FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dullard-like phosphatase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEA5_LEIBR

TriTrypDb:

LbrM.25.1590 , LBRM2903_250029300

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0016791	phosphatase activity	5	17
GO:0042578	phosphoric ester hydrolase activity	4	17
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.577
CLV_C14_Caspase3-7	345	349	PF00656	0.349
CLV_NRD_NRD_1	55	57	PF00675	0.487
CLV_PCSK_KEX2_1	55	57	PF00082	0.487
CLV_Separin_Metazoa	326	330	PF03568	0.363
DEG_Nend_UBRbox_2	1	3	PF02207	0.718
DEG_SPOP_SBC_1	32	36	PF00917	0.687
DEG_SPOP_SBC_1	65	69	PF00917	0.580
DOC_CDC14_PxL_1	328	336	PF14671	0.352
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.484
DOC_MAPK_gen_1	179	188	PF00069	0.248
DOC_MAPK_gen_1	260	269	PF00069	0.212
DOC_MAPK_MEF2A_6	179	188	PF00069	0.283
DOC_MAPK_MEF2A_6	202	211	PF00069	0.243
DOC_MAPK_NFAT4_5	181	189	PF00069	0.271
DOC_MAPK_RevD_3	168	182	PF00069	0.361
DOC_USP7_MATH_1	126	130	PF00917	0.639
DOC_USP7_MATH_1	314	318	PF00917	0.216
DOC_USP7_MATH_1	32	36	PF00917	0.648
DOC_WW_Pin1_4	157	162	PF00397	0.386
DOC_WW_Pin1_4	298	303	PF00397	0.274
DOC_WW_Pin1_4	61	66	PF00397	0.662
DOC_WW_Pin1_4	69	74	PF00397	0.623
DOC_WW_Pin1_4	7	12	PF00397	0.679
LIG_14-3-3_CanoR_1	30	40	PF00244	0.489
LIG_APCC_ABBA_1	267	272	PF00400	0.304
LIG_FHA_1	141	147	PF00498	0.521
LIG_FHA_1	157	163	PF00498	0.369
LIG_FHA_1	242	248	PF00498	0.242
LIG_FHA_1	277	283	PF00498	0.307
LIG_FHA_1	72	78	PF00498	0.771
LIG_FHA_2	247	253	PF00498	0.247
LIG_FHA_2	340	346	PF00498	0.285
LIG_LIR_Apic_2	248	253	PF02991	0.246
LIG_LIR_Gen_1	341	352	PF02991	0.294
LIG_LIR_Nem_3	12	18	PF02991	0.494
LIG_LIR_Nem_3	341	347	PF02991	0.280
LIG_LIR_Nem_3	348	353	PF02991	0.303
LIG_MYND_1	168	172	PF01753	0.419
LIG_SH2_CRK	350	354	PF00017	0.261
LIG_SH2_STAP1	203	207	PF00017	0.329
LIG_SH2_STAT3	305	308	PF00017	0.269
LIG_SH2_STAT5	151	154	PF00017	0.437
LIG_SH2_STAT5	220	223	PF00017	0.278
LIG_SH2_STAT5	250	253	PF00017	0.280
LIG_SH2_STAT5	281	284	PF00017	0.297
LIG_SH2_STAT5	305	308	PF00017	0.216
LIG_SH3_3	202	208	PF00018	0.304
LIG_SUMO_SIM_anti_2	284	289	PF11976	0.220
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.250
LIG_SUMO_SIM_par_1	184	191	PF11976	0.271
LIG_SUMO_SIM_par_1	207	212	PF11976	0.397
LIG_UBA3_1	254	260	PF00899	0.363
MOD_CK1_1	131	137	PF00069	0.597
MOD_CK1_1	196	202	PF00069	0.166
MOD_CK1_1	246	252	PF00069	0.247
MOD_CK1_1	36	42	PF00069	0.617
MOD_CK1_1	67	73	PF00069	0.642
MOD_CK2_1	319	325	PF00069	0.392
MOD_GlcNHglycan	109	113	PF01048	0.749
MOD_GlcNHglycan	114	118	PF01048	0.686
MOD_GlcNHglycan	49	52	PF01048	0.557
MOD_GSK3_1	126	133	PF00069	0.621
MOD_GSK3_1	162	169	PF00069	0.425
MOD_GSK3_1	188	195	PF00069	0.297
MOD_GSK3_1	241	248	PF00069	0.217
MOD_GSK3_1	272	279	PF00069	0.309
MOD_GSK3_1	32	39	PF00069	0.604
MOD_GSK3_1	61	68	PF00069	0.602
MOD_GSK3_1	69	76	PF00069	0.600
MOD_GSK3_1	78	85	PF00069	0.609
MOD_N-GLC_1	157	162	PF02516	0.397
MOD_N-GLC_1	7	12	PF02516	0.720
MOD_NEK2_1	113	118	PF00069	0.513
MOD_NEK2_1	192	197	PF00069	0.287
MOD_NEK2_1	243	248	PF00069	0.279
MOD_NEK2_1	33	38	PF00069	0.659
MOD_PIKK_1	21	27	PF00454	0.563
MOD_PIKK_1	82	88	PF00454	0.491
MOD_PIKK_1	92	98	PF00454	0.769
MOD_PKA_2	36	42	PF00069	0.543
MOD_PKA_2	4	10	PF00069	0.757
MOD_Plk_1	162	168	PF00069	0.305
MOD_Plk_1	188	194	PF00069	0.269
MOD_Plk_1	283	289	PF00069	0.243
MOD_Plk_2-3	339	345	PF00069	0.346
MOD_Plk_4	166	172	PF00069	0.392
MOD_Plk_4	188	194	PF00069	0.286
MOD_Plk_4	272	278	PF00069	0.226
MOD_Plk_4	283	289	PF00069	0.187
MOD_Plk_4	314	320	PF00069	0.297
MOD_Plk_4	339	345	PF00069	0.312
MOD_Plk_4	73	79	PF00069	0.473
MOD_ProDKin_1	157	163	PF00069	0.390
MOD_ProDKin_1	298	304	PF00069	0.274
MOD_ProDKin_1	61	67	PF00069	0.662
MOD_ProDKin_1	69	75	PF00069	0.621
MOD_ProDKin_1	7	13	PF00069	0.678
TRG_DiLeu_BaEn_1	326	331	PF01217	0.274
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.210
TRG_DiLeu_LyEn_5	326	331	PF01217	0.269
TRG_ENDOCYTIC_2	220	223	PF00928	0.257
TRG_ENDOCYTIC_2	344	347	PF00928	0.307
TRG_ENDOCYTIC_2	350	353	PF00928	0.307
TRG_ER_diArg_1	137	140	PF00400	0.570
TRG_ER_diArg_1	148	151	PF00400	0.435
TRG_ER_diArg_1	54	56	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG96	Leptomonas seymouri	67%	100%
A0A0S4IMS1	Bodo saltans	66%	100%
A0A0S4JCX0	Bodo saltans	46%	100%
A0A1X0NYI7	Trypanosomatidae	45%	92%
A0A3Q8IDG4	Leishmania donovani	88%	100%
A0A3S7WZH2	Leishmania donovani	51%	100%
A0A422P4K3	Trypanosoma rangeli	51%	89%
A4HEM1	Leishmania braziliensis	50%	100%
A4I1Q1	Leishmania infantum	88%	100%
A4I1V3	Leishmania infantum	50%	100%
A4QNX6	Danio rerio	34%	80%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	87%
E9AXT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
M9PFN0	Drosophila melanogaster	39%	100%
Q4Q9H6	Leishmania major	51%	100%
Q4Q9N6	Leishmania major	86%	99%