(d)CMP kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

(d)CMP kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEA4_LEIBR

TriTrypDb:

LbrM.25.1580 , LBRM2903_250029200

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0004127	cytidylate kinase activity	6	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0019205	nucleobase-containing compound kinase activity	5	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0050145	nucleoside monophosphate kinase activity	5	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.532
CLV_NRD_NRD_1	268	270	PF00675	0.383
CLV_NRD_NRD_1	60	62	PF00675	0.506
CLV_PCSK_KEX2_1	169	171	PF00082	0.516
CLV_PCSK_KEX2_1	268	270	PF00082	0.383
CLV_PCSK_KEX2_1	43	45	PF00082	0.558
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.516
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.607
CLV_PCSK_SKI1_1	121	125	PF00082	0.446
CLV_PCSK_SKI1_1	126	130	PF00082	0.379
CLV_PCSK_SKI1_1	152	156	PF00082	0.536
CLV_PCSK_SKI1_1	169	173	PF00082	0.301
CLV_PCSK_SKI1_1	182	186	PF00082	0.500
CLV_PCSK_SKI1_1	292	296	PF00082	0.611
CLV_PCSK_SKI1_1	62	66	PF00082	0.338
DEG_Nend_UBRbox_3	1	3	PF02207	0.655
DOC_AGCK_PIF_1	136	141	PF00069	0.380
DOC_CKS1_1	199	204	PF01111	0.467
DOC_CKS1_1	249	254	PF01111	0.293
DOC_CYCLIN_yClb5_NLxxxL_5	154	163	PF00134	0.328
DOC_MAPK_MEF2A_6	51	60	PF00069	0.435
DOC_MAPK_RevD_3	255	269	PF00069	0.391
DOC_PP1_RVXF_1	124	131	PF00149	0.400
DOC_PP1_RVXF_1	167	174	PF00149	0.400
DOC_PP2B_LxvP_1	257	260	PF13499	0.532
DOC_USP7_MATH_1	94	98	PF00917	0.572
DOC_WW_Pin1_4	198	203	PF00397	0.500
DOC_WW_Pin1_4	248	253	PF00397	0.381
DOC_WW_Pin1_4	283	288	PF00397	0.371
DOC_WW_Pin1_4	69	74	PF00397	0.587
LIG_14-3-3_CanoR_1	137	142	PF00244	0.359
LIG_14-3-3_CanoR_1	170	174	PF00244	0.461
LIG_14-3-3_CanoR_1	242	247	PF00244	0.386
LIG_BIR_III_2	122	126	PF00653	0.475
LIG_FHA_1	158	164	PF00498	0.398
LIG_FHA_1	186	192	PF00498	0.524
LIG_FHA_1	199	205	PF00498	0.473
LIG_FHA_1	222	228	PF00498	0.529
LIG_FHA_1	3	9	PF00498	0.399
LIG_FHA_1	86	92	PF00498	0.423
LIG_FHA_2	181	187	PF00498	0.498
LIG_FHA_2	213	219	PF00498	0.415
LIG_FHA_2	284	290	PF00498	0.410
LIG_LIR_Gen_1	138	147	PF02991	0.349
LIG_LIR_Gen_1	233	239	PF02991	0.502
LIG_LIR_Gen_1	29	37	PF02991	0.386
LIG_LIR_Nem_3	138	142	PF02991	0.340
LIG_LIR_Nem_3	233	238	PF02991	0.504
LIG_LIR_Nem_3	29	33	PF02991	0.389
LIG_PDZ_Class_3	297	302	PF00595	0.370
LIG_SH2_CRK	139	143	PF00017	0.375
LIG_SH2_CRK	235	239	PF00017	0.387
LIG_SH2_STAT5	139	142	PF00017	0.379
LIG_SH2_STAT5	248	251	PF00017	0.435
LIG_SUMO_SIM_anti_2	160	168	PF11976	0.312
LIG_SUMO_SIM_par_1	160	168	PF11976	0.312
LIG_TRAF2_1	287	290	PF00917	0.640
LIG_TRAF2_1	83	86	PF00917	0.491
LIG_UBA3_1	163	169	PF00899	0.301
LIG_UBA3_1	91	98	PF00899	0.414
MOD_CDK_SPxK_1	248	254	PF00069	0.374
MOD_CDK_SPxxK_3	69	76	PF00069	0.572
MOD_CK1_1	72	78	PF00069	0.411
MOD_CK2_1	162	168	PF00069	0.525
MOD_CK2_1	186	192	PF00069	0.339
MOD_CK2_1	212	218	PF00069	0.419
MOD_CK2_1	283	289	PF00069	0.599
MOD_CK2_1	31	37	PF00069	0.454
MOD_CK2_1	80	86	PF00069	0.476
MOD_GlcNHglycan	108	111	PF01048	0.432
MOD_GlcNHglycan	147	150	PF01048	0.328
MOD_GlcNHglycan	230	233	PF01048	0.558
MOD_GlcNHglycan	65	68	PF01048	0.559
MOD_GlcNHglycan	82	85	PF01048	0.498
MOD_GSK3_1	108	115	PF00069	0.412
MOD_GSK3_1	194	201	PF00069	0.446
MOD_GSK3_1	203	210	PF00069	0.456
MOD_GSK3_1	29	36	PF00069	0.459
MOD_N-GLC_1	157	162	PF02516	0.337
MOD_N-GLC_1	283	288	PF02516	0.544
MOD_NEK2_1	108	113	PF00069	0.405
MOD_NEK2_1	185	190	PF00069	0.531
MOD_NEK2_1	203	208	PF00069	0.630
MOD_PIKK_1	212	218	PF00454	0.413
MOD_PIKK_1	240	246	PF00454	0.472
MOD_PKA_1	169	175	PF00069	0.518
MOD_PKA_2	169	175	PF00069	0.518
MOD_Plk_2-3	157	163	PF00069	0.552
MOD_Plk_4	137	143	PF00069	0.377
MOD_Plk_4	162	168	PF00069	0.467
MOD_Plk_4	194	200	PF00069	0.386
MOD_ProDKin_1	198	204	PF00069	0.492
MOD_ProDKin_1	248	254	PF00069	0.374
MOD_ProDKin_1	283	289	PF00069	0.376
MOD_ProDKin_1	69	75	PF00069	0.587
TRG_DiLeu_BaEn_1	162	167	PF01217	0.304
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.553
TRG_ENDOCYTIC_2	139	142	PF00928	0.357
TRG_ENDOCYTIC_2	235	238	PF00928	0.387
TRG_NES_CRM1_1	247	261	PF08389	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G0	Leptomonas seymouri	78%	100%
A0A0S4IKR6	Bodo saltans	54%	100%
A0A1X0NZI5	Trypanosomatidae	62%	100%
A0A3S7WZD1	Leishmania donovani	87%	99%
A0A422P4M6	Trypanosoma rangeli	58%	100%
A4I1Q0	Leishmania infantum	87%	99%
C9ZKA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9AXT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q9N7	Leishmania major	86%	100%
V5BMH9	Trypanosoma cruzi	61%	100%