DUF3137 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEA6_LEIBR

TriTrypDb:

LbrM.25.1600 , LBRM2903_250029400

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HEA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.397
CLV_C14_Caspase3-7	97	101	PF00656	0.498
CLV_PCSK_KEX2_1	134	136	PF00082	0.682
CLV_PCSK_KEX2_1	168	170	PF00082	0.695
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.682
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.698
DEG_APCC_DBOX_1	357	365	PF00400	0.434
DEG_Nend_UBRbox_2	1	3	PF02207	0.342
DOC_CYCLIN_RxL_1	215	226	PF00134	0.252
DOC_MAPK_gen_1	239	249	PF00069	0.394
DOC_MAPK_gen_1	55	64	PF00069	0.686
DOC_MAPK_MEF2A_6	339	347	PF00069	0.252
DOC_PP1_RVXF_1	219	226	PF00149	0.426
DOC_PP1_RVXF_1	344	350	PF00149	0.384
DOC_PP4_FxxP_1	237	240	PF00568	0.359
DOC_PP4_FxxP_1	53	56	PF00568	0.665
DOC_USP7_MATH_1	178	182	PF00917	0.499
DOC_USP7_MATH_1	243	247	PF00917	0.420
DOC_WW_Pin1_4	62	67	PF00397	0.537
DOC_WW_Pin1_4	76	81	PF00397	0.530
LIG_14-3-3_CanoR_1	155	161	PF00244	0.330
LIG_14-3-3_CanoR_1	242	248	PF00244	0.394
LIG_BIR_III_2	303	307	PF00653	0.377
LIG_BIR_III_4	274	278	PF00653	0.432
LIG_BRCT_BRCA1_1	9	13	PF00533	0.473
LIG_Clathr_ClatBox_1	145	149	PF01394	0.387
LIG_Clathr_ClatBox_1	222	226	PF01394	0.421
LIG_FHA_1	128	134	PF00498	0.419
LIG_FHA_1	196	202	PF00498	0.385
LIG_FHA_1	336	342	PF00498	0.381
LIG_FHA_1	367	373	PF00498	0.345
LIG_FHA_2	262	268	PF00498	0.407
LIG_FHA_2	355	361	PF00498	0.431
LIG_FXI_DFP_1	222	226	PF00024	0.602
LIG_HP1_1	39	43	PF01393	0.475
LIG_LIR_Gen_1	212	222	PF02991	0.362
LIG_LIR_Gen_1	224	233	PF02991	0.360
LIG_LIR_Gen_1	342	352	PF02991	0.406
LIG_LIR_Gen_1	69	78	PF02991	0.457
LIG_LIR_Nem_3	118	123	PF02991	0.369
LIG_LIR_Nem_3	212	217	PF02991	0.364
LIG_LIR_Nem_3	224	228	PF02991	0.311
LIG_LIR_Nem_3	291	296	PF02991	0.459
LIG_LIR_Nem_3	342	347	PF02991	0.345
LIG_LIR_Nem_3	69	73	PF02991	0.457
LIG_PCNA_PIPBox_1	42	51	PF02747	0.475
LIG_Pex14_2	195	199	PF04695	0.403
LIG_Pex14_2	228	232	PF04695	0.305
LIG_SH2_CRK	293	297	PF00017	0.463
LIG_SH2_STAP1	197	201	PF00017	0.430
LIG_SH2_STAP1	359	363	PF00017	0.351
LIG_SH2_STAT3	197	200	PF00017	0.435
LIG_SH2_STAT5	197	200	PF00017	0.384
LIG_SH2_STAT5	219	222	PF00017	0.412
LIG_SH2_STAT5	344	347	PF00017	0.347
LIG_SH2_STAT5	49	52	PF00017	0.389
LIG_SH2_STAT5	72	75	PF00017	0.417
LIG_SH3_3	305	311	PF00018	0.545
LIG_SH3_3	33	39	PF00018	0.475
LIG_SxIP_EBH_1	119	128	PF03271	0.351
LIG_TRAF2_1	264	267	PF00917	0.356
LIG_TYR_ITIM	217	222	PF00017	0.417
LIG_TYR_ITSM	289	296	PF00017	0.456
LIG_WRC_WIRS_1	201	206	PF05994	0.378
LIG_WRC_WIRS_1	67	72	PF05994	0.449
LIG_WW_3	239	243	PF00397	0.442
MOD_CK1_1	282	288	PF00069	0.450
MOD_CK2_1	178	184	PF00069	0.502
MOD_CK2_1	254	260	PF00069	0.428
MOD_CK2_1	261	267	PF00069	0.382
MOD_CK2_1	354	360	PF00069	0.408
MOD_CK2_1	90	96	PF00069	0.465
MOD_GlcNHglycan	349	352	PF01048	0.578
MOD_GSK3_1	178	185	PF00069	0.495
MOD_GSK3_1	195	202	PF00069	0.379
MOD_GSK3_1	261	268	PF00069	0.436
MOD_GSK3_1	278	285	PF00069	0.304
MOD_GSK3_1	62	69	PF00069	0.504
MOD_GSK3_1	7	14	PF00069	0.493
MOD_GSK3_1	72	79	PF00069	0.274
MOD_N-GLC_1	347	352	PF02516	0.605
MOD_NEK2_1	199	204	PF00069	0.337
MOD_NEK2_1	265	270	PF00069	0.382
MOD_NEK2_1	347	352	PF00069	0.350
MOD_PIKK_1	366	372	PF00454	0.340
MOD_PKA_2	127	133	PF00069	0.389
MOD_PKA_2	374	380	PF00069	0.433
MOD_PKB_1	169	177	PF00069	0.513
MOD_Plk_1	288	294	PF00069	0.450
MOD_Plk_1	366	372	PF00069	0.480
MOD_Plk_2-3	11	17	PF00069	0.333
MOD_Plk_4	127	133	PF00069	0.405
MOD_Plk_4	182	188	PF00069	0.495
MOD_Plk_4	243	249	PF00069	0.392
MOD_Plk_4	377	383	PF00069	0.448
MOD_Plk_4	66	72	PF00069	0.490
MOD_Plk_4	90	96	PF00069	0.410
MOD_ProDKin_1	62	68	PF00069	0.537
MOD_ProDKin_1	76	82	PF00069	0.523
MOD_SUMO_for_1	133	136	PF00179	0.472
MOD_SUMO_for_1	299	302	PF00179	0.475
MOD_SUMO_for_1	314	317	PF00179	0.403
MOD_SUMO_rev_2	317	323	PF00179	0.490
TRG_AP2beta_CARGO_1	212	221	PF09066	0.422
TRG_AP2beta_CARGO_1	226	235	PF09066	0.401
TRG_DiLeu_BaEn_2	181	187	PF01217	0.492
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.427
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.475
TRG_ENDOCYTIC_2	219	222	PF00928	0.412
TRG_ENDOCYTIC_2	293	296	PF00928	0.445
TRG_ENDOCYTIC_2	344	347	PF00928	0.379
TRG_ENDOCYTIC_2	49	52	PF00928	0.364
TRG_ER_diArg_1	23	26	PF00400	0.324
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I861	Leptomonas seymouri	65%	99%
A0A0S4JNZ4	Bodo saltans	31%	100%
A0A1X0NY60	Trypanosomatidae	38%	100%
A0A3R7MC60	Trypanosoma rangeli	36%	100%
A0A3S7WZB8	Leishmania donovani	88%	100%
A4I1Q2	Leishmania infantum	88%	100%
C9ZKA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AXT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9N5	Leishmania major	88%	99%
V5BHZ5	Trypanosoma cruzi	35%	100%