Phosphopantothenate--cysteine ligase (CTP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantothenate--cysteine ligase, putative

Species:

Leishmania braziliensis

UniProt:

A4HE92_LEIBR

TriTrypDb:

LbrM.25.1460 , LBRM2903_250028000

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HE92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE92

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009152	purine ribonucleotide biosynthetic process	7	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0015936	coenzyme A metabolic process	6	11
GO:0015937	coenzyme A biosynthetic process	7	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033866	nucleoside bisphosphate biosynthetic process	6	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072522	purine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004632	phosphopantothenate--cysteine ligase activity	5	2
GO:0016874	ligase activity	2	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.285
CLV_NRD_NRD_1	257	259	PF00675	0.323
CLV_PCSK_KEX2_1	101	103	PF00082	0.288
CLV_PCSK_KEX2_1	257	259	PF00082	0.323
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.323
CLV_PCSK_SKI1_1	101	105	PF00082	0.351
CLV_PCSK_SKI1_1	222	226	PF00082	0.381
CLV_PCSK_SKI1_1	63	67	PF00082	0.266
DEG_APCC_DBOX_1	100	108	PF00400	0.237
DEG_Nend_UBRbox_3	1	3	PF02207	0.347
DOC_CYCLIN_RxL_1	216	230	PF00134	0.300
DOC_PP2B_LxvP_1	218	221	PF13499	0.166
DOC_USP7_MATH_1	115	119	PF00917	0.308
DOC_USP7_MATH_1	190	194	PF00917	0.247
DOC_USP7_MATH_1	200	204	PF00917	0.247
DOC_WW_Pin1_4	122	127	PF00397	0.510
LIG_14-3-3_CanoR_1	20	28	PF00244	0.391
LIG_eIF4E_1	280	286	PF01652	0.325
LIG_FHA_1	107	113	PF00498	0.296
LIG_FHA_1	142	148	PF00498	0.409
LIG_FHA_1	212	218	PF00498	0.312
LIG_FHA_1	244	250	PF00498	0.261
LIG_FHA_1	52	58	PF00498	0.379
LIG_FHA_2	118	124	PF00498	0.483
LIG_FHA_2	153	159	PF00498	0.263
LIG_FHA_2	249	255	PF00498	0.266
LIG_FHA_2	78	84	PF00498	0.261
LIG_LIR_Apic_2	193	198	PF02991	0.247
LIG_LIR_Gen_1	158	166	PF02991	0.298
LIG_LIR_Gen_1	282	287	PF02991	0.362
LIG_LIR_Gen_1	83	91	PF02991	0.379
LIG_LIR_Nem_3	158	162	PF02991	0.332
LIG_LIR_Nem_3	193	199	PF02991	0.276
LIG_LIR_Nem_3	282	286	PF02991	0.366
LIG_LIR_Nem_3	313	318	PF02991	0.345
LIG_LIR_Nem_3	83	89	PF02991	0.379
LIG_NRP_CendR_1	320	321	PF00754	0.540
LIG_PCNA_PIPBox_1	2	11	PF02747	0.452
LIG_PCNA_PIPBox_1	25	34	PF02747	0.242
LIG_PCNA_yPIPBox_3	20	32	PF02747	0.240
LIG_Pex14_1	283	287	PF04695	0.405
LIG_Pex14_2	243	247	PF04695	0.261
LIG_Pex14_2	64	68	PF04695	0.326
LIG_PTB_Apo_2	3	10	PF02174	0.242
LIG_PTB_Phospho_1	3	9	PF10480	0.236
LIG_SH2_PTP2	159	162	PF00017	0.402
LIG_SH2_PTP2	196	199	PF00017	0.370
LIG_SH2_STAP1	9	13	PF00017	0.444
LIG_SH2_STAT5	150	153	PF00017	0.313
LIG_SH2_STAT5	159	162	PF00017	0.331
LIG_SH2_STAT5	196	199	PF00017	0.268
LIG_SH2_STAT5	287	290	PF00017	0.390
LIG_SH2_STAT5	47	50	PF00017	0.305
LIG_SH2_STAT5	76	79	PF00017	0.201
LIG_SH3_1	37	43	PF00018	0.416
LIG_SH3_3	194	200	PF00018	0.370
LIG_SH3_3	37	43	PF00018	0.472
LIG_SUMO_SIM_par_1	161	167	PF11976	0.333
LIG_TRAF2_1	251	254	PF00917	0.266
LIG_TYR_ITIM	157	162	PF00017	0.336
LIG_WRC_WIRS_1	244	249	PF05994	0.247
LIG_WRC_WIRS_1	28	33	PF05994	0.362
MOD_CK1_1	291	297	PF00069	0.397
MOD_CK1_1	50	56	PF00069	0.284
MOD_CK2_1	117	123	PF00069	0.518
MOD_CK2_1	152	158	PF00069	0.271
MOD_CK2_1	248	254	PF00069	0.266
MOD_CK2_1	27	33	PF00069	0.354
MOD_CK2_1	276	282	PF00069	0.405
MOD_CK2_1	77	83	PF00069	0.261
MOD_GlcNHglycan	13	16	PF01048	0.466
MOD_GlcNHglycan	207	210	PF01048	0.266
MOD_GlcNHglycan	21	24	PF01048	0.486
MOD_GlcNHglycan	292	296	PF01048	0.464
MOD_GlcNHglycan	49	52	PF01048	0.263
MOD_GlcNHglycan	69	72	PF01048	0.118
MOD_GSK3_1	46	53	PF00069	0.245
MOD_GSK3_1	63	70	PF00069	0.232
MOD_N-GLC_1	11	16	PF02516	0.267
MOD_N-GLC_1	66	71	PF02516	0.247
MOD_NEK2_1	170	175	PF00069	0.333
MOD_NEK2_1	243	248	PF00069	0.424
MOD_NEK2_1	77	82	PF00069	0.197
MOD_PIKK_1	237	243	PF00454	0.323
MOD_PKA_2	19	25	PF00069	0.396
MOD_Plk_1	211	217	PF00069	0.166
MOD_Plk_4	152	158	PF00069	0.289
MOD_Plk_4	24	30	PF00069	0.402
MOD_ProDKin_1	122	128	PF00069	0.510
MOD_SUMO_for_1	247	250	PF00179	0.247
TRG_DiLeu_BaEn_1	158	163	PF01217	0.266
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.308
TRG_ENDOCYTIC_2	150	153	PF00928	0.308
TRG_ENDOCYTIC_2	159	162	PF00928	0.323
TRG_ENDOCYTIC_2	196	199	PF00928	0.379
TRG_ER_diArg_1	100	102	PF00400	0.288
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I9	Leptomonas seymouri	69%	100%
A0A0S4JKM7	Bodo saltans	35%	87%
A0A1X0NYS8	Trypanosomatidae	43%	99%
A0A3Q8ICG6	Leishmania donovani	77%	82%
A0A3R7MC75	Trypanosoma rangeli	43%	100%
A4I1N8	Leishmania infantum	77%	82%
C9ZK87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	81%
P40506	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	88%
Q0J7N5	Oryza sativa subsp. japonica	34%	99%
Q4Q9P9	Leishmania major	75%	100%
Q69S81	Oryza sativa subsp. japonica	39%	100%
Q8GXR5	Arabidopsis thaliana	34%	100%
Q8VDG5	Mus musculus	33%	100%
Q9HAB8	Homo sapiens	34%	100%
Q9LZM3	Arabidopsis thaliana	33%	100%
Q9USK7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
V5BS04	Trypanosoma cruzi	45%	100%