Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein 24 kDa

Species:

Leishmania braziliensis

UniProt:

A4HE80_LEIBR

TriTrypDb:

LbrM.25.1340 , LBRM2903_250023700

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HE80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HE80

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.551
CLV_NRD_NRD_1	218	220	PF00675	0.661
CLV_NRD_NRD_1	83	85	PF00675	0.683
CLV_PCSK_KEX2_1	117	119	PF00082	0.590
CLV_PCSK_KEX2_1	218	220	PF00082	0.661
CLV_PCSK_KEX2_1	82	84	PF00082	0.682
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.651
CLV_PCSK_SKI1_1	192	196	PF00082	0.622
DOC_CKS1_1	154	159	PF01111	0.440
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.642
DOC_MAPK_DCC_7	99	108	PF00069	0.622
DOC_MAPK_JIP1_4	197	203	PF00069	0.645
DOC_MAPK_MEF2A_6	197	205	PF00069	0.635
DOC_PP1_RVXF_1	82	89	PF00149	0.680
DOC_USP7_MATH_1	129	133	PF00917	0.580
DOC_USP7_MATH_1	173	177	PF00917	0.538
DOC_USP7_MATH_1	61	65	PF00917	0.683
DOC_WW_Pin1_4	122	127	PF00397	0.748
DOC_WW_Pin1_4	153	158	PF00397	0.438
LIG_14-3-3_CanoR_1	192	201	PF00244	0.614
LIG_14-3-3_CanoR_1	218	224	PF00244	0.682
LIG_14-3-3_CanoR_1	82	87	PF00244	0.731
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BRCT_BRCA1_1	131	135	PF00533	0.548
LIG_CtBP_PxDLS_1	105	109	PF00389	0.574
LIG_deltaCOP1_diTrp_1	243	249	PF00928	0.595
LIG_eIF4E_1	69	75	PF01652	0.634
LIG_FHA_2	210	216	PF00498	0.551
LIG_LIR_Gen_1	12	22	PF02991	0.489
LIG_LIR_Gen_1	30	39	PF02991	0.469
LIG_LIR_Gen_1	85	96	PF02991	0.735
LIG_LIR_Nem_3	12	17	PF02991	0.570
LIG_LIR_Nem_3	30	34	PF02991	0.425
LIG_LIR_Nem_3	85	91	PF02991	0.707
LIG_MYND_1	101	105	PF01753	0.623
LIG_PCNA_yPIPBox_3	68	82	PF02747	0.683
LIG_SH2_CRK	14	18	PF00017	0.590
LIG_SH2_GRB2like	202	205	PF00017	0.549
LIG_SH2_SRC	147	150	PF00017	0.492
LIG_SH2_STAP1	227	231	PF00017	0.498
LIG_SH2_STAT5	113	116	PF00017	0.554
LIG_SH2_STAT5	147	150	PF00017	0.458
LIG_SH2_STAT5	16	19	PF00017	0.510
LIG_SH2_STAT5	161	164	PF00017	0.516
LIG_SH2_STAT5	202	205	PF00017	0.549
LIG_SH2_STAT5	227	230	PF00017	0.497
LIG_SH2_STAT5	69	72	PF00017	0.703
LIG_SH3_3	154	160	PF00018	0.458
LIG_SH3_3	30	36	PF00018	0.544
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.543
LIG_SUMO_SIM_par_1	9	15	PF11976	0.603
LIG_TRAF2_1	212	215	PF00917	0.665
LIG_TRAF2_1	237	240	PF00917	0.660
LIG_TYR_ITIM	200	205	PF00017	0.564
LIG_WRC_WIRS_1	93	98	PF05994	0.704
LIG_WW_3	189	193	PF00397	0.653
MOD_CDK_SPxK_1	153	159	PF00069	0.548
MOD_CK1_1	226	232	PF00069	0.702
MOD_CK1_1	60	66	PF00069	0.610
MOD_CK2_1	209	215	PF00069	0.653
MOD_CK2_1	233	239	PF00069	0.664
MOD_CK2_1	45	51	PF00069	0.588
MOD_CMANNOS	246	249	PF00535	0.598
MOD_GlcNHglycan	131	134	PF01048	0.750
MOD_GlcNHglycan	140	143	PF01048	0.657
MOD_GlcNHglycan	229	232	PF01048	0.736
MOD_GlcNHglycan	235	238	PF01048	0.657
MOD_GlcNHglycan	47	50	PF01048	0.607
MOD_GlcNHglycan	59	62	PF01048	0.675
MOD_GlcNHglycan	96	99	PF01048	0.487
MOD_GSK3_1	219	226	PF00069	0.623
MOD_GSK3_1	229	236	PF00069	0.667
MOD_GSK3_1	57	64	PF00069	0.593
MOD_PIKK_1	192	198	PF00454	0.598
MOD_PIKK_1	69	75	PF00454	0.688
MOD_PKA_1	218	224	PF00069	0.682
MOD_PKA_1	82	88	PF00069	0.733
MOD_PKA_2	129	135	PF00069	0.783
MOD_PKA_2	218	224	PF00069	0.671
MOD_PKA_2	82	88	PF00069	0.733
MOD_Plk_4	219	225	PF00069	0.450
MOD_Plk_4	6	12	PF00069	0.651
MOD_Plk_4	61	67	PF00069	0.683
MOD_ProDKin_1	122	128	PF00069	0.752
MOD_ProDKin_1	153	159	PF00069	0.445
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.446
TRG_ENDOCYTIC_2	14	17	PF00928	0.580
TRG_ENDOCYTIC_2	147	150	PF00928	0.540
TRG_ENDOCYTIC_2	202	205	PF00928	0.549
TRG_ER_diArg_1	116	119	PF00400	0.580
TRG_ER_diArg_1	217	219	PF00400	0.672
TRG_ER_diArg_1	81	84	PF00400	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN1	Leptomonas seymouri	57%	97%
A0A1X0NM21	Trypanosomatidae	27%	100%
A0A3S5H7E8	Leishmania donovani	86%	96%
A4I1I9	Leishmania infantum	86%	96%
C9ZJX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	97%
Q4Q9U8	Leishmania major	88%	100%