RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE95_LEIBR

TriTrypDb:

LbrM.25.1490 , LBRM2903_250028300

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE95

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.633
CLV_NRD_NRD_1	129	131	PF00675	0.472
CLV_NRD_NRD_1	211	213	PF00675	0.487
CLV_NRD_NRD_1	221	223	PF00675	0.520
CLV_PCSK_KEX2_1	128	130	PF00082	0.437
CLV_PCSK_KEX2_1	151	153	PF00082	0.358
CLV_PCSK_KEX2_1	213	215	PF00082	0.493
CLV_PCSK_KEX2_1	221	223	PF00082	0.520
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.437
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.358
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.493
CLV_PCSK_PC7_1	125	131	PF00082	0.373
CLV_PCSK_SKI1_1	125	129	PF00082	0.485
CLV_PCSK_SKI1_1	37	41	PF00082	0.433
DEG_SPOP_SBC_1	78	82	PF00917	0.463
DOC_CYCLIN_RxL_1	189	199	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	119	122	PF00134	0.469
DOC_PP2B_LxvP_1	119	122	PF13499	0.469
DOC_PP2B_LxvP_1	194	197	PF13499	0.647
DOC_USP7_MATH_1	101	105	PF00917	0.528
DOC_USP7_MATH_1	77	81	PF00917	0.663
DOC_WW_Pin1_4	14	19	PF00397	0.460
LIG_14-3-3_CanoR_1	37	44	PF00244	0.439
LIG_Actin_WH2_2	112	127	PF00022	0.479
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_FHA_1	15	21	PF00498	0.496
LIG_FHA_1	28	34	PF00498	0.512
LIG_FHA_1	48	54	PF00498	0.391
LIG_FHA_1	79	85	PF00498	0.622
LIG_FHA_1	98	104	PF00498	0.439
LIG_IRF3_LxIS_1	18	24	PF10401	0.459
LIG_LIR_Apic_2	51	57	PF02991	0.480
LIG_LIR_Apic_2	69	73	PF02991	0.471
LIG_LIR_Gen_1	133	143	PF02991	0.500
LIG_LIR_Nem_3	133	139	PF02991	0.509
LIG_LIR_Nem_3	24	29	PF02991	0.418
LIG_SH2_CRK	54	58	PF00017	0.466
LIG_SH2_CRK	70	74	PF00017	0.440
LIG_SH2_GRB2like	54	57	PF00017	0.464
LIG_SH2_NCK_1	136	140	PF00017	0.450
LIG_SH2_NCK_1	54	58	PF00017	0.474
LIG_SH2_NCK_1	70	74	PF00017	0.440
LIG_SH2_STAP1	136	140	PF00017	0.477
LIG_SH2_STAP1	29	33	PF00017	0.379
LIG_SH2_STAT5	140	143	PF00017	0.381
LIG_SH2_STAT5	146	149	PF00017	0.362
LIG_SH2_STAT5	29	32	PF00017	0.368
LIG_SH2_STAT5	38	41	PF00017	0.382
LIG_SH2_STAT5	54	57	PF00017	0.391
LIG_SH3_3	157	163	PF00018	0.441
LIG_SUMO_SIM_par_1	19	24	PF11976	0.396
LIG_TRFH_1	70	74	PF08558	0.553
MOD_GlcNHglycan	109	112	PF01048	0.658
MOD_GlcNHglycan	11	14	PF01048	0.503
MOD_GlcNHglycan	165	169	PF01048	0.662
MOD_GlcNHglycan	218	221	PF01048	0.623
MOD_GlcNHglycan	223	226	PF01048	0.654
MOD_GlcNHglycan	227	230	PF01048	0.686
MOD_GlcNHglycan	23	26	PF01048	0.363
MOD_GlcNHglycan	75	78	PF01048	0.650
MOD_GlcNHglycan	81	84	PF01048	0.674
MOD_GlcNHglycan	92	95	PF01048	0.666
MOD_GSK3_1	147	154	PF00069	0.476
MOD_GSK3_1	221	228	PF00069	0.683
MOD_GSK3_1	48	55	PF00069	0.437
MOD_GSK3_1	73	80	PF00069	0.539
MOD_GSK3_1	97	104	PF00069	0.637
MOD_NEK2_1	21	26	PF00069	0.408
MOD_NEK2_1	215	220	PF00069	0.633
MOD_PKA_1	151	157	PF00069	0.373
MOD_PKA_1	221	227	PF00069	0.656
MOD_PKA_2	107	113	PF00069	0.456
MOD_PKA_2	151	157	PF00069	0.544
MOD_PKA_2	215	221	PF00069	0.629
MOD_PKB_1	212	220	PF00069	0.570
MOD_ProDKin_1	14	20	PF00069	0.447
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.516
TRG_ENDOCYTIC_2	136	139	PF00928	0.502
TRG_ER_diArg_1	129	131	PF00400	0.373
TRG_ER_diArg_1	211	214	PF00400	0.529
TRG_NLS_MonoExtC_3	211	216	PF00514	0.490
TRG_NLS_MonoExtN_4	212	217	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I303	Leptomonas seymouri	64%	100%
A0A0S4JSH4	Bodo saltans	29%	100%
A0A1X0NZI8	Trypanosomatidae	46%	91%
A0A3R7P4N9	Trypanosoma rangeli	44%	98%
A0A3S7WZA1	Leishmania donovani	85%	100%
A4I1P1	Leishmania infantum	85%	100%
C9ZK90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q9P6	Leishmania major	82%	100%