Acylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acylphosphatase

Gene product:

acylphosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HE98_LEIBR

TriTrypDb:

LbrM.25.1520 , LBRM2903_250028600

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE98

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0003998	acylphosphatase activity	6	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.478
CLV_NRD_NRD_1	112	114	PF00675	0.273
CLV_NRD_NRD_1	191	193	PF00675	0.484
DOC_ANK_TNKS_1	129	136	PF00023	0.273
DOC_CYCLIN_RxL_1	43	54	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.474
DOC_PP4_FxxP_1	36	39	PF00568	0.489
DOC_WW_Pin1_4	156	161	PF00397	0.277
DOC_WW_Pin1_4	184	189	PF00397	0.527
DOC_WW_Pin1_4	37	42	PF00397	0.487
DOC_WW_Pin1_4	63	68	PF00397	0.506
LIG_14-3-3_CanoR_1	24	29	PF00244	0.507
LIG_14-3-3_CanoR_1	61	65	PF00244	0.497
LIG_14-3-3_CanoR_1	94	100	PF00244	0.496
LIG_Actin_WH2_2	103	121	PF00022	0.273
LIG_FHA_1	124	130	PF00498	0.273
LIG_FHA_1	185	191	PF00498	0.666
LIG_FHA_1	96	102	PF00498	0.273
LIG_FHA_2	163	169	PF00498	0.273
LIG_LIR_Nem_3	98	102	PF02991	0.273
LIG_SH2_CRK	115	119	PF00017	0.284
LIG_SH2_CRK	3	7	PF00017	0.460
LIG_SH2_STAT5	115	118	PF00017	0.273
LIG_SH2_STAT5	3	6	PF00017	0.461
LIG_SH2_STAT5	75	78	PF00017	0.468
LIG_SH2_STAT5	95	98	PF00017	0.352
LIG_SH3_3	46	52	PF00018	0.462
LIG_SH3_3	61	67	PF00018	0.482
LIG_SUMO_SIM_par_1	47	54	PF11976	0.469
MOD_CDK_SPxxK_3	63	70	PF00069	0.477
MOD_CK1_1	179	185	PF00069	0.736
MOD_CK1_1	53	59	PF00069	0.489
MOD_CK1_1	60	66	PF00069	0.461
MOD_CK1_1	84	90	PF00069	0.439
MOD_CK2_1	63	69	PF00069	0.578
MOD_GlcNHglycan	103	106	PF01048	0.273
MOD_GlcNHglycan	83	86	PF01048	0.427
MOD_GSK3_1	51	58	PF00069	0.482
MOD_GSK3_1	86	93	PF00069	0.421
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	123	128	PF00069	0.284
MOD_NEK2_1	55	60	PF00069	0.471
MOD_NEK2_1	90	95	PF00069	0.419
MOD_NEK2_2	12	17	PF00069	0.468
MOD_PIKK_1	143	149	PF00454	0.236
MOD_PIKK_1	170	176	PF00454	0.446
MOD_PKA_1	113	119	PF00069	0.273
MOD_PKA_1	192	198	PF00069	0.436
MOD_PKA_2	60	66	PF00069	0.509
MOD_Plk_1	170	176	PF00069	0.254
MOD_Plk_1	90	96	PF00069	0.423
MOD_ProDKin_1	156	162	PF00069	0.277
MOD_ProDKin_1	184	190	PF00069	0.526
MOD_ProDKin_1	37	43	PF00069	0.488
MOD_ProDKin_1	63	69	PF00069	0.505
TRG_ENDOCYTIC_2	115	118	PF00928	0.284
TRG_ENDOCYTIC_2	3	6	PF00928	0.461
TRG_ENDOCYTIC_2	99	102	PF00928	0.273
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDK0	Leishmania donovani	77%	100%
Q4Q9P3	Leishmania major	71%	100%