Vacuolar protein sorting 55

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting 55, putative

Species:

Leishmania braziliensis

UniProt:

A4HE90_LEIBR

TriTrypDb:

LbrM.25.1440 , LBRM2903_250027800

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HE90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE90

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	30	32	PF00082	0.359
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.361
DOC_USP7_MATH_1	118	122	PF00917	0.453
DOC_USP7_MATH_1	35	39	PF00917	0.407
DOC_WW_Pin1_4	42	47	PF00397	0.241
LIG_BIR_II_1	1	5	PF00653	0.350
LIG_BRCT_BRCA1_1	57	61	PF00533	0.326
LIG_FHA_1	117	123	PF00498	0.299
LIG_FHA_1	72	78	PF00498	0.365
LIG_FHA_1	95	101	PF00498	0.479
LIG_FHA_2	124	130	PF00498	0.269
LIG_IRF3_LxIS_1	4	10	PF10401	0.311
LIG_LIR_Gen_1	10	20	PF02991	0.376
LIG_LIR_Nem_3	10	15	PF02991	0.376
LIG_LIR_Nem_3	70	75	PF02991	0.336
LIG_NRBOX	105	111	PF00104	0.194
LIG_PDZ_Class_2	133	138	PF00595	0.436
LIG_SH2_STAT5	42	45	PF00017	0.407
LIG_SUMO_SIM_par_1	105	111	PF11976	0.211
LIG_SUMO_SIM_par_1	118	123	PF11976	0.211
LIG_TRAF2_1	127	130	PF00917	0.174
MOD_CK2_1	123	129	PF00069	0.260
MOD_GlcNHglycan	102	105	PF01048	0.370
MOD_GlcNHglycan	110	113	PF01048	0.384
MOD_GlcNHglycan	85	88	PF01048	0.341
MOD_GlcNHglycan	9	12	PF01048	0.363
MOD_GSK3_1	116	123	PF00069	0.353
MOD_NEK2_1	105	110	PF00069	0.294
MOD_NEK2_1	116	121	PF00069	0.314
MOD_NEK2_1	122	127	PF00069	0.246
MOD_NEK2_1	23	28	PF00069	0.202
MOD_NEK2_1	7	12	PF00069	0.328
MOD_NEK2_1	83	88	PF00069	0.340
MOD_NEK2_1	94	99	PF00069	0.305
MOD_Plk_4	105	111	PF00069	0.231
MOD_Plk_4	23	29	PF00069	0.336
MOD_Plk_4	35	41	PF00069	0.221
MOD_Plk_4	95	101	PF00069	0.480
MOD_ProDKin_1	42	48	PF00069	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL8	Leptomonas seymouri	69%	100%
A0A0S4JPU8	Bodo saltans	37%	100%
A0A1X0NY46	Trypanosomatidae	43%	100%
A0A3R7KZE9	Trypanosoma rangeli	38%	100%
A0A3S7WZC0	Leishmania donovani	81%	99%
A4I1N6	Leishmania infantum	81%	99%
C9ZK85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	88%
E9AXS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
O89013	Mus musculus	28%	100%
O95214	Homo sapiens	28%	100%
Q18319	Caenorhabditis elegans	26%	100%
Q32PD8	Bos taurus	28%	100%
Q4Q9Q1	Leishmania major	78%	100%
Q54VP1	Dictyostelium discoideum	27%	100%
Q561T9	Danio rerio	28%	100%
Q5RDE9	Pongo abelii	28%	100%
Q6PDU4	Rattus norvegicus	28%	100%
Q9AST6	Arabidopsis thaliana	27%	99%
Q9CQ74	Mus musculus	28%	100%
Q9UUH1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%