Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HE87_LEIBR

TriTrypDb:

LbrM.25.1410 , LBRM2903_250027500

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	11
GO:0005840	ribosome	5	16
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	16
GO:0043228	non-membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043232	intracellular non-membrane-bounded organelle	4	16
GO:0071013	catalytic step 2 spliceosome	3	11
GO:0110165	cellular anatomical entity	1	16
GO:0140513	nuclear protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990904	ribonucleoprotein complex	2	16
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HE87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE87

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.671
CLV_NRD_NRD_1	220	222	PF00675	0.564
CLV_NRD_NRD_1	41	43	PF00675	0.744
CLV_NRD_NRD_1	59	61	PF00675	0.445
CLV_PCSK_KEX2_1	108	110	PF00082	0.586
CLV_PCSK_KEX2_1	220	222	PF00082	0.564
CLV_PCSK_KEX2_1	40	42	PF00082	0.592
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.554
CLV_PCSK_SKI1_1	156	160	PF00082	0.393
CLV_PCSK_SKI1_1	184	188	PF00082	0.450
CLV_PCSK_SKI1_1	259	263	PF00082	0.333
CLV_PCSK_SKI1_1	336	340	PF00082	0.279
CLV_PCSK_SKI1_1	371	375	PF00082	0.234
CLV_PCSK_SKI1_1	442	446	PF00082	0.288
CLV_PCSK_SKI1_1	486	490	PF00082	0.457
CLV_PCSK_SKI1_1	507	511	PF00082	0.291
DEG_SPOP_SBC_1	203	207	PF00917	0.580
DEG_SPOP_SBC_1	88	92	PF00917	0.505
DOC_CKS1_1	7	12	PF01111	0.497
DOC_CYCLIN_yCln2_LP_2	499	505	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.400
DOC_MAPK_gen_1	486	496	PF00069	0.454
DOC_PP1_RVXF_1	422	429	PF00149	0.449
DOC_PP2B_LxvP_1	159	162	PF13499	0.394
DOC_PP4_FxxP_1	158	161	PF00568	0.382
DOC_PP4_FxxP_1	187	190	PF00568	0.537
DOC_USP7_MATH_1	118	122	PF00917	0.594
DOC_USP7_MATH_1	125	129	PF00917	0.551
DOC_USP7_MATH_1	202	206	PF00917	0.653
DOC_USP7_MATH_1	271	275	PF00917	0.467
DOC_USP7_MATH_1	282	286	PF00917	0.422
DOC_USP7_MATH_1	417	421	PF00917	0.485
DOC_USP7_MATH_1	88	92	PF00917	0.605
DOC_USP7_UBL2_3	482	486	PF12436	0.471
DOC_WW_Pin1_4	136	141	PF00397	0.511
DOC_WW_Pin1_4	385	390	PF00397	0.492
DOC_WW_Pin1_4	52	57	PF00397	0.513
DOC_WW_Pin1_4	6	11	PF00397	0.526
LIG_14-3-3_CanoR_1	131	140	PF00244	0.441
LIG_14-3-3_CanoR_1	252	262	PF00244	0.461
LIG_14-3-3_CanoR_1	379	385	PF00244	0.478
LIG_14-3-3_CanoR_1	463	470	PF00244	0.419
LIG_APCC_ABBA_1	425	430	PF00400	0.338
LIG_APCC_ABBAyCdc20_2	424	430	PF00400	0.347
LIG_CSL_BTD_1	499	502	PF09270	0.384
LIG_EVH1_1	63	67	PF00568	0.568
LIG_FHA_1	111	117	PF00498	0.533
LIG_FHA_1	128	134	PF00498	0.668
LIG_FHA_1	2	8	PF00498	0.677
LIG_FHA_1	256	262	PF00498	0.510
LIG_FHA_1	267	273	PF00498	0.468
LIG_FHA_1	284	290	PF00498	0.456
LIG_FHA_1	402	408	PF00498	0.406
LIG_FHA_1	479	485	PF00498	0.280
LIG_FHA_1	504	510	PF00498	0.447
LIG_FHA_2	105	111	PF00498	0.499
LIG_FHA_2	306	312	PF00498	0.402
LIG_FHA_2	372	378	PF00498	0.432
LIG_FHA_2	409	415	PF00498	0.489
LIG_FHA_2	52	58	PF00498	0.510
LIG_FHA_2	7	13	PF00498	0.675
LIG_Integrin_isoDGR_2	22	24	PF01839	0.422
LIG_LIR_Apic_2	157	161	PF02991	0.381
LIG_LIR_Apic_2	383	389	PF02991	0.492
LIG_LIR_Apic_2	51	56	PF02991	0.586
LIG_LIR_Nem_3	497	503	PF02991	0.345
LIG_PCNA_PIPBox_1	493	502	PF02747	0.440
LIG_PCNA_yPIPBox_3	40	50	PF02747	0.444
LIG_PCNA_yPIPBox_3	486	500	PF02747	0.448
LIG_PDZ_Wminus1_1	519	521	PF00595	0.338
LIG_SH2_CRK	386	390	PF00017	0.496
LIG_SH2_NCK_1	193	197	PF00017	0.456
LIG_SH2_NCK_1	53	57	PF00017	0.642
LIG_SH2_SRC	34	37	PF00017	0.543
LIG_SH2_STAP1	193	197	PF00017	0.419
LIG_SH2_STAP1	340	344	PF00017	0.329
LIG_SH2_STAT5	153	156	PF00017	0.512
LIG_SH2_STAT5	34	37	PF00017	0.697
LIG_SH2_STAT5	353	356	PF00017	0.439
LIG_SH2_STAT5	464	467	PF00017	0.444
LIG_SH2_STAT5	475	478	PF00017	0.444
LIG_SH2_STAT5	53	56	PF00017	0.443
LIG_SH3_1	61	67	PF00018	0.562
LIG_SH3_2	502	507	PF14604	0.363
LIG_SH3_3	407	413	PF00018	0.461
LIG_SH3_3	499	505	PF00018	0.401
LIG_SH3_3	61	67	PF00018	0.562
LIG_SUMO_SIM_par_1	290	297	PF11976	0.410
LIG_SUMO_SIM_par_1	48	55	PF11976	0.642
LIG_WRC_WIRS_1	262	267	PF05994	0.438
LIG_WW_1	235	238	PF00397	0.483
LIG_WW_3	178	182	PF00397	0.413
MOD_CK1_1	117	123	PF00069	0.597
MOD_CK1_1	195	201	PF00069	0.718
MOD_CK1_1	285	291	PF00069	0.434
MOD_CK1_1	367	373	PF00069	0.536
MOD_CK1_1	97	103	PF00069	0.687
MOD_CK2_1	104	110	PF00069	0.579
MOD_CK2_1	131	137	PF00069	0.730
MOD_CK2_1	154	160	PF00069	0.489
MOD_CK2_1	161	167	PF00069	0.493
MOD_CK2_1	371	377	PF00069	0.432
MOD_CK2_1	408	414	PF00069	0.491
MOD_CK2_1	42	48	PF00069	0.612
MOD_CK2_1	51	57	PF00069	0.549
MOD_GlcNHglycan	116	119	PF01048	0.643
MOD_GlcNHglycan	133	136	PF01048	0.494
MOD_GlcNHglycan	194	197	PF01048	0.487
MOD_GlcNHglycan	200	203	PF01048	0.603
MOD_GlcNHglycan	221	224	PF01048	0.526
MOD_GlcNHglycan	225	228	PF01048	0.616
MOD_GlcNHglycan	243	246	PF01048	0.400
MOD_GlcNHglycan	299	302	PF01048	0.283
MOD_GlcNHglycan	449	452	PF01048	0.336
MOD_GlcNHglycan	466	469	PF01048	0.385
MOD_GlcNHglycan	96	99	PF01048	0.657
MOD_GSK3_1	110	117	PF00069	0.532
MOD_GSK3_1	127	134	PF00069	0.526
MOD_GSK3_1	198	205	PF00069	0.650
MOD_GSK3_1	219	226	PF00069	0.559
MOD_GSK3_1	271	278	PF00069	0.458
MOD_GSK3_1	285	292	PF00069	0.503
MOD_GSK3_1	367	374	PF00069	0.538
MOD_GSK3_1	445	452	PF00069	0.449
MOD_GSK3_1	48	55	PF00069	0.447
MOD_GSK3_1	503	510	PF00069	0.364
MOD_GSK3_1	89	96	PF00069	0.692
MOD_LATS_1	440	446	PF00433	0.337
MOD_N-GLC_1	254	259	PF02516	0.490
MOD_N-GLC_1	361	366	PF02516	0.232
MOD_N-GLC_1	42	47	PF02516	0.508
MOD_NEK2_1	104	109	PF00069	0.706
MOD_NEK2_1	116	121	PF00069	0.662
MOD_NEK2_1	154	159	PF00069	0.435
MOD_NEK2_1	253	258	PF00069	0.451
MOD_NEK2_1	261	266	PF00069	0.508
MOD_NEK2_1	275	280	PF00069	0.577
MOD_NEK2_1	361	366	PF00069	0.454
MOD_NEK2_1	484	489	PF00069	0.395
MOD_NEK2_1	494	499	PF00069	0.480
MOD_PIKK_1	266	272	PF00454	0.451
MOD_PIKK_1	408	414	PF00454	0.491
MOD_PK_1	42	48	PF00069	0.533
MOD_PKA_2	219	225	PF00069	0.587
MOD_Plk_1	361	367	PF00069	0.466
MOD_Plk_1	377	383	PF00069	0.444
MOD_Plk_1	42	48	PF00069	0.507
MOD_Plk_1	484	490	PF00069	0.488
MOD_Plk_1	75	81	PF00069	0.474
MOD_Plk_2-3	75	81	PF00069	0.489
MOD_Plk_4	154	160	PF00069	0.519
MOD_Plk_4	161	167	PF00069	0.557
MOD_Plk_4	34	40	PF00069	0.586
MOD_Plk_4	356	362	PF00069	0.438
MOD_Plk_4	48	54	PF00069	0.516
MOD_Plk_4	66	72	PF00069	0.777
MOD_Plk_4	75	81	PF00069	0.662
MOD_ProDKin_1	136	142	PF00069	0.496
MOD_ProDKin_1	385	391	PF00069	0.489
MOD_ProDKin_1	52	58	PF00069	0.511
MOD_ProDKin_1	6	12	PF00069	0.518
TRG_DiLeu_BaEn_1	325	330	PF01217	0.460
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.414
TRG_ENDOCYTIC_2	238	241	PF00928	0.408
TRG_ER_diArg_1	435	438	PF00400	0.363
TRG_NLS_MonoExtC_3	104	109	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB3	Leptomonas seymouri	69%	98%
A0A1X0NZP7	Trypanosomatidae	52%	100%
A0A3Q8IDI9	Leishmania donovani	86%	100%
A0A3R7NW31	Trypanosoma rangeli	50%	100%
A0A3S7WR72	Leishmania donovani	23%	100%
A4H666	Leishmania braziliensis	22%	100%
A4HUJ0	Leishmania infantum	23%	100%
A4I1N3	Leishmania infantum	86%	100%
C9ZK82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AXR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q9Q4	Leishmania major	86%	100%
Q4QHD6	Leishmania major	23%	100%
V5BRZ9	Trypanosoma cruzi	51%	98%