P)H] activity	5	1
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	1
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	1
GO:0098809	nitrite reductase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	392	396	PF00656	0.453
CLV_NRD_NRD_1	175	177	PF00675	0.687
CLV_NRD_NRD_1	306	308	PF00675	0.431
CLV_NRD_NRD_1	314	316	PF00675	0.522
CLV_NRD_NRD_1	367	369	PF00675	0.516
CLV_NRD_NRD_1	452	454	PF00675	0.542
CLV_NRD_NRD_1	493	495	PF00675	0.323
CLV_PCSK_KEX2_1	133	135	PF00082	0.579
CLV_PCSK_KEX2_1	14	16	PF00082	0.441
CLV_PCSK_KEX2_1	175	177	PF00082	0.687
CLV_PCSK_KEX2_1	305	307	PF00082	0.454
CLV_PCSK_KEX2_1	367	369	PF00082	0.551
CLV_PCSK_KEX2_1	493	495	PF00082	0.348
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.579
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.441
CLV_PCSK_SKI1_1	78	82	PF00082	0.446
DEG_APCC_DBOX_1	38	46	PF00400	0.475
DOC_CDC14_PxL_1	416	424	PF14671	0.568
DOC_CKS1_1	461	466	PF01111	0.503
DOC_CYCLIN_RxL_1	9	22	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.529
DOC_MAPK_gen_1	110	119	PF00069	0.410
DOC_MAPK_gen_1	207	216	PF00069	0.685
DOC_MAPK_gen_1	450	460	PF00069	0.552
DOC_MAPK_MEF2A_6	207	216	PF00069	0.762
DOC_MAPK_MEF2A_6	453	462	PF00069	0.516
DOC_PP1_RVXF_1	12	19	PF00149	0.475
DOC_PP1_RVXF_1	370	376	PF00149	0.517
DOC_PP2B_LxvP_1	214	217	PF13499	0.674
DOC_PP2B_LxvP_1	272	275	PF13499	0.432
DOC_PP2B_LxvP_1	344	347	PF13499	0.549
DOC_PP4_FxxP_1	461	464	PF00568	0.465
DOC_USP7_MATH_1	103	107	PF00917	0.516
DOC_USP7_MATH_1	159	163	PF00917	0.782
DOC_USP7_MATH_1	230	234	PF00917	0.618
DOC_USP7_MATH_1	291	295	PF00917	0.678
DOC_USP7_MATH_1	333	337	PF00917	0.451
DOC_USP7_MATH_1	378	382	PF00917	0.344
DOC_USP7_MATH_1	480	484	PF00917	0.496
DOC_USP7_MATH_1	73	77	PF00917	0.421
DOC_WW_Pin1_4	226	231	PF00397	0.769
DOC_WW_Pin1_4	460	465	PF00397	0.581
DOC_WW_Pin1_4	475	480	PF00397	0.693
LIG_14-3-3_CanoR_1	225	230	PF00244	0.733
LIG_14-3-3_CanoR_1	453	457	PF00244	0.451
LIG_Actin_WH2_2	247	264	PF00022	0.538
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_FHA_1	197	203	PF00498	0.711
LIG_FHA_1	229	235	PF00498	0.544
LIG_FHA_1	28	34	PF00498	0.466
LIG_FHA_1	375	381	PF00498	0.481
LIG_FHA_1	476	482	PF00498	0.674
LIG_FHA_1	526	532	PF00498	0.505
LIG_FHA_2	3	9	PF00498	0.422
LIG_FHA_2	307	313	PF00498	0.362
LIG_FHA_2	325	331	PF00498	0.254
LIG_FHA_2	356	362	PF00498	0.448
LIG_KLC1_Yacidic_2	395	400	PF13176	0.539
LIG_LIR_Apic_2	459	464	PF02991	0.507
LIG_LIR_Gen_1	122	132	PF02991	0.445
LIG_LIR_Gen_1	136	145	PF02991	0.462
LIG_LIR_Gen_1	268	276	PF02991	0.561
LIG_LIR_Gen_1	383	393	PF02991	0.369
LIG_LIR_Gen_1	499	508	PF02991	0.470
LIG_LIR_Nem_3	122	127	PF02991	0.409
LIG_LIR_Nem_3	268	272	PF02991	0.539
LIG_LIR_Nem_3	383	389	PF02991	0.385
LIG_LIR_Nem_3	499	504	PF02991	0.433
LIG_LIR_Nem_3	85	91	PF02991	0.416
LIG_Pex14_1	428	432	PF04695	0.541
LIG_Pex14_1	89	93	PF04695	0.364
LIG_PTB_Apo_2	44	51	PF02174	0.319
LIG_PTB_Phospho_1	44	50	PF10480	0.318
LIG_SH2_CRK	386	390	PF00017	0.391
LIG_SH2_PTP2	124	127	PF00017	0.456
LIG_SH2_PTP2	269	272	PF00017	0.503
LIG_SH2_STAP1	456	460	PF00017	0.274
LIG_SH2_STAT5	11	14	PF00017	0.449
LIG_SH2_STAT5	124	127	PF00017	0.433
LIG_SH2_STAT5	269	272	PF00017	0.491
LIG_SH2_STAT5	398	401	PF00017	0.658
LIG_SH2_STAT5	507	510	PF00017	0.547
LIG_SH2_STAT5	516	519	PF00017	0.494
LIG_SH3_3	181	187	PF00018	0.502
LIG_SH3_3	343	349	PF00018	0.437
LIG_SH3_3	482	488	PF00018	0.573
LIG_SH3_3	514	520	PF00018	0.409
LIG_Sin3_3	257	264	PF02671	0.337
LIG_SUMO_SIM_par_1	125	130	PF11976	0.440
LIG_SUMO_SIM_par_1	54	60	PF11976	0.475
LIG_UBA3_1	319	325	PF00899	0.412
MOD_CDK_SPxK_1	460	466	PF00069	0.336
MOD_CK1_1	193	199	PF00069	0.563
MOD_CK1_1	2	8	PF00069	0.701
MOD_CK1_1	228	234	PF00069	0.671
MOD_CK1_1	293	299	PF00069	0.714
MOD_CK1_1	328	334	PF00069	0.466
MOD_CK1_1	381	387	PF00069	0.398
MOD_CK1_1	444	450	PF00069	0.747
MOD_CK1_1	475	481	PF00069	0.695
MOD_CK2_1	432	438	PF00069	0.526
MOD_Cter_Amidation	12	15	PF01082	0.449
MOD_Cter_Amidation	313	316	PF01082	0.598
MOD_GlcNHglycan	1	4	PF01048	0.731
MOD_GlcNHglycan	128	132	PF01048	0.540
MOD_GlcNHglycan	176	179	PF01048	0.619
MOD_GlcNHglycan	195	198	PF01048	0.721
MOD_GlcNHglycan	327	330	PF01048	0.511
MOD_GlcNHglycan	333	336	PF01048	0.453
MOD_GlcNHglycan	383	386	PF01048	0.249
MOD_GlcNHglycan	443	446	PF01048	0.711
MOD_GlcNHglycan	501	504	PF01048	0.540
MOD_GlcNHglycan	508	511	PF01048	0.486
MOD_GlcNHglycan	532	535	PF01048	0.480
MOD_GSK3_1	225	232	PF00069	0.643
MOD_GSK3_1	289	296	PF00069	0.694
MOD_GSK3_1	324	331	PF00069	0.449
MOD_GSK3_1	374	381	PF00069	0.399
MOD_GSK3_1	389	396	PF00069	0.475
MOD_GSK3_1	432	439	PF00069	0.663
MOD_GSK3_1	536	543	PF00069	0.457
MOD_N-GLC_1	19	24	PF02516	0.449
MOD_N-GLC_1	389	394	PF02516	0.509
MOD_N-GLC_1	412	417	PF02516	0.551
MOD_N-GLC_2	243	245	PF02516	0.430
MOD_N-GLC_2	47	49	PF02516	0.328
MOD_N-GLC_2	482	484	PF02516	0.612
MOD_NEK2_1	16	21	PF00069	0.352
MOD_NEK2_1	202	207	PF00069	0.708
MOD_NEK2_1	212	217	PF00069	0.673
MOD_NEK2_1	234	239	PF00069	0.463
MOD_NEK2_1	374	379	PF00069	0.400
MOD_NEK2_1	388	393	PF00069	0.354
MOD_NEK2_1	452	457	PF00069	0.496
MOD_PIKK_1	202	208	PF00454	0.551
MOD_PIKK_1	328	334	PF00454	0.579
MOD_PKA_1	133	139	PF00069	0.538
MOD_PKA_1	306	312	PF00069	0.408
MOD_PKA_2	133	139	PF00069	0.538
MOD_PKA_2	159	165	PF00069	0.671
MOD_PKA_2	174	180	PF00069	0.481
MOD_PKA_2	306	312	PF00069	0.408
MOD_PKA_2	452	458	PF00069	0.546
MOD_Plk_1	389	395	PF00069	0.526
MOD_Plk_1	412	418	PF00069	0.489
MOD_Plk_4	230	236	PF00069	0.510
MOD_Plk_4	393	399	PF00069	0.614
MOD_Plk_4	512	518	PF00069	0.364
MOD_Plk_4	536	542	PF00069	0.561
MOD_ProDKin_1	226	232	PF00069	0.758
MOD_ProDKin_1	460	466	PF00069	0.602
MOD_ProDKin_1	475	481	PF00069	0.693
MOD_SUMO_for_1	132	135	PF00179	0.488
TRG_DiLeu_BaEn_1	122	127	PF01217	0.290
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.328
TRG_ENDOCYTIC_2	124	127	PF00928	0.433
TRG_ENDOCYTIC_2	139	142	PF00928	0.461
TRG_ENDOCYTIC_2	269	272	PF00928	0.491
TRG_ENDOCYTIC_2	386	389	PF00928	0.368
TRG_ENDOCYTIC_2	88	91	PF00928	0.447
TRG_ER_diArg_1	304	307	PF00400	0.438
TRG_ER_diArg_1	366	368	PF00400	0.518
TRG_ER_diArg_1	493	495	PF00400	0.465
TRG_NES_CRM1_1	265	278	PF08389	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I7	Leptomonas seymouri	60%	100%
A0A0S4JP70	Bodo saltans	36%	100%
A0A1X0NYR2	Trypanosomatidae	36%	100%
A0A3S5ISQ1	Trypanosoma rangeli	35%	100%
A0A3S7WZH8	Leishmania donovani	73%	100%
A4I1Q5	Leishmania infantum	73%	100%
C9ZKA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AXT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q9N2	Leishmania major	72%	99%
V5BS23	Trypanosoma cruzi	35%	100%