Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

Stage II sporulation protein E (SpoIIE), putative

Species:

Leishmania braziliensis

UniProt:

A4HEA8_LEIBR

TriTrypDb:

LbrM.25.1620 , LBRM2903_250029600

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HEA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004721	phosphoprotein phosphatase activity	3	13
GO:0004722	protein serine/threonine phosphatase activity	4	13
GO:0005488	binding	1	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016791	phosphatase activity	5	13
GO:0017018	myosin phosphatase activity	5	13
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	354	360	PF00089	0.425
CLV_NRD_NRD_1	175	177	PF00675	0.277
CLV_NRD_NRD_1	72	74	PF00675	0.487
CLV_NRD_NRD_1	75	77	PF00675	0.474
CLV_NRD_NRD_1	81	83	PF00675	0.466
CLV_PCSK_FUR_1	73	77	PF00082	0.488
CLV_PCSK_KEX2_1	74	76	PF00082	0.479
CLV_PCSK_KEX2_1	83	85	PF00082	0.493
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.496
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.471
CLV_PCSK_SKI1_1	156	160	PF00082	0.280
CLV_PCSK_SKI1_1	313	317	PF00082	0.500
DEG_SPOP_SBC_1	165	169	PF00917	0.463
DOC_CKS1_1	31	36	PF01111	0.620
DOC_MAPK_gen_1	156	165	PF00069	0.533
DOC_MAPK_gen_1	344	353	PF00069	0.397
DOC_MAPK_gen_1	82	90	PF00069	0.470
DOC_MAPK_MEF2A_6	347	355	PF00069	0.391
DOC_PP1_RVXF_1	199	206	PF00149	0.368
DOC_PP4_FxxP_1	214	217	PF00568	0.442
DOC_USP7_MATH_1	21	25	PF00917	0.355
DOC_USP7_MATH_1	3	7	PF00917	0.740
DOC_USP7_MATH_1	330	334	PF00917	0.382
DOC_WW_Pin1_4	278	283	PF00397	0.634
DOC_WW_Pin1_4	30	35	PF00397	0.608
DOC_WW_Pin1_4	326	331	PF00397	0.388
DOC_WW_Pin1_4	4	9	PF00397	0.624
DOC_WW_Pin1_4	58	63	PF00397	0.444
LIG_14-3-3_CanoR_1	357	364	PF00244	0.371
LIG_14-3-3_CanoR_1	75	80	PF00244	0.476
LIG_14-3-3_CanoR_1	82	88	PF00244	0.469
LIG_BIR_III_4	342	346	PF00653	0.394
LIG_BRCT_BRCA1_1	51	55	PF00533	0.433
LIG_BRCT_BRCA1_2	51	57	PF00533	0.435
LIG_FHA_1	153	159	PF00498	0.508
LIG_FHA_1	167	173	PF00498	0.374
LIG_FHA_1	182	188	PF00498	0.433
LIG_FHA_1	254	260	PF00498	0.475
LIG_FHA_1	350	356	PF00498	0.371
LIG_FHA_1	44	50	PF00498	0.525
LIG_FHA_1	5	11	PF00498	0.490
LIG_FHA_1	83	89	PF00498	0.611
LIG_FHA_2	21	27	PF00498	0.660
LIG_FHA_2	31	37	PF00498	0.607
LIG_FHA_2	358	364	PF00498	0.373
LIG_LIR_Apic_2	29	34	PF02991	0.511
LIG_LIR_Apic_2	303	307	PF02991	0.495
LIG_LIR_Gen_1	151	162	PF02991	0.455
LIG_LIR_Gen_1	329	338	PF02991	0.398
LIG_LIR_Gen_1	85	94	PF02991	0.417
LIG_LIR_Nem_3	151	157	PF02991	0.455
LIG_LIR_Nem_3	85	90	PF02991	0.455
LIG_Pex14_2	214	218	PF04695	0.442
LIG_Pex14_2	260	264	PF04695	0.463
LIG_RPA_C_Fungi	258	270	PF08784	0.363
LIG_SH2_CRK	103	107	PF00017	0.294
LIG_SH2_CRK	154	158	PF00017	0.389
LIG_SH2_PTP2	304	307	PF00017	0.439
LIG_SH2_SRC	304	307	PF00017	0.439
LIG_SH2_STAP1	154	158	PF00017	0.443
LIG_SH2_STAT5	154	157	PF00017	0.443
LIG_SH2_STAT5	304	307	PF00017	0.403
LIG_SH3_3	5	11	PF00018	0.696
LIG_SH3_4	59	66	PF00018	0.617
LIG_SPRY_1	363	368	PF00622	0.551
LIG_SUMO_SIM_anti_2	192	199	PF11976	0.323
LIG_SUMO_SIM_anti_2	250	257	PF11976	0.363
LIG_SUMO_SIM_anti_2	349	356	PF11976	0.384
LIG_SUMO_SIM_par_1	349	356	PF11976	0.384
LIG_TRAF2_1	360	363	PF00917	0.412
LIG_UBA3_1	292	301	PF00899	0.556
MOD_CDK_SPxK_1	58	64	PF00069	0.529
MOD_CDK_SPxxK_3	278	285	PF00069	0.635
MOD_CK1_1	30	36	PF00069	0.654
MOD_CK1_1	356	362	PF00069	0.394
MOD_CK2_1	356	362	PF00069	0.367
MOD_CK2_1	83	89	PF00069	0.469
MOD_GlcNHglycan	15	18	PF01048	0.677
MOD_GlcNHglycan	192	195	PF01048	0.294
MOD_GlcNHglycan	23	26	PF01048	0.602
MOD_GlcNHglycan	293	296	PF01048	0.550
MOD_GSK3_1	26	33	PF00069	0.620
MOD_GSK3_1	326	333	PF00069	0.413
MOD_GSK3_1	349	356	PF00069	0.373
MOD_N-GLC_1	365	370	PF02516	0.530
MOD_NEK2_1	136	141	PF00069	0.377
MOD_NEK2_1	190	195	PF00069	0.363
MOD_NEK2_1	20	25	PF00069	0.442
MOD_NEK2_1	291	296	PF00069	0.523
MOD_NEK2_2	171	176	PF00069	0.422
MOD_NEK2_2	93	98	PF00069	0.326
MOD_NMyristoyl	1	7	PF02799	0.604
MOD_PK_1	75	81	PF00069	0.575
MOD_PKA_1	75	81	PF00069	0.485
MOD_PKA_1	82	88	PF00069	0.465
MOD_PKA_2	240	246	PF00069	0.339
MOD_PKA_2	356	362	PF00069	0.366
MOD_PKA_2	75	81	PF00069	0.481
MOD_PKA_2	83	89	PF00069	0.470
MOD_PKB_1	73	81	PF00069	0.485
MOD_Plk_1	26	32	PF00069	0.504
MOD_Plk_1	349	355	PF00069	0.354
MOD_Plk_1	93	99	PF00069	0.316
MOD_Plk_4	120	126	PF00069	0.357
MOD_Plk_4	330	336	PF00069	0.376
MOD_Plk_4	83	89	PF00069	0.473
MOD_Plk_4	93	99	PF00069	0.319
MOD_ProDKin_1	278	284	PF00069	0.634
MOD_ProDKin_1	30	36	PF00069	0.618
MOD_ProDKin_1	326	332	PF00069	0.383
MOD_ProDKin_1	4	10	PF00069	0.623
MOD_ProDKin_1	58	64	PF00069	0.460
MOD_SUMO_rev_2	294	302	PF00179	0.525
MOD_SUMO_rev_2	36	45	PF00179	0.522
TRG_DiLeu_BaEn_2	93	99	PF01217	0.327
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.492
TRG_ENDOCYTIC_2	103	106	PF00928	0.338
TRG_ENDOCYTIC_2	154	157	PF00928	0.389
TRG_ER_diArg_1	198	201	PF00400	0.308
TRG_ER_diArg_1	73	76	PF00400	0.487
TRG_ER_diArg_1	81	84	PF00400	0.484
TRG_NLS_MonoExtN_4	73	78	PF00514	0.536
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z6	Leptomonas seymouri	82%	100%
A0A0N1IH92	Leptomonas seymouri	26%	100%
A0A0S4IN49	Bodo saltans	34%	100%
A0A0S4JK95	Bodo saltans	63%	100%
A0A0S4JS91	Bodo saltans	63%	100%
A0A1X0NY52	Trypanosomatidae	61%	97%
A0A1X0P4F0	Trypanosomatidae	26%	100%
A0A1X0P973	Trypanosomatidae	29%	100%
A0A3Q8IBW1	Leishmania donovani	94%	100%
A0A3R7N5R3	Trypanosoma rangeli	27%	100%
A0A3R7RFR7	Trypanosoma rangeli	29%	100%
A0A422P4L0	Trypanosoma rangeli	67%	100%
A4I1Q4	Leishmania infantum	94%	100%
B3MTI8	Drosophila ananassae	32%	100%
B3P5D3	Drosophila erecta	38%	100%
B4G653	Drosophila persimilis	33%	100%
B4HZE7	Drosophila sechellia	37%	100%
B4JYN1	Drosophila grimshawi	35%	100%
B4K616	Drosophila mojavensis	38%	100%
B4M5T5	Drosophila virilis	36%	100%
B4NBL6	Drosophila willistoni	36%	100%
B4PPK3	Drosophila yakuba	37%	100%
B4R089	Drosophila simulans	37%	100%
C9ZKA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
C9ZN10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A5X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O64730	Arabidopsis thaliana	32%	100%
P38797	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q09189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q29AP0	Drosophila pseudoobscura pseudoobscura	35%	100%
Q339D2	Oryza sativa subsp. japonica	30%	80%
Q4Q9N3	Leishmania major	92%	99%
Q5U3N5	Danio rerio	37%	100%
Q6GR25	Xenopus laevis	37%	100%
Q6H7J3	Oryza sativa subsp. japonica	32%	100%
Q6H7J4	Oryza sativa subsp. japonica	29%	100%
Q6NVE9	Mus musculus	38%	100%
Q8NI37	Homo sapiens	38%	100%
Q942P9	Oryza sativa subsp. japonica	30%	100%
Q9LVQ8	Arabidopsis thaliana	35%	89%
Q9SUK9	Arabidopsis thaliana	33%	79%
Q9VAH4	Drosophila melanogaster	37%	100%
V5AT69	Trypanosoma cruzi	26%	100%
V5AUW7	Trypanosoma cruzi	31%	100%
V5BMI3	Trypanosoma cruzi	65%	85%