Proteasome assembly chaperone 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE91_LEIBR

TriTrypDb:

LbrM.25.1450 , LBRM2903_250027900

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE91

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0043248	proteasome assembly	6	6
GO:0043933	protein-containing complex organization	4	6
GO:0065003	protein-containing complex assembly	5	6
GO:0071840	cellular component organization or biogenesis	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.501
CLV_NRD_NRD_1	201	203	PF00675	0.529
CLV_PCSK_FUR_1	199	203	PF00082	0.529
CLV_PCSK_KEX2_1	201	203	PF00082	0.529
CLV_PCSK_SKI1_1	124	128	PF00082	0.606
CLV_PCSK_SKI1_1	207	211	PF00082	0.529
CLV_PCSK_SKI1_1	228	232	PF00082	0.574
DEG_APCC_DBOX_1	206	214	PF00400	0.529
DEG_Nend_UBRbox_1	1	4	PF02207	0.583
DEG_SPOP_SBC_1	71	75	PF00917	0.567
DOC_CYCLIN_RxL_1	225	233	PF00134	0.599
DOC_MAPK_FxFP_2	97	100	PF00069	0.608
DOC_MAPK_MEF2A_6	124	131	PF00069	0.583
DOC_MAPK_MEF2A_6	207	215	PF00069	0.529
DOC_MAPK_NFAT4_5	124	132	PF00069	0.586
DOC_PP1_RVXF_1	91	98	PF00149	0.629
DOC_PP4_FxxP_1	97	100	PF00568	0.645
DOC_USP7_MATH_1	21	25	PF00917	0.546
DOC_USP7_MATH_1	72	76	PF00917	0.637
DOC_USP7_MATH_1	79	83	PF00917	0.525
DOC_WW_Pin1_4	169	174	PF00397	0.529
DOC_WW_Pin1_4	19	24	PF00397	0.551
DOC_WW_Pin1_4	246	251	PF00397	0.759
DOC_WW_Pin1_4	26	31	PF00397	0.571
DOC_WW_Pin1_4	41	46	PF00397	0.712
DOC_WW_Pin1_4	75	80	PF00397	0.802
LIG_14-3-3_CanoR_1	60	66	PF00244	0.739
LIG_14-3-3_CanoR_1	81	85	PF00244	0.644
LIG_BIR_III_4	118	122	PF00653	0.478
LIG_BRCT_BRCA1_1	173	177	PF00533	0.529
LIG_eIF4E_1	234	240	PF01652	0.343
LIG_FHA_1	170	176	PF00498	0.529
LIG_FHA_1	187	193	PF00498	0.249
LIG_FHA_1	204	210	PF00498	0.249
LIG_FHA_1	81	87	PF00498	0.525
LIG_FHA_2	108	114	PF00498	0.547
LIG_FHA_2	216	222	PF00498	0.261
LIG_LIR_Apic_2	94	100	PF02991	0.634
LIG_LIR_Gen_1	136	145	PF02991	0.569
LIG_LIR_Gen_1	174	183	PF02991	0.529
LIG_LIR_Nem_3	136	140	PF02991	0.440
LIG_LIR_Nem_3	174	180	PF02991	0.529
LIG_SH2_CRK	156	160	PF00017	0.643
LIG_SH2_NCK_1	156	160	PF00017	0.643
LIG_SH2_SRC	48	51	PF00017	0.546
LIG_SH2_STAP1	48	52	PF00017	0.544
LIG_SH2_STAT5	137	140	PF00017	0.562
LIG_SH2_STAT5	234	237	PF00017	0.304
LIG_SH3_3	2	8	PF00018	0.551
LIG_SH3_3	62	68	PF00018	0.714
LIG_SH3_CIN85_PxpxPR_1	7	12	PF14604	0.550
LIG_TYR_ITIM	135	140	PF00017	0.588
MOD_CDK_SPxK_1	75	81	PF00069	0.555
MOD_CK1_1	104	110	PF00069	0.680
MOD_CK1_1	19	25	PF00069	0.550
MOD_CK1_1	63	69	PF00069	0.634
MOD_CK1_1	75	81	PF00069	0.745
MOD_CK2_1	107	113	PF00069	0.546
MOD_CK2_1	211	217	PF00069	0.261
MOD_CK2_1	79	85	PF00069	0.540
MOD_GlcNHglycan	103	106	PF01048	0.490
MOD_GlcNHglycan	163	166	PF01048	0.467
MOD_GlcNHglycan	223	226	PF01048	0.426
MOD_GlcNHglycan	38	41	PF01048	0.559
MOD_GlcNHglycan	74	77	PF01048	0.562
MOD_GSK3_1	101	108	PF00069	0.743
MOD_GSK3_1	140	147	PF00069	0.493
MOD_GSK3_1	171	178	PF00069	0.472
MOD_GSK3_1	21	28	PF00069	0.544
MOD_GSK3_1	211	218	PF00069	0.529
MOD_GSK3_1	71	78	PF00069	0.658
MOD_N-GLC_1	16	21	PF02516	0.562
MOD_N-GLC_1	41	46	PF02516	0.552
MOD_N-GLC_1	61	66	PF02516	0.482
MOD_NEK2_1	127	132	PF00069	0.467
MOD_NEK2_1	175	180	PF00069	0.315
MOD_NEK2_1	191	196	PF00069	0.479
MOD_NEK2_1	211	216	PF00069	0.199
MOD_NEK2_1	54	59	PF00069	0.551
MOD_NEK2_1	61	66	PF00069	0.671
MOD_PKA_2	80	86	PF00069	0.533
MOD_Plk_1	16	22	PF00069	0.560
MOD_Plk_1	175	181	PF00069	0.261
MOD_Plk_1	61	67	PF00069	0.546
MOD_Plk_1	79	85	PF00069	0.485
MOD_Plk_2-3	171	177	PF00069	0.529
MOD_Plk_2-3	80	86	PF00069	0.533
MOD_Plk_4	211	217	PF00069	0.529
MOD_ProDKin_1	169	175	PF00069	0.529
MOD_ProDKin_1	19	25	PF00069	0.550
MOD_ProDKin_1	26	32	PF00069	0.573
MOD_ProDKin_1	41	47	PF00069	0.706
MOD_ProDKin_1	75	81	PF00069	0.803
MOD_SUMO_for_1	1	4	PF00179	0.583
TRG_DiLeu_LyEn_5	205	210	PF01217	0.529
TRG_ENDOCYTIC_2	137	140	PF00928	0.562
TRG_ER_diArg_1	199	202	PF00400	0.529
TRG_ER_diArg_1	90	93	PF00400	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGP4	Leishmania donovani	76%	100%
A4I1N7	Leishmania infantum	76%	100%
E9AXS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q9Q0	Leishmania major	75%	100%