Putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HEA3_LEIBR

TriTrypDb:

LbrM.25.1570 , LBRM2903_250029100

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016829	lyase activity	2	6
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016832	aldehyde-lyase activity	4	1
GO:0016853	isomerase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.431
CLV_C14_Caspase3-7	89	93	PF00656	0.431
CLV_PCSK_SKI1_1	132	136	PF00082	0.296
CLV_PCSK_SKI1_1	189	193	PF00082	0.258
CLV_PCSK_SKI1_1	235	239	PF00082	0.299
CLV_PCSK_SKI1_1	258	262	PF00082	0.507
DOC_MAPK_gen_1	13	23	PF00069	0.311
DOC_MAPK_gen_1	213	221	PF00069	0.493
DOC_MAPK_MEF2A_6	213	221	PF00069	0.493
DOC_USP7_MATH_1	50	54	PF00917	0.467
DOC_USP7_MATH_1	86	90	PF00917	0.469
DOC_WW_Pin1_4	195	200	PF00397	0.471
DOC_WW_Pin1_4	24	29	PF00397	0.514
DOC_WW_Pin1_4	46	51	PF00397	0.516
LIG_14-3-3_CanoR_1	73	83	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_FHA_1	117	123	PF00498	0.458
LIG_FHA_1	203	209	PF00498	0.455
LIG_FHA_1	224	230	PF00498	0.466
LIG_LIR_Apic_2	187	193	PF02991	0.471
LIG_LIR_Gen_1	234	242	PF02991	0.468
LIG_LIR_Gen_1	37	46	PF02991	0.458
LIG_LIR_Nem_3	234	240	PF02991	0.468
LIG_LIR_Nem_3	37	42	PF02991	0.477
LIG_SH2_GRB2like	98	101	PF00017	0.471
LIG_SH2_PTP2	190	193	PF00017	0.458
LIG_SH2_STAP1	39	43	PF00017	0.458
LIG_SH2_STAT3	123	126	PF00017	0.458
LIG_SH2_STAT5	137	140	PF00017	0.535
LIG_SH2_STAT5	190	193	PF00017	0.460
LIG_SH2_STAT5	196	199	PF00017	0.461
LIG_SH2_STAT5	98	101	PF00017	0.458
LIG_SH3_3	119	125	PF00018	0.458
LIG_SH3_3	91	97	PF00018	0.458
MOD_CK1_1	241	247	PF00069	0.480
MOD_GlcNHglycan	2	5	PF01048	0.432
MOD_GlcNHglycan	24	27	PF01048	0.265
MOD_GlcNHglycan	275	278	PF01048	0.497
MOD_GlcNHglycan	36	39	PF01048	0.244
MOD_GlcNHglycan	88	91	PF01048	0.227
MOD_GSK3_1	114	121	PF00069	0.590
MOD_GSK3_1	204	211	PF00069	0.504
MOD_GSK3_1	269	276	PF00069	0.509
MOD_GSK3_1	46	53	PF00069	0.467
MOD_NEK2_1	179	184	PF00069	0.458
MOD_NEK2_1	208	213	PF00069	0.553
MOD_NEK2_1	22	27	PF00069	0.458
MOD_NEK2_1	34	39	PF00069	0.479
MOD_NEK2_2	118	123	PF00069	0.458
MOD_PIKK_1	74	80	PF00454	0.553
MOD_Plk_4	204	210	PF00069	0.489
MOD_Plk_4	252	258	PF00069	0.564
MOD_ProDKin_1	195	201	PF00069	0.471
MOD_ProDKin_1	24	30	PF00069	0.514
MOD_ProDKin_1	46	52	PF00069	0.516
MOD_SUMO_for_1	8	11	PF00179	0.381
MOD_SUMO_rev_2	2	10	PF00179	0.415
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.553
TRG_ENDOCYTIC_2	39	42	PF00928	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0F7GG11	Hapsidospora irregularis	28%	100%
A0A0N1IMC5	Leptomonas seymouri	89%	100%
A0A0S4IKN3	Bodo saltans	67%	92%
A0A1X0NYC8	Trypanosomatidae	78%	100%
A0A3S7WZB1	Leishmania donovani	95%	100%
A0A422P4M7	Trypanosoma rangeli	78%	100%
A1AD97	Escherichia coli O1:K1 / APEC	31%	100%
A1AG35	Escherichia coli O1:K1 / APEC	29%	100%
A4I1P9	Leishmania infantum	95%	100%
A4WEU6	Enterobacter sp. (strain 638)	31%	100%
A6TBU6	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	30%	100%
A6TEE9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	31%	100%
A6THU5	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	33%	100%
A7ZS18	Escherichia coli O139:H28 (strain E24377A / ETEC)	29%	100%
A8A2B1	Escherichia coli O9:H4 (strain HS)	31%	100%
A8A4T9	Escherichia coli O9:H4 (strain HS)	29%	100%
A8A876	Escherichia coli O9:H4 (strain HS)	33%	100%
A8AQ14	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	30%	100%
A9MH59	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	33%	100%
A9MPQ4	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	30%	100%
A9N5C4	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	31%	100%
A9N6T0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	33%	100%
A9N6Z0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	30%	100%
B1IRJ2	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	29%	100%
B1IS70	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	33%	100%
B1IXU2	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	31%	100%
B1LFM7	Escherichia coli (strain SMS-3-5 / SECEC)	29%	100%
B1LLJ9	Escherichia coli (strain SMS-3-5 / SECEC)	31%	100%
B1X8V8	Escherichia coli (strain K12 / DH10B)	31%	100%
B1XGT9	Escherichia coli (strain K12 / DH10B)	29%	100%
B2TZN1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	33%	100%
B2U092	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	29%	100%
B4SYW1	Salmonella newport (strain SL254)	31%	100%
B4T2T9	Salmonella newport (strain SL254)	33%	100%
B4T6B6	Salmonella newport (strain SL254)	30%	100%
B4TBF6	Salmonella heidelberg (strain SL476)	31%	100%
B4TEM9	Salmonella heidelberg (strain SL476)	33%	100%
B4TIX5	Salmonella heidelberg (strain SL476)	30%	100%
B4TPH2	Salmonella schwarzengrund (strain CVM19633)	31%	100%
B4TSL7	Salmonella schwarzengrund (strain CVM19633)	33%	100%
B4TVY2	Salmonella schwarzengrund (strain CVM19633)	30%	100%
B5BBH8	Salmonella paratyphi A (strain AKU_12601)	33%	100%
B5BCQ6	Salmonella paratyphi A (strain AKU_12601)	31%	100%
B5EZG8	Salmonella agona (strain SL483)	31%	100%
B5F1Y9	Salmonella agona (strain SL483)	33%	100%
B5F6Q5	Salmonella agona (strain SL483)	30%	100%
B5FHY2	Salmonella dublin (strain CT_02021853)	30%	100%
B5FNS9	Salmonella dublin (strain CT_02021853)	31%	100%
B5FR34	Salmonella dublin (strain CT_02021853)	33%	100%
B5QZS6	Salmonella enteritidis PT4 (strain P125109)	30%	100%
B5R043	Salmonella enteritidis PT4 (strain P125109)	33%	100%
B5R262	Salmonella enteritidis PT4 (strain P125109)	31%	100%
B5R6F7	Salmonella gallinarum (strain 287/91 / NCTC 13346)	33%	100%
B5RCB4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	31%	100%
B5REK4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	29%	100%
B5Y2D2	Klebsiella pneumoniae (strain 342)	32%	100%
B5YS14	Escherichia coli O157:H7 (strain EC4115 / EHEC)	29%	100%
B6I1J9	Escherichia coli (strain SE11)	29%	100%
B6I2N1	Escherichia coli (strain SE11)	33%	100%
B7LH62	Escherichia coli (strain 55989 / EAEC)	29%	100%
B7LMV6	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	30%	100%
B7M032	Escherichia coli O8 (strain IAI1)	29%	100%
B7MB51	Escherichia coli O45:K1 (strain S88 / ExPEC)	29%	100%
B7MG11	Escherichia coli O45:K1 (strain S88 / ExPEC)	31%	100%
B7MXS6	Escherichia coli O81 (strain ED1a)	31%	100%
B7N5L0	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	31%	100%
B7NDB2	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	29%	100%
B7NJZ1	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	29%	100%
B7NN63	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	30%	100%
B7UJ26	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	29%	100%
C0PZ22	Salmonella paratyphi C (strain RKS4594)	30%	100%
C0Q079	Salmonella paratyphi C (strain RKS4594)	31%	100%
C0Q8A0	Salmonella paratyphi C (strain RKS4594)	33%	100%
C4ZR38	Escherichia coli (strain K12 / MC4100 / BW2952)	29%	100%
C4ZU87	Escherichia coli (strain K12 / MC4100 / BW2952)	31%	100%
E9AXT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O05151	Rhodococcus jostii (strain RHA1)	32%	100%
O86013	Novosphingobium aromaticivorans	34%	100%
P0DOV8	Pseudomonas putida	33%	100%
P23522	Escherichia coli (strain K12)	29%	100%
P76469	Escherichia coli (strain K12)	31%	100%
Q0TCY1	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	29%	100%
Q0TFJ7	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	30%	100%
Q1R6L1	Escherichia coli (strain UTI89 / UPEC)	29%	100%
Q1R9H0	Escherichia coli (strain UTI89 / UPEC)	31%	100%
Q31SY8	Shigella boydii serotype 4 (strain Sb227)	33%	100%
Q31WQ5	Shigella boydii serotype 4 (strain Sb227)	29%	100%
Q31Z78	Shigella boydii serotype 4 (strain Sb227)	30%	100%
Q32BJ0	Shigella dysenteriae serotype 1 (strain Sd197)	29%	100%
Q32DU2	Shigella dysenteriae serotype 1 (strain Sd197)	29%	100%
Q3YU43	Shigella sonnei (strain Ss046)	33%	100%
Q3YXA5	Shigella sonnei (strain Ss046)	29%	100%
Q3YZW1	Shigella sonnei (strain Ss046)	30%	100%
Q47098	Escherichia coli	33%	100%
Q4Q9N8	Leishmania major	95%	100%
Q57JL0	Salmonella choleraesuis (strain SC-B67)	30%	100%
Q57M64	Salmonella choleraesuis (strain SC-B67)	31%	100%
Q57QP9	Salmonella choleraesuis (strain SC-B67)	33%	100%
Q5PCB8	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	30%	100%
Q5PG96	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	33%	100%
Q5PI50	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	31%	100%
Q7CPQ8	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	30%	100%
Q83P19	Shigella flexneri	33%	100%
Q8FDB8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	29%	100%
Q8FFN0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
Q8XAE3	Escherichia coli O157:H7	29%	100%
Q8XE09	Escherichia coli O157:H7	31%	100%
Q8XGF9	Salmonella typhi	30%	100%
Q8Z549	Salmonella typhi	30%	100%
Q8Z7P9	Salmonella typhi	33%	100%
Q8ZNG0	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	100%
Q8ZQ47	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
Q9RPV0	Salmonella dublin	33%	100%
V5BHY9	Trypanosoma cruzi	78%	100%