Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HEA1_LEIBR

TriTrypDb:

LbrM.25.1550 , LBRM2903_250028900

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEA1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	15
GO:0006793	phosphorus metabolic process	3	15
GO:0006796	phosphate-containing compound metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009987	cellular process	1	15
GO:0016310	phosphorylation	5	15
GO:0019538	protein metabolic process	3	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0004672	protein kinase activity	3	15
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0016301	kinase activity	4	15
GO:0016740	transferase activity	2	15
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	15
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140096	catalytic activity, acting on a protein	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	378	380	PF00675	0.494
CLV_NRD_NRD_1	427	429	PF00675	0.524
CLV_NRD_NRD_1	76	78	PF00675	0.259
CLV_NRD_NRD_1	8	10	PF00675	0.333
CLV_PCSK_KEX2_1	276	278	PF00082	0.450
CLV_PCSK_KEX2_1	427	429	PF00082	0.524
CLV_PCSK_KEX2_1	76	78	PF00082	0.259
CLV_PCSK_KEX2_1	99	101	PF00082	0.185
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.463
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.163
CLV_PCSK_SKI1_1	114	118	PF00082	0.307
CLV_PCSK_SKI1_1	132	136	PF00082	0.261
CLV_PCSK_SKI1_1	277	281	PF00082	0.408
CLV_PCSK_SKI1_1	428	432	PF00082	0.669
DEG_APCC_DBOX_1	113	121	PF00400	0.283
DEG_Nend_UBRbox_2	1	3	PF02207	0.375
DEG_SCF_FBW7_1	160	166	PF00400	0.163
DEG_SPOP_SBC_1	472	476	PF00917	0.445
DOC_ANK_TNKS_1	75	82	PF00023	0.264
DOC_CDC14_PxL_1	431	439	PF14671	0.534
DOC_CKS1_1	140	145	PF01111	0.264
DOC_CKS1_1	160	165	PF01111	0.218
DOC_CKS1_1	200	205	PF01111	0.259
DOC_MAPK_gen_1	132	141	PF00069	0.241
DOC_MAPK_gen_1	76	84	PF00069	0.259
DOC_MAPK_MEF2A_6	494	501	PF00069	0.465
DOC_MAPK_MEF2A_6	76	84	PF00069	0.260
DOC_PP4_MxPP_1	501	504	PF00568	0.467
DOC_USP7_MATH_1	163	167	PF00917	0.163
DOC_USP7_MATH_1	170	174	PF00917	0.152
DOC_USP7_MATH_1	179	183	PF00917	0.138
DOC_USP7_MATH_1	258	262	PF00917	0.684
DOC_USP7_MATH_1	450	454	PF00917	0.632
DOC_USP7_MATH_1	473	477	PF00917	0.661
DOC_USP7_MATH_1	480	484	PF00917	0.601
DOC_USP7_MATH_1	514	518	PF00917	0.524
DOC_USP7_MATH_1	532	536	PF00917	0.616
DOC_USP7_MATH_1	547	551	PF00917	0.671
DOC_USP7_UBL2_3	276	280	PF12436	0.646
DOC_USP7_UBL2_3	6	10	PF12436	0.283
DOC_WW_Pin1_4	139	144	PF00397	0.375
DOC_WW_Pin1_4	159	164	PF00397	0.264
DOC_WW_Pin1_4	181	186	PF00397	0.406
DOC_WW_Pin1_4	199	204	PF00397	0.242
DOC_WW_Pin1_4	259	264	PF00397	0.672
DOC_WW_Pin1_4	331	336	PF00397	0.276
DOC_WW_Pin1_4	493	498	PF00397	0.697
DOC_WW_Pin1_4	499	504	PF00397	0.701
DOC_WW_Pin1_4	75	80	PF00397	0.241
LIG_14-3-3_CanoR_1	363	370	PF00244	0.342
LIG_14-3-3_CanoR_1	427	431	PF00244	0.584
LIG_14-3-3_CanoR_1	486	493	PF00244	0.674
LIG_14-3-3_CanoR_1	531	540	PF00244	0.551
LIG_Actin_WH2_2	347	365	PF00022	0.300
LIG_FHA_1	111	117	PF00498	0.275
LIG_FHA_1	124	130	PF00498	0.224
LIG_FHA_1	260	266	PF00498	0.515
LIG_FHA_2	291	297	PF00498	0.282
LIG_FHA_2	301	307	PF00498	0.259
LIG_FHA_2	363	369	PF00498	0.330
LIG_FHA_2	427	433	PF00498	0.761
LIG_FHA_2	555	561	PF00498	0.503
LIG_LIR_Apic_2	202	208	PF02991	0.293
LIG_LIR_Apic_2	268	274	PF02991	0.613
LIG_LIR_Apic_2	35	41	PF02991	0.264
LIG_LIR_Apic_2	467	473	PF02991	0.450
LIG_LIR_Gen_1	303	313	PF02991	0.259
LIG_LIR_Gen_1	517	527	PF02991	0.435
LIG_LIR_Gen_1	560	568	PF02991	0.579
LIG_LIR_Nem_3	269	275	PF02991	0.607
LIG_LIR_Nem_3	303	308	PF02991	0.259
LIG_LIR_Nem_3	429	434	PF02991	0.665
LIG_LIR_Nem_3	517	523	PF02991	0.434
LIG_LIR_Nem_3	556	561	PF02991	0.534
LIG_LYPXL_yS_3	445	448	PF13949	0.433
LIG_MYND_1	373	377	PF01753	0.264
LIG_SH2_CRK	272	276	PF00017	0.591
LIG_SH2_CRK	520	524	PF00017	0.425
LIG_SH2_GRB2like	271	274	PF00017	0.593
LIG_SH2_NCK_1	305	309	PF00017	0.348
LIG_SH2_PTP2	157	160	PF00017	0.163
LIG_SH2_SRC	157	160	PF00017	0.163
LIG_SH2_STAP1	112	116	PF00017	0.259
LIG_SH2_STAP1	229	233	PF00017	0.465
LIG_SH2_STAP1	291	295	PF00017	0.289
LIG_SH2_STAP1	358	362	PF00017	0.375
LIG_SH2_STAT5	112	115	PF00017	0.280
LIG_SH2_STAT5	122	125	PF00017	0.275
LIG_SH2_STAT5	157	160	PF00017	0.163
LIG_SH2_STAT5	195	198	PF00017	0.375
LIG_SH2_STAT5	291	294	PF00017	0.268
LIG_SH2_STAT5	88	91	PF00017	0.313
LIG_SH2_STAT5	96	99	PF00017	0.370
LIG_SH3_3	157	163	PF00018	0.375
LIG_SH3_3	197	203	PF00018	0.259
LIG_SH3_3	333	339	PF00018	0.260
LIG_SH3_3	440	446	PF00018	0.615
LIG_SH3_3	466	472	PF00018	0.737
LIG_SUMO_SIM_anti_2	560	566	PF11976	0.406
LIG_TRAF2_1	44	47	PF00917	0.351
LIG_TYR_ITSM	301	308	PF00017	0.318
LIG_WW_1	263	266	PF00397	0.656
MOD_CDK_SPK_2	181	186	PF00069	0.225
MOD_CDK_SPxxK_3	139	146	PF00069	0.375
MOD_CDK_SPxxK_3	181	188	PF00069	0.225
MOD_CK1_1	238	244	PF00069	0.496
MOD_CK1_1	319	325	PF00069	0.373
MOD_CK1_1	453	459	PF00069	0.593
MOD_CK1_1	488	494	PF00069	0.712
MOD_CK1_1	506	512	PF00069	0.646
MOD_CK1_1	535	541	PF00069	0.651
MOD_CK1_1	90	96	PF00069	0.375
MOD_CK2_1	238	244	PF00069	0.687
MOD_CK2_1	300	306	PF00069	0.259
MOD_CK2_1	362	368	PF00069	0.297
MOD_CK2_1	397	403	PF00069	0.614
MOD_CK2_1	506	512	PF00069	0.628
MOD_CK2_1	554	560	PF00069	0.505
MOD_GlcNHglycan	165	168	PF01048	0.210
MOD_GlcNHglycan	248	251	PF01048	0.526
MOD_GlcNHglycan	293	296	PF01048	0.323
MOD_GlcNHglycan	321	324	PF01048	0.325
MOD_GlcNHglycan	387	390	PF01048	0.709
MOD_GlcNHglycan	456	459	PF01048	0.698
MOD_GlcNHglycan	476	479	PF01048	0.684
MOD_GlcNHglycan	534	537	PF01048	0.598
MOD_GlcNHglycan	540	543	PF01048	0.636
MOD_GlcNHglycan	549	552	PF01048	0.708
MOD_GlcNHglycan	89	92	PF01048	0.405
MOD_GSK3_1	159	166	PF00069	0.207
MOD_GSK3_1	195	202	PF00069	0.353
MOD_GSK3_1	235	242	PF00069	0.736
MOD_GSK3_1	285	292	PF00069	0.254
MOD_GSK3_1	296	303	PF00069	0.209
MOD_GSK3_1	446	453	PF00069	0.598
MOD_GSK3_1	495	502	PF00069	0.687
MOD_N-GLC_1	235	240	PF02516	0.494
MOD_N-GLC_1	403	408	PF02516	0.528
MOD_NEK2_1	123	128	PF00069	0.375
MOD_NEK2_1	251	256	PF00069	0.742
MOD_NEK2_1	265	270	PF00069	0.608
MOD_NEK2_1	362	367	PF00069	0.368
MOD_NEK2_1	454	459	PF00069	0.633
MOD_NEK2_1	487	492	PF00069	0.555
MOD_NEK2_1	554	559	PF00069	0.674
MOD_NEK2_2	480	485	PF00069	0.506
MOD_PIKK_1	170	176	PF00454	0.163
MOD_PKA_1	379	385	PF00069	0.575
MOD_PKA_2	104	110	PF00069	0.206
MOD_PKA_2	170	176	PF00069	0.226
MOD_PKA_2	362	368	PF00069	0.322
MOD_PKA_2	426	432	PF00069	0.590
MOD_PKA_2	485	491	PF00069	0.701
MOD_PKA_2	530	536	PF00069	0.621
MOD_Plk_4	300	306	PF00069	0.290
MOD_Plk_4	450	456	PF00069	0.443
MOD_Plk_4	495	501	PF00069	0.599
MOD_ProDKin_1	139	145	PF00069	0.375
MOD_ProDKin_1	159	165	PF00069	0.264
MOD_ProDKin_1	181	187	PF00069	0.406
MOD_ProDKin_1	199	205	PF00069	0.242
MOD_ProDKin_1	259	265	PF00069	0.673
MOD_ProDKin_1	331	337	PF00069	0.276
MOD_ProDKin_1	493	499	PF00069	0.698
MOD_ProDKin_1	75	81	PF00069	0.241
TRG_DiLeu_BaEn_1	560	565	PF01217	0.408
TRG_DiLeu_BaEn_2	346	352	PF01217	0.264
TRG_DiLeu_BaEn_4	46	52	PF01217	0.163
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.535
TRG_ENDOCYTIC_2	157	160	PF00928	0.163
TRG_ENDOCYTIC_2	20	23	PF00928	0.348
TRG_ENDOCYTIC_2	272	275	PF00928	0.597
TRG_ENDOCYTIC_2	305	308	PF00928	0.323
TRG_ENDOCYTIC_2	445	448	PF00928	0.445
TRG_ENDOCYTIC_2	520	523	PF00928	0.416
TRG_ENDOCYTIC_2	558	561	PF00928	0.438
TRG_ER_diArg_1	185	188	PF00400	0.379
TRG_ER_diArg_1	523	526	PF00400	0.544
TRG_NES_CRM1_1	118	133	PF08389	0.375
TRG_NLS_MonoExtN_4	277	284	PF00514	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W2	Leptomonas seymouri	55%	95%
A0A0N1HZY0	Leptomonas seymouri	27%	95%
A0A0S4JPZ7	Bodo saltans	26%	100%
A0A1X0NYS1	Trypanosomatidae	42%	100%
A0A3S7WY10	Leishmania donovani	26%	100%
A0A3S7WZA6	Leishmania donovani	78%	99%
A0A422P4L8	Trypanosoma rangeli	45%	100%
A4H459	Leishmania braziliensis	25%	100%
A4HD79	Leishmania braziliensis	26%	100%
A4HFC9	Leishmania braziliensis	24%	86%
A4I1P7	Leishmania infantum	77%	98%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AXT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q1PFB9	Arabidopsis thaliana	25%	100%
Q4Q9P0	Leishmania major	77%	100%
Q4QH29	Leishmania major	24%	100%
Q54JG7	Dictyostelium discoideum	24%	100%
Q99078	Ustilago maydis (strain 521 / FGSC 9021)	25%	100%