Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HE89_LEIBR

TriTrypDb:

LbrM.25.1430 , LBRM2903_250027700

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HE89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.523
CLV_NRD_NRD_1	220	222	PF00675	0.584
CLV_NRD_NRD_1	251	253	PF00675	0.434
CLV_NRD_NRD_1	27	29	PF00675	0.620
CLV_NRD_NRD_1	277	279	PF00675	0.710
CLV_NRD_NRD_1	339	341	PF00675	0.669
CLV_NRD_NRD_1	372	374	PF00675	0.617
CLV_NRD_NRD_1	84	86	PF00675	0.587
CLV_NRD_NRD_1	93	95	PF00675	0.599
CLV_PCSK_FUR_1	275	279	PF00082	0.710
CLV_PCSK_KEX2_1	220	222	PF00082	0.505
CLV_PCSK_KEX2_1	251	253	PF00082	0.434
CLV_PCSK_KEX2_1	27	29	PF00082	0.620
CLV_PCSK_KEX2_1	277	279	PF00082	0.710
CLV_PCSK_KEX2_1	339	341	PF00082	0.669
CLV_PCSK_KEX2_1	83	85	PF00082	0.625
CLV_PCSK_SKI1_1	277	281	PF00082	0.620
CLV_PCSK_SKI1_1	85	89	PF00082	0.563
DEG_Nend_UBRbox_2	1	3	PF02207	0.723
DOC_MAPK_gen_1	83	90	PF00069	0.541
DOC_MAPK_gen_1	92	101	PF00069	0.651
DOC_MAPK_MEF2A_6	83	90	PF00069	0.541
DOC_MAPK_NFAT4_5	83	91	PF00069	0.540
DOC_PP2B_LxvP_1	145	148	PF13499	0.576
DOC_USP7_MATH_1	214	218	PF00917	0.468
DOC_USP7_MATH_1	9	13	PF00917	0.674
DOC_WW_Pin1_4	100	105	PF00397	0.723
DOC_WW_Pin1_4	172	177	PF00397	0.807
DOC_WW_Pin1_4	185	190	PF00397	0.612
LIG_14-3-3_CanoR_1	191	198	PF00244	0.582
LIG_14-3-3_CanoR_1	235	241	PF00244	0.629
LIG_14-3-3_CanoR_1	35	41	PF00244	0.621
LIG_14-3-3_CterR_2	373	376	PF00244	0.499
LIG_Clathr_ClatBox_1	13	17	PF01394	0.648
LIG_eIF4E_1	253	259	PF01652	0.439
LIG_FHA_1	167	173	PF00498	0.761
LIG_FHA_1	198	204	PF00498	0.742
LIG_FHA_1	31	37	PF00498	0.719
LIG_FHA_1	318	324	PF00498	0.468
LIG_FHA_1	348	354	PF00498	0.408
LIG_FHA_1	77	83	PF00498	0.732
LIG_FHA_2	153	159	PF00498	0.573
LIG_FHA_2	202	208	PF00498	0.800
LIG_FHA_2	314	320	PF00498	0.520
LIG_LIR_Nem_3	162	168	PF02991	0.679
LIG_LIR_Nem_3	62	67	PF02991	0.716
LIG_MYND_1	143	147	PF01753	0.572
LIG_RPA_C_Fungi	79	91	PF08784	0.633
LIG_RPA_C_Plants	328	339	PF08784	0.541
LIG_SH2_CRK	64	68	PF00017	0.703
LIG_SH2_NCK_1	135	139	PF00017	0.580
LIG_SH2_SRC	253	256	PF00017	0.671
LIG_SH2_SRC	282	285	PF00017	0.714
LIG_SH2_STAP1	236	240	PF00017	0.456
LIG_SH2_STAP1	253	257	PF00017	0.583
LIG_SH2_STAP1	348	352	PF00017	0.579
LIG_SH3_1	141	147	PF00018	0.772
LIG_SH3_3	140	146	PF00018	0.755
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.654
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.559
LIG_SUMO_SIM_par_1	12	17	PF11976	0.592
LIG_SUMO_SIM_par_1	255	262	PF11976	0.457
LIG_TRAF2_1	21	24	PF00917	0.711
LIG_UBA3_1	48	53	PF00899	0.579
LIG_WW_2	143	146	PF00397	0.572
LIG_WW_3	188	192	PF00397	0.639
MOD_CDC14_SPxK_1	188	191	PF00782	0.684
MOD_CDK_SPxK_1	185	191	PF00069	0.826
MOD_CK1_1	317	323	PF00069	0.395
MOD_CK1_1	56	62	PF00069	0.568
MOD_CK2_1	152	158	PF00069	0.583
MOD_CK2_1	201	207	PF00069	0.807
MOD_CK2_1	287	293	PF00069	0.561
MOD_CK2_1	313	319	PF00069	0.519
MOD_GlcNHglycan	148	151	PF01048	0.705
MOD_GlcNHglycan	49	52	PF01048	0.662
MOD_GlcNHglycan	5	8	PF01048	0.608
MOD_GlcNHglycan	74	77	PF01048	0.532
MOD_GSK3_1	166	173	PF00069	0.552
MOD_GSK3_1	197	204	PF00069	0.793
MOD_GSK3_1	264	271	PF00069	0.659
MOD_GSK3_1	282	289	PF00069	0.449
MOD_GSK3_1	313	320	PF00069	0.413
MOD_GSK3_1	59	66	PF00069	0.607
MOD_GSK3_1	68	75	PF00069	0.593
MOD_N-GLC_1	72	77	PF02516	0.559
MOD_NEK2_1	72	77	PF00069	0.686
MOD_PIKK_1	152	158	PF00454	0.642
MOD_PIKK_1	166	172	PF00454	0.729
MOD_PK_1	53	59	PF00069	0.506
MOD_PKA_2	190	196	PF00069	0.668
MOD_Plk_1	198	204	PF00069	0.573
MOD_Plk_2-3	264	270	PF00069	0.504
MOD_Plk_4	110	116	PF00069	0.504
MOD_Plk_4	214	220	PF00069	0.462
MOD_Plk_4	253	259	PF00069	0.679
MOD_Plk_4	44	50	PF00069	0.520
MOD_Plk_4	56	62	PF00069	0.454
MOD_Plk_4	9	15	PF00069	0.746
MOD_ProDKin_1	100	106	PF00069	0.721
MOD_ProDKin_1	172	178	PF00069	0.809
MOD_ProDKin_1	185	191	PF00069	0.613
TRG_DiLeu_BaEn_1	110	115	PF01217	0.505
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.715
TRG_ENDOCYTIC_2	334	337	PF00928	0.552
TRG_ENDOCYTIC_2	64	67	PF00928	0.709
TRG_ER_diArg_1	219	221	PF00400	0.493
TRG_ER_diArg_1	250	252	PF00400	0.565
TRG_ER_diArg_1	26	28	PF00400	0.619
TRG_ER_diArg_1	275	278	PF00400	0.707
TRG_ER_diArg_1	339	341	PF00400	0.662
TRG_ER_diArg_1	82	85	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G6	Leptomonas seymouri	37%	100%
A0A3Q8IDF4	Leishmania donovani	72%	99%
A4I1N5	Leishmania infantum	73%	76%
E9AXR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q9Q2	Leishmania major	71%	100%