Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE96_LEIBR

TriTrypDb:

LbrM.25.1500 , LBRM2903_250028400

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.547
CLV_C14_Caspase3-7	584	588	PF00656	0.414
CLV_NRD_NRD_1	323	325	PF00675	0.435
CLV_NRD_NRD_1	501	503	PF00675	0.627
CLV_NRD_NRD_1	84	86	PF00675	0.517
CLV_PCSK_FUR_1	499	503	PF00082	0.554
CLV_PCSK_KEX2_1	104	106	PF00082	0.252
CLV_PCSK_KEX2_1	323	325	PF00082	0.431
CLV_PCSK_KEX2_1	501	503	PF00082	0.627
CLV_PCSK_KEX2_1	84	86	PF00082	0.517
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.511
CLV_PCSK_SKI1_1	101	105	PF00082	0.537
CLV_PCSK_SKI1_1	113	117	PF00082	0.476
CLV_PCSK_SKI1_1	227	231	PF00082	0.545
CLV_PCSK_SKI1_1	382	386	PF00082	0.583
CLV_PCSK_SKI1_1	452	456	PF00082	0.493
CLV_PCSK_SKI1_1	502	506	PF00082	0.721
CLV_PCSK_SKI1_1	576	580	PF00082	0.558
CLV_Separin_Metazoa	146	150	PF03568	0.501
DEG_APCC_DBOX_1	451	459	PF00400	0.551
DEG_APCC_DBOX_1	83	91	PF00400	0.495
DEG_Nend_UBRbox_3	1	3	PF02207	0.615
DEG_SPOP_SBC_1	152	156	PF00917	0.413
DOC_CKS1_1	172	177	PF01111	0.615
DOC_CKS1_1	431	436	PF01111	0.563
DOC_CYCLIN_yClb5_NLxxxL_5	71	80	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.550
DOC_MAPK_gen_1	101	111	PF00069	0.501
DOC_MAPK_MEF2A_6	104	111	PF00069	0.559
DOC_PP2B_LxvP_1	316	319	PF13499	0.592
DOC_PP2B_LxvP_1	76	79	PF13499	0.542
DOC_USP7_MATH_1	152	156	PF00917	0.413
DOC_USP7_MATH_1	274	278	PF00917	0.648
DOC_USP7_MATH_1	299	303	PF00917	0.655
DOC_USP7_MATH_1	337	341	PF00917	0.404
DOC_USP7_MATH_1	344	348	PF00917	0.308
DOC_USP7_MATH_1	474	478	PF00917	0.585
DOC_USP7_MATH_1	516	520	PF00917	0.446
DOC_USP7_MATH_1	659	663	PF00917	0.673
DOC_WW_Pin1_4	158	163	PF00397	0.447
DOC_WW_Pin1_4	171	176	PF00397	0.553
DOC_WW_Pin1_4	430	435	PF00397	0.562
LIG_14-3-3_CanoR_1	117	123	PF00244	0.537
LIG_14-3-3_CanoR_1	338	342	PF00244	0.493
LIG_14-3-3_CanoR_1	499	505	PF00244	0.619
LIG_14-3-3_CanoR_1	515	525	PF00244	0.422
LIG_14-3-3_CanoR_1	543	550	PF00244	0.425
LIG_14-3-3_CanoR_1	561	567	PF00244	0.528
LIG_14-3-3_CanoR_1	84	88	PF00244	0.388
LIG_14-3-3_CterR_2	661	664	PF00244	0.626
LIG_APCC_ABBAyCdc20_2	487	493	PF00400	0.419
LIG_BIR_III_2	201	205	PF00653	0.518
LIG_BRCT_BRCA1_1	362	366	PF00533	0.299
LIG_Clathr_ClatBox_1	563	567	PF01394	0.588
LIG_FAT_LD_1	54	62	PF03623	0.308
LIG_FHA_1	118	124	PF00498	0.539
LIG_FHA_1	154	160	PF00498	0.521
LIG_FHA_1	28	34	PF00498	0.615
LIG_FHA_1	303	309	PF00498	0.656
LIG_FHA_1	356	362	PF00498	0.540
LIG_FHA_1	39	45	PF00498	0.466
LIG_FHA_1	431	437	PF00498	0.637
LIG_FHA_1	520	526	PF00498	0.496
LIG_FHA_1	577	583	PF00498	0.501
LIG_FHA_1	655	661	PF00498	0.575
LIG_FHA_1	95	101	PF00498	0.602
LIG_FHA_2	246	252	PF00498	0.377
LIG_FHA_2	405	411	PF00498	0.540
LIG_FHA_2	422	428	PF00498	0.454
LIG_FHA_2	503	509	PF00498	0.712
LIG_FHA_2	612	618	PF00498	0.353
LIG_FHA_2	94	100	PF00498	0.618
LIG_GBD_Chelix_1	482	490	PF00786	0.604
LIG_Integrin_RGD_1	199	201	PF01839	0.537
LIG_LIR_Gen_1	139	148	PF02991	0.493
LIG_LIR_Gen_1	363	374	PF02991	0.552
LIG_LIR_Gen_1	43	53	PF02991	0.505
LIG_LIR_Nem_3	139	144	PF02991	0.475
LIG_LIR_Nem_3	163	168	PF02991	0.455
LIG_LIR_Nem_3	287	291	PF02991	0.453
LIG_LIR_Nem_3	362	368	PF02991	0.544
LIG_LIR_Nem_3	41	45	PF02991	0.551
LIG_LIR_Nem_3	74	80	PF02991	0.508
LIG_MLH1_MIPbox_1	362	366	PF16413	0.299
LIG_NRBOX	53	59	PF00104	0.556
LIG_PCNA_yPIPBox_3	386	397	PF02747	0.502
LIG_Pex14_2	364	368	PF04695	0.558
LIG_PTB_Apo_2	89	96	PF02174	0.335
LIG_SH2_CRK	322	326	PF00017	0.296
LIG_SH2_GRB2like	388	391	PF00017	0.560
LIG_SH2_NCK_1	45	49	PF00017	0.579
LIG_SH2_STAP1	597	601	PF00017	0.511
LIG_SH2_STAT5	291	294	PF00017	0.580
LIG_SH3_3	169	175	PF00018	0.585
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.305
LIG_SUMO_SIM_anti_2	233	239	PF11976	0.359
LIG_SUMO_SIM_par_1	154	161	PF11976	0.553
LIG_SUMO_SIM_par_1	30	37	PF11976	0.338
LIG_TRAF2_1	249	252	PF00917	0.611
LIG_TRAF2_1	624	627	PF00917	0.382
LIG_UBA3_1	53	62	PF00899	0.486
LIG_UBA3_1	647	652	PF00899	0.379
LIG_UBA3_1	76	81	PF00899	0.551
LIG_WRC_WIRS_1	361	366	PF05994	0.548
LIG_WRC_WIRS_1	601	606	PF05994	0.541
MOD_CK1_1	155	161	PF00069	0.453
MOD_CK1_1	233	239	PF00069	0.452
MOD_CK1_1	302	308	PF00069	0.619
MOD_CK1_1	360	366	PF00069	0.515
MOD_CK1_1	401	407	PF00069	0.648
MOD_CK1_1	519	525	PF00069	0.542
MOD_CK2_1	158	164	PF00069	0.497
MOD_CK2_1	245	251	PF00069	0.458
MOD_CK2_1	281	287	PF00069	0.507
MOD_CK2_1	40	46	PF00069	0.541
MOD_CK2_1	421	427	PF00069	0.515
MOD_CK2_1	502	508	PF00069	0.733
MOD_CK2_1	93	99	PF00069	0.619
MOD_CMANNOS	514	517	PF00535	0.553
MOD_GlcNHglycan	124	127	PF01048	0.510
MOD_GlcNHglycan	242	245	PF01048	0.663
MOD_GlcNHglycan	283	286	PF01048	0.579
MOD_GlcNHglycan	296	300	PF01048	0.462
MOD_GlcNHglycan	341	344	PF01048	0.308
MOD_GlcNHglycan	401	404	PF01048	0.763
MOD_GlcNHglycan	427	431	PF01048	0.722
MOD_GlcNHglycan	445	448	PF01048	0.536
MOD_GlcNHglycan	536	539	PF01048	0.641
MOD_GlcNHglycan	544	547	PF01048	0.541
MOD_GlcNHglycan	583	586	PF01048	0.549
MOD_GSK3_1	113	120	PF00069	0.468
MOD_GSK3_1	151	158	PF00069	0.460
MOD_GSK3_1	178	185	PF00069	0.544
MOD_GSK3_1	291	298	PF00069	0.480
MOD_GSK3_1	360	367	PF00069	0.535
MOD_GSK3_1	397	404	PF00069	0.638
MOD_GSK3_1	426	433	PF00069	0.723
MOD_GSK3_1	435	442	PF00069	0.682
MOD_GSK3_1	474	481	PF00069	0.553
MOD_GSK3_1	516	523	PF00069	0.476
MOD_GSK3_1	576	583	PF00069	0.503
MOD_GSK3_1	613	620	PF00069	0.543
MOD_NEK2_1	153	158	PF00069	0.512
MOD_NEK2_1	16	21	PF00069	0.506
MOD_NEK2_1	230	235	PF00069	0.571
MOD_NEK2_1	364	369	PF00069	0.554
MOD_NEK2_1	397	402	PF00069	0.623
MOD_NEK2_1	436	441	PF00069	0.510
MOD_NEK2_1	478	483	PF00069	0.501
MOD_NEK2_1	524	529	PF00069	0.398
MOD_NEK2_1	536	541	PF00069	0.676
MOD_NEK2_1	581	586	PF00069	0.520
MOD_PIKK_1	133	139	PF00454	0.445
MOD_PIKK_1	302	308	PF00454	0.674
MOD_PIKK_1	516	522	PF00454	0.324
MOD_PIKK_1	606	612	PF00454	0.362
MOD_PKA_2	116	122	PF00069	0.536
MOD_PKA_2	337	343	PF00069	0.441
MOD_PKA_2	421	427	PF00069	0.515
MOD_PKA_2	500	506	PF00069	0.536
MOD_PKA_2	520	526	PF00069	0.567
MOD_PKA_2	534	540	PF00069	0.532
MOD_PKA_2	542	548	PF00069	0.534
MOD_PKA_2	571	577	PF00069	0.513
MOD_PKA_2	83	89	PF00069	0.378
MOD_Plk_1	107	113	PF00069	0.420
MOD_Plk_1	295	301	PF00069	0.458
MOD_Plk_1	426	432	PF00069	0.757
MOD_Plk_1	654	660	PF00069	0.608
MOD_Plk_2-3	357	363	PF00069	0.569
MOD_Plk_4	107	113	PF00069	0.369
MOD_Plk_4	208	214	PF00069	0.585
MOD_Plk_4	233	239	PF00069	0.460
MOD_Plk_4	360	366	PF00069	0.554
MOD_Plk_4	40	46	PF00069	0.578
MOD_Plk_4	474	480	PF00069	0.490
MOD_Plk_4	509	515	PF00069	0.597
MOD_Plk_4	520	526	PF00069	0.482
MOD_Plk_4	617	623	PF00069	0.399
MOD_ProDKin_1	158	164	PF00069	0.444
MOD_ProDKin_1	171	177	PF00069	0.559
MOD_ProDKin_1	430	436	PF00069	0.561
MOD_SUMO_rev_2	639	644	PF00179	0.431
TRG_DiLeu_BaEn_1	164	169	PF01217	0.445
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.452
TRG_ENDOCYTIC_2	165	168	PF00928	0.500
TRG_ENDOCYTIC_2	322	325	PF00928	0.550
TRG_ENDOCYTIC_2	353	356	PF00928	0.575
TRG_ENDOCYTIC_2	45	48	PF00928	0.506
TRG_ER_diArg_1	322	324	PF00400	0.434
TRG_ER_diArg_1	420	423	PF00400	0.514
TRG_ER_diArg_1	499	502	PF00400	0.645
TRG_ER_diArg_1	83	85	PF00400	0.588
TRG_NES_CRM1_1	558	571	PF08389	0.522
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9N5	Leptomonas seymouri	39%	100%
A0A3Q8INM1	Leishmania donovani	78%	100%
A4I1P2	Leishmania infantum	77%	100%
C9ZK91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AXS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q9P5	Leishmania major	76%	100%