Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HE84_LEIBR

TriTrypDb:

LbrM.25.1380 , LBRM2903_250027200

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HE84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.701
CLV_NRD_NRD_1	112	114	PF00675	0.459
CLV_NRD_NRD_1	115	117	PF00675	0.413
CLV_NRD_NRD_1	130	132	PF00675	0.399
CLV_NRD_NRD_1	135	137	PF00675	0.363
CLV_NRD_NRD_1	145	147	PF00675	0.466
CLV_NRD_NRD_1	181	183	PF00675	0.674
CLV_NRD_NRD_1	788	790	PF00675	0.755
CLV_NRD_NRD_1	815	817	PF00675	0.686
CLV_NRD_NRD_1	98	100	PF00675	0.655
CLV_PCSK_FUR_1	113	117	PF00082	0.613
CLV_PCSK_KEX2_1	111	113	PF00082	0.640
CLV_PCSK_KEX2_1	115	117	PF00082	0.581
CLV_PCSK_KEX2_1	129	131	PF00082	0.406
CLV_PCSK_KEX2_1	135	137	PF00082	0.363
CLV_PCSK_KEX2_1	181	183	PF00082	0.657
CLV_PCSK_KEX2_1	817	819	PF00082	0.748
CLV_PCSK_PC1ET2_1	817	819	PF00082	0.748
CLV_PCSK_PC7_1	107	113	PF00082	0.588
CLV_PCSK_PC7_1	131	137	PF00082	0.601
CLV_PCSK_SKI1_1	100	104	PF00082	0.599
CLV_PCSK_SKI1_1	130	134	PF00082	0.611
CLV_PCSK_SKI1_1	303	307	PF00082	0.552
DEG_SPOP_SBC_1	227	231	PF00917	0.754
DOC_CDC14_PxL_1	61	69	PF14671	0.689
DOC_PP1_SILK_1	309	314	PF00149	0.532
DOC_USP7_MATH_1	180	184	PF00917	0.697
DOC_USP7_MATH_1	245	249	PF00917	0.658
DOC_USP7_MATH_1	27	31	PF00917	0.551
DOC_USP7_MATH_1	362	366	PF00917	0.564
DOC_USP7_MATH_1	501	505	PF00917	0.653
DOC_USP7_MATH_1	697	701	PF00917	0.560
DOC_USP7_MATH_1	776	780	PF00917	0.706
DOC_USP7_MATH_1	833	837	PF00917	0.584
DOC_USP7_UBL2_3	535	539	PF12436	0.589
DOC_USP7_UBL2_3	731	735	PF12436	0.581
DOC_WW_Pin1_4	46	51	PF00397	0.728
DOC_WW_Pin1_4	487	492	PF00397	0.669
DOC_WW_Pin1_4	514	519	PF00397	0.576
DOC_WW_Pin1_4	683	688	PF00397	0.552
DOC_WW_Pin1_4	710	715	PF00397	0.574
DOC_WW_Pin1_4	780	785	PF00397	0.644
DOC_WW_Pin1_4	804	809	PF00397	0.760
DOC_WW_Pin1_4	831	836	PF00397	0.570
LIG_14-3-3_CanoR_1	12	17	PF00244	0.811
LIG_14-3-3_CanoR_1	326	331	PF00244	0.565
LIG_14-3-3_CanoR_1	37	45	PF00244	0.810
LIG_Actin_WH2_2	298	315	PF00022	0.545
LIG_APCC_ABBA_1	82	87	PF00400	0.660
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BIR_III_2	295	299	PF00653	0.557
LIG_BRCT_BRCA1_1	314	318	PF00533	0.542
LIG_FHA_1	215	221	PF00498	0.571
LIG_FHA_1	523	529	PF00498	0.610
LIG_FHA_1	719	725	PF00498	0.607
LIG_FHA_1	775	781	PF00498	0.567
LIG_FHA_2	272	278	PF00498	0.690
LIG_FHA_2	410	416	PF00498	0.749
LIG_FHA_2	527	533	PF00498	0.671
LIG_FHA_2	606	612	PF00498	0.597
LIG_FHA_2	723	729	PF00498	0.637
LIG_HCF-1_HBM_1	223	226	PF13415	0.756
LIG_LIR_Gen_1	484	491	PF02991	0.560
LIG_LIR_Gen_1	680	687	PF02991	0.549
LIG_LIR_Nem_3	19	25	PF02991	0.622
LIG_LIR_Nem_3	484	488	PF02991	0.562
LIG_LIR_Nem_3	680	684	PF02991	0.553
LIG_MYND_1	91	95	PF01753	0.586
LIG_Pex14_2	427	431	PF04695	0.569
LIG_Pex14_2	623	627	PF04695	0.565
LIG_SH2_GRB2like	249	252	PF00017	0.572
LIG_SH2_STAP1	39	43	PF00017	0.735
LIG_SH2_STAP1	485	489	PF00017	0.567
LIG_SH2_STAP1	681	685	PF00017	0.554
LIG_SH2_STAT5	226	229	PF00017	0.757
LIG_SH2_STAT5	357	360	PF00017	0.567
LIG_SH2_STAT5	388	391	PF00017	0.751
LIG_SH2_STAT5	454	457	PF00017	0.777
LIG_SH2_STAT5	584	587	PF00017	0.549
LIG_SH2_STAT5	650	653	PF00017	0.582
LIG_SH3_1	171	177	PF00018	0.747
LIG_SH3_3	171	177	PF00018	0.747
LIG_SH3_3	265	271	PF00018	0.752
LIG_SH3_3	441	447	PF00018	0.759
LIG_SH3_3	62	68	PF00018	0.778
LIG_SH3_3	637	643	PF00018	0.627
LIG_SH3_3	827	833	PF00018	0.718
LIG_SH3_4	535	542	PF00018	0.589
LIG_SH3_4	731	738	PF00018	0.586
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.575
LIG_SUMO_SIM_anti_2	698	703	PF11976	0.564
LIG_TRAF2_1	274	277	PF00917	0.765
LIG_TRAF2_1	391	394	PF00917	0.646
LIG_TRAF2_1	412	415	PF00917	0.667
LIG_TRAF2_1	477	480	PF00917	0.760
LIG_TRAF2_1	551	554	PF00917	0.595
LIG_TRAF2_1	587	590	PF00917	0.541
LIG_TRAF2_1	608	611	PF00917	0.633
LIG_TRAF2_1	673	676	PF00917	0.577
LIG_TRAF2_1	747	750	PF00917	0.585
LIG_TRAF2_1	76	79	PF00917	0.679
LIG_TRAF2_1	794	797	PF00917	0.546
LIG_TRFH_1	72	76	PF08558	0.674
LIG_TYR_ITIM	483	488	PF00017	0.561
LIG_TYR_ITIM	679	684	PF00017	0.552
MOD_CDC14_SPxK_1	490	493	PF00782	0.562
MOD_CDC14_SPxK_1	686	689	PF00782	0.556
MOD_CDC14_SPxK_1	807	810	PF00782	0.765
MOD_CDK_SPK_2	487	492	PF00069	0.561
MOD_CDK_SPK_2	683	688	PF00069	0.552
MOD_CDK_SPxK_1	487	493	PF00069	0.562
MOD_CDK_SPxK_1	683	689	PF00069	0.554
MOD_CDK_SPxK_1	804	810	PF00069	0.764
MOD_CK1_1	167	173	PF00069	0.650
MOD_CK1_1	183	189	PF00069	0.571
MOD_CK1_1	229	235	PF00069	0.751
MOD_CK1_1	23	29	PF00069	0.801
MOD_CK1_1	238	244	PF00069	0.646
MOD_CK1_1	247	253	PF00069	0.543
MOD_CK1_1	307	313	PF00069	0.704
MOD_CK1_1	314	320	PF00069	0.663
MOD_CK1_1	321	327	PF00069	0.579
MOD_CK1_1	430	436	PF00069	0.757
MOD_CK1_1	495	501	PF00069	0.655
MOD_CK1_1	56	62	PF00069	0.608
MOD_CK1_1	576	582	PF00069	0.559
MOD_CK1_1	626	632	PF00069	0.693
MOD_CK1_1	691	697	PF00069	0.560
MOD_CK1_1	771	777	PF00069	0.754
MOD_CK1_1	821	827	PF00069	0.766
MOD_CK1_1	834	840	PF00069	0.705
MOD_CK2_1	27	33	PF00069	0.550
MOD_CK2_1	271	277	PF00069	0.571
MOD_CK2_1	409	415	PF00069	0.674
MOD_CK2_1	474	480	PF00069	0.583
MOD_CK2_1	501	507	PF00069	0.572
MOD_CK2_1	526	532	PF00069	0.618
MOD_CK2_1	542	548	PF00069	0.560
MOD_CK2_1	605	611	PF00069	0.593
MOD_CK2_1	670	676	PF00069	0.581
MOD_CK2_1	697	703	PF00069	0.564
MOD_CK2_1	722	728	PF00069	0.619
MOD_CK2_1	738	744	PF00069	0.558
MOD_CK2_1	835	841	PF00069	0.762
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.728
MOD_GlcNHglycan	177	180	PF01048	0.782
MOD_GlcNHglycan	182	185	PF01048	0.798
MOD_GlcNHglycan	231	234	PF01048	0.746
MOD_GlcNHglycan	237	240	PF01048	0.685
MOD_GlcNHglycan	25	28	PF01048	0.748
MOD_GlcNHglycan	382	385	PF01048	0.751
MOD_GlcNHglycan	41	44	PF01048	0.602
MOD_GlcNHglycan	474	477	PF01048	0.603
MOD_GlcNHglycan	543	547	PF01048	0.597
MOD_GlcNHglycan	578	581	PF01048	0.706
MOD_GlcNHglycan	670	673	PF01048	0.587
MOD_GlcNHglycan	739	743	PF01048	0.641
MOD_GlcNHglycan	774	777	PF01048	0.745
MOD_GlcNHglycan	825	828	PF01048	0.722
MOD_GSK3_1	12	19	PF00069	0.823
MOD_GSK3_1	160	167	PF00069	0.661
MOD_GSK3_1	225	232	PF00069	0.753
MOD_GSK3_1	23	30	PF00069	0.643
MOD_GSK3_1	240	247	PF00069	0.582
MOD_GSK3_1	303	310	PF00069	0.694
MOD_GSK3_1	312	319	PF00069	0.654
MOD_GSK3_1	321	328	PF00069	0.548
MOD_GSK3_1	375	382	PF00069	0.742
MOD_GSK3_1	46	53	PF00069	0.763
MOD_GSK3_1	492	499	PF00069	0.680
MOD_GSK3_1	522	529	PF00069	0.584
MOD_GSK3_1	56	63	PF00069	0.637
MOD_GSK3_1	571	578	PF00069	0.616
MOD_GSK3_1	688	695	PF00069	0.559
MOD_GSK3_1	718	725	PF00069	0.580
MOD_GSK3_1	767	774	PF00069	0.749
MOD_GSK3_1	776	783	PF00069	0.647
MOD_GSK3_1	818	825	PF00069	0.759
MOD_GSK3_1	831	838	PF00069	0.600
MOD_N-GLC_1	373	378	PF02516	0.572
MOD_N-GLC_1	496	501	PF02516	0.592
MOD_N-GLC_1	692	697	PF02516	0.553
MOD_N-GLC_1	771	776	PF02516	0.570
MOD_NEK2_1	312	317	PF00069	0.537
MOD_NEK2_1	318	323	PF00069	0.531
MOD_NEK2_1	375	380	PF00069	0.563
MOD_NEK2_1	38	43	PF00069	0.604
MOD_NEK2_1	427	432	PF00069	0.755
MOD_NEK2_1	573	578	PF00069	0.605
MOD_NEK2_1	623	628	PF00069	0.566
MOD_NEK2_1	822	827	PF00069	0.757
MOD_PIKK_1	373	379	PF00454	0.570
MOD_PIKK_1	548	554	PF00454	0.595
MOD_PIKK_1	744	750	PF00454	0.604
MOD_PK_1	12	18	PF00069	0.738
MOD_PKA_1	492	498	PF00069	0.606
MOD_PKA_1	688	694	PF00069	0.561
MOD_PKA_2	158	164	PF00069	0.635
MOD_PKA_2	180	186	PF00069	0.798
MOD_PKA_2	214	220	PF00069	0.573
MOD_PKA_2	23	29	PF00069	0.778
MOD_PKA_2	307	313	PF00069	0.648
MOD_PKA_2	325	331	PF00069	0.532
MOD_PKB_1	816	824	PF00069	0.572
MOD_Plk_1	277	283	PF00069	0.714
MOD_Plk_1	362	368	PF00069	0.749
MOD_Plk_1	427	433	PF00069	0.571
MOD_Plk_1	501	507	PF00069	0.572
MOD_Plk_1	623	629	PF00069	0.566
MOD_Plk_1	697	703	PF00069	0.564
MOD_Plk_1	70	76	PF00069	0.672
MOD_Plk_1	818	824	PF00069	0.574
MOD_Plk_2-3	277	283	PF00069	0.751
MOD_Plk_2-3	467	473	PF00069	0.593
MOD_Plk_2-3	663	669	PF00069	0.584
MOD_Plk_4	307	313	PF00069	0.538
MOD_Plk_4	501	507	PF00069	0.572
MOD_Plk_4	697	703	PF00069	0.564
MOD_Plk_4	818	824	PF00069	0.574
MOD_ProDKin_1	46	52	PF00069	0.729
MOD_ProDKin_1	487	493	PF00069	0.670
MOD_ProDKin_1	514	520	PF00069	0.579
MOD_ProDKin_1	683	689	PF00069	0.554
MOD_ProDKin_1	710	716	PF00069	0.574
MOD_ProDKin_1	780	786	PF00069	0.645
MOD_ProDKin_1	804	810	PF00069	0.764
MOD_ProDKin_1	831	837	PF00069	0.572
MOD_SUMO_for_1	342	345	PF00179	0.679
MOD_SUMO_for_1	794	797	PF00179	0.546
MOD_SUMO_rev_2	275	280	PF00179	0.572
MOD_SUMO_rev_2	393	398	PF00179	0.584
MOD_SUMO_rev_2	467	475	PF00179	0.593
MOD_SUMO_rev_2	532	537	PF00179	0.765
MOD_SUMO_rev_2	589	594	PF00179	0.608
MOD_SUMO_rev_2	663	671	PF00179	0.585
MOD_SUMO_rev_2	728	733	PF00179	0.732
TRG_DiLeu_BaEn_1	89	94	PF01217	0.594
TRG_ENDOCYTIC_2	485	488	PF00928	0.566
TRG_ENDOCYTIC_2	681	684	PF00928	0.553
TRG_ENDOCYTIC_2	85	88	PF00928	0.729
TRG_ER_diArg_1	111	113	PF00400	0.636
TRG_ER_diArg_1	114	116	PF00400	0.593
TRG_ER_diArg_1	129	131	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZ94	Leishmania donovani	66%	100%
E9AXR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	99%
Q4Q9Q7	Leishmania major	66%	100%