TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE94_LEIBR

TriTrypDb:

LbrM.25.1480 , LBRM2903_250028200

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4
GO:0031514	motile cilium	5	3

Expansion

Sequence features

A4HE94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE94

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.366
CLV_NRD_NRD_1	158	160	PF00675	0.461
CLV_NRD_NRD_1	183	185	PF00675	0.358
CLV_NRD_NRD_1	73	75	PF00675	0.583
CLV_NRD_NRD_1	9	11	PF00675	0.693
CLV_PCSK_FUR_1	71	75	PF00082	0.467
CLV_PCSK_KEX2_1	183	185	PF00082	0.358
CLV_PCSK_KEX2_1	31	33	PF00082	0.677
CLV_PCSK_KEX2_1	73	75	PF00082	0.595
CLV_PCSK_KEX2_1	97	99	PF00082	0.603
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.677
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.603
CLV_PCSK_SKI1_1	159	163	PF00082	0.442
CLV_PCSK_SKI1_1	26	30	PF00082	0.671
CLV_PCSK_SKI1_1	41	45	PF00082	0.679
CLV_Separin_Metazoa	180	184	PF03568	0.332
DEG_APCC_DBOX_1	470	478	PF00400	0.498
DEG_Nend_UBRbox_2	1	3	PF02207	0.481
DOC_MAPK_MEF2A_6	331	338	PF00069	0.418
DOC_MAPK_NFAT4_5	331	339	PF00069	0.421
DOC_PP1_RVXF_1	166	172	PF00149	0.335
DOC_PP2B_LxvP_1	391	394	PF13499	0.423
DOC_PP4_FxxP_1	162	165	PF00568	0.333
DOC_PP4_FxxP_1	291	294	PF00568	0.389
DOC_USP7_MATH_1	13	17	PF00917	0.656
DOC_USP7_MATH_1	21	25	PF00917	0.640
DOC_USP7_MATH_1	475	479	PF00917	0.509
DOC_WW_Pin1_4	36	41	PF00397	0.618
DOC_WW_Pin1_4	50	55	PF00397	0.617
LIG_14-3-3_CanoR_1	159	165	PF00244	0.275
LIG_14-3-3_CanoR_1	183	192	PF00244	0.336
LIG_14-3-3_CanoR_1	32	40	PF00244	0.499
LIG_14-3-3_CanoR_1	342	348	PF00244	0.496
LIG_14-3-3_CanoR_1	61	65	PF00244	0.717
LIG_BRCT_BRCA1_1	121	125	PF00533	0.345
LIG_BRCT_BRCA1_1	157	161	PF00533	0.464
LIG_FHA_1	359	365	PF00498	0.406
LIG_FHA_1	399	405	PF00498	0.331
LIG_FHA_1	437	443	PF00498	0.408
LIG_FHA_1	53	59	PF00498	0.738
LIG_FHA_1	76	82	PF00498	0.734
LIG_FHA_2	238	244	PF00498	0.510
LIG_FHA_2	378	384	PF00498	0.466
LIG_FHA_2	51	57	PF00498	0.480
LIG_FHA_2	70	76	PF00498	0.626
LIG_Integrin_RGD_1	331	333	PF01839	0.500
LIG_Integrin_RGD_1	448	450	PF01839	0.478
LIG_LIR_Gen_1	186	192	PF02991	0.370
LIG_LIR_Gen_1	2	13	PF02991	0.518
LIG_LIR_Gen_1	236	243	PF02991	0.289
LIG_LIR_Gen_1	460	470	PF02991	0.364
LIG_LIR_Nem_3	158	164	PF02991	0.496
LIG_LIR_Nem_3	186	191	PF02991	0.352
LIG_LIR_Nem_3	2	8	PF02991	0.671
LIG_LIR_Nem_3	236	241	PF02991	0.265
LIG_LIR_Nem_3	343	347	PF02991	0.288
LIG_LIR_Nem_3	460	465	PF02991	0.353
LIG_Pex14_2	421	425	PF04695	0.381
LIG_Rb_LxCxE_1	414	435	PF01857	0.264
LIG_SH2_CRK	321	325	PF00017	0.399
LIG_SH2_CRK	344	348	PF00017	0.243
LIG_SH2_NCK_1	208	212	PF00017	0.435
LIG_SH2_NCK_1	301	305	PF00017	0.409
LIG_SH2_PTP2	140	143	PF00017	0.327
LIG_SH2_SRC	208	211	PF00017	0.462
LIG_SH2_STAP1	208	212	PF00017	0.364
LIG_SH2_STAP1	215	219	PF00017	0.286
LIG_SH2_STAP1	255	259	PF00017	0.390
LIG_SH2_STAP1	301	305	PF00017	0.409
LIG_SH2_STAT5	140	143	PF00017	0.334
LIG_SH2_STAT5	201	204	PF00017	0.321
LIG_SH2_STAT5	301	304	PF00017	0.534
LIG_SH2_STAT5	452	455	PF00017	0.366
LIG_SH2_STAT5	462	465	PF00017	0.322
LIG_SH2_STAT5	467	470	PF00017	0.339
LIG_SH3_3	6	12	PF00018	0.669
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.335
LIG_SUMO_SIM_par_1	112	119	PF11976	0.475
LIG_TRAF2_1	240	243	PF00917	0.460
LIG_TRAF2_1	380	383	PF00917	0.428
LIG_TRAF2_1	83	86	PF00917	0.495
LIG_TRFH_1	5	9	PF08558	0.468
LIG_TYR_ITIM	465	470	PF00017	0.428
LIG_WRC_WIRS_1	238	243	PF05994	0.377
MOD_CDK_SPK_2	36	41	PF00069	0.503
MOD_CK1_1	3	9	PF00069	0.684
MOD_CK1_1	343	349	PF00069	0.250
MOD_CK1_1	35	41	PF00069	0.732
MOD_CK2_1	13	19	PF00069	0.583
MOD_CK2_1	174	180	PF00069	0.331
MOD_CK2_1	183	189	PF00069	0.368
MOD_CK2_1	237	243	PF00069	0.505
MOD_CK2_1	377	383	PF00069	0.432
MOD_CK2_1	69	75	PF00069	0.624
MOD_GlcNHglycan	15	18	PF01048	0.541
MOD_GlcNHglycan	176	179	PF01048	0.324
MOD_GlcNHglycan	2	5	PF01048	0.726
MOD_GlcNHglycan	23	26	PF01048	0.704
MOD_GlcNHglycan	321	324	PF01048	0.370
MOD_GlcNHglycan	44	47	PF01048	0.598
MOD_GlcNHglycan	477	480	PF01048	0.527
MOD_GSK3_1	115	122	PF00069	0.366
MOD_GSK3_1	222	229	PF00069	0.502
MOD_GSK3_1	32	39	PF00069	0.691
MOD_GSK3_1	81	88	PF00069	0.663
MOD_N-GLC_1	36	41	PF02516	0.665
MOD_NEK2_1	33	38	PF00069	0.575
MOD_NEK2_1	375	380	PF00069	0.479
MOD_NEK2_1	421	426	PF00069	0.417
MOD_NEK2_1	436	441	PF00069	0.249
MOD_NEK2_1	66	71	PF00069	0.495
MOD_NEK2_2	358	363	PF00069	0.358
MOD_PIKK_1	81	87	PF00454	0.565
MOD_PK_1	160	166	PF00069	0.270
MOD_PKA_1	183	189	PF00069	0.350
MOD_PKA_2	119	125	PF00069	0.508
MOD_PKA_2	183	189	PF00069	0.350
MOD_PKA_2	222	228	PF00069	0.366
MOD_PKA_2	60	66	PF00069	0.558
MOD_PKA_2	81	87	PF00069	0.482
MOD_Plk_1	226	232	PF00069	0.565
MOD_Plk_1	267	273	PF00069	0.422
MOD_Plk_1	421	427	PF00069	0.411
MOD_ProDKin_1	36	42	PF00069	0.619
MOD_ProDKin_1	50	56	PF00069	0.618
MOD_SUMO_for_1	373	376	PF00179	0.513
MOD_SUMO_rev_2	107	112	PF00179	0.444
TRG_DiLeu_BaEn_4	368	374	PF01217	0.486
TRG_ENDOCYTIC_2	140	143	PF00928	0.418
TRG_ENDOCYTIC_2	238	241	PF00928	0.344
TRG_ENDOCYTIC_2	255	258	PF00928	0.310
TRG_ENDOCYTIC_2	321	324	PF00928	0.378
TRG_ENDOCYTIC_2	344	347	PF00928	0.325
TRG_ENDOCYTIC_2	462	465	PF00928	0.338
TRG_ENDOCYTIC_2	467	470	PF00928	0.367
TRG_ER_diArg_1	182	184	PF00400	0.353
TRG_ER_diArg_1	408	411	PF00400	0.489
TRG_ER_diArg_1	71	74	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG68	Leptomonas seymouri	71%	91%
A0A1X0NYE0	Trypanosomatidae	49%	95%
A0A3Q8ICL8	Leishmania donovani	79%	98%
A0A3R7MX90	Trypanosoma rangeli	46%	100%
A4I1P0	Leishmania infantum	79%	98%
C9ZK89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q32NR4	Xenopus laevis	23%	99%
Q4Q9P7	Leishmania major	77%	100%
Q4R6M4	Macaca fascicularis	24%	100%
Q6AYP3	Rattus norvegicus	25%	100%
Q80VM3	Mus musculus	25%	100%
Q8NA56	Homo sapiens	23%	100%
V5B2E8	Trypanosoma cruzi	47%	100%