TPM_phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HE88_LEIBR

TriTrypDb:

LbrM.25.1420 , LBRM2903_250027600

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HE88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.396
CLV_PCSK_KEX2_1	22	24	PF00082	0.281
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.281
CLV_PCSK_PC7_1	18	24	PF00082	0.361
CLV_PCSK_SKI1_1	146	150	PF00082	0.285
CLV_PCSK_SKI1_1	157	161	PF00082	0.371
CLV_PCSK_SKI1_1	18	22	PF00082	0.339
CLV_PCSK_SKI1_1	226	230	PF00082	0.629
CLV_PCSK_SKI1_1	299	303	PF00082	0.502
CLV_PCSK_SKI1_1	312	316	PF00082	0.522
CLV_PCSK_SKI1_1	95	99	PF00082	0.341
DEG_APCC_DBOX_1	311	319	PF00400	0.321
DEG_Nend_UBRbox_2	1	3	PF02207	0.544
DOC_CDC14_PxL_1	179	187	PF14671	0.386
DOC_CKS1_1	64	69	PF01111	0.422
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.390
DOC_MAPK_gen_1	154	162	PF00069	0.648
DOC_MAPK_gen_1	21	30	PF00069	0.538
DOC_MAPK_MEF2A_6	180	189	PF00069	0.458
DOC_MAPK_MEF2A_6	343	350	PF00069	0.388
DOC_MAPK_MEF2A_6	51	58	PF00069	0.538
DOC_PP1_RVXF_1	165	171	PF00149	0.536
DOC_PP2B_LxvP_1	160	163	PF13499	0.556
DOC_PP4_FxxP_1	115	118	PF00568	0.486
DOC_USP7_UBL2_3	285	289	PF12436	0.308
DOC_WW_Pin1_4	63	68	PF00397	0.425
LIG_14-3-3_CanoR_1	23	31	PF00244	0.428
LIG_BRCT_BRCA1_1	72	76	PF00533	0.423
LIG_deltaCOP1_diTrp_1	327	333	PF00928	0.344
LIG_FHA_1	135	141	PF00498	0.448
LIG_FHA_1	194	200	PF00498	0.329
LIG_FHA_1	23	29	PF00498	0.538
LIG_FHA_1	278	284	PF00498	0.282
LIG_FHA_1	96	102	PF00498	0.462
LIG_FHA_2	151	157	PF00498	0.448
LIG_LIR_Apic_2	112	118	PF02991	0.483
LIG_LIR_Apic_2	61	67	PF02991	0.422
LIG_LIR_Gen_1	10	20	PF02991	0.549
LIG_LIR_Nem_3	10	16	PF02991	0.509
LIG_LIR_Nem_3	122	127	PF02991	0.428
LIG_LIR_Nem_3	327	333	PF02991	0.344
LIG_MLH1_MIPbox_1	72	76	PF16413	0.538
LIG_PDZ_Class_2	345	350	PF00595	0.426
LIG_Pex14_1	246	250	PF04695	0.227
LIG_Pex14_2	111	115	PF04695	0.428
LIG_PTB_Apo_2	69	76	PF02174	0.483
LIG_SH2_CRK	331	335	PF00017	0.329
LIG_SH2_CRK	64	68	PF00017	0.413
LIG_SH2_NCK_1	303	307	PF00017	0.385
LIG_SH2_SRC	142	145	PF00017	0.437
LIG_SH2_STAP1	331	335	PF00017	0.362
LIG_SH2_STAT5	110	113	PF00017	0.472
LIG_SH2_STAT5	184	187	PF00017	0.278
LIG_SH2_STAT5	250	253	PF00017	0.424
LIG_SH2_STAT5	279	282	PF00017	0.268
LIG_SH2_STAT5	64	67	PF00017	0.438
LIG_SH3_3	120	126	PF00018	0.538
LIG_SH3_3	311	317	PF00018	0.333
LIG_SH3_3	54	60	PF00018	0.428
LIG_SUMO_SIM_par_1	158	164	PF11976	0.587
LIG_SUMO_SIM_par_1	55	61	PF11976	0.428
LIG_TRAF2_1	106	109	PF00917	0.444
LIG_TYR_ITIM	182	187	PF00017	0.220
LIG_UBA3_1	159	167	PF00899	0.487
LIG_UBA3_1	287	293	PF00899	0.386
LIG_UBA3_1	42	51	PF00899	0.185
MOD_CDK_SPK_2	63	68	PF00069	0.272
MOD_CK1_1	103	109	PF00069	0.361
MOD_CK1_1	134	140	PF00069	0.292
MOD_CK2_1	103	109	PF00069	0.396
MOD_CK2_1	150	156	PF00069	0.353
MOD_CK2_1	289	295	PF00069	0.409
MOD_GlcNHglycan	102	105	PF01048	0.378
MOD_GlcNHglycan	32	35	PF01048	0.359
MOD_GSK3_1	335	342	PF00069	0.493
MOD_GSK3_1	45	52	PF00069	0.377
MOD_GSK3_1	58	65	PF00069	0.208
MOD_N-GLC_2	238	240	PF02516	0.346
MOD_NEK2_1	190	195	PF00069	0.333
MOD_NEK2_1	203	208	PF00069	0.406
MOD_NEK2_1	301	306	PF00069	0.480
MOD_NEK2_1	70	75	PF00069	0.302
MOD_OFUCOSY	276	281	PF10250	0.332
MOD_PIKK_1	131	137	PF00454	0.417
MOD_PIKK_1	198	204	PF00454	0.490
MOD_PIKK_1	335	341	PF00454	0.495
MOD_PKA_1	22	28	PF00069	0.262
MOD_PKA_1	299	305	PF00069	0.476
MOD_PKA_2	22	28	PF00069	0.262
MOD_Plk_1	220	226	PF00069	0.396
MOD_Plk_1	95	101	PF00069	0.274
MOD_Plk_4	193	199	PF00069	0.194
MOD_Plk_4	253	259	PF00069	0.513
MOD_Plk_4	70	76	PF00069	0.262
MOD_ProDKin_1	63	69	PF00069	0.259
TRG_ENDOCYTIC_2	184	187	PF00928	0.270
TRG_ENDOCYTIC_2	242	245	PF00928	0.344
TRG_ENDOCYTIC_2	319	322	PF00928	0.490
TRG_ENDOCYTIC_2	331	334	PF00928	0.391
TRG_ENDOCYTIC_2	6	9	PF00928	0.359
TRG_ER_FFAT_2	275	284	PF00635	0.398
TRG_NLS_Bipartite_1	7	25	PF00514	0.398
TRG_NLS_MonoExtC_3	20	26	PF00514	0.359
TRG_NLS_MonoExtN_4	18	25	PF00514	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC6	Leptomonas seymouri	85%	79%
A0A0S4JYA2	Bodo saltans	63%	83%
A0A1X0NZJ4	Trypanosomatidae	62%	71%
A0A3Q8IDD5	Leishmania donovani	89%	80%
A0A3R7N4K9	Trypanosoma rangeli	67%	76%
A4I1N4	Leishmania infantum	89%	80%
C9ZK83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	87%
C9ZK84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	96%
E9AXR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	80%
Q4Q9Q3	Leishmania major	89%	100%
V5BHX3	Trypanosoma cruzi	68%	80%