Putative helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

helicase-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEA7_LEIBR

TriTrypDb:

LbrM.25.1610 , LBRM2903_250029500

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004386	helicase activity	2	9
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0008094	ATP-dependent activity, acting on DNA	2	14
GO:0016491	oxidoreductase activity	2	13
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051213	dioxygenase activity	3	13
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140097	catalytic activity, acting on DNA	3	14
GO:0140640	catalytic activity, acting on a nucleic acid	2	14
GO:0140657	ATP-dependent activity	1	14
GO:0140658	ATP-dependent chromatin remodeler activity	3	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003682	chromatin binding	2	1
GO:0005515	protein binding	2	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	545	549	PF00656	0.420
CLV_C14_Caspase3-7	712	716	PF00656	0.518
CLV_NRD_NRD_1	279	281	PF00675	0.279
CLV_NRD_NRD_1	310	312	PF00675	0.258
CLV_NRD_NRD_1	337	339	PF00675	0.220
CLV_NRD_NRD_1	399	401	PF00675	0.270
CLV_NRD_NRD_1	49	51	PF00675	0.580
CLV_NRD_NRD_1	640	642	PF00675	0.406
CLV_PCSK_KEX2_1	18	20	PF00082	0.709
CLV_PCSK_KEX2_1	279	281	PF00082	0.380
CLV_PCSK_KEX2_1	307	309	PF00082	0.259
CLV_PCSK_KEX2_1	312	314	PF00082	0.239
CLV_PCSK_KEX2_1	399	401	PF00082	0.270
CLV_PCSK_KEX2_1	44	46	PF00082	0.649
CLV_PCSK_KEX2_1	482	484	PF00082	0.563
CLV_PCSK_KEX2_1	49	51	PF00082	0.619
CLV_PCSK_KEX2_1	802	804	PF00082	0.417
CLV_PCSK_KEX2_1	812	814	PF00082	0.556
CLV_PCSK_KEX2_1	882	884	PF00082	0.419
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.709
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.256
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.238
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.563
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.457
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.576
CLV_PCSK_PC1ET2_1	812	814	PF00082	0.581
CLV_PCSK_PC1ET2_1	882	884	PF00082	0.365
CLV_PCSK_PC7_1	308	314	PF00082	0.244
CLV_PCSK_PC7_1	45	51	PF00082	0.601
CLV_PCSK_SKI1_1	172	176	PF00082	0.506
CLV_PCSK_SKI1_1	271	275	PF00082	0.263
CLV_PCSK_SKI1_1	282	286	PF00082	0.238
CLV_PCSK_SKI1_1	307	311	PF00082	0.248
CLV_PCSK_SKI1_1	338	342	PF00082	0.229
CLV_PCSK_SKI1_1	44	48	PF00082	0.595
CLV_PCSK_SKI1_1	681	685	PF00082	0.459
CLV_PCSK_SKI1_1	733	737	PF00082	0.545
DEG_APCC_DBOX_1	949	957	PF00400	0.461
DEG_COP1_1	414	424	PF00400	0.375
DEG_SPOP_SBC_1	27	31	PF00917	0.728
DEG_SPOP_SBC_1	701	705	PF00917	0.490
DOC_CKS1_1	120	125	PF01111	0.326
DOC_CKS1_1	297	302	PF01111	0.429
DOC_CKS1_1	86	91	PF01111	0.511
DOC_CYCLIN_RxL_1	41	48	PF00134	0.682
DOC_MAPK_DCC_7	950	958	PF00069	0.460
DOC_MAPK_FxFP_2	366	369	PF00069	0.420
DOC_MAPK_gen_1	289	297	PF00069	0.429
DOC_MAPK_gen_1	307	318	PF00069	0.442
DOC_MAPK_gen_1	399	409	PF00069	0.435
DOC_MAPK_gen_1	618	627	PF00069	0.250
DOC_MAPK_MEF2A_6	265	272	PF00069	0.441
DOC_MAPK_MEF2A_6	311	320	PF00069	0.522
DOC_MAPK_MEF2A_6	400	409	PF00069	0.440
DOC_MAPK_NFAT4_5	402	410	PF00069	0.422
DOC_MAPK_RevD_3	36	50	PF00069	0.604
DOC_PP1_RVXF_1	517	524	PF00149	0.453
DOC_PP2B_LxvP_1	38	41	PF13499	0.634
DOC_PP2B_LxvP_1	407	410	PF13499	0.420
DOC_PP4_FxxP_1	366	369	PF00568	0.420
DOC_USP7_MATH_1	114	118	PF00917	0.469
DOC_USP7_MATH_1	228	232	PF00917	0.524
DOC_USP7_MATH_1	26	30	PF00917	0.674
DOC_USP7_MATH_1	283	287	PF00917	0.550
DOC_USP7_MATH_1	3	7	PF00917	0.636
DOC_USP7_MATH_1	332	336	PF00917	0.524
DOC_USP7_MATH_1	566	570	PF00917	0.483
DOC_USP7_MATH_1	701	705	PF00917	0.520
DOC_USP7_MATH_1	714	718	PF00917	0.557
DOC_USP7_MATH_1	881	885	PF00917	0.462
DOC_USP7_UBL2_3	690	694	PF12436	0.502
DOC_WW_Pin1_4	119	124	PF00397	0.393
DOC_WW_Pin1_4	296	301	PF00397	0.429
DOC_WW_Pin1_4	348	353	PF00397	0.453
DOC_WW_Pin1_4	669	674	PF00397	0.524
DOC_WW_Pin1_4	697	702	PF00397	0.468
DOC_WW_Pin1_4	761	766	PF00397	0.636
DOC_WW_Pin1_4	85	90	PF00397	0.627
DOC_WW_Pin1_4	91	96	PF00397	0.602
LIG_14-3-3_CanoR_1	101	107	PF00244	0.676
LIG_14-3-3_CanoR_1	313	319	PF00244	0.540
LIG_14-3-3_CanoR_1	338	346	PF00244	0.446
LIG_14-3-3_CanoR_1	540	545	PF00244	0.483
LIG_14-3-3_CanoR_1	674	680	PF00244	0.420
LIG_14-3-3_CanoR_1	813	818	PF00244	0.383
LIG_Actin_WH2_2	158	174	PF00022	0.517
LIG_Actin_WH2_2	728	746	PF00022	0.327
LIG_APCC_ABBAyCdc20_2	733	739	PF00400	0.300
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_BIR_III_4	858	862	PF00653	0.383
LIG_BIR_III_4	917	921	PF00653	0.494
LIG_BRCT_BRCA1_1	567	571	PF00533	0.420
LIG_BRCT_BRCA1_1	843	847	PF00533	0.336
LIG_Clathr_ClatBox_1	302	306	PF01394	0.444
LIG_Clathr_ClatBox_1	735	739	PF01394	0.329
LIG_deltaCOP1_diTrp_1	359	366	PF00928	0.420
LIG_DLG_GKlike_1	540	547	PF00625	0.483
LIG_eIF4E_1	424	430	PF01652	0.438
LIG_FHA_1	225	231	PF00498	0.441
LIG_FHA_1	258	264	PF00498	0.445
LIG_FHA_1	297	303	PF00498	0.429
LIG_FHA_1	315	321	PF00498	0.507
LIG_FHA_1	416	422	PF00498	0.473
LIG_FHA_1	525	531	PF00498	0.420
LIG_FHA_1	589	595	PF00498	0.429
LIG_FHA_1	59	65	PF00498	0.497
LIG_FHA_1	615	621	PF00498	0.408
LIG_FHA_1	670	676	PF00498	0.665
LIG_FHA_1	921	927	PF00498	0.551
LIG_FHA_2	399	405	PF00498	0.517
LIG_FHA_2	526	532	PF00498	0.524
LIG_FHA_2	585	591	PF00498	0.437
LIG_FHA_2	628	634	PF00498	0.369
LIG_FHA_2	663	669	PF00498	0.764
LIG_FHA_2	674	680	PF00498	0.536
LIG_FHA_2	76	82	PF00498	0.640
LIG_FHA_2	8	14	PF00498	0.510
LIG_FHA_2	909	915	PF00498	0.525
LIG_LIR_Apic_2	117	123	PF02991	0.415
LIG_LIR_Apic_2	365	369	PF02991	0.483
LIG_LIR_Gen_1	147	157	PF02991	0.471
LIG_LIR_Gen_1	359	369	PF02991	0.450
LIG_LIR_Gen_1	423	432	PF02991	0.531
LIG_LIR_Gen_1	543	548	PF02991	0.517
LIG_LIR_Gen_1	568	579	PF02991	0.420
LIG_LIR_Gen_1	844	855	PF02991	0.355
LIG_LIR_Nem_3	147	153	PF02991	0.375
LIG_LIR_Nem_3	365	371	PF02991	0.483
LIG_LIR_Nem_3	423	427	PF02991	0.531
LIG_LIR_Nem_3	543	547	PF02991	0.517
LIG_LIR_Nem_3	568	574	PF02991	0.420
LIG_LIR_Nem_3	844	850	PF02991	0.322
LIG_LYPXL_S_1	367	371	PF13949	0.241
LIG_LYPXL_yS_3	368	371	PF13949	0.483
LIG_MYND_1	91	95	PF01753	0.510
LIG_NRBOX	428	434	PF00104	0.444
LIG_NRBOX	59	65	PF00104	0.457
LIG_PCNA_yPIPBox_3	419	433	PF02747	0.530
LIG_PCNA_yPIPBox_3	610	623	PF02747	0.502
LIG_Pex14_2	135	139	PF04695	0.286
LIG_Pex14_2	153	157	PF04695	0.482
LIG_Pex14_2	366	370	PF04695	0.505
LIG_Pex14_2	595	599	PF04695	0.483
LIG_REV1ctd_RIR_1	154	164	PF16727	0.359
LIG_SH2_NCK_1	563	567	PF00017	0.444
LIG_SH2_NCK_1	921	925	PF00017	0.483
LIG_SH2_PTP2	395	398	PF00017	0.483
LIG_SH2_PTP2	424	427	PF00017	0.375
LIG_SH2_SRC	375	378	PF00017	0.438
LIG_SH2_STAT5	395	398	PF00017	0.483
LIG_SH2_STAT5	424	427	PF00017	0.438
LIG_SH2_STAT5	505	508	PF00017	0.524
LIG_SH2_STAT5	644	647	PF00017	0.416
LIG_SH2_STAT5	854	857	PF00017	0.335
LIG_SH2_STAT5	887	890	PF00017	0.295
LIG_SH3_3	22	28	PF00018	0.640
LIG_SH3_3	294	300	PF00018	0.441
LIG_SH3_3	30	36	PF00018	0.548
LIG_SH3_3	376	382	PF00018	0.503
LIG_SH3_3	410	416	PF00018	0.469
LIG_SH3_3	775	781	PF00018	0.381
LIG_SH3_3	86	92	PF00018	0.682
LIG_SUMO_SIM_anti_2	527	534	PF11976	0.430
LIG_SUMO_SIM_anti_2	53	64	PF11976	0.599
LIG_SUMO_SIM_par_1	316	322	PF11976	0.432
LIG_SUMO_SIM_par_1	428	434	PF11976	0.573
LIG_SUMO_SIM_par_1	527	534	PF11976	0.494
LIG_SUMO_SIM_par_1	55	66	PF11976	0.504
LIG_SUMO_SIM_par_1	590	596	PF11976	0.450
LIG_SUMO_SIM_par_1	954	960	PF11976	0.456
LIG_TRAF2_1	437	440	PF00917	0.444
LIG_TRAF2_1	630	633	PF00917	0.302
LIG_TRAF2_1	969	972	PF00917	0.496
LIG_TYR_ITIM	393	398	PF00017	0.335
LIG_UBA3_1	302	307	PF00899	0.280
LIG_UBA3_1	509	514	PF00899	0.393
LIG_WRC_WIRS_1	363	368	PF05994	0.323
LIG_WW_3	409	413	PF00397	0.305
LIG_WW_3	803	807	PF00397	0.456
MOD_CDC14_SPxK_1	764	767	PF00782	0.578
MOD_CDK_SPK_2	669	674	PF00069	0.464
MOD_CDK_SPxK_1	761	767	PF00069	0.623
MOD_CK1_1	124	130	PF00069	0.568
MOD_CK1_1	254	260	PF00069	0.286
MOD_CK1_1	362	368	PF00069	0.319
MOD_CK1_1	431	437	PF00069	0.393
MOD_CK1_1	524	530	PF00069	0.306
MOD_CK1_1	6	12	PF00069	0.562
MOD_CK1_1	700	706	PF00069	0.697
MOD_CK1_1	717	723	PF00069	0.650
MOD_CK1_1	898	904	PF00069	0.501
MOD_CK1_1	939	945	PF00069	0.550
MOD_CK2_1	627	633	PF00069	0.347
MOD_CK2_1	707	713	PF00069	0.762
MOD_CK2_1	954	960	PF00069	0.586
MOD_Cter_Amidation	800	803	PF01082	0.332
MOD_GlcNHglycan	109	112	PF01048	0.633
MOD_GlcNHglycan	124	127	PF01048	0.377
MOD_GlcNHglycan	214	217	PF01048	0.292
MOD_GlcNHglycan	230	233	PF01048	0.194
MOD_GlcNHglycan	285	288	PF01048	0.336
MOD_GlcNHglycan	30	33	PF01048	0.717
MOD_GlcNHglycan	334	337	PF01048	0.280
MOD_GlcNHglycan	442	445	PF01048	0.275
MOD_GlcNHglycan	498	502	PF01048	0.336
MOD_GlcNHglycan	719	722	PF01048	0.690
MOD_GlcNHglycan	725	728	PF01048	0.569
MOD_GlcNHglycan	745	748	PF01048	0.398
MOD_GlcNHglycan	806	809	PF01048	0.490
MOD_GlcNHglycan	858	862	PF01048	0.628
MOD_GlcNHglycan	902	905	PF01048	0.612
MOD_GSK3_1	102	109	PF00069	0.647
MOD_GSK3_1	224	231	PF00069	0.293
MOD_GSK3_1	278	285	PF00069	0.293
MOD_GSK3_1	3	10	PF00069	0.686
MOD_GSK3_1	328	335	PF00069	0.321
MOD_GSK3_1	521	528	PF00069	0.349
MOD_GSK3_1	584	591	PF00069	0.284
MOD_GSK3_1	669	676	PF00069	0.634
MOD_GSK3_1	697	704	PF00069	0.709
MOD_GSK3_1	715	722	PF00069	0.756
MOD_GSK3_1	837	844	PF00069	0.303
MOD_GSK3_1	87	94	PF00069	0.654
MOD_GSK3_1	895	902	PF00069	0.444
MOD_N-GLC_1	257	262	PF02516	0.183
MOD_N-GLC_1	473	478	PF02516	0.406
MOD_N-GLC_1	524	529	PF02516	0.246
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	205	210	PF00069	0.415
MOD_NEK2_1	224	229	PF00069	0.249
MOD_NEK2_1	233	238	PF00069	0.292
MOD_NEK2_1	398	403	PF00069	0.264
MOD_NEK2_1	438	443	PF00069	0.388
MOD_NEK2_1	521	526	PF00069	0.255
MOD_NEK2_1	547	552	PF00069	0.319
MOD_NEK2_1	573	578	PF00069	0.280
MOD_NEK2_1	63	68	PF00069	0.650
MOD_NEK2_1	743	748	PF00069	0.398
MOD_NEK2_1	786	791	PF00069	0.357
MOD_NEK2_1	837	842	PF00069	0.332
MOD_NEK2_1	857	862	PF00069	0.442
MOD_NEK2_1	896	901	PF00069	0.476
MOD_NEK2_2	191	196	PF00069	0.414
MOD_NEK2_2	566	571	PF00069	0.335
MOD_NEK2_2	881	886	PF00069	0.448
MOD_OFUCOSY	885	890	PF10250	0.438
MOD_PIKK_1	473	479	PF00454	0.614
MOD_PIKK_1	63	69	PF00454	0.653
MOD_PKA_1	338	344	PF00069	0.276
MOD_PKA_2	127	133	PF00069	0.401
MOD_PKA_2	20	26	PF00069	0.508
MOD_PKA_2	278	284	PF00069	0.299
MOD_PKA_2	398	404	PF00069	0.246
MOD_PKA_2	662	668	PF00069	0.704
MOD_PKA_2	673	679	PF00069	0.411
MOD_PKA_2	708	714	PF00069	0.579
MOD_PKA_2	72	78	PF00069	0.499
MOD_PKA_2	743	749	PF00069	0.527
MOD_PKA_2	867	873	PF00069	0.503
MOD_PKB_1	280	288	PF00069	0.256
MOD_PKB_1	661	669	PF00069	0.503
MOD_Plk_1	58	64	PF00069	0.380
MOD_Plk_1	75	81	PF00069	0.487
MOD_Plk_1	939	945	PF00069	0.694
MOD_Plk_4	314	320	PF00069	0.340
MOD_Plk_4	362	368	PF00069	0.335
MOD_Plk_4	420	426	PF00069	0.330
MOD_Plk_4	428	434	PF00069	0.394
MOD_Plk_4	505	511	PF00069	0.299
MOD_Plk_4	58	64	PF00069	0.380
MOD_Plk_4	588	594	PF00069	0.259
MOD_Plk_4	703	709	PF00069	0.572
MOD_Plk_4	954	960	PF00069	0.664
MOD_ProDKin_1	119	125	PF00069	0.392
MOD_ProDKin_1	296	302	PF00069	0.259
MOD_ProDKin_1	348	354	PF00069	0.292
MOD_ProDKin_1	669	675	PF00069	0.508
MOD_ProDKin_1	697	703	PF00069	0.468
MOD_ProDKin_1	761	767	PF00069	0.623
MOD_ProDKin_1	85	91	PF00069	0.623
MOD_SUMO_rev_2	875	881	PF00179	0.433
TRG_DiLeu_BaEn_1	359	364	PF01217	0.259
TRG_DiLeu_BaEn_1	59	64	PF01217	0.454
TRG_DiLeu_BaEn_2	200	206	PF01217	0.385
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.596
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.354
TRG_DiLeu_BaLyEn_6	781	786	PF01217	0.402
TRG_DiLeu_BaLyEn_6	860	865	PF01217	0.505
TRG_ENDOCYTIC_2	368	371	PF00928	0.321
TRG_ENDOCYTIC_2	395	398	PF00928	0.335
TRG_ENDOCYTIC_2	424	427	PF00928	0.251
TRG_ENDOCYTIC_2	544	547	PF00928	0.393
TRG_ENDOCYTIC_2	854	857	PF00928	0.329
TRG_ENDOCYTIC_2	871	874	PF00928	0.386
TRG_ER_diArg_1	279	282	PF00400	0.280
TRG_ER_diArg_1	310	313	PF00400	0.265
TRG_ER_diArg_1	398	400	PF00400	0.316
TRG_ER_diArg_1	661	664	PF00400	0.522
TRG_NES_CRM1_1	169	185	PF08389	0.330
TRG_NLS_MonoExtN_4	308	315	PF00514	0.280
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	853	858	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE28	Leptomonas seymouri	69%	96%
A0A0S4JP66	Bodo saltans	43%	87%
A0A1X0NY53	Trypanosomatidae	55%	99%
A0A3S7WZF4	Leishmania donovani	84%	93%
A0A422P4R6	Trypanosoma rangeli	57%	100%
A4HGB7	Leishmania braziliensis	24%	100%
A4I1Q3	Leishmania infantum	84%	93%
C9ZKA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AXT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	93%
E9AZN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q9N4	Leishmania major	83%	100%
V5DIY2	Trypanosoma cruzi	57%	100%