Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE93_LEIBR

TriTrypDb:

LbrM.25.1470 , LBRM2903_250028100

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.724
CLV_NRD_NRD_1	16	18	PF00675	0.476
CLV_NRD_NRD_1	192	194	PF00675	0.527
CLV_NRD_NRD_1	248	250	PF00675	0.697
CLV_NRD_NRD_1	261	263	PF00675	0.632
CLV_NRD_NRD_1	398	400	PF00675	0.400
CLV_PCSK_KEX2_1	192	194	PF00082	0.679
CLV_PCSK_KEX2_1	261	263	PF00082	0.720
CLV_PCSK_KEX2_1	398	400	PF00082	0.347
CLV_PCSK_SKI1_1	270	274	PF00082	0.761
DEG_APCC_DBOX_1	316	324	PF00400	0.519
DEG_SPOP_SBC_1	199	203	PF00917	0.421
DEG_SPOP_SBC_1	294	298	PF00917	0.532
DOC_CKS1_1	27	32	PF01111	0.480
DOC_CYCLIN_yCln2_LP_2	323	326	PF00134	0.462
DOC_MAPK_MEF2A_6	222	231	PF00069	0.488
DOC_PP2B_LxvP_1	323	326	PF13499	0.500
DOC_USP7_MATH_1	199	203	PF00917	0.440
DOC_USP7_MATH_1	275	279	PF00917	0.674
DOC_USP7_MATH_1	306	310	PF00917	0.717
DOC_USP7_MATH_1	348	352	PF00917	0.651
DOC_USP7_MATH_1	402	406	PF00917	0.513
DOC_USP7_UBL2_3	270	274	PF12436	0.761
DOC_WW_Pin1_4	174	179	PF00397	0.801
DOC_WW_Pin1_4	237	242	PF00397	0.552
DOC_WW_Pin1_4	26	31	PF00397	0.479
DOC_WW_Pin1_4	344	349	PF00397	0.499
DOC_WW_Pin1_4	41	46	PF00397	0.449
DOC_WW_Pin1_4	91	96	PF00397	0.428
LIG_14-3-3_CanoR_1	111	118	PF00244	0.503
LIG_14-3-3_CanoR_1	149	157	PF00244	0.460
LIG_14-3-3_CanoR_1	192	200	PF00244	0.726
LIG_14-3-3_CanoR_1	261	269	PF00244	0.509
LIG_14-3-3_CanoR_1	317	321	PF00244	0.563
LIG_14-3-3_CanoR_1	327	335	PF00244	0.452
LIG_Actin_WH2_2	308	324	PF00022	0.588
LIG_Actin_WH2_2	403	420	PF00022	0.568
LIG_Actin_WH2_2	72	90	PF00022	0.381
LIG_Clathr_ClatBox_1	81	85	PF01394	0.365
LIG_CtBP_PxDLS_1	40	44	PF00389	0.493
LIG_DLG_GKlike_1	413	421	PF00625	0.465
LIG_FHA_1	160	166	PF00498	0.345
LIG_FHA_1	224	230	PF00498	0.540
LIG_FHA_1	238	244	PF00498	0.446
LIG_FHA_1	30	36	PF00498	0.492
LIG_FHA_1	406	412	PF00498	0.304
LIG_FHA_1	72	78	PF00498	0.380
LIG_FHA_2	129	135	PF00498	0.503
LIG_GBD_Chelix_1	79	87	PF00786	0.368
LIG_LIR_Gen_1	146	154	PF02991	0.486
LIG_LIR_Gen_1	50	60	PF02991	0.472
LIG_LIR_Nem_3	120	126	PF02991	0.285
LIG_LIR_Nem_3	146	150	PF02991	0.439
LIG_LIR_Nem_3	50	56	PF02991	0.481
LIG_MYND_1	37	41	PF01753	0.488
LIG_PDZ_Class_3	431	436	PF00595	0.654
LIG_Pex14_1	118	122	PF04695	0.414
LIG_RPA_C_Fungi	408	420	PF08784	0.307
LIG_SH2_CRK	123	127	PF00017	0.288
LIG_SH2_CRK	53	57	PF00017	0.473
LIG_SH2_STAP1	225	229	PF00017	0.590
LIG_SH2_STAT5	225	228	PF00017	0.535
LIG_SH2_STAT5	333	336	PF00017	0.480
LIG_SH3_3	166	172	PF00018	0.661
LIG_SH3_3	34	40	PF00018	0.492
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.362
LIG_SUMO_SIM_par_1	159	164	PF11976	0.338
LIG_SUMO_SIM_par_1	225	230	PF11976	0.593
LIG_SUMO_SIM_par_1	371	377	PF11976	0.570
LIG_SUMO_SIM_par_1	78	85	PF11976	0.362
LIG_TRAF2_1	156	159	PF00917	0.306
LIG_TRAF2_1	254	257	PF00917	0.568
LIG_TRAF2_1	278	281	PF00917	0.505
LIG_TRAF2_1	420	423	PF00917	0.313
LIG_TYR_ITIM	121	126	PF00017	0.283
LIG_UBA3_1	372	378	PF00899	0.444
LIG_WW_1	325	328	PF00397	0.516
LIG_WW_3	324	328	PF00397	0.506
MOD_CDK_SPxxK_3	41	48	PF00069	0.494
MOD_CDK_SPxxK_3	91	98	PF00069	0.405
MOD_CK1_1	201	207	PF00069	0.423
MOD_CK1_1	260	266	PF00069	0.620
MOD_CK1_1	288	294	PF00069	0.668
MOD_CK1_1	405	411	PF00069	0.569
MOD_CK1_1	89	95	PF00069	0.532
MOD_CK2_1	128	134	PF00069	0.477
MOD_CK2_1	153	159	PF00069	0.505
MOD_CK2_1	161	167	PF00069	0.580
MOD_CK2_1	274	280	PF00069	0.686
MOD_CK2_1	378	384	PF00069	0.544
MOD_GlcNHglycan	196	199	PF01048	0.720
MOD_GlcNHglycan	2	5	PF01048	0.498
MOD_GlcNHglycan	300	303	PF01048	0.758
MOD_GlcNHglycan	349	353	PF01048	0.787
MOD_GlcNHglycan	404	407	PF01048	0.555
MOD_GSK3_1	149	156	PF00069	0.510
MOD_GSK3_1	161	168	PF00069	0.578
MOD_GSK3_1	174	181	PF00069	0.689
MOD_GSK3_1	194	201	PF00069	0.681
MOD_GSK3_1	223	230	PF00069	0.515
MOD_GSK3_1	260	267	PF00069	0.701
MOD_GSK3_1	294	301	PF00069	0.638
MOD_GSK3_1	31	38	PF00069	0.494
MOD_GSK3_1	344	351	PF00069	0.651
MOD_GSK3_1	401	408	PF00069	0.565
MOD_GSK3_1	71	78	PF00069	0.554
MOD_LATS_1	191	197	PF00433	0.517
MOD_N-GLC_1	352	357	PF02516	0.801
MOD_N-GLC_2	242	244	PF02516	0.654
MOD_NEK2_1	161	166	PF00069	0.493
MOD_NEK2_1	200	205	PF00069	0.383
MOD_NEK2_1	285	290	PF00069	0.530
MOD_NEK2_1	31	36	PF00069	0.494
MOD_PIKK_1	149	155	PF00454	0.563
MOD_PKA_1	192	198	PF00069	0.510
MOD_PKA_2	110	116	PF00069	0.413
MOD_PKA_2	148	154	PF00069	0.487
MOD_PKA_2	192	198	PF00069	0.510
MOD_PKA_2	260	266	PF00069	0.680
MOD_PKA_2	316	322	PF00069	0.478
MOD_Plk_4	117	123	PF00069	0.512
MOD_Plk_4	268	274	PF00069	0.715
MOD_Plk_4	316	322	PF00069	0.549
MOD_ProDKin_1	174	180	PF00069	0.803
MOD_ProDKin_1	237	243	PF00069	0.554
MOD_ProDKin_1	26	32	PF00069	0.479
MOD_ProDKin_1	344	350	PF00069	0.505
MOD_ProDKin_1	41	47	PF00069	0.449
MOD_ProDKin_1	91	97	PF00069	0.413
MOD_SUMO_rev_2	246	252	PF00179	0.590
MOD_SUMO_rev_2	264	272	PF00179	0.755
TRG_DiLeu_BaEn_1	281	286	PF01217	0.801
TRG_DiLeu_BaEn_1	316	321	PF01217	0.556
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.566
TRG_ENDOCYTIC_2	123	126	PF00928	0.289
TRG_ENDOCYTIC_2	391	394	PF00928	0.292
TRG_ENDOCYTIC_2	53	56	PF00928	0.475
TRG_ER_diArg_1	192	194	PF00400	0.527
TRG_NES_CRM1_1	153	167	PF08389	0.330
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I869	Leptomonas seymouri	44%	100%
A0A3Q8IFE5	Leishmania donovani	67%	100%
A4I1N9	Leishmania infantum	67%	100%
C9ZK88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AXS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q9P8	Leishmania major	66%	96%
V5BHX9	Trypanosoma cruzi	25%	100%